KR100699396B1 - 자기 공명 연구 방법 - Google Patents
자기 공명 연구 방법 Download PDFInfo
- Publication number
- KR100699396B1 KR100699396B1 KR1020007007423A KR20007007423A KR100699396B1 KR 100699396 B1 KR100699396 B1 KR 100699396B1 KR 1020007007423 A KR1020007007423 A KR 1020007007423A KR 20007007423 A KR20007007423 A KR 20007007423A KR 100699396 B1 KR100699396 B1 KR 100699396B1
- Authority
- KR
- South Korea
- Prior art keywords
- delete delete
- formulation
- agent
- magnetic field
- polarization
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 *C(c1c(*)c(C(*)=O)c(*)c(C(*)=O)c1*)=O Chemical compound *C(c1c(*)c(C(*)=O)c(*)c(C(*)=O)c1*)=O 0.000 description 11
- CDAISMWEOUEBRE-UHFFFAOYSA-N OC(C(C(C(C1O)O)O)O)C1O Chemical compound OC(C(C(C(C1O)O)O)O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/1806—Suspensions, emulsions, colloids, dispersions
- A61K49/1815—Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/28—Details of apparatus provided for in groups G01R33/44 - G01R33/64
- G01R33/282—Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Physics & Mathematics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- High Energy & Nuclear Physics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- General Induction Heating (AREA)
- Magnetic Ceramics (AREA)
- Control Of Motors That Do Not Use Commutators (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9800158.9A GB9800158D0 (en) | 1998-01-05 | 1998-01-05 | Method |
| GB9800158.9 | 1998-01-05 | ||
| GB9813795.3 | 1998-06-25 | ||
| GBGB9813795.3A GB9813795D0 (en) | 1998-06-25 | 1998-06-25 | Method |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20010040318A KR20010040318A (ko) | 2001-05-15 |
| KR100699396B1 true KR100699396B1 (ko) | 2007-03-27 |
Family
ID=26312888
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020007007423A Expired - Fee Related KR100699396B1 (ko) | 1998-01-05 | 1998-12-23 | 자기 공명 연구 방법 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US6278893B1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2119457B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4764548B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR100699396B1 (cg-RX-API-DMAC7.html) |
| CN (2) | CN1138154C (cg-RX-API-DMAC7.html) |
| AU (1) | AU752308C (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI9813244B1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2317526C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2393833T3 (cg-RX-API-DMAC7.html) |
| HU (1) | HU229718B1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL136780A0 (cg-RX-API-DMAC7.html) |
| NO (1) | NO334035B1 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ505151A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2221255C2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO1999035508A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (150)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2186405C2 (ru) * | 1996-03-29 | 2002-07-27 | Лоренс Беркли Нэшнл Лэборэтори | Усиление ядерного магнитного резонанса (ямр) и магниторезонансной визуализации (мрв) в присутствии гиперполяризованных благородных газов |
| WO2009081360A1 (en) * | 2007-12-20 | 2009-07-02 | Koninklijke Philips Electronics N.V. | Magnetic resonance imaging using hyperpolarization of liquids or solids by light with orbital angular momentum |
| US8765099B2 (en) * | 1996-04-08 | 2014-07-01 | Koninklijke Philips N.V. | Magnetic resonance imaging hyperpolarization of liquids or solids by light with orbital angular momentum |
| EP0951650B1 (en) * | 1997-01-08 | 2003-12-10 | Amersham Health AS | Method of magnetic resonance imaging |
| US6278893B1 (en) * | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| WO1999066254A1 (en) * | 1998-06-17 | 1999-12-23 | Medi-Physics, Inc. | Hyperpolarized gas transport device and associated transport method |
| US6237363B1 (en) * | 1998-09-30 | 2001-05-29 | Medi-Physics, Inc. | Hyperpolarized noble gas extraction methods masking methods and associated transport containers |
| US6284222B1 (en) | 1998-11-03 | 2001-09-04 | Medi--Physics, Inc. | Hyperpolarized helium-3 microbubble gas entrapment methods |
| US7501236B1 (en) * | 1998-12-30 | 2009-03-10 | Ge Healthcare Limited | NMR spectroscopic in vitro assay using hyperpolarization |
| US6566875B1 (en) | 1999-02-23 | 2003-05-20 | Medi-Physics, Inc. | Portable hyperpolarized gas monitoring systems, computer program products, and related methods using NMR and/or MRI during transport |
| US6574496B1 (en) * | 1999-05-19 | 2003-06-03 | Amersham Health As | Magnetic resonance imaging |
| US20020058869A1 (en) * | 1999-05-19 | 2002-05-16 | Oskar Axelsson | Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials |
| US6295834B1 (en) | 1999-06-30 | 2001-10-02 | Medi-Physics, Inc. | NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production |
| DE10009166A1 (de) * | 2000-02-26 | 2001-08-30 | Philips Corp Intellectual Pty | Verfahren zur Lokalisierung von Objekten in der interventionellen Radiologie |
| US6630126B2 (en) | 2000-03-13 | 2003-10-07 | Medi-Physics, Inc. | Diagnostic procedures using direct injection of gaseous hyperpolarized 129Xe and associated systems and products |
| GB0009353D0 (en) | 2000-04-14 | 2000-05-31 | Nycomed Imaging As | Method |
| GB0014463D0 (en) * | 2000-06-14 | 2000-08-09 | Nycomed Amersham Plc | NMR Method |
| JP2004515263A (ja) * | 2000-07-13 | 2004-05-27 | メディ−フィジックス・インコーポレイテッド | 129Xeスペクトル法特有の化学シフトを用いて、病変をインビボで検出する診断法 |
| GB0022341D0 (en) * | 2000-09-12 | 2000-10-25 | Nycomed Imaging As | Method |
| NO20004561D0 (no) * | 2000-09-13 | 2000-09-13 | Nycomed Imaging As | Metode for magnetisk resonansavbildning |
| AU1403902A (en) * | 2000-11-03 | 2002-05-15 | Amersham Health As | Methods and devices for polarised nmr samples |
| DK1330659T3 (da) | 2000-11-03 | 2006-12-18 | Amersham Health As | Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser |
| US7126332B2 (en) * | 2001-07-20 | 2006-10-24 | Baker Hughes Incorporated | Downhole high resolution NMR spectroscopy with polarization enhancement |
| GB0122049D0 (en) * | 2001-09-12 | 2001-10-31 | Nycomed Imaging As | Method |
| RU2281527C2 (ru) * | 2001-11-02 | 2006-08-10 | Амершем Хелт АС | Способ и устройство для плавления поляризованных ямр-образцов |
| NO20023357D0 (no) * | 2002-04-19 | 2002-07-11 | Amersham Health As | Blanding |
| GB0219954D0 (en) * | 2002-08-29 | 2002-10-02 | Amersham Health R & D Ab | Method and apparatus for producing contrast agents for magnetic resonance imaging |
| NO20025124D0 (no) | 2002-10-25 | 2002-10-25 | Amersham Health As | Metode |
| NO20025711D0 (no) * | 2002-11-27 | 2002-11-27 | Amersham Health As | Magnetisk resonansmetode |
| US20060173283A1 (en) * | 2002-11-27 | 2006-08-03 | Oskar Axelsson | Method of magnetic resonance imaging |
| NO20025738D0 (no) * | 2002-11-29 | 2002-11-29 | Amersham Health As | Metode |
| DE10259793B4 (de) * | 2002-12-19 | 2009-10-15 | Siemens Ag | Verfahren zur Bildgebung eines Stoffwechselvorgangs eines Lebewesens |
| DE10335663A1 (de) * | 2003-08-04 | 2005-03-10 | Siemens Ag | Verfahren zur automatischen Kalibrierung von Perfusionsparameterbildern |
| AU2005267670B2 (en) * | 2004-07-30 | 2011-03-03 | Ge Healthcare As | Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process |
| AU2005267669B2 (en) * | 2004-07-30 | 2011-02-24 | Ge Healthcare As | MR imaging method for the discrimination between healthy and tumour tissue |
| RU2374252C2 (ru) * | 2004-07-30 | 2009-11-27 | Джи-И Хелткер АС | Способ получения жидкой композиции, содержащей гиперполяризованный 13c-пируват, композиция, содержащая гиперполяризованный 13c-пируват (варианты), ее применение (варианты), радикал и его применение |
| NO338547B1 (no) * | 2004-07-30 | 2016-09-05 | Ge Healthcare As | Fremgangsmåte for fremstilling av en flytende sammensetning omfattende hyperpolarisert 13C-pyruvat, sammensetningen og anvendelse av den for fremstilling av hyperpolarisert 13C-pyruvat |
| BRPI0518302A2 (pt) * | 2004-11-19 | 2008-11-11 | Ge Healthcare As | mÉtodo de formaÇço de imagens por rm |
| US7276905B2 (en) * | 2005-07-11 | 2007-10-02 | General Electric Company | Method and system of tracking an intracorporeal device with MR imaging |
| JP2007021008A (ja) * | 2005-07-20 | 2007-02-01 | Hitachi Ltd | Dnp過分極手段を備えた磁気共鳴イメージング装置 |
| US20070025918A1 (en) * | 2005-07-28 | 2007-02-01 | General Electric Company | Magnetic resonance imaging (MRI) agents: water soluble carbon-13 enriched fullerene and carbon nanotubes for use with dynamic nuclear polarization |
| WO2007035871A1 (en) * | 2005-09-21 | 2007-03-29 | Massachusetts Institute Of Technology | Systems and methods for tuning properties of nanoparticles |
| JP2009510081A (ja) * | 2005-09-28 | 2009-03-12 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 磁気共鳴イメージングにおける造影剤としての使用のための長いスピン緩和時間を有する過分極化された固形物 |
| ES2654520T3 (es) * | 2005-10-11 | 2018-02-14 | Huntington Medical Research Institutes | Agentes de formación de imágenes y métodos de uso de los mismos |
| EP1948248A2 (en) * | 2005-11-06 | 2008-07-30 | Katz-Brull, Rachel | Magnetic resonance imaging and spectroscopy means and methods thereof |
| WO2007064226A2 (en) | 2005-12-01 | 2007-06-07 | Ge Healthcare As | Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion |
| NO20055681D0 (no) * | 2005-12-01 | 2005-12-01 | Amersham Health As | Method of dynamic nuclear polarisation |
| EP1968442A4 (en) * | 2005-12-10 | 2009-11-04 | Harvard College | In situ hyperpolarization of imaging agents |
| EP1962912B1 (en) * | 2005-12-16 | 2012-09-26 | Ge Healthcare As | Method to produce hyperpolarised carboxylates of organic amines |
| JP2009523172A (ja) * | 2006-01-11 | 2009-06-18 | プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ | 造影剤のエクスビボ過分極 |
| KR101095943B1 (ko) | 2006-02-21 | 2011-12-19 | 밀리켈빈 테크놀로지스 엘엘씨 | 과분극화 방법, 시스템 및 조성물 |
| AU2013205838B2 (en) * | 2006-02-21 | 2016-03-17 | Avrum Belzer | Hyperpolarization Methods, Systems and Compositions |
| US8703102B2 (en) | 2008-04-04 | 2014-04-22 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| US20100233096A1 (en) * | 2006-03-29 | 2010-09-16 | Lerche Mathilde H | Method to produce hyperpolarised carboxylates and sulphonates |
| US7205764B1 (en) * | 2006-04-11 | 2007-04-17 | Varian, Inc. | Method and apparatus for increasing the detection sensitivity in a high resolution NMR analysis |
| CN101437645B (zh) * | 2006-05-11 | 2010-12-01 | 贝尔直升机泰克斯特龙公司 | 修复结构部件的设备和方法 |
| WO2008048714A2 (en) * | 2006-05-12 | 2008-04-24 | Massachusetts Institute Of Technology | Biradical polarizing agents for dynamic nuclear polarization |
| US20090311189A1 (en) * | 2006-05-12 | 2009-12-17 | Massachusetts Institute Of Technology | Temperature-jump dynamic nuclear polarization |
| US8623327B2 (en) | 2006-06-19 | 2014-01-07 | Beth Israel Deaconess Medical Center, Inc. | Imaging agents for use in magnetic resonance blood flow/perfusion imaging |
| JP5363320B2 (ja) * | 2006-08-18 | 2013-12-11 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 細胞死の13c−mrイメージング又は分光法 |
| EP2057131B1 (en) | 2006-08-30 | 2013-08-21 | Ge Healthcare As | Method of dynamic nuclear polarisation (dnp) and compounds and compositions for use in the method |
| US20100027864A1 (en) | 2006-10-03 | 2010-02-04 | Bastiaan Driehuys | Systems and Methods for Assessing Pulmonary Gas Transfer using Hyperpolarized 129XE MRI |
| US7631507B2 (en) | 2006-11-02 | 2009-12-15 | General Electric Company | Methods and devices for polarized samples for use in MRI |
| US8849372B2 (en) * | 2006-11-22 | 2014-09-30 | The General Hospital Corporation | Method for magnetic resonance imaging using stimulus induced rotary saturation with a contrast agent |
| US8076937B2 (en) * | 2006-12-11 | 2011-12-13 | Koninklijke Philips Electronics N.V. | Fibre tracking on the basis of macroscopic information |
| WO2008086534A1 (en) | 2007-01-11 | 2008-07-17 | Huntington Medical Research Institutes | Imaging agents and methods of use thereof |
| US20080240998A1 (en) | 2007-03-28 | 2008-10-02 | Urbahn John A | Fluid path system for dissolution and transport of a hyperpolarized material |
| US20080275668A1 (en) * | 2007-05-02 | 2008-11-06 | General Electric Company | Apparatus and method for fully automated closed system optical measurement of volume |
| US7519492B2 (en) * | 2007-05-02 | 2009-04-14 | General Electric Company | Apparatus and method for fully automated closed system quality control of a substance |
| US7610157B2 (en) * | 2007-05-02 | 2009-10-27 | General Electric Company | Apparatus and method for fully automated closed system pH measurement |
| US7741844B2 (en) | 2007-05-07 | 2010-06-22 | General Electric Company | Method and system for magnetic resonance imaging using labeled contrast agents |
| US9042978B2 (en) * | 2007-05-11 | 2015-05-26 | Neurometrix, Inc. | Method and apparatus for quantitative nerve localization |
| GB2450316A (en) * | 2007-06-18 | 2008-12-24 | Univ York | Hyperpolarizing nuclei |
| DE102007028901B4 (de) * | 2007-06-22 | 2010-07-22 | Siemens Ag | Verfahren und Vorrichtung zur automatischen Bestimmung von Perfusion mittels einer Magnetresonanzanlage |
| US9227173B2 (en) | 2007-06-22 | 2016-01-05 | General Electric Company | Methods for dynamic filtration of pharmaceutical products |
| US20080314836A1 (en) * | 2007-06-22 | 2008-12-25 | General Electric Company | Methods and devices for dynamic filtration of pharmaceutical products |
| GB0713074D0 (en) * | 2007-07-05 | 2007-08-15 | Univ London | A method of hyperpolarising a magnetic resonance agent |
| ES2375083T3 (es) * | 2007-08-27 | 2012-02-24 | Ge Healthcare Limited | Medio de formación de imagen que comprende 13c-acetat-hiperpolarizado y uso del mismo. |
| US20100233089A1 (en) * | 2007-10-05 | 2010-09-16 | Huntington Medical Research Institutes | Imaging of genetic material with magnetic resonance |
| EP2072061A1 (en) | 2007-12-19 | 2009-06-24 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
| JP4871311B2 (ja) * | 2008-02-26 | 2012-02-08 | 株式会社日立製作所 | 核磁気共鳴装置、磁気共鳴イメージング装置および磁気共鳴分析装置 |
| GB0804422D0 (en) * | 2008-03-10 | 2008-04-16 | Univ Southampton | An agent for transporting nuclear spin order and for magnetic resonance imaging |
| US20140223923A1 (en) * | 2008-04-04 | 2014-08-14 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| WO2009129265A1 (en) * | 2008-04-14 | 2009-10-22 | Huntington Medical Research Institutes | Methods and apparatus for pasadena hyperpolarization |
| US8763410B2 (en) * | 2008-04-21 | 2014-07-01 | General Electric Company | Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media |
| EP2268321B1 (en) | 2008-05-02 | 2013-10-09 | General Electric Company | Method of determining alanine transaminase (ALT) activity by 13C-MR detection using hyperpolarised 13C-pyruvate |
| US9658300B1 (en) * | 2008-08-19 | 2017-05-23 | California Institute Of Technology | Method and apparatus for preparation of spin polarized reagents |
| US9289518B2 (en) * | 2008-08-22 | 2016-03-22 | The Brigham And Women's Hospital | Enhanced 13C NMR by thermal mixing with hyperpolarized 129XE |
| US7633290B1 (en) | 2008-09-09 | 2009-12-15 | General Electric Company | Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent |
| US20100092390A1 (en) * | 2008-10-09 | 2010-04-15 | President And Fellows Of Harvard College | Methods for Making Particles Having Long Spin-Lattice Relaxation Times |
| US20110274626A1 (en) | 2008-12-10 | 2011-11-10 | University Of York | Pulse sequencing with hyperpolarisable nuclei |
| CN102388317B (zh) | 2009-04-02 | 2015-11-25 | 通用电气健康护理有限公司 | 包含超极化13c丙酮酸盐的磁共振成像介质用于检测炎症或感染的用途 |
| JP2012529960A (ja) * | 2009-06-19 | 2012-11-29 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 軌道角運動量を持つ光子を使用した過分極装置と組み合わせたmri温度測定 |
| AU2010286413B2 (en) | 2009-08-31 | 2014-11-20 | Millikelvin Technologies Llc | Systems and methods for producing hyperpolarized materials and mixtures thereof |
| CA2772489A1 (en) | 2009-08-31 | 2011-03-03 | Brain Watch Ltd. | Isotopically labeled neurochemical agents and uses thereof for diagnosing conditions and disorders |
| US8968703B2 (en) | 2009-09-10 | 2015-03-03 | Ge Healthcare Limited | 13C-MR detection using hyperpolarised 13C-fructose |
| US8427161B2 (en) * | 2009-12-18 | 2013-04-23 | General Electric Company | Method and apparatus for generating hyperpolarized materials |
| EP2343568A1 (en) * | 2009-12-30 | 2011-07-13 | Koninklijke Philips Electronics N.V. | Dynamic nuclear polarization apparatus with sample transport system |
| WO2011101765A1 (en) * | 2010-02-16 | 2011-08-25 | Koninklijke Philips Electronics N.V. | Optical hyperpolarisation with light endowed with orbital angular momentum |
| JP5758982B2 (ja) | 2010-04-08 | 2015-08-05 | ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. | 過分極基質の製造方法およびmriのための方法 |
| US8970217B1 (en) | 2010-04-14 | 2015-03-03 | Hypres, Inc. | System and method for noise reduction in magnetic resonance imaging |
| US9259490B2 (en) | 2010-05-03 | 2016-02-16 | Ge Healthcare Limited | Hyperpolarized lactate contrast agent for determination of LDH activity |
| DE102010017568B4 (de) | 2010-06-24 | 2012-09-13 | Johann Wolfgang Goethe-Universität Frankfurt am Main | Hyperpolarisationseinrichtung und Verfahren zur Verabreichung eines hyperpolarisierten flüssigen Kontrastmittels |
| WO2012056447A1 (en) | 2010-10-25 | 2012-05-03 | Brain Watch Ltd. | Isotopically labeled deoxy-glucose and derivatives thereof, compositions comprising them and uses thereof |
| US8786284B2 (en) * | 2011-01-11 | 2014-07-22 | Bridge12 Technologies, Inc. | Integrated high-frequency generator system utilizing the magnetic field of the target application |
| EP2689239A4 (en) * | 2011-03-23 | 2014-12-24 | Millikelvin Technologies Llc | IMPROVED TECHNIQUES, ENHANCED SYSTEMS, AND COMPUTER-READABLE ENHANCED PROGRAMS FOR MAGNETIC RESONANCE |
| US20140099262A1 (en) | 2011-06-01 | 2014-04-10 | Brain Watch Ltd. | Isotopically labeled cdp-choline and uses thereof |
| WO2013053839A1 (en) | 2011-10-12 | 2013-04-18 | Bracco Imaging Spa | Process for the preparation of hyperpolarized derivatives for use in mri analysis |
| US9693828B2 (en) | 2011-12-05 | 2017-07-04 | Bracco Imaging S.P.A. | Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis |
| GB2498181A (en) | 2011-12-29 | 2013-07-10 | Bruker Biospin Gmbh | Device and method for rapid dynamic nuclear polarisation |
| IL223935A (en) | 2012-01-13 | 2016-11-30 | Gen Electric | Fluid track system for decomposition and transport of hyper-polarized material |
| EP2624004A1 (en) * | 2012-02-06 | 2013-08-07 | Koninklijke Philips Electronics N.V. | Temperature determination using magnetic resonance B1 field mapping |
| US8715621B2 (en) | 2012-03-15 | 2014-05-06 | Massachusetts Institute Of Technology | Radical polarizing agents for dynamic nuclear polarization |
| EP2642310A1 (en) * | 2012-03-22 | 2013-09-25 | Koninklijke Philips N.V. | Interpolated three-dimensional thermal dose estimates using magnetic resonance imaging |
| US9925280B2 (en) | 2012-04-02 | 2018-03-27 | Bracco Imaging S.P.A. | Hyperpolarized amino acids |
| US9329245B2 (en) * | 2012-04-11 | 2016-05-03 | Bruker Biospin Ag | MRI compatible method and device for rapid DNP on a solid state hyperpolarized sample material |
| WO2013167587A1 (en) | 2012-05-07 | 2013-11-14 | Albeda Innovation Aps | Intra-operative cancer diagnosis based on a hyperpolarized marker |
| US8825132B2 (en) | 2012-07-04 | 2014-09-02 | Bruker Biospin Gmbh | Field cycling method for magnetic resonance |
| WO2014009240A1 (en) | 2012-07-13 | 2014-01-16 | Bracco Imaging Spa | Triarylmethyl radicals |
| US9329246B2 (en) | 2012-10-03 | 2016-05-03 | Bruker Biospin Ag | Method for hyperpolarization transfer in the liquid state |
| WO2014064194A1 (en) | 2012-10-25 | 2014-05-01 | Bracco Imaging Spa | Hyperpolarized 2-oxoglutarate as metabolic agent in mr |
| US9404984B2 (en) | 2012-11-06 | 2016-08-02 | Bruker Uk Limited | Method of hyperpolarization applying brute force using particulate acceleration agents |
| US20140200437A1 (en) * | 2013-01-16 | 2014-07-17 | Empire Technology Development Llc | Detection of internal gas leakage |
| WO2014118258A1 (en) | 2013-01-31 | 2014-08-07 | Bracco Imaging Spa | Hyperpolarized esters as metabolic markers in mr |
| EP3016687B1 (en) * | 2013-07-01 | 2017-08-09 | Bracco Imaging S.p.A | Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr |
| US9642924B2 (en) * | 2013-08-29 | 2017-05-09 | Duke University | Contrast agents based on long-lived nuclear singlet states and related methods |
| US9874622B2 (en) | 2013-09-27 | 2018-01-23 | General Electric Company | Hyperpolarized media transport vessel |
| EP2863229A1 (en) | 2013-10-15 | 2015-04-22 | Technische Universität München | pH-biosensors based on compounds with pH-sensitive enolic groups for magnetic resonance imaging and spectroscopy and their uses |
| EP2891500B1 (en) | 2014-01-07 | 2018-08-01 | Cambridge Enterprise Limited | Contrast agent for determination of aldehyde dehydrogenase (ALDH) activity |
| EP3015855A1 (en) | 2014-10-27 | 2016-05-04 | Klinikum rechts der Isar der Technischen Universität München | Metal biosensors based on compounds with metal-sensitive chemical shifts for magnetic resonance spectroscopy and imaging |
| US10088536B2 (en) * | 2015-03-27 | 2018-10-02 | Bruker Biospin Corporation | Sample introduction system and method for polarization |
| US10649044B2 (en) * | 2015-05-22 | 2020-05-12 | Universität Ulm | Method for the hyperpolarisation of nuclear spins |
| CA2997791A1 (en) | 2015-09-30 | 2017-04-06 | Duke University | Ascorbate formulations and methods of use as contrast agents |
| CN105738397B (zh) * | 2016-02-04 | 2017-09-29 | 浙江大学 | 化合物中季碳纵向驰豫时间(t1)的分析方法 |
| CN105866158B (zh) * | 2016-03-31 | 2017-12-15 | 武汉大学 | 基于磁共振耦合的无损溶液浓度检测装置及检测方法 |
| EP3258285B1 (en) | 2016-06-14 | 2020-10-21 | Bruker BioSpin GmbH | Method for predicting chemical shift values of nmr spin systems in a sample of a fluid class, in particular in a sample of a biofluid |
| US10390727B2 (en) * | 2017-04-21 | 2019-08-27 | The Charles Stark Draper Laboratory, Inc. | Apparatus and method for imaging currents using nanoparticles and low-field magnetic resonance imaging (MRI) |
| GB201710677D0 (en) | 2017-07-03 | 2017-08-16 | Univ York | Polorisation transfer via a second metal complex |
| WO2019055358A1 (en) * | 2017-09-12 | 2019-03-21 | Memorial Sloan Kettering Cancer Center | HYPERPOLARIZED UREA, ARGININE, GLUTAMINE AND XANTHINE PROBES, HYPERPOLARIZED 13C FOR DEUTERIUM AND 15N-MARKED EXCHANGE |
| US10520561B2 (en) | 2017-09-27 | 2019-12-31 | General Electric Company | System and method for hyperpolarizing a substance and quenching radicals therein |
| WO2019145955A1 (en) * | 2018-01-26 | 2019-08-01 | Hadasit Medical Research Services & Development Limited | Non-metallic magnetic resonance contrast agent |
| US10942237B2 (en) | 2019-05-07 | 2021-03-09 | GE Precision Healthcare LLC | System and method for hyperpolarizing a substance |
| US11428763B2 (en) * | 2020-02-28 | 2022-08-30 | Government Of The United States Of America, As Represented By The Secretary Of Commerce | Planar inverse anapole microresonator and performing inductive-detection electron paramagnetic resonance spectroscopy |
| WO2021198776A2 (en) * | 2020-03-31 | 2021-10-07 | Nvision Imaging Technologies Gmbh | Systems and method for generation of hyperpolarized materials |
| CN112268918A (zh) * | 2020-07-10 | 2021-01-26 | 中国科学院过程工程研究所 | 一种基于固体核磁共振波谱仪的材料吸附气体原位分析装置 |
| CN115989083A (zh) * | 2020-08-25 | 2023-04-18 | 生物石墨烯有限公司 | 包括含碳13的石墨烯量子点的mri造影剂及其制备方法 |
| CN114690099B (zh) * | 2020-12-30 | 2025-05-06 | 中国科学技术大学 | 光超极化核磁共振成像装置及方法 |
| EP4359014A1 (en) * | 2021-06-25 | 2024-05-01 | Beacon MRI Ltd | Particles for use in hyperpolarization |
| GB202111734D0 (en) | 2021-08-16 | 2021-09-29 | Cambridge Entpr Ltd | Hyperpolarisation method and product |
| WO2024191654A1 (en) * | 2023-03-10 | 2024-09-19 | North Carolina State University | Magnetic field control of sabre hyperpolarized molecules for processing and administration |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997037239A1 (en) * | 1996-03-29 | 1997-10-09 | Lawrence Berkeley National Laboratory | Enhancement of nmr and mri in the presence of hyperpolarized noble gases |
| WO1998001766A1 (en) * | 1996-07-05 | 1998-01-15 | Nycomed Imaging As | Method of electron spin resonance enhanced magnetic resonance imaging (esremri) with ex vivo dynamic nuclear polarisaton of an mr imaging agent |
| WO1998030918A1 (en) * | 1997-01-08 | 1998-07-16 | Nycomed Imaging As | Method of magnetic resonance imaging |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0296833B1 (en) | 1987-06-23 | 1991-09-25 | Hafslund Nycomed Innovation AB | Improvements in and relating to magnetic resonance imaging |
| GB8817137D0 (en) | 1988-07-19 | 1988-08-24 | Nycomed As | Compositions |
| GB8819753D0 (en) * | 1988-08-19 | 1988-09-21 | Nycomed As | Apparatus |
| JPH02111747A (ja) * | 1988-10-21 | 1990-04-24 | Nippon Steel Chem Co Ltd | 炭素13標識5‐アミノレブリン酸及びその誘導体の製造方法 |
| JP3166160B2 (ja) * | 1989-02-15 | 2001-05-14 | 味の素株式会社 | 新規な▲上1▼▲上3▼c標識アミノ酸及びその発酵的又は酵素的製造法 |
| FI923589L (fi) | 1990-02-12 | 1992-08-11 | Hafslund Nycomed Innovation | Triarylmetylradikaler och anvaendning av inerta fria kolradikaler i mri. |
| US5413917A (en) * | 1990-07-18 | 1995-05-09 | Board Of Regents, The University Of Texas System | Method of determining sources of acetyl-CoA under nonsteady-state conditions |
| ES2114566T3 (es) | 1991-08-09 | 1998-06-01 | Nycomed Innovation Ab | Uso de radicales libres persistentes en formacion de imagenes por resonancia magnetica nuclear. |
| JPH0597711A (ja) * | 1991-10-04 | 1993-04-20 | 節 ▲築▼山 | 生体組織代謝検査法 |
| RU2063702C1 (ru) * | 1992-07-20 | 1996-07-20 | Леонид Аврамович Тютин | Способ магнитно-резонансной томографии и устройство для его осуществления |
| US5464696A (en) * | 1992-08-13 | 1995-11-07 | Bracco International B.V. | Particles for NMR imaging |
| GB9305351D0 (en) * | 1993-03-16 | 1993-05-05 | Nycomed Imaging As | Improvements in or relating to contrast agents |
| US5545396A (en) | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
| US5479925A (en) | 1994-06-23 | 1996-01-02 | General Electric Company | Magnetic resonance (MR) angiography in a low-field imaging magnet |
| GB9419203D0 (en) | 1994-09-23 | 1994-11-09 | Nycomed Innovation Ab | Contrast media |
| US5617859A (en) | 1995-10-02 | 1997-04-08 | General Electric Company | Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures |
| JP3897841B2 (ja) * | 1995-10-31 | 2007-03-28 | 独立行政法人科学技術振興機構 | 標識アシル−l−カルニチンを用いた疾患診断剤 |
| US6278893B1 (en) * | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
| US6125654A (en) | 1998-10-16 | 2000-10-03 | Syracuse University | Bulk production and usage of hyperpolarized 129 Xenon |
| FR2833953B1 (fr) | 2001-12-21 | 2004-12-03 | Sanofi Synthelabo | DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
-
1998
- 1998-10-09 US US09/169,148 patent/US6278893B1/en not_active Expired - Lifetime
- 1998-12-23 KR KR1020007007423A patent/KR100699396B1/ko not_active Expired - Fee Related
- 1998-12-23 CN CNB988129531A patent/CN1138154C/zh not_active Expired - Fee Related
- 1998-12-23 CA CA002317526A patent/CA2317526C/en not_active Expired - Fee Related
- 1998-12-23 NZ NZ505151A patent/NZ505151A/xx not_active IP Right Cessation
- 1998-12-23 HU HU0102093A patent/HU229718B1/hu not_active IP Right Cessation
- 1998-12-23 JP JP2000527838A patent/JP4764548B2/ja not_active Expired - Fee Related
- 1998-12-23 WO PCT/GB1998/003904 patent/WO1999035508A1/en not_active Ceased
- 1998-12-23 EP EP09009608A patent/EP2119457B1/en not_active Expired - Lifetime
- 1998-12-23 ES ES09009608T patent/ES2393833T3/es not_active Expired - Lifetime
- 1998-12-23 AU AU17753/99A patent/AU752308C/en not_active Ceased
- 1998-12-23 BR BRPI9813244A patent/BRPI9813244B1/pt not_active IP Right Cessation
- 1998-12-23 EP EP98962629A patent/EP1046051A1/en not_active Withdrawn
- 1998-12-23 IL IL13678098A patent/IL136780A0/xx not_active IP Right Cessation
- 1998-12-23 CN CNB2003101131420A patent/CN100347562C/zh not_active Expired - Fee Related
- 1998-12-23 RU RU2000120670/09A patent/RU2221255C2/ru not_active IP Right Cessation
-
2000
- 2000-06-22 NO NO20003251A patent/NO334035B1/no not_active IP Right Cessation
- 2000-06-30 US US09/609,153 patent/US6466814B1/en not_active Expired - Lifetime
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997037239A1 (en) * | 1996-03-29 | 1997-10-09 | Lawrence Berkeley National Laboratory | Enhancement of nmr and mri in the presence of hyperpolarized noble gases |
| WO1998001766A1 (en) * | 1996-07-05 | 1998-01-15 | Nycomed Imaging As | Method of electron spin resonance enhanced magnetic resonance imaging (esremri) with ex vivo dynamic nuclear polarisaton of an mr imaging agent |
| WO1998030918A1 (en) * | 1997-01-08 | 1998-07-16 | Nycomed Imaging As | Method of magnetic resonance imaging |
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI9813244B1 (pt) | 2016-12-13 |
| WO1999035508A1 (en) | 1999-07-15 |
| EP1046051A1 (en) | 2000-10-25 |
| JP4764548B2 (ja) | 2011-09-07 |
| AU1775399A (en) | 1999-07-26 |
| US6278893B1 (en) | 2001-08-21 |
| HK1069635A1 (zh) | 2005-05-27 |
| CA2317526A1 (en) | 1999-07-15 |
| NZ505151A (en) | 2002-11-26 |
| HUP0102093A3 (en) | 2004-09-28 |
| RU2221255C2 (ru) | 2004-01-10 |
| IL136780A0 (en) | 2001-06-14 |
| AU752308B2 (en) | 2002-09-12 |
| HUP0102093A2 (hu) | 2001-09-28 |
| AU752308C (en) | 2003-05-15 |
| KR20010040318A (ko) | 2001-05-15 |
| EP2119457B1 (en) | 2012-10-03 |
| CN1527066A (zh) | 2004-09-08 |
| CN100347562C (zh) | 2007-11-07 |
| NO20003251D0 (no) | 2000-06-22 |
| JP2002501006A (ja) | 2002-01-15 |
| US6466814B1 (en) | 2002-10-15 |
| CA2317526C (en) | 2008-09-16 |
| BR9813244A (pt) | 2000-10-10 |
| NO20003251L (no) | 2000-06-22 |
| HU229718B1 (hu) | 2014-05-28 |
| CN1138154C (zh) | 2004-02-11 |
| ES2393833T3 (es) | 2012-12-28 |
| EP2119457A1 (en) | 2009-11-18 |
| NO334035B1 (no) | 2013-11-25 |
| CN1285044A (zh) | 2001-02-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR100699396B1 (ko) | 자기 공명 연구 방법 | |
| US6453188B1 (en) | Method of magnetic resonance imaging | |
| US6311086B1 (en) | Overhauser magnetic resonance imaging (ORMI) method comprising ex vivo polarization of a magnetic resonance (MR) imaging agent | |
| US20020058869A1 (en) | Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials | |
| RU2271017C2 (ru) | Способ исследования образца методом магнитного резонанса с применением магнитно-резонансного агента визуализации, поляризованного по ядерному спину (варианты) | |
| IE63397B1 (en) | Magnetic resonance imaging | |
| Albert et al. | Hyperpolarized and inert gas MRI: From technology to application in research and medicine | |
| US7251519B2 (en) | MR-method for the in vivo measurement of temperature or pH-value by means of a hyperpolarised contrast agent | |
| JP2010536521A (ja) | 方法及び該方法で使用するためのイメージング媒体 | |
| ES2274272T3 (es) | Procedimiento para la produccion de 129xe hiperpolarizado. | |
| WO2000072031A1 (en) | Methods of magnetic resonance imaging (mri) using contract agent solutions formed from the dissolution of hyperpolarised materials | |
| Suh et al. | The Chemistry of Hyperpolarized Magnetic Resonance Probes | |
| Chupp | Medical Imaging with Laser Polarized Noble Gases | |
| JP2010532195A (ja) | 磁気共鳴剤の過分極方法 | |
| HK1069635B (en) | Method of magnetic resonance investigation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
St.27 status event code: A-0-1-A10-A15-nap-PA0105 |
|
| PG1501 | Laying open of application |
St.27 status event code: A-1-1-Q10-Q12-nap-PG1501 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R13-asn-PN2301 St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-3-3-R10-R18-oth-X000 |
|
| A201 | Request for examination | ||
| AMND | Amendment | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PA0201 | Request for examination |
St.27 status event code: A-1-2-D10-D11-exm-PA0201 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| AMND | Amendment | ||
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| E601 | Decision to refuse application | ||
| PE0601 | Decision on rejection of patent |
St.27 status event code: N-2-6-B10-B15-exm-PE0601 |
|
| J201 | Request for trial against refusal decision | ||
| PJ0201 | Trial against decision of rejection |
St.27 status event code: A-3-3-V10-V11-apl-PJ0201 |
|
| AMND | Amendment | ||
| E13-X000 | Pre-grant limitation requested |
St.27 status event code: A-2-3-E10-E13-lim-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| PB0901 | Examination by re-examination before a trial |
St.27 status event code: A-6-3-E10-E12-rex-PB0901 |
|
| PN2301 | Change of applicant |
St.27 status event code: A-3-3-R10-R13-asn-PN2301 St.27 status event code: A-3-3-R10-R11-asn-PN2301 |
|
| E902 | Notification of reason for refusal | ||
| PE0902 | Notice of grounds for rejection |
St.27 status event code: A-1-2-D10-D21-exm-PE0902 |
|
| T11-X000 | Administrative time limit extension requested |
St.27 status event code: U-3-3-T10-T11-oth-X000 |
|
| P11-X000 | Amendment of application requested |
St.27 status event code: A-2-2-P10-P11-nap-X000 |
|
| P13-X000 | Application amended |
St.27 status event code: A-2-2-P10-P13-nap-X000 |
|
| B701 | Decision to grant | ||
| PB0701 | Decision of registration after re-examination before a trial |
St.27 status event code: A-3-4-F10-F13-rex-PB0701 |
|
| GRNT | Written decision to grant | ||
| PR0701 | Registration of establishment |
St.27 status event code: A-2-4-F10-F11-exm-PR0701 |
|
| PR1002 | Payment of registration fee |
St.27 status event code: A-2-2-U10-U12-oth-PR1002 Fee payment year number: 1 |
|
| PG1601 | Publication of registration |
St.27 status event code: A-4-4-Q10-Q13-nap-PG1601 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 4 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 5 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 6 |
|
| FPAY | Annual fee payment |
Payment date: 20130308 Year of fee payment: 7 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 7 |
|
| FPAY | Annual fee payment |
Payment date: 20140310 Year of fee payment: 8 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 8 |
|
| FPAY | Annual fee payment |
Payment date: 20150306 Year of fee payment: 9 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 9 |
|
| FPAY | Annual fee payment |
Payment date: 20160308 Year of fee payment: 10 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 10 |
|
| FPAY | Annual fee payment |
Payment date: 20170314 Year of fee payment: 11 |
|
| PR1001 | Payment of annual fee |
St.27 status event code: A-4-4-U10-U11-oth-PR1001 Fee payment year number: 11 |
|
| P22-X000 | Classification modified |
St.27 status event code: A-4-4-P10-P22-nap-X000 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-5-5-R10-R18-oth-X000 |
|
| LAPS | Lapse due to unpaid annual fee | ||
| PC1903 | Unpaid annual fee |
St.27 status event code: A-4-4-U10-U13-oth-PC1903 Not in force date: 20180320 Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE |
|
| PC1903 | Unpaid annual fee |
St.27 status event code: N-4-6-H10-H13-oth-PC1903 Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE Not in force date: 20180320 |
|
| P22-X000 | Classification modified |
St.27 status event code: A-4-4-P10-P22-nap-X000 |
|
| R18-X000 | Changes to party contact information recorded |
St.27 status event code: A-5-5-R10-R18-oth-X000 |