KR100683614B1 - 항-비만 및 항-당뇨 특성을 갖는 아릴에탄올아민 유도체의제조 방법 - Google Patents

항-비만 및 항-당뇨 특성을 갖는 아릴에탄올아민 유도체의제조 방법 Download PDF

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KR100683614B1
KR100683614B1 KR1020027007383A KR20027007383A KR100683614B1 KR 100683614 B1 KR100683614 B1 KR 100683614B1 KR 1020027007383 A KR1020027007383 A KR 1020027007383A KR 20027007383 A KR20027007383 A KR 20027007383A KR 100683614 B1 KR100683614 B1 KR 100683614B1
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formula
alkyl
compound
hydrogen
amino
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Korean (ko)
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KR20020061636A (ko
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로니 맥스웰 로렌스
앨란 밀러
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글락소 그룹 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C237/06—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Glass Compositions (AREA)
  • Iron Core Of Rotating Electric Machines (AREA)
KR1020027007383A 1999-12-11 2000-12-08 항-비만 및 항-당뇨 특성을 갖는 아릴에탄올아민 유도체의제조 방법 Expired - Fee Related KR100683614B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9929297.1A GB9929297D0 (en) 1999-12-11 1999-12-11 Process
GB9929297.1 1999-12-11

Publications (2)

Publication Number Publication Date
KR20020061636A KR20020061636A (ko) 2002-07-24
KR100683614B1 true KR100683614B1 (ko) 2007-02-16

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ID=10866125

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KR1020027007383A Expired - Fee Related KR100683614B1 (ko) 1999-12-11 2000-12-08 항-비만 및 항-당뇨 특성을 갖는 아릴에탄올아민 유도체의제조 방법

Country Status (23)

Country Link
US (1) US6548523B2 (enExample)
EP (1) EP1235788B1 (enExample)
JP (1) JP4903964B2 (enExample)
KR (1) KR100683614B1 (enExample)
CN (1) CN1224609C (enExample)
AT (1) ATE292110T1 (enExample)
AU (1) AU769387B2 (enExample)
BR (1) BRPI0016187B1 (enExample)
CA (1) CA2394117C (enExample)
CZ (1) CZ303143B6 (enExample)
DE (1) DE60019157T2 (enExample)
ES (1) ES2236020T3 (enExample)
GB (1) GB9929297D0 (enExample)
HK (1) HK1045988B (enExample)
HU (1) HU229043B1 (enExample)
IL (1) IL149585A0 (enExample)
NO (1) NO323239B1 (enExample)
NZ (1) NZ518795A (enExample)
PL (1) PL200540B1 (enExample)
PT (1) PT1235788E (enExample)
TR (1) TR200201528T2 (enExample)
WO (1) WO2001042195A1 (enExample)
ZA (1) ZA200204585B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10230147A1 (de) * 2001-10-09 2004-01-15 Profos Ag Verfahren zur unspezifischen Anreicherung von Bakterienzellen
US7158049B2 (en) * 2003-03-24 2007-01-02 Schlumberger Technology Corporation Wireless communication circuit
US8213085B2 (en) * 2008-01-18 2012-07-03 Visera Technologies Company Limited Image sensor device with high photosensitivity
US8778998B2 (en) 2009-04-10 2014-07-15 Auspex Pharmaceuticals, Inc. Biphenyl-3-carboxylic acid modulators of beta-3-adrenoreceptor
EA030145B1 (ru) 2010-08-03 2018-06-29 Велисепт Терапьютикс, Инк. Комбинации агонистов бета-3-адренергических рецепторов и антагонистов мускариновых рецепторов для лечения гиперактивности мочевого пузыря
US9907767B2 (en) 2010-08-03 2018-03-06 Velicept Therapeutics, Inc. Pharmaceutical compositions and the treatment of overactive bladder
CA2864173A1 (en) 2012-02-09 2013-08-15 Altherx, Inc. Combination of muscarinic receptor antagonists and beta-3 adrenoceptor agonists for treating overactive bladder
EP3226849A4 (en) 2014-12-03 2018-05-09 Velicept Therapeutics, Inc. Compositions and methods of using modified release solabegron for lower urinary tract symptoms
FI3365321T3 (fi) 2015-10-23 2024-01-02 B3Ar Therapeutics Inc Solabegron-Zwitterioni ja sen käyttöjä

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1551260A (en) * 1976-02-09 1979-08-30 Allen & Hanburys Ltd Phenylethanolamine derivatives
JP2577222B2 (ja) * 1987-04-10 1997-01-29 興和株式会社 新規な置換アニリド誘導体
NO179246C (no) 1991-11-20 1996-09-04 Sankyo Co Aromatiske amino-alkoholderivater og mellomprodukter til fremstilling derav
GB9525121D0 (en) * 1995-12-08 1996-02-07 Glaxo Group Ltd Chemical compounds
WO1999057098A2 (en) * 1998-05-01 1999-11-11 Abbott Laboratories Substituted beta-amino acid inhibitors of methionine aminopeptidase-2
GB9812709D0 (en) * 1998-06-13 1998-08-12 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
IL149585A0 (en) 2002-11-10
CZ303143B6 (cs) 2012-05-02
ZA200204585B (en) 2003-12-31
DE60019157D1 (de) 2005-05-04
US20020198220A1 (en) 2002-12-26
HUP0203640A3 (en) 2003-08-28
CN1409700A (zh) 2003-04-09
NO20022758D0 (no) 2002-06-10
EP1235788B1 (en) 2005-03-30
BR0016187A (pt) 2002-08-13
PT1235788E (pt) 2005-08-31
PL356483A1 (en) 2004-06-28
CA2394117A1 (en) 2001-06-14
AU2191101A (en) 2001-06-18
EP1235788A1 (en) 2002-09-04
PL200540B1 (pl) 2009-01-30
HUP0203640A2 (hu) 2003-02-28
NO20022758L (no) 2002-07-01
WO2001042195A1 (en) 2001-06-14
CN1224609C (zh) 2005-10-26
ES2236020T3 (es) 2005-07-16
HK1045988A1 (en) 2002-12-20
HK1045988B (en) 2005-07-15
NO323239B1 (no) 2007-02-05
KR20020061636A (ko) 2002-07-24
CZ20022017A3 (cs) 2003-01-15
HU229043B1 (hu) 2013-07-29
JP2003516383A (ja) 2003-05-13
TR200201528T2 (tr) 2002-09-23
NZ518795A (en) 2004-02-27
BRPI0016187B1 (pt) 2016-08-02
JP4903964B2 (ja) 2012-03-28
CA2394117C (en) 2011-10-04
ATE292110T1 (de) 2005-04-15
DE60019157T2 (de) 2006-02-02
GB9929297D0 (en) 2000-02-02
AU769387B2 (en) 2004-01-22
US6548523B2 (en) 2003-04-15

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