KR100699396B1 - 자기 공명 연구 방법 - Google Patents

자기 공명 연구 방법 Download PDF

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KR100699396B1
KR100699396B1 KR1020007007423A KR20007007423A KR100699396B1 KR 100699396 B1 KR100699396 B1 KR 100699396B1 KR 1020007007423 A KR1020007007423 A KR 1020007007423A KR 20007007423 A KR20007007423 A KR 20007007423A KR 100699396 B1 KR100699396 B1 KR 100699396B1
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formulation
agent
magnetic field
polarization
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Korean (ko)
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KR20010040318A (ko
Inventor
잔 헨릭 아르덴크쟤르-라센
오스카 악셀슨
클래스 골만
라르스-고란 위스트랜드
죠르주 한슨
이브 레은바흐
스테판 피터슨
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지이 헬스케어 에이에스
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Priority claimed from GBGB9800158.9A external-priority patent/GB9800158D0/en
Priority claimed from GBGB9813795.3A external-priority patent/GB9813795D0/en
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806Suspensions, emulsions, colloids, dispersions
    • A61K49/1815Suspensions, emulsions, colloids, dispersions compo-inhalant, e.g. breath tests
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/28Details of apparatus provided for in groups G01R33/44 - G01R33/64
    • G01R33/282Means specially adapted for hyperpolarisation or for hyperpolarised contrast agents, e.g. for the generation of hyperpolarised gases using optical pumping cells, for storing hyperpolarised contrast agents or for the determination of the polarisation of a hyperpolarised contrast agent
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

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  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Physics & Mathematics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • General Induction Heating (AREA)
  • Magnetic Ceramics (AREA)
  • Control Of Motors That Do Not Use Commutators (AREA)
KR1020007007423A 1998-01-05 1998-12-23 자기 공명 연구 방법 Expired - Fee Related KR100699396B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GBGB9800158.9A GB9800158D0 (en) 1998-01-05 1998-01-05 Method
GB9800158.9 1998-01-05
GB9813795.3 1998-06-25
GBGB9813795.3A GB9813795D0 (en) 1998-06-25 1998-06-25 Method

Publications (2)

Publication Number Publication Date
KR20010040318A KR20010040318A (ko) 2001-05-15
KR100699396B1 true KR100699396B1 (ko) 2007-03-27

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KR1020007007423A Expired - Fee Related KR100699396B1 (ko) 1998-01-05 1998-12-23 자기 공명 연구 방법

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US (2) US6278893B1 (cg-RX-API-DMAC7.html)
EP (2) EP2119457B1 (cg-RX-API-DMAC7.html)
JP (1) JP4764548B2 (cg-RX-API-DMAC7.html)
KR (1) KR100699396B1 (cg-RX-API-DMAC7.html)
CN (2) CN1138154C (cg-RX-API-DMAC7.html)
AU (1) AU752308C (cg-RX-API-DMAC7.html)
BR (1) BRPI9813244B1 (cg-RX-API-DMAC7.html)
CA (1) CA2317526C (cg-RX-API-DMAC7.html)
ES (1) ES2393833T3 (cg-RX-API-DMAC7.html)
HU (1) HU229718B1 (cg-RX-API-DMAC7.html)
IL (1) IL136780A0 (cg-RX-API-DMAC7.html)
NO (1) NO334035B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ505151A (cg-RX-API-DMAC7.html)
RU (1) RU2221255C2 (cg-RX-API-DMAC7.html)
WO (1) WO1999035508A1 (cg-RX-API-DMAC7.html)

Families Citing this family (150)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2186405C2 (ru) * 1996-03-29 2002-07-27 Лоренс Беркли Нэшнл Лэборэтори Усиление ядерного магнитного резонанса (ямр) и магниторезонансной визуализации (мрв) в присутствии гиперполяризованных благородных газов
WO2009081360A1 (en) * 2007-12-20 2009-07-02 Koninklijke Philips Electronics N.V. Magnetic resonance imaging using hyperpolarization of liquids or solids by light with orbital angular momentum
US8765099B2 (en) * 1996-04-08 2014-07-01 Koninklijke Philips N.V. Magnetic resonance imaging hyperpolarization of liquids or solids by light with orbital angular momentum
EP0951650B1 (en) * 1997-01-08 2003-12-10 Amersham Health AS Method of magnetic resonance imaging
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
WO1999066254A1 (en) * 1998-06-17 1999-12-23 Medi-Physics, Inc. Hyperpolarized gas transport device and associated transport method
US6237363B1 (en) * 1998-09-30 2001-05-29 Medi-Physics, Inc. Hyperpolarized noble gas extraction methods masking methods and associated transport containers
US6284222B1 (en) 1998-11-03 2001-09-04 Medi--Physics, Inc. Hyperpolarized helium-3 microbubble gas entrapment methods
US7501236B1 (en) * 1998-12-30 2009-03-10 Ge Healthcare Limited NMR spectroscopic in vitro assay using hyperpolarization
US6566875B1 (en) 1999-02-23 2003-05-20 Medi-Physics, Inc. Portable hyperpolarized gas monitoring systems, computer program products, and related methods using NMR and/or MRI during transport
US6574496B1 (en) * 1999-05-19 2003-06-03 Amersham Health As Magnetic resonance imaging
US20020058869A1 (en) * 1999-05-19 2002-05-16 Oskar Axelsson Methods of magnetic resonance imaging (MRI) using contract agent solutions formed from the dissolution of hyperpolarised materials
US6295834B1 (en) 1999-06-30 2001-10-02 Medi-Physics, Inc. NMR polarization monitoring coils, hyperpolarizers with same, and methods for determining the polarization level of accumulated hyperpolarized noble gases during production
DE10009166A1 (de) * 2000-02-26 2001-08-30 Philips Corp Intellectual Pty Verfahren zur Lokalisierung von Objekten in der interventionellen Radiologie
US6630126B2 (en) 2000-03-13 2003-10-07 Medi-Physics, Inc. Diagnostic procedures using direct injection of gaseous hyperpolarized 129Xe and associated systems and products
GB0009353D0 (en) 2000-04-14 2000-05-31 Nycomed Imaging As Method
GB0014463D0 (en) * 2000-06-14 2000-08-09 Nycomed Amersham Plc NMR Method
JP2004515263A (ja) * 2000-07-13 2004-05-27 メディ−フィジックス・インコーポレイテッド 129Xeスペクトル法特有の化学シフトを用いて、病変をインビボで検出する診断法
GB0022341D0 (en) * 2000-09-12 2000-10-25 Nycomed Imaging As Method
NO20004561D0 (no) * 2000-09-13 2000-09-13 Nycomed Imaging As Metode for magnetisk resonansavbildning
AU1403902A (en) * 2000-11-03 2002-05-15 Amersham Health As Methods and devices for polarised nmr samples
DK1330659T3 (da) 2000-11-03 2006-12-18 Amersham Health As Fremgangsmåde og indretning til oplösning af hyperpolariseret, fast materiale til NMR-analyser
US7126332B2 (en) * 2001-07-20 2006-10-24 Baker Hughes Incorporated Downhole high resolution NMR spectroscopy with polarization enhancement
GB0122049D0 (en) * 2001-09-12 2001-10-31 Nycomed Imaging As Method
RU2281527C2 (ru) * 2001-11-02 2006-08-10 Амершем Хелт АС Способ и устройство для плавления поляризованных ямр-образцов
NO20023357D0 (no) * 2002-04-19 2002-07-11 Amersham Health As Blanding
GB0219954D0 (en) * 2002-08-29 2002-10-02 Amersham Health R & D Ab Method and apparatus for producing contrast agents for magnetic resonance imaging
NO20025124D0 (no) 2002-10-25 2002-10-25 Amersham Health As Metode
NO20025711D0 (no) * 2002-11-27 2002-11-27 Amersham Health As Magnetisk resonansmetode
US20060173283A1 (en) * 2002-11-27 2006-08-03 Oskar Axelsson Method of magnetic resonance imaging
NO20025738D0 (no) * 2002-11-29 2002-11-29 Amersham Health As Metode
DE10259793B4 (de) * 2002-12-19 2009-10-15 Siemens Ag Verfahren zur Bildgebung eines Stoffwechselvorgangs eines Lebewesens
DE10335663A1 (de) * 2003-08-04 2005-03-10 Siemens Ag Verfahren zur automatischen Kalibrierung von Perfusionsparameterbildern
AU2005267670B2 (en) * 2004-07-30 2011-03-03 Ge Healthcare As Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process
AU2005267669B2 (en) * 2004-07-30 2011-02-24 Ge Healthcare As MR imaging method for the discrimination between healthy and tumour tissue
RU2374252C2 (ru) * 2004-07-30 2009-11-27 Джи-И Хелткер АС Способ получения жидкой композиции, содержащей гиперполяризованный 13c-пируват, композиция, содержащая гиперполяризованный 13c-пируват (варианты), ее применение (варианты), радикал и его применение
NO338547B1 (no) * 2004-07-30 2016-09-05 Ge Healthcare As Fremgangsmåte for fremstilling av en flytende sammensetning omfattende hyperpolarisert 13C-pyruvat, sammensetningen og anvendelse av den for fremstilling av hyperpolarisert 13C-pyruvat
BRPI0518302A2 (pt) * 2004-11-19 2008-11-11 Ge Healthcare As mÉtodo de formaÇço de imagens por rm
US7276905B2 (en) * 2005-07-11 2007-10-02 General Electric Company Method and system of tracking an intracorporeal device with MR imaging
JP2007021008A (ja) * 2005-07-20 2007-02-01 Hitachi Ltd Dnp過分極手段を備えた磁気共鳴イメージング装置
US20070025918A1 (en) * 2005-07-28 2007-02-01 General Electric Company Magnetic resonance imaging (MRI) agents: water soluble carbon-13 enriched fullerene and carbon nanotubes for use with dynamic nuclear polarization
WO2007035871A1 (en) * 2005-09-21 2007-03-29 Massachusetts Institute Of Technology Systems and methods for tuning properties of nanoparticles
JP2009510081A (ja) * 2005-09-28 2009-03-12 プレジデント アンド フェローズ オブ ハーバード カレッジ 磁気共鳴イメージングにおける造影剤としての使用のための長いスピン緩和時間を有する過分極化された固形物
ES2654520T3 (es) * 2005-10-11 2018-02-14 Huntington Medical Research Institutes Agentes de formación de imágenes y métodos de uso de los mismos
EP1948248A2 (en) * 2005-11-06 2008-07-30 Katz-Brull, Rachel Magnetic resonance imaging and spectroscopy means and methods thereof
WO2007064226A2 (en) 2005-12-01 2007-06-07 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion
NO20055681D0 (no) * 2005-12-01 2005-12-01 Amersham Health As Method of dynamic nuclear polarisation
EP1968442A4 (en) * 2005-12-10 2009-11-04 Harvard College In situ hyperpolarization of imaging agents
EP1962912B1 (en) * 2005-12-16 2012-09-26 Ge Healthcare As Method to produce hyperpolarised carboxylates of organic amines
JP2009523172A (ja) * 2006-01-11 2009-06-18 プレジデント・アンド・フエローズ・オブ・ハーバード・カレツジ 造影剤のエクスビボ過分極
KR101095943B1 (ko) 2006-02-21 2011-12-19 밀리켈빈 테크놀로지스 엘엘씨 과분극화 방법, 시스템 및 조성물
AU2013205838B2 (en) * 2006-02-21 2016-03-17 Avrum Belzer Hyperpolarization Methods, Systems and Compositions
US8703102B2 (en) 2008-04-04 2014-04-22 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
US20100233096A1 (en) * 2006-03-29 2010-09-16 Lerche Mathilde H Method to produce hyperpolarised carboxylates and sulphonates
US7205764B1 (en) * 2006-04-11 2007-04-17 Varian, Inc. Method and apparatus for increasing the detection sensitivity in a high resolution NMR analysis
CN101437645B (zh) * 2006-05-11 2010-12-01 贝尔直升机泰克斯特龙公司 修复结构部件的设备和方法
WO2008048714A2 (en) * 2006-05-12 2008-04-24 Massachusetts Institute Of Technology Biradical polarizing agents for dynamic nuclear polarization
US20090311189A1 (en) * 2006-05-12 2009-12-17 Massachusetts Institute Of Technology Temperature-jump dynamic nuclear polarization
US8623327B2 (en) 2006-06-19 2014-01-07 Beth Israel Deaconess Medical Center, Inc. Imaging agents for use in magnetic resonance blood flow/perfusion imaging
JP5363320B2 (ja) * 2006-08-18 2013-12-11 ジーイー・ヘルスケア・アクスイェ・セルスカプ 細胞死の13c−mrイメージング又は分光法
EP2057131B1 (en) 2006-08-30 2013-08-21 Ge Healthcare As Method of dynamic nuclear polarisation (dnp) and compounds and compositions for use in the method
US20100027864A1 (en) 2006-10-03 2010-02-04 Bastiaan Driehuys Systems and Methods for Assessing Pulmonary Gas Transfer using Hyperpolarized 129XE MRI
US7631507B2 (en) 2006-11-02 2009-12-15 General Electric Company Methods and devices for polarized samples for use in MRI
US8849372B2 (en) * 2006-11-22 2014-09-30 The General Hospital Corporation Method for magnetic resonance imaging using stimulus induced rotary saturation with a contrast agent
US8076937B2 (en) * 2006-12-11 2011-12-13 Koninklijke Philips Electronics N.V. Fibre tracking on the basis of macroscopic information
WO2008086534A1 (en) 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof
US20080240998A1 (en) 2007-03-28 2008-10-02 Urbahn John A Fluid path system for dissolution and transport of a hyperpolarized material
US20080275668A1 (en) * 2007-05-02 2008-11-06 General Electric Company Apparatus and method for fully automated closed system optical measurement of volume
US7519492B2 (en) * 2007-05-02 2009-04-14 General Electric Company Apparatus and method for fully automated closed system quality control of a substance
US7610157B2 (en) * 2007-05-02 2009-10-27 General Electric Company Apparatus and method for fully automated closed system pH measurement
US7741844B2 (en) 2007-05-07 2010-06-22 General Electric Company Method and system for magnetic resonance imaging using labeled contrast agents
US9042978B2 (en) * 2007-05-11 2015-05-26 Neurometrix, Inc. Method and apparatus for quantitative nerve localization
GB2450316A (en) * 2007-06-18 2008-12-24 Univ York Hyperpolarizing nuclei
DE102007028901B4 (de) * 2007-06-22 2010-07-22 Siemens Ag Verfahren und Vorrichtung zur automatischen Bestimmung von Perfusion mittels einer Magnetresonanzanlage
US9227173B2 (en) 2007-06-22 2016-01-05 General Electric Company Methods for dynamic filtration of pharmaceutical products
US20080314836A1 (en) * 2007-06-22 2008-12-25 General Electric Company Methods and devices for dynamic filtration of pharmaceutical products
GB0713074D0 (en) * 2007-07-05 2007-08-15 Univ London A method of hyperpolarising a magnetic resonance agent
ES2375083T3 (es) * 2007-08-27 2012-02-24 Ge Healthcare Limited Medio de formación de imagen que comprende 13c-acetat-hiperpolarizado y uso del mismo.
US20100233089A1 (en) * 2007-10-05 2010-09-16 Huntington Medical Research Institutes Imaging of genetic material with magnetic resonance
EP2072061A1 (en) 2007-12-19 2009-06-24 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
JP4871311B2 (ja) * 2008-02-26 2012-02-08 株式会社日立製作所 核磁気共鳴装置、磁気共鳴イメージング装置および磁気共鳴分析装置
GB0804422D0 (en) * 2008-03-10 2008-04-16 Univ Southampton An agent for transporting nuclear spin order and for magnetic resonance imaging
US20140223923A1 (en) * 2008-04-04 2014-08-14 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
WO2009129265A1 (en) * 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
US8763410B2 (en) * 2008-04-21 2014-07-01 General Electric Company Method and apparatus for the dissolution and filtration of a hyperpolarized agent with a neutral dissolution media
EP2268321B1 (en) 2008-05-02 2013-10-09 General Electric Company Method of determining alanine transaminase (ALT) activity by 13C-MR detection using hyperpolarised 13C-pyruvate
US9658300B1 (en) * 2008-08-19 2017-05-23 California Institute Of Technology Method and apparatus for preparation of spin polarized reagents
US9289518B2 (en) * 2008-08-22 2016-03-22 The Brigham And Women's Hospital Enhanced 13C NMR by thermal mixing with hyperpolarized 129XE
US7633290B1 (en) 2008-09-09 2009-12-15 General Electric Company Apparatus and method for a fully automated preparation of a hyperpolarizing imaging agent
US20100092390A1 (en) * 2008-10-09 2010-04-15 President And Fellows Of Harvard College Methods for Making Particles Having Long Spin-Lattice Relaxation Times
US20110274626A1 (en) 2008-12-10 2011-11-10 University Of York Pulse sequencing with hyperpolarisable nuclei
CN102388317B (zh) 2009-04-02 2015-11-25 通用电气健康护理有限公司 包含超极化13c丙酮酸盐的磁共振成像介质用于检测炎症或感染的用途
JP2012529960A (ja) * 2009-06-19 2012-11-29 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 軌道角運動量を持つ光子を使用した過分極装置と組み合わせたmri温度測定
AU2010286413B2 (en) 2009-08-31 2014-11-20 Millikelvin Technologies Llc Systems and methods for producing hyperpolarized materials and mixtures thereof
CA2772489A1 (en) 2009-08-31 2011-03-03 Brain Watch Ltd. Isotopically labeled neurochemical agents and uses thereof for diagnosing conditions and disorders
US8968703B2 (en) 2009-09-10 2015-03-03 Ge Healthcare Limited 13C-MR detection using hyperpolarised 13C-fructose
US8427161B2 (en) * 2009-12-18 2013-04-23 General Electric Company Method and apparatus for generating hyperpolarized materials
EP2343568A1 (en) * 2009-12-30 2011-07-13 Koninklijke Philips Electronics N.V. Dynamic nuclear polarization apparatus with sample transport system
WO2011101765A1 (en) * 2010-02-16 2011-08-25 Koninklijke Philips Electronics N.V. Optical hyperpolarisation with light endowed with orbital angular momentum
JP5758982B2 (ja) 2010-04-08 2015-08-05 ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. 過分極基質の製造方法およびmriのための方法
US8970217B1 (en) 2010-04-14 2015-03-03 Hypres, Inc. System and method for noise reduction in magnetic resonance imaging
US9259490B2 (en) 2010-05-03 2016-02-16 Ge Healthcare Limited Hyperpolarized lactate contrast agent for determination of LDH activity
DE102010017568B4 (de) 2010-06-24 2012-09-13 Johann Wolfgang Goethe-Universität Frankfurt am Main Hyperpolarisationseinrichtung und Verfahren zur Verabreichung eines hyperpolarisierten flüssigen Kontrastmittels
WO2012056447A1 (en) 2010-10-25 2012-05-03 Brain Watch Ltd. Isotopically labeled deoxy-glucose and derivatives thereof, compositions comprising them and uses thereof
US8786284B2 (en) * 2011-01-11 2014-07-22 Bridge12 Technologies, Inc. Integrated high-frequency generator system utilizing the magnetic field of the target application
EP2689239A4 (en) * 2011-03-23 2014-12-24 Millikelvin Technologies Llc IMPROVED TECHNIQUES, ENHANCED SYSTEMS, AND COMPUTER-READABLE ENHANCED PROGRAMS FOR MAGNETIC RESONANCE
US20140099262A1 (en) 2011-06-01 2014-04-10 Brain Watch Ltd. Isotopically labeled cdp-choline and uses thereof
WO2013053839A1 (en) 2011-10-12 2013-04-18 Bracco Imaging Spa Process for the preparation of hyperpolarized derivatives for use in mri analysis
US9693828B2 (en) 2011-12-05 2017-07-04 Bracco Imaging S.P.A. Composition comprising acetic anhydride and a gadolinium complex, and method for the use in hyperpolarisation in MRI analysis
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
IL223935A (en) 2012-01-13 2016-11-30 Gen Electric Fluid track system for decomposition and transport of hyper-polarized material
EP2624004A1 (en) * 2012-02-06 2013-08-07 Koninklijke Philips Electronics N.V. Temperature determination using magnetic resonance B1 field mapping
US8715621B2 (en) 2012-03-15 2014-05-06 Massachusetts Institute Of Technology Radical polarizing agents for dynamic nuclear polarization
EP2642310A1 (en) * 2012-03-22 2013-09-25 Koninklijke Philips N.V. Interpolated three-dimensional thermal dose estimates using magnetic resonance imaging
US9925280B2 (en) 2012-04-02 2018-03-27 Bracco Imaging S.P.A. Hyperpolarized amino acids
US9329245B2 (en) * 2012-04-11 2016-05-03 Bruker Biospin Ag MRI compatible method and device for rapid DNP on a solid state hyperpolarized sample material
WO2013167587A1 (en) 2012-05-07 2013-11-14 Albeda Innovation Aps Intra-operative cancer diagnosis based on a hyperpolarized marker
US8825132B2 (en) 2012-07-04 2014-09-02 Bruker Biospin Gmbh Field cycling method for magnetic resonance
WO2014009240A1 (en) 2012-07-13 2014-01-16 Bracco Imaging Spa Triarylmethyl radicals
US9329246B2 (en) 2012-10-03 2016-05-03 Bruker Biospin Ag Method for hyperpolarization transfer in the liquid state
WO2014064194A1 (en) 2012-10-25 2014-05-01 Bracco Imaging Spa Hyperpolarized 2-oxoglutarate as metabolic agent in mr
US9404984B2 (en) 2012-11-06 2016-08-02 Bruker Uk Limited Method of hyperpolarization applying brute force using particulate acceleration agents
US20140200437A1 (en) * 2013-01-16 2014-07-17 Empire Technology Development Llc Detection of internal gas leakage
WO2014118258A1 (en) 2013-01-31 2014-08-07 Bracco Imaging Spa Hyperpolarized esters as metabolic markers in mr
EP3016687B1 (en) * 2013-07-01 2017-08-09 Bracco Imaging S.p.A Hyperpolarized 1-13c-1,1-bis(acetoxy(methyl))-2,2'-cyclopropane as metabolic marker for mr
US9642924B2 (en) * 2013-08-29 2017-05-09 Duke University Contrast agents based on long-lived nuclear singlet states and related methods
US9874622B2 (en) 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
EP2863229A1 (en) 2013-10-15 2015-04-22 Technische Universität München pH-biosensors based on compounds with pH-sensitive enolic groups for magnetic resonance imaging and spectroscopy and their uses
EP2891500B1 (en) 2014-01-07 2018-08-01 Cambridge Enterprise Limited Contrast agent for determination of aldehyde dehydrogenase (ALDH) activity
EP3015855A1 (en) 2014-10-27 2016-05-04 Klinikum rechts der Isar der Technischen Universität München Metal biosensors based on compounds with metal-sensitive chemical shifts for magnetic resonance spectroscopy and imaging
US10088536B2 (en) * 2015-03-27 2018-10-02 Bruker Biospin Corporation Sample introduction system and method for polarization
US10649044B2 (en) * 2015-05-22 2020-05-12 Universität Ulm Method for the hyperpolarisation of nuclear spins
CA2997791A1 (en) 2015-09-30 2017-04-06 Duke University Ascorbate formulations and methods of use as contrast agents
CN105738397B (zh) * 2016-02-04 2017-09-29 浙江大学 化合物中季碳纵向驰豫时间(t1)的分析方法
CN105866158B (zh) * 2016-03-31 2017-12-15 武汉大学 基于磁共振耦合的无损溶液浓度检测装置及检测方法
EP3258285B1 (en) 2016-06-14 2020-10-21 Bruker BioSpin GmbH Method for predicting chemical shift values of nmr spin systems in a sample of a fluid class, in particular in a sample of a biofluid
US10390727B2 (en) * 2017-04-21 2019-08-27 The Charles Stark Draper Laboratory, Inc. Apparatus and method for imaging currents using nanoparticles and low-field magnetic resonance imaging (MRI)
GB201710677D0 (en) 2017-07-03 2017-08-16 Univ York Polorisation transfer via a second metal complex
WO2019055358A1 (en) * 2017-09-12 2019-03-21 Memorial Sloan Kettering Cancer Center HYPERPOLARIZED UREA, ARGININE, GLUTAMINE AND XANTHINE PROBES, HYPERPOLARIZED 13C FOR DEUTERIUM AND 15N-MARKED EXCHANGE
US10520561B2 (en) 2017-09-27 2019-12-31 General Electric Company System and method for hyperpolarizing a substance and quenching radicals therein
WO2019145955A1 (en) * 2018-01-26 2019-08-01 Hadasit Medical Research Services & Development Limited Non-metallic magnetic resonance contrast agent
US10942237B2 (en) 2019-05-07 2021-03-09 GE Precision Healthcare LLC System and method for hyperpolarizing a substance
US11428763B2 (en) * 2020-02-28 2022-08-30 Government Of The United States Of America, As Represented By The Secretary Of Commerce Planar inverse anapole microresonator and performing inductive-detection electron paramagnetic resonance spectroscopy
WO2021198776A2 (en) * 2020-03-31 2021-10-07 Nvision Imaging Technologies Gmbh Systems and method for generation of hyperpolarized materials
CN112268918A (zh) * 2020-07-10 2021-01-26 中国科学院过程工程研究所 一种基于固体核磁共振波谱仪的材料吸附气体原位分析装置
CN115989083A (zh) * 2020-08-25 2023-04-18 生物石墨烯有限公司 包括含碳13的石墨烯量子点的mri造影剂及其制备方法
CN114690099B (zh) * 2020-12-30 2025-05-06 中国科学技术大学 光超极化核磁共振成像装置及方法
EP4359014A1 (en) * 2021-06-25 2024-05-01 Beacon MRI Ltd Particles for use in hyperpolarization
GB202111734D0 (en) 2021-08-16 2021-09-29 Cambridge Entpr Ltd Hyperpolarisation method and product
WO2024191654A1 (en) * 2023-03-10 2024-09-19 North Carolina State University Magnetic field control of sabre hyperpolarized molecules for processing and administration

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037239A1 (en) * 1996-03-29 1997-10-09 Lawrence Berkeley National Laboratory Enhancement of nmr and mri in the presence of hyperpolarized noble gases
WO1998001766A1 (en) * 1996-07-05 1998-01-15 Nycomed Imaging As Method of electron spin resonance enhanced magnetic resonance imaging (esremri) with ex vivo dynamic nuclear polarisaton of an mr imaging agent
WO1998030918A1 (en) * 1997-01-08 1998-07-16 Nycomed Imaging As Method of magnetic resonance imaging

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0296833B1 (en) 1987-06-23 1991-09-25 Hafslund Nycomed Innovation AB Improvements in and relating to magnetic resonance imaging
GB8817137D0 (en) 1988-07-19 1988-08-24 Nycomed As Compositions
GB8819753D0 (en) * 1988-08-19 1988-09-21 Nycomed As Apparatus
JPH02111747A (ja) * 1988-10-21 1990-04-24 Nippon Steel Chem Co Ltd 炭素13標識5‐アミノレブリン酸及びその誘導体の製造方法
JP3166160B2 (ja) * 1989-02-15 2001-05-14 味の素株式会社 新規な▲上1▼▲上3▼c標識アミノ酸及びその発酵的又は酵素的製造法
FI923589L (fi) 1990-02-12 1992-08-11 Hafslund Nycomed Innovation Triarylmetylradikaler och anvaendning av inerta fria kolradikaler i mri.
US5413917A (en) * 1990-07-18 1995-05-09 Board Of Regents, The University Of Texas System Method of determining sources of acetyl-CoA under nonsteady-state conditions
ES2114566T3 (es) 1991-08-09 1998-06-01 Nycomed Innovation Ab Uso de radicales libres persistentes en formacion de imagenes por resonancia magnetica nuclear.
JPH0597711A (ja) * 1991-10-04 1993-04-20 節 ▲築▼山 生体組織代謝検査法
RU2063702C1 (ru) * 1992-07-20 1996-07-20 Леонид Аврамович Тютин Способ магнитно-резонансной томографии и устройство для его осуществления
US5464696A (en) * 1992-08-13 1995-11-07 Bracco International B.V. Particles for NMR imaging
GB9305351D0 (en) * 1993-03-16 1993-05-05 Nycomed Imaging As Improvements in or relating to contrast agents
US5545396A (en) 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases
US5479925A (en) 1994-06-23 1996-01-02 General Electric Company Magnetic resonance (MR) angiography in a low-field imaging magnet
GB9419203D0 (en) 1994-09-23 1994-11-09 Nycomed Innovation Ab Contrast media
US5617859A (en) 1995-10-02 1997-04-08 General Electric Company Apparatus and methods for magnetic resonance (MR) imaging of cavities using fluids polarized at low temperatures
JP3897841B2 (ja) * 1995-10-31 2007-03-28 独立行政法人科学技術振興機構 標識アシル−l−カルニチンを用いた疾患診断剤
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent
US6125654A (en) 1998-10-16 2000-10-03 Syracuse University Bulk production and usage of hyperpolarized 129 Xenon
FR2833953B1 (fr) 2001-12-21 2004-12-03 Sanofi Synthelabo DERIVES DE 3-HETEROARYL-3,5-DIHYDRO-4-OXO-4H-PYRIDAZINO [4,5-b]INDOLE-1-CARBOXAMIDE, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997037239A1 (en) * 1996-03-29 1997-10-09 Lawrence Berkeley National Laboratory Enhancement of nmr and mri in the presence of hyperpolarized noble gases
WO1998001766A1 (en) * 1996-07-05 1998-01-15 Nycomed Imaging As Method of electron spin resonance enhanced magnetic resonance imaging (esremri) with ex vivo dynamic nuclear polarisaton of an mr imaging agent
WO1998030918A1 (en) * 1997-01-08 1998-07-16 Nycomed Imaging As Method of magnetic resonance imaging

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