KR100554319B1 - 염증성 질환 치료용 의약의 제조에 있어서 가바펜틴 등의감마-아미노부티르산 동족체의 용도 - Google Patents
염증성 질환 치료용 의약의 제조에 있어서 가바펜틴 등의감마-아미노부티르산 동족체의 용도 Download PDFInfo
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- KR100554319B1 KR100554319B1 KR1019997012256A KR19997012256A KR100554319B1 KR 100554319 B1 KR100554319 B1 KR 100554319B1 KR 1019997012256 A KR1019997012256 A KR 1019997012256A KR 19997012256 A KR19997012256 A KR 19997012256A KR 100554319 B1 KR100554319 B1 KR 100554319B1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- Orthopedic Medicine & Surgery (AREA)
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- Physical Education & Sports Medicine (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Description
제21일 PG-PS 유발시험 | 제22일 | 제23일 | 제24일 | |||
종창 (델타 부종, mL) | 0 | 0.20 | 0.45 | 0.50 | 0 (n=6) | 경구 투여용 프리가발린(㎎/㎏) |
0 | 0.12 | 0.38 | 0.50 | 3.0 (n=6) | ||
0 | 0.04 | 0.25 | 0.31 | 10.0 (n=6) | ||
0 | 0.06 | 0.20 | 0.21 | 30.0 (n=6) |
PWL (초) | PWL (기준선의 %) | 행동 점수 | 주위 (cm) | 주위 (기준선에 대한% ) | |
기준선 | 11.47 ±0.56 | 100 | 0 | 5.18 ±0.04 | 100 |
관절염(4 시간) | 8.66 ±0.56* | 76.42 ±3.10* | 1.25 ±0.13* | 5.92 ±0.09* | 114.38 ±1.86* |
*p<0.01 |
기준선 (대조군의 %) | PWL (약물을 주입한 지 1.5 시간 후) | PWL (약물을 주사한 지 4 시간 후) | 행동 점수 (약물을 주사한 지 4 시간 후) | 주위 (약물을 주사한 지 4 시간 후) | |
가바펜틴 | 100 | 105.18 ±4.56 | 100.03 ±4.37 | 0.67 ±0.30 | 114.20 ±1.53* |
aCSF(n은 6임) | 100 | 93.12 ±6.31 | 74.47 ±3.44* | 1.33 ±0.2* | 114.87 ±1.74* |
*p<0.01 |
카올린 및 카라게난을 주사한지 4 시간 후에, 동물 모두 PWL 반응 및 자발적 통증 관련 행동이 감소되었음을 보여주었다. 가바펜틴을 척수로 주입한 군에서는 PWL이 기준선 측정값의 약 81%로 감소하였다(p<0.01, 짝을 이룬 t-시험). 척수로 가바펜틴을 주입한지 1.5 시간 후까지는 PWL이 기주선으로 되돌아오고 발가락은 거의 펴졌다.
PWL 또는 주위 (대조군의 %) | PWL (관절염 4 시간 후) | PWL (관절염 5.5 시간 후) | 행동 점수 (관절염 5.5 시간 후) | 주위 (관절염 5.5 시간 후) | |
가바펜틴 (척수) (n은 6임) | 100 | 80.71 ±3,23* | 100.85 ±10.63 | 0.50 ±0.20 | 122.22 ±2.32* |
가바펜틴 (피하) (n은 6임) | 100 | 85.05 ±3.68* | 81.89 ±4.43* | 1.17 ±0.29* | 120.66 ±3.59* |
aCSF (척수) (n은 6임) | 100 | 78.37 ±5.37* | 78.57 ±4.38* | 1.17 ±0.28* | 113.89 ±3.49* |
*p<0.01 |
Claims (11)
- 삭제
- 제1항에 있어서, 화학식 Ⅰ의 화합물이 가바펜틴인 조성물.
- 제1항에 있어서, 화학식 Ⅰ의 화합물의 환형 고리가 메틸 및 에틸로 이루어진 군으로부터 선택된 하나 이상의 기로 치환된 것인 조성물.
- 제4항에 있어서, 화학식 Ⅰ의 화합물이 (1-아미노메틸-3-메틸시클로헥실)아세트산인 조성물.
- 제4항에 있어서, 화학식 Ⅰ의 화합물이 (1-아미노메틸-3-메틸시클로펜틸)아세트산인 조성물.
- 제4항에 있어서, 화학식 Ⅰ의 화합물이 (1-아미노메틸-3,4-디메틸시클로펜틸)아세트산인 조성물.
- 제8항에 있어서, 화학식 II의 화합물이 프리가발린(pregabalin)인 조성물.
- 제8항에 있어서, 화학식 II의 화합물이 (R)-3-(아미노메틸)-5-메틸-헥산산인 조성물.
- 제8항에 있어서, 화학식 II의 화합물이 3-(1-아미노에틸)-5-메틸-헥산산인 조성물.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US5073697P | 1997-06-25 | 1997-06-25 | |
US60/050,736 | 1997-06-25 | ||
US8418398P | 1998-05-04 | 1998-05-04 | |
US60/084,183 | 1998-05-04 | ||
PCT/US1998/013107 WO1998058641A1 (en) | 1997-06-25 | 1998-06-24 | Use of gaba analogs such as gabapentin in the manufacture of a medicament for treating inflammatory diseases |
Publications (2)
Publication Number | Publication Date |
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KR20010020509A KR20010020509A (ko) | 2001-03-15 |
KR100554319B1 true KR100554319B1 (ko) | 2006-02-22 |
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KR1019997012256A KR100554319B1 (ko) | 1997-06-25 | 1998-06-24 | 염증성 질환 치료용 의약의 제조에 있어서 가바펜틴 등의감마-아미노부티르산 동족체의 용도 |
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EP (1) | EP0994704B1 (ko) |
JP (2) | JP3884486B2 (ko) |
KR (1) | KR100554319B1 (ko) |
AT (1) | ATE297722T1 (ko) |
AU (1) | AU735675B2 (ko) |
CA (1) | CA2294607C (ko) |
CO (1) | CO4940456A1 (ko) |
DE (1) | DE69830586T2 (ko) |
DK (1) | DK0994704T3 (ko) |
ES (1) | ES2244070T3 (ko) |
HR (1) | HRP980342A2 (ko) |
HU (1) | HU228454B1 (ko) |
IL (2) | IL132709A0 (ko) |
IS (1) | IS2279B (ko) |
NO (1) | NO329321B1 (ko) |
NZ (1) | NZ501626A (ko) |
PL (1) | PL191370B1 (ko) |
PT (1) | PT994704E (ko) |
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KR100491282B1 (ko) | 1996-07-24 | 2005-05-24 | 워너-램버트 캄파니 엘엘씨 | 통증 치료용 이소부틸가바 및 그의 유도체 |
TR200001170T2 (tr) | 1997-10-27 | 2000-10-23 | Warner-Lambert Company | Farmasötik maddeler olarak faydalı siklo amino asitler ve bunların türevleri |
CA2309354A1 (en) * | 1998-01-23 | 1999-07-29 | Leslie Magnus-Miller | Gabapentin and its derivatives for the treatment of muscular and skeletal pain |
EP0974351A3 (en) * | 1998-04-24 | 2000-12-13 | Jouveinal | Medicament for preventing and treating gastrointestinal damage |
AU767119B2 (en) | 1999-07-22 | 2003-10-30 | University Of Rochester | Method of treating symptoms of hormonal variation, including hot flashes |
US6620829B2 (en) | 2000-10-17 | 2003-09-16 | Warner-Lambert Company | Method of treating noninflammatory cartilage damage |
CA2451267A1 (en) * | 2002-12-13 | 2004-06-13 | Warner-Lambert Company Llc | Pharmaceutical uses for alpha2delta ligands |
EP1543831A1 (en) * | 2003-12-18 | 2005-06-22 | Pfizer GmbH Arzneimittelwerk Gödecke | Pregabalin composition |
WO2006008640A1 (en) * | 2004-07-15 | 2006-01-26 | Pharmacia & Upjohn Company Llc | Non-aqueous suspension containing a drug having an unpleasant taste |
EP2240158A2 (en) * | 2007-12-28 | 2010-10-20 | Intas Pharmaceuticals Limited | Stabilized injectable formulation of pregabalin |
HU230031B1 (hu) | 2010-03-01 | 2015-05-28 | Egis Gyógyszergyár Nyilvánosan Működő Részvénytársaság | Pregabalint és izomaltot tartalmazó stabilizált gyógyszerkészítmény |
IN2012MN02923A (ko) | 2010-06-01 | 2015-06-05 | Rubicon Res Private Ltd | |
WO2016032000A1 (ja) * | 2014-08-29 | 2016-03-03 | わかもと製薬株式会社 | 乳酸菌含有組成物 |
GB201617380D0 (en) | 2016-10-13 | 2016-11-30 | St George's Hospital Medical School | Treatment for Osteoarthritis |
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JPS6036413A (ja) * | 1983-08-09 | 1985-02-25 | Kaneshiro Nagai | 炎症治癒促進剤 |
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DE2460891C2 (de) * | 1974-12-21 | 1982-09-23 | Gödecke AG, 1000 Berlin | 1-Aminomethyl-1-cycloalkanessigsäuren und deren Ester, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
US6197819B1 (en) * | 1990-11-27 | 2001-03-06 | Northwestern University | Gamma amino butyric acid analogs and optical isomers |
JPH0636413A (ja) * | 1992-07-21 | 1994-02-10 | Nakamichi Corp | テ−プレコ−ダのテ−プガイド装置 |
KR100491282B1 (ko) * | 1996-07-24 | 2005-05-24 | 워너-램버트 캄파니 엘엘씨 | 통증 치료용 이소부틸가바 및 그의 유도체 |
BR9712651A (pt) * | 1996-10-23 | 1999-10-26 | Warner Lambert Co | cidos gama-aminobutìricos substituìdos com agentes farmacêuticos. |
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PT994704E (pt) | 2005-08-31 |
KR20010020509A (ko) | 2001-03-15 |
DE69830586D1 (de) | 2005-07-21 |
NZ501626A (en) | 2002-03-28 |
ES2244070T3 (es) | 2005-12-01 |
HUP0003730A3 (en) | 2002-01-28 |
JP3884486B2 (ja) | 2007-02-21 |
DK0994704T3 (da) | 2005-10-03 |
CA2294607C (en) | 2007-09-25 |
SI0994704T1 (en) | 2005-10-31 |
NO329321B1 (no) | 2010-09-27 |
PL191370B1 (pl) | 2006-05-31 |
HUP0003730A1 (hu) | 2001-04-28 |
DE69830586T2 (de) | 2005-12-15 |
IS5239A (is) | 1999-11-05 |
HRP980342A2 (en) | 1999-02-28 |
IL132709A (en) | 2006-10-05 |
IS2279B (is) | 2007-09-15 |
JP4452255B2 (ja) | 2010-04-21 |
NO996468D0 (no) | 1999-12-23 |
HU228454B1 (en) | 2013-03-28 |
AU8375898A (en) | 1999-01-04 |
WO1998058641A1 (en) | 1998-12-30 |
JP2002506449A (ja) | 2002-02-26 |
EP0994704A1 (en) | 2000-04-26 |
PL337847A1 (en) | 2000-09-11 |
ATE297722T1 (de) | 2005-07-15 |
AU735675B2 (en) | 2001-07-12 |
EP0994704B1 (en) | 2005-06-15 |
CO4940456A1 (es) | 2000-07-24 |
CA2294607A1 (en) | 1998-12-30 |
NO996468L (no) | 2000-02-21 |
IL132709A0 (en) | 2001-03-19 |
JP2006298929A (ja) | 2006-11-02 |
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