KR100669836B1 - 신규한 아릴옥시-알킬-디알킬아민 및 이의 제조 방법 - Google Patents

신규한 아릴옥시-알킬-디알킬아민 및 이의 제조 방법 Download PDF

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Publication number
KR100669836B1
KR100669836B1 KR1020007004031A KR20007004031A KR100669836B1 KR 100669836 B1 KR100669836 B1 KR 100669836B1 KR 1020007004031 A KR1020007004031 A KR 1020007004031A KR 20007004031 A KR20007004031 A KR 20007004031A KR 100669836 B1 KR100669836 B1 KR 100669836B1
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South Korea
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alkyl
group
substituted
formula
unsubstituted
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English (en)
Korean (ko)
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KR20010024505A (ko
Inventor
래빈드래내쓰파놀릴
젤디스조셉
비드갤리나
포토스키존리차드
렌장진
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와이어쓰
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/32—Antioestrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pregnancy & Childbirth (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Detergent Compositions (AREA)
  • Indole Compounds (AREA)
KR1020007004031A 1997-10-15 1998-10-14 신규한 아릴옥시-알킬-디알킬아민 및 이의 제조 방법 Expired - Fee Related KR100669836B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US95081897A 1997-10-15 1997-10-15
US08/950,818 1997-10-15
US09/161,653 US6005102A (en) 1997-10-15 1998-09-28 Aryloxy-alkyl-dialkylamines
US09/161,653 1998-09-28
PCT/US1998/021609 WO1999019293A1 (en) 1997-10-15 1998-10-14 Novel aryloxy-alkyl-dialkylamines

Publications (2)

Publication Number Publication Date
KR20010024505A KR20010024505A (ko) 2001-03-26
KR100669836B1 true KR100669836B1 (ko) 2007-01-18

Family

ID=26858006

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007004031A Expired - Fee Related KR100669836B1 (ko) 1997-10-15 1998-10-14 신규한 아릴옥시-알킬-디알킬아민 및 이의 제조 방법

Country Status (26)

Country Link
EP (2) EP1777214A3 (enExample)
JP (1) JP2001519410A (enExample)
KR (1) KR100669836B1 (enExample)
CN (1) CN1231458C (enExample)
AR (1) AR015183A1 (enExample)
AT (1) ATE355264T1 (enExample)
AU (1) AU757630C (enExample)
BR (1) BR9813069A (enExample)
CA (1) CA2306343C (enExample)
CY (1) CY1106497T1 (enExample)
DE (1) DE69837210T2 (enExample)
DK (1) DK1025077T3 (enExample)
EA (1) EA003937B1 (enExample)
EE (1) EE200000225A (enExample)
ES (1) ES2281937T3 (enExample)
HU (1) HUP0004419A3 (enExample)
ID (1) ID24417A (enExample)
IL (2) IL135343A0 (enExample)
NO (1) NO20001938L (enExample)
NZ (1) NZ503793A (enExample)
PL (1) PL198443B1 (enExample)
PT (1) PT1025077E (enExample)
SI (1) SI1025077T1 (enExample)
SK (1) SK286460B6 (enExample)
TR (1) TR200001012T2 (enExample)
WO (1) WO1999019293A1 (enExample)

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US6479535B1 (en) 1998-05-15 2002-11-12 Wyeth 2-phenyl-1-[4-(2-aminoethoxy)-benzyl]-indole and estrogen formulations
BR9911040A (pt) * 1998-05-15 2001-02-13 American Home Prod 2-fenil-1-[4-(2-aminoetóxi)-benzil]-indol em combinação com estrogêneos
TWI287018B (en) * 1999-09-13 2007-09-21 Wyeth Corp Glucopyranosides conjugates of 2-(4-hydroxy-phenyl)-3-methyl-1-[4-(2-amin-1-yl-ethoxy)-benzyl]-1H-indol-5-ols
US6369051B1 (en) 2000-07-06 2002-04-09 American Home Products Corporation Combinations of SSRI and estrogenic agents
AR029539A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Combinaciones de estatinas y agentes estrogenicos
US6455568B2 (en) 2000-07-06 2002-09-24 Wyeth Combination therapy for inhibiting sphincter incontinence
US6358991B2 (en) 2000-07-06 2002-03-19 American Home Products Corporation Methods of treating neuropeptide Y-related conditions
EP1990051A1 (en) 2000-07-06 2008-11-12 Wyeth Combinations of SSRI and estrogenic agents
AR029538A1 (es) 2000-07-06 2003-07-02 Wyeth Corp Composiciones farmaceuticas de agentes estrogenicos
US6376486B1 (en) 2000-07-06 2002-04-23 American Home Products Corporation Methods of inhibiting sphincter incontinence
AU2001271782A1 (en) 2000-07-06 2002-01-21 Wyeth Use of substituted insole compounds for treating excessive intraocular pressure
EP1656938A1 (en) 2000-07-06 2006-05-17 Wyeth Combinations of SSRI and estrogenic agents
CA2441080A1 (en) * 2001-03-23 2002-10-03 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine h3 receptor antagonists, preparation and therapeutic uses
WO2002094788A1 (en) 2001-05-22 2002-11-28 Eli Lilly And Company 2-substituted 1,2,3,4-tetrahydroquinolines and derivatives thereof, compositions and methods
PT1401446E (pt) 2001-05-22 2005-05-31 Lilly Co Eli Derivados de tetrahidroquinolina para a inibicao de doencas associadas com a privacao de estrogenio ou com uma resposta fisiologica aberrante ao estrogenio endogeno
US7314937B2 (en) 2002-03-21 2008-01-01 Eli Lilly And Company Non-imidazole aryl alkylamines compounds as histamine H3 receptor antagonists, preparation and therapeutic uses
US7098241B2 (en) 2002-12-16 2006-08-29 Hoffmann-La Roche Inc. Thiophene hydroxamic acid derivatives
EP1732890A1 (en) 2004-04-07 2006-12-20 Wyeth Crystalline polymorph of a bazedoxifene acetate
BRPI0509257A (pt) 2004-04-07 2007-09-11 Wyeth Corp polimorfo cristalino de acetato de bazedoxifeno, composição, processo para preparar um polimorfo e para aumentar a proporção de acetato de bazedoxifeno forma b em uma composição, métodos de tratar um mamìfero, cáncer de mama e uma mulher em pós-menopausa para um ou mais distúrbios vasomotores, de abaixar colesterol e de inibir perda óssea em um mamìfero e uso de um polimorfo
JP2007532556A (ja) 2004-04-08 2007-11-15 ワイス 選択的エストロゲン受容体調節剤としてのアスコルビン酸バゼドキシフェン
CN1993322A (zh) * 2004-08-05 2007-07-04 惠氏公司 哌多昔芬盐酸盐一水合物的结晶多晶型物
GT200600010A (es) * 2005-01-13 2006-08-16 Wyeth Corp Procedimientos para la preparacion de alcoholes aminoetoxibencilicos
US20100087661A1 (en) * 2007-02-12 2010-04-08 Josef Jirman Method for the preparation of 5-benzyloxy-2-(4-benzyloxphenyl)-3-methyl-1h-indole
WO2009102771A1 (en) * 2008-02-11 2009-08-20 Wyeth Methods of converting polymorphic form b of bazedoxifene acetate to polymorphic form a of bazedoxifene acetate
CN102395561A (zh) * 2009-04-13 2012-03-28 桑多斯股份公司 合成巴多昔芬乙酸酯及其中间体的方法
US8569483B2 (en) 2011-06-21 2013-10-29 Divi's Laboratories, Ltd. Process for the preparation of bazedoxifene acetate and intermediates thereof
CN104151265B (zh) * 2013-05-13 2016-10-05 上海医药工业研究院 醋酸巴多昔芬中间体的制备方法
US9751835B2 (en) 2013-05-15 2017-09-05 Indiana University Research And Technology Corporation Processes and intermediates for preparing indole pharmaceuticals
IT201800006562A1 (it) * 2018-06-21 2019-12-21 Procedimento e intermedi utili per la preparazione di indoli
IT201900001923A1 (it) 2019-02-11 2020-08-11 Erregierre Spa Sali di bazedoxifene utili per la preparazione di bazedoxifene acetato

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0428312A2 (en) * 1989-11-13 1991-05-22 Pfizer Inc. Oxazolidinedione hypoglycemic agents

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EE04295B1 (et) * 1997-02-27 2004-06-15 American Cyanamid Company N-hüdroksü-2-(alküül-, arüül- või heteroarüülsulfanüül-, -sulfinüül- või-sulfonüül-)-3-asendatud-alküülamiidid, -arüülamiidid või -heteroarüülamiididkui maatriksmetalloproteinaasi inhibiitorid
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Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0428312A2 (en) * 1989-11-13 1991-05-22 Pfizer Inc. Oxazolidinedione hypoglycemic agents

Non-Patent Citations (1)

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Also Published As

Publication number Publication date
AU757630B2 (en) 2003-02-27
SI1025077T1 (sl) 2007-06-30
PL198443B1 (pl) 2008-06-30
EP1777214A3 (en) 2007-05-09
DE69837210T2 (de) 2007-12-27
NO20001938L (no) 2000-06-07
HUP0004419A2 (hu) 2001-07-30
CN1281429A (zh) 2001-01-24
SK286460B6 (sk) 2008-10-07
ATE355264T1 (de) 2006-03-15
EE200000225A (et) 2001-06-15
PT1025077E (pt) 2007-05-31
NO20001938D0 (no) 2000-04-13
TR200001012T2 (tr) 2000-09-21
AU757630C (en) 2006-10-26
ID24417A (id) 2000-07-20
IL135343A0 (en) 2001-05-20
EP1777214A2 (en) 2007-04-25
EP1025077B1 (en) 2007-02-28
EA200000416A1 (ru) 2000-10-30
EA003937B1 (ru) 2003-10-30
CA2306343A1 (en) 1999-04-22
HUP0004419A3 (en) 2002-01-28
DK1025077T3 (da) 2007-05-07
SK5372000A3 (en) 2000-11-07
EP1025077A1 (en) 2000-08-09
CN1231458C (zh) 2005-12-14
WO1999019293A1 (en) 1999-04-22
KR20010024505A (ko) 2001-03-26
ES2281937T3 (es) 2007-10-01
PL339908A1 (en) 2001-01-15
JP2001519410A (ja) 2001-10-23
NZ503793A (en) 2002-10-25
HK1026889A1 (en) 2000-12-29
AU1083199A (en) 1999-05-03
IL135343A (en) 2007-12-03
CA2306343C (en) 2010-08-03
DE69837210D1 (de) 2007-04-12
AR015183A1 (es) 2001-04-18
CY1106497T1 (el) 2012-01-25
BR9813069A (pt) 2000-08-22

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