KR100668024B1 - 유방암, 난소암, 자궁내막암, 골수종 및 수막종 치료용 약제를 제조하기 위한 11베타-(4-아세틸페닐)-17베타-히드록시-17알파-(1,1,2,2,2-펜타플루오로에틸)에스트라-4,9-디엔-3-온의 용도 - Google Patents

유방암, 난소암, 자궁내막암, 골수종 및 수막종 치료용 약제를 제조하기 위한 11베타-(4-아세틸페닐)-17베타-히드록시-17알파-(1,1,2,2,2-펜타플루오로에틸)에스트라-4,9-디엔-3-온의 용도 Download PDF

Info

Publication number
KR100668024B1
KR100668024B1 KR1020037005360A KR20037005360A KR100668024B1 KR 100668024 B1 KR100668024 B1 KR 100668024B1 KR 1020037005360 A KR1020037005360 A KR 1020037005360A KR 20037005360 A KR20037005360 A KR 20037005360A KR 100668024 B1 KR100668024 B1 KR 100668024B1
Authority
KR
South Korea
Prior art keywords
antiprogestin
treatment
cell
tumor
breast cancer
Prior art date
Application number
KR1020037005360A
Other languages
English (en)
Korean (ko)
Other versions
KR20030057540A (ko
Inventor
옌스 호프만
로제마리 리흐트너
게르하르트 지마이스터
마르틴 슈나이더
울리케 푸르만
Original Assignee
쉐링 악티엔게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 쉐링 악티엔게젤샤프트 filed Critical 쉐링 악티엔게젤샤프트
Publication of KR20030057540A publication Critical patent/KR20030057540A/ko
Application granted granted Critical
Publication of KR100668024B1 publication Critical patent/KR100668024B1/ko

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020037005360A 2000-10-18 2001-10-17 유방암, 난소암, 자궁내막암, 골수종 및 수막종 치료용 약제를 제조하기 위한 11베타-(4-아세틸페닐)-17베타-히드록시-17알파-(1,1,2,2,2-펜타플루오로에틸)에스트라-4,9-디엔-3-온의 용도 KR100668024B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US24099100P 2000-10-18 2000-10-18
EP00250342.3 2000-10-18
EP00250342 2000-10-18
US60/240,991 2000-10-18
PCT/EP2001/012006 WO2002032432A1 (en) 2000-10-18 2001-10-17 Use of antiprogestins for the induction of apoptosis in a cell

Publications (2)

Publication Number Publication Date
KR20030057540A KR20030057540A (ko) 2003-07-04
KR100668024B1 true KR100668024B1 (ko) 2007-01-15

Family

ID=26072952

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020037005360A KR100668024B1 (ko) 2000-10-18 2001-10-17 유방암, 난소암, 자궁내막암, 골수종 및 수막종 치료용 약제를 제조하기 위한 11베타-(4-아세틸페닐)-17베타-히드록시-17알파-(1,1,2,2,2-펜타플루오로에틸)에스트라-4,9-디엔-3-온의 용도

Country Status (29)

Country Link
EP (1) EP1326617B9 (el)
JP (1) JP2004511523A (el)
KR (1) KR100668024B1 (el)
CN (1) CN1209111C (el)
AT (1) ATE334683T1 (el)
AU (2) AU2361902A (el)
BG (1) BG107744A (el)
BR (1) BR0114696A (el)
CA (1) CA2423020C (el)
CY (1) CY1105745T1 (el)
CZ (1) CZ299823B6 (el)
DE (1) DE60121980T2 (el)
DK (1) DK1326617T3 (el)
EA (1) EA010593B1 (el)
EE (1) EE200300157A (el)
ES (1) ES2269492T3 (el)
HK (1) HK1062273A1 (el)
HR (1) HRP20030388A2 (el)
HU (1) HUP0301433A3 (el)
IL (2) IL154976A0 (el)
MX (1) MXPA03002955A (el)
NO (1) NO20031741L (el)
NZ (1) NZ538347A (el)
PL (1) PL360157A1 (el)
PT (1) PT1326617E (el)
SI (1) SI1326617T1 (el)
SK (1) SK4702003A3 (el)
UA (1) UA76729C2 (el)
WO (1) WO2002032432A1 (el)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY27301A1 (es) * 2001-05-25 2003-02-28 Schering Ag Uso y composiciones de antiprogestinas para el tratamiento de enfermedades de la próstata
US20040242551A1 (en) * 2003-05-28 2004-12-02 Schering Ag Composition comprising antiprogestins and pure antiestrogens for prophylaxis and treatment of hormone-dependent diseases
WO2008128791A2 (en) * 2007-04-23 2008-10-30 Bayer Schering Pharma Aktiengesellschaft Progesterone-receptor antagonist for use in brca-mediated cancer alone or as combination with antiestrogen
US20080268041A1 (en) * 2007-04-23 2008-10-30 Jens Hoffmann Combination of progesterone-receptor antagonist together with none-steroidal antiestrogen for use in brca mediated diseases
JP2010524996A (ja) * 2007-04-23 2010-07-22 バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト Brca媒介性疾患における使用のための、プロゲステロン受容体拮抗薬と、ルテインホルモン放出ホルモン作動薬および拮抗薬との組み合わせ
GB0718167D0 (en) 2007-09-18 2007-10-31 Cancer Rec Tech Ltd Cancer marker and therapeutic target
CN103957920B (zh) * 2011-10-04 2018-04-20 因维维斯制药公司 用于鉴定和治疗抗黄体制剂敏感性肿瘤的方法和系统

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19706061A1 (de) * 1997-02-07 1998-08-13 Schering Ag Antigestagen wirksame Steroide mit fluorierter 17alpha-Alkylkette

Also Published As

Publication number Publication date
ES2269492T3 (es) 2007-04-01
MXPA03002955A (es) 2003-08-07
KR20030057540A (ko) 2003-07-04
CN1209111C (zh) 2005-07-06
DE60121980D1 (de) 2006-09-14
EP1326617B9 (en) 2006-10-25
CA2423020A1 (en) 2002-04-25
UA76729C2 (uk) 2006-09-15
CN1469749A (zh) 2004-01-21
EE200300157A (et) 2003-08-15
NO20031741L (no) 2003-06-17
WO2002032432A1 (en) 2002-04-25
CY1105745T1 (el) 2010-12-22
HUP0301433A3 (en) 2010-01-28
CZ299823B6 (cs) 2008-12-03
PT1326617E (pt) 2006-12-29
EP1326617B1 (en) 2006-08-02
ATE334683T1 (de) 2006-08-15
SI1326617T1 (sl) 2007-02-28
DK1326617T3 (da) 2006-12-18
CA2423020C (en) 2009-01-20
BG107744A (bg) 2004-02-27
NZ538347A (en) 2007-03-30
AU2002223619B2 (en) 2006-08-24
JP2004511523A (ja) 2004-04-15
HUP0301433A2 (hu) 2003-10-28
HRP20030388A2 (en) 2005-04-30
AU2361902A (en) 2002-04-29
IL154976A0 (en) 2003-10-31
BR0114696A (pt) 2003-11-18
HK1062273A1 (en) 2004-10-29
PL360157A1 (en) 2004-09-06
NO20031741D0 (no) 2003-04-15
IL154976A (en) 2007-05-15
DE60121980T2 (de) 2007-03-01
EA010593B1 (ru) 2008-10-30
EP1326617A1 (en) 2003-07-16
EA200300479A1 (ru) 2003-10-30
SK4702003A3 (en) 2004-01-08

Similar Documents

Publication Publication Date Title
KR100632908B1 (ko) 호르몬-의존성 질병의 예방 및 치료를 위한항프로게스틴의 용도
AU2002218243A1 (en) Use of antiprogestins for prophylaxis and treatment of hormone-dependent diseases
KR100668024B1 (ko) 유방암, 난소암, 자궁내막암, 골수종 및 수막종 치료용 약제를 제조하기 위한 11베타-(4-아세틸페닐)-17베타-히드록시-17알파-(1,1,2,2,2-펜타플루오로에틸)에스트라-4,9-디엔-3-온의 용도
Yano et al. Inhibition of growth of MCF-7 MIII human breast carcinoma in nude mice by treatment with agonists or antagonists of LH-RH
AU2002223619A1 (en) Use of antiprogestins for the induction of apoptosis in a cell
US20040072811A1 (en) Use of antiprogestins for the induction of apoptosis in a cell
US20040053898A1 (en) Combination preparation with a erbeta selective estrogen and serm or antiestorgen
KR20060005412A (ko) 호르몬-의존성 질환의 예방 및 치료를 위한 항프로게스틴및 순수한 항에스트로겐을 포함하는 조성물
TWI306403B (en) Use of antiprogestings for the induction of apoptosis in a cell
TWI312680B (en) Use of antiprogesting for prophylaxis and treatment of hormone-dependent diseases
EA007529B1 (ru) Применение антипрогестинов для профилактики и лечения гормонозависимых заболеваний

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
LAPS Lapse due to unpaid annual fee