KR100629834B1 - 염증 및 다른 질병의 치료를 위한2-시아노-4-아미노-피리미딘 구조 및 카텝신 ｋ 저해활성을 갖는 시스테인 프로테아제 저해제 - Google Patents

염증 및 다른 질병의 치료를 위한2-시아노-4-아미노-피리미딘 구조 및 카텝신 ｋ 저해활성을 갖는 시스테인 프로테아제 저해제 Download PDF

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Publication number
KR100629834B1
KR100629834B1 KR1020047002973A KR20047002973A KR100629834B1 KR 100629834 B1 KR100629834 B1 KR 100629834B1 KR 1020047002973 A KR1020047002973 A KR 1020047002973A KR 20047002973 A KR20047002973 A KR 20047002973A KR 100629834 B1 KR100629834 B1 KR 100629834B1
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KR
South Korea
Prior art keywords
dimethyl
piperazin
phenyl
ethyl
propylamino
Prior art date
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Expired - Fee Related
Application number
KR1020047002973A
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English (en)
Korean (ko)
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KR20040029101A (ko
Inventor
에바 알트만
겐지 하야까와
겐지 이와사끼
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노파르티스 아게
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Priority claimed from GBGB0121026.9A external-priority patent/GB0121026D0/en
Priority claimed from GB0121024A external-priority patent/GB0121024D0/en
Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20040029101A publication Critical patent/KR20040029101A/ko
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Publication of KR100629834B1 publication Critical patent/KR100629834B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A61P33/12—Schistosomicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020047002973A 2001-08-30 2002-08-29 염증 및 다른 질병의 치료를 위한2-시아노-4-아미노-피리미딘 구조 및 카텝신 ｋ 저해활성을 갖는 시스테인 프로테아제 저해제 Expired - Fee Related KR100629834B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB0121026.9A GB0121026D0 (en) 2001-08-30 2001-08-30 Organic compounds
GB0121024.4 2001-08-30
GB0121026.9 2001-08-30
GB0121024A GB0121024D0 (en) 2001-08-30 2001-08-30 Organic compounds
PCT/EP2002/009661 WO2003020278A1 (en) 2001-08-30 2002-08-29 Cysteine protease inhibitors with 2-cyano-4-amino-pyrimidine structure and cathepsin k inhibitory activity for the treatment of inflammations and other diseases

Publications (2)

Publication Number Publication Date
KR20040029101A KR20040029101A (ko) 2004-04-03
KR100629834B1 true KR100629834B1 (ko) 2006-09-29

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020047002973A Expired - Fee Related KR100629834B1 (ko) 2001-08-30 2002-08-29 염증 및 다른 질병의 치료를 위한2-시아노-4-아미노-피리미딘 구조 및 카텝신 ｋ 저해활성을 갖는 시스테인 프로테아제 저해제

Country Status (22)

Country Link
US (2) US7112589B2 (https=)
EP (1) EP1423121B1 (https=)
JP (1) JP4131701B2 (https=)
KR (1) KR100629834B1 (https=)
CN (1) CN1549717B (https=)
AR (1) AR036375A1 (https=)
AT (1) ATE345136T1 (https=)
AU (1) AU2002333758B2 (https=)
BR (1) BR0212141A (https=)
CA (1) CA2456127C (https=)
CO (1) CO5560576A2 (https=)
DE (1) DE60216122T2 (https=)
ES (1) ES2275946T3 (https=)
HU (1) HUP0401431A3 (https=)
IL (1) IL160295A0 (https=)
MX (1) MXPA04001930A (https=)
NZ (1) NZ531287A (https=)
PE (1) PE20030772A1 (https=)
PL (1) PL208280B1 (https=)
PT (1) PT1423121E (https=)
RU (1) RU2326119C2 (https=)
WO (1) WO2003020278A1 (https=)

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KR20170093182A (ko) 2014-12-11 2017-08-14 인바이오모션 에스.엘. 인간 c-maf에 대한 결합 구성원
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Publication number Publication date
EP1423121B1 (en) 2006-11-15
EP1423121A1 (en) 2004-06-02
CA2456127A1 (en) 2003-03-13
US7112589B2 (en) 2006-09-26
HUP0401431A3 (en) 2004-11-29
PL208280B1 (pl) 2011-04-29
US20040249153A1 (en) 2004-12-09
ATE345136T1 (de) 2006-12-15
WO2003020278A1 (en) 2003-03-13
DE60216122T2 (de) 2007-09-06
HUP0401431A2 (hu) 2004-10-28
NZ531287A (en) 2005-12-23
RU2004109812A (ru) 2005-10-20
IL160295A0 (en) 2004-07-25
JP2005505550A (ja) 2005-02-24
CO5560576A2 (es) 2005-09-30
PL367821A1 (en) 2005-03-07
BR0212141A (pt) 2004-08-24
US20060074092A1 (en) 2006-04-06
JP4131701B2 (ja) 2008-08-13
AR036375A1 (es) 2004-09-01
DE60216122D1 (de) 2006-12-28
CN1549717B (zh) 2011-08-17
ES2275946T3 (es) 2007-06-16
PE20030772A1 (es) 2003-10-02
KR20040029101A (ko) 2004-04-03
CN1549717A (zh) 2004-11-24
AU2002333758B2 (en) 2006-01-19
RU2326119C2 (ru) 2008-06-10
MXPA04001930A (es) 2004-06-15
CA2456127C (en) 2009-10-20
PT1423121E (pt) 2007-02-28

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