CA2309354A1 - Gabapentin and its derivatives for the treatment of muscular and skeletal pain - Google Patents

Gabapentin and its derivatives for the treatment of muscular and skeletal pain Download PDF

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CA2309354A1
CA2309354A1 CA002309354A CA2309354A CA2309354A1 CA 2309354 A1 CA2309354 A1 CA 2309354A1 CA 002309354 A CA002309354 A CA 002309354A CA 2309354 A CA2309354 A CA 2309354A CA 2309354 A1 CA2309354 A1 CA 2309354A1
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pain
gabapentin
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muscular
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Leslie Magnus-Miller
Catherine A. Segal
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Warner Lambert Co LLC
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • A61K31/195Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid

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Abstract

The instant invention is a method of using certain analogs of glutamic acid and gamma-aminobutyric acid to relieve muscular/skeletal back pain.

Description

GABAPENTIN AND ITS DERIVATIVES FOR THE
TREATMENT OF MUSCULAR AND SKELETAL PAIN
BACKGROUND OF THE INVENTION
1. Field Of The Invention The present invention relates to the use of analogs of glutamic acid and gamma-aminobutyric acid (GABA) for the treatment of muscular and skeletal pain. More particularly, the invention relates to the use of gabapentin for the treatment of non-neuropathic muscular and skeletal pain.
2. Description of Related Art The compounds of the invention are known agents useful in antiseizure therapy for central nervous system disorders such as epilepsy, Huntington's chorea, cerebral ischemia, Parkinson's disease, tardive dyskinesia, and spasticity.
It has also been suggested that the compounds can be used as antidepressants, anxiolytics, and antipsychotics. See WO 92/09560 (United States Serial Number 618,692 filed November 27, 1990) and WP 93/23383 (United States Serial Number 886,080 filed May 20, 1992).
WO 97/33858 teaches that compounds related to gabapentin are useful or treating epilespy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, and neuropathological disorders. WO 97/33858 does not specific what forms of pain are treated.
Additionally, the compounds of the invention are known for treatment of neuropathic pain. For example, see Rosner H; Rubin L; Kestenbaum A., Gabapentin adjunctive therapy in neuropathic pain states. Clin J Pain, 1996 Mar, 12:1, 56-8; Segal AZ; Rordorf G., Gabapentin as a novel treatment for postherpetic neuralgia. Neurology, 1996 Apr, 46:4, 1175-6; Wetzel CH; Connelly JF., Use of gabapentin in pain management. Ann Pharmacother, 1997 Sep, 31:9, 1082-3; Zapp JJ., Postpoliomyelitis pain treated with gabapentin [letter]. Am Fam Physician, 1996 Jun, 53:8, 2442, 2445; Cheville A, et al., Neuropathic pain in radiation myelopathy: a case report. Program book, American Pain Society ( 14th Annual Scientific Meeting). Abstract #95823, p. A-i 15; Sist T; Filadora V;
Miner M; Lema M., Gabapentin for idiopathic trigeminal neuralgia: report of two cases. Neurology, 1997 May, 48:5, 1467; Waldman SD, Tutorial 28: Evaluation and Treatment of Trigeminal Neuralgia. Pain Digest (1997) 7:21-24; Mellick LB; Mellick GA., Successful treatment of reflex sympathetic dystrophy with gabapentin [letter]. Am J Emerg Med, 1995 Jan, 13:1, 96; Mellick GA; Seng ML, The use of gabapentin in the treatment of reflex sympathetic dystrophy and a phobic disorder. Am J Pain Manage 1995; 5:7-9; Mellick GA; Mellicy LB;
Mellick LB., Gabapentin in the management of reflex sympathetic dystrophy [letter]. J Pain Symptom Manage, 1995 May, 10:4, 265-6; Mellick GA; Mellick LB., Reflex sympathetic dystrophy treated with gabapentin. Arch Phys Med Rehabil, 1997 Jan, 78:1, 98-105 and Mackin GA:, Medical and pharmacologic management of upper extremity neuropathic pain syndromes. J Hand Ther, 1997 Apr-Jun, 10:2, 96-109.
Rosenberg et al., The effect of gabapentin on neuropathic pain, Clin. J.
Pain, 1997 Sept, 1393), pp. 251-3 discloses a retrospective review of patients that were treated with gabapentin. One of the groups of patients was reported to have low back pain. These patients did not report improved pain scores after using gapapentin.
Muscular and skeletal pain is caused by a variety of physical injuries or damage to the muscles, bones and tissues of the body. A particularly debilitating form of this pain is chronic lower back pain. Chronic lower back pain is a general condition of pain related to physical damage to the muscles (eg, muscle trauma or overexertion), bones (eg, osteoarthritis of the lumber spine) and/or tissues (eg, fibromyalgia) of the back. Low back pain can also result from inflammation of the axial skeleton (eg, ankylosing spondylitis), conditions that create physical pressure on the nerves and tissues surrounding the spine (eg, sciatica and degenerative disk disease), or conditions/treatments that directly damage nerve WO 99/37296 PCTNS99l01290 tissue (eg, postpoliomyelitis and chronic progressive radiation myelopathy [CPRM]).
In contrast, neuropathic pain is chronic pain that can develop after alteration and/or injury to any level of the nervous system, peripheral or central.
The pain is typically burning and is associated with pressure on a nerve and/or actual damage to nervous tissue. Some types of chronic low back pain can have a neuropathic component (eg, sciatica, postpoliomyelitis and CPRM). Neuropathic conditions that have been treated with gabapentin include: postherpetic neuralgia, postpoliomyelitis, CPRM, HIV-related neuropathy, trigeminal neuralgia, diabetic neuropathy and Reflex Sympathetic Dystrophy (RSD). Of these, the cases of postpoliomyelitis and CPRM had pain associated with the back. The main distinction between back pain that is neuropathy in nature, and muscular/skeletal lower back pain is that nerve damage itself is the cause of pain. In the other conditions, properly working nerves are detecting body tissue damage and pressure secondary to inflammation. The two neuropathic conditions that reported a low back pain component clearly had the formation of anomalous nerve tissue or remodelling of the nerve pathway as the cause of pain.
Musculoskeletal pain is the unpleasant experience created by disease or dysfunction in the muscles, connective tissues, or by the stretching of the natural coverings of bones and joints. This type of condition can occur even when the associated sensory nerve fibers, by which the nociceptive impulses are sent from muscular tissue to the brain, are fully normal. On the other hand, neuropathic pain is the sensation created when any combination of pathophysiological processes causes sensory nerves to function badly, or in a hyperexcitable manner. One of the notable characteristics of neuropathic pain is that it can create the sensation that the source of symptoms is within its associated tissue, even when the nonneural tissue is perfectly healthy.
In attempting to understand the pain of spinal and paraspinal disorders, such as that which occurs in syndromes related to the low back, there is often a temptation to separate causes of such suffering into musculoskeletal pain from neuropathic pain. There are patients whose low back pain may be predominantly musculoskeletal or neuropathic. In other patients the resulting symptoms are due to some degree of dysfunction of both types.
Many patients who seek medical treatment for low back pain are often able to associate the onset of their symptoms to sudden mechanical trauma, such as a vehicular accident or more often a lifting or bending injury. The main reason for this is that the low back is more prone to abnormal or poorly coordinated movement than most other portions of the musculoskeletal system. In part this is due to the fact that the lumbar spine is a weak zones between two larger body regions. The general thickness of the chest and upper abdomen and the size of the pelvis and proximal lower extremities are physically greater and therefore less mobile. The only thing that supports the segment of the spinal column from the 12'~ dorsal or thoracic vertebra to the sacrum is the paravertebral muscles and ligaments.
Adults who do not have adequate muscle tone or strength to support the spine, i.e. those in whom the paraspinal muscles are deconditioned, are unable to prevent the vertebrae or intervertebral discs from being bent, stretched or twisted out of place. During sudden or prolonged, intense spinal activity against weight or resistance, this weaker zone is susceptible to many different types of pain-producing mechanism.
For example, joints, including the spinal facets, may be twisted and become inflamed. Paraspinal muscles may be stretched to the point of having small penetrating vessels torn within the muscle tissue. Consequently the tissue repair response may create the lying down of multiple small areas of scar tissue within the muscle, which can stimulate further pain symptoms during contraction.
Similarly ligaments may be stretched and their sites of attachment may be tom away leaving microscopic hemorrhages and spinal instability.
Disc materials may be Iwisted in a manner where undue pressure from above causing an actual internal shift of the nuclear material, resulting in a bulging or distortion of the shape of the disc. Despite longstanding opinions that disc capsules do not have adequate innervation to produce clinical pain when they are mechanically displaced, it has been confirmed that the posterior aspects of discs do indeed have innervation which creates pain when the disc capsule (annulus fibrosis) is stretched. Severe or sudden mechanical force can cause its jelly-like contents (nucleus pulpous) to shift and create pressure gradients against the inside wall of the disc capsule (annulus fibrosis) great enough for the disc to rupture.
Once the disc material is extruded outside its usual boundaries, it can put pressure on the nerve roots that are attempting to exit from the spinal canal.
If enough of the disc material is ruptured or protruding, it may place true mechanical compression on the blood vessels which provide nutrition and oxygen to the nerve (versa nervure). The resulting schema will then make the nerve root dysfunctional, creating a specific form of neuropathic pain known as radiculopathy.
Because the pathological conditions that create radicular pain are based on a direct involvement of nerves, and not just a set of messages that have been detected by healthy nerve endings in painful muscle, this type of pain is better classified as neuropathic than musculoskeletal.
Reflex Sympathetic Dystrophy (RSD) is a form of neuropathic pain that persists long after the cessation of cellular damage or healing of a physical injury.
It is characterized by a severe burning pain secondary to autonomic (increased sympathetic activity) and/or dystrophic (skin and bone atrophy, increased hair and nail growth, cellular fibrosis, and possible alterations in cellular norepinephrine and sympathetic receptor sensitivity) changes in the tissue of the affected region.
Such pain in the absence of any ongoing tissue damage along with the autonomic and/or dystrophic changes are distinguishing characteristics from conditions causing general low back pain. Moreover, the continued pain of RSD is typically out of proportion to the initial tissue damage and generally affects an extremity (eg, right shoulder and arm).

The current treatments for lower back pain include exercise, spinal manipulation, bed rest, traction and/or drug therapy. Drugs used to treat lower back pain include acetaminophen, tizanidine, mefenamic acid, chlormethoxazone, -paracetamol, ethoheptazine-aspirin-meprobamate, piroxicam, diflunisal, naproxen sodium, tricyclic antidepressants, indomethacin, cyclobenzaprine, baclofen and ibuprofen.
Until the present invention, there has not been any report of using gabapentin, which was originally used for treating the neurological disorder epilepsy, and has been further used to treat neurologically based pain (neuropathic pain), to treat muscular/skeletal based pain, such as chronic lower back pain.
Nor has gabapentin been studied in low back pain conditions where the nervous system is functioning normally.
SUMMARY OF THE INVENTION
This invention provides a method for treating muscular and skeletal pain comprising administering to a subject suffering from such pain an effective amount of a GABA analog. A preferred embodiment utilizes a cyclic amino acid compound of Formula I

I
(CH2)n wherein Rl is hydrogen or lower alkyl and n is an integer of from 4 to 6, and the pharmaceutically acceptable salts thereof. An especially preferred embodiment utilizes a compound of Formula I where Rl is hydrogen and n is 4, which compound is 1-(aminomethyl)-cyclohexane acetic acid, known generically as gabapentin.

In another embodiment, the invention includes treating muscular and skeletal pain with a compound of Formula II.
Formula II

or a pharmaceutically acceptable salt thereof wherein Rl is a straight or branched alkyl of from 1 to 6 carbon atoms, phenyl, or cycloalkyl of from 3 to 6 carbon atoms;
R2 is hydrogen or methyl; and R3 is hydrogen, methyl, or carboxyl.
Preferred compounds of the invention are those wherein R3 and R2 are hydrogen, and R1 is -(CH2)0-2-1 C4H9 ~ ~ (R), (S), or (R,S) isomer.
The more preferred compounds of Formula II invention are (S)-3-(aminomethyl)-5-methylhexanoic acid and 3-aminomethyl-5-methyl-hexanoic acid, now known generically as pregabalin.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
The method of this invention utilizes any GABA analog. A GABA analog is any compound derived from or based upon gamma-aminobutyric acid. The compounds are readily available, either commercially, or by synthetic methodology well known to those skilled in the art of organic chemistry. The preferred GABA analogs to be utilized in the method of this invention are cyclic amino acids of Formula I. These are described in U.S. Patent 4,024,175, which is incorporated herein by reference. Another preferred method utilizes the GABA
analogs of Formula II, and these are described in U.S. Patent 5,563,175, which is -8- _ incorporated herein by reference.
All that is required to practice the method of this invention is to administer a GABA analog in an amount that is effective to treat the muscular andlor skeletal S pain. Such anti-pain amount will generally be from about 1 to about 300 mg per kg of subject body weight. Typical doses will be from about 10 to about 5000 mg per day for an adult subject of normal weight. It is expected that common doses that might be administered for muscular and skeletal pain could be from 100 mg.
Three times a day up to 600 mg. Four times a day. Commercially available capsules of 100 mg, 300 mg, 600 mg and 800 mg of gabapentin can be administered. Alternate forms include liquids and commercially available film-coated tablets.
The compounds of the present invention may form pharmaceutically acceptable salts with both organic and inorganic acids or bases. For example, the acid addition salts of the basic compounds are prepared either by dissolving the free base in aqueous or aqueous alcohol solution or other suitable solvents containing the appropriate acid and isolating the salt by evaporating the solution.
Examples of pharmaceutically acceptable salts are hydrochlorides, hydrobromides, hydrosulfates, etc. as well as sodium, potassium, and magnesium, etc. salts.
The compounds of the Formula II can contain one or several asymmetric carbon atoms. The invention includes the individual diastereomers or enantiomers, and the mixtures thereof. The individual diastereomers or enantiomers may be prepared or isolated by methods already well known in the art.
Formulating the active compound in dosage unit form with a pharmaceutical carrier produces pharmaceutical compositions useful in the present invention. Some examples of dosage unit forms are tablets, capsules, pills, powders, aqueous and nonaqueous oral solutions and suspensions, and parenteral solutions packaged in containers containing either one or some larger number of dosage units and capable of being subdivided into individual doses.

Some examples of suitable pharmaceutical carriers, including pharmaceutical diluents, are gelatin capsules; sugars such as lactose and sucrose;
starches such as corn starch and potato starch, cellulose derivatives such as sodium carboxymethyl cellulose, ethyl cellulose, methyl cellulose, and cellulose acetate phthalate; gelatin; talc; stearic acid; magnesium stearate; vegetable oils such as peanut oil, cottonseed oil, sesame oil, olive oil, corn oil, and oil of theobroma; propylene glycol, glycerin; sorbitol; polyethylene glycol; water;
agar;
alginic acid; isotonic saline, and phosphate buffer solutions; as well as other compatible substances normally used in pharmaceutical formulations. The compositions of the invention can also contain other components such as coloring agents, flavoring agents, and/or preservatives. These materials, if present, are usually used in relatively small amounts. The compositions can, if desired, also contain other therapeutic agents.
The percentage of the active ingredients in the foregoing compositions can be varied within wide limits, but for practical purposes it is preferably present in a concentration of at least 10% in a solid composition and at least 2% in a primary liquid composition. The most satisfactory compositions are those in which a much higher proportion of the active ingredient is present.
Routes of administration of the subject compound or its salts are oral Qr parenteral. For example, a useful intravenous dose is between 5 and 50 mg and a useful oral dosage is between 20 and 800 mg. The dosage is within the dosing range used in treatment of pain or as would be with the needs of the patient as described by the physician.
A unit dosage form of the GABA analog to be used in this invention may also comprise other compounds useful in the treatment of pain.
The advantages of using the compounds of Formula I and II, especially gabapentin and pregabalin, in the present invention include the relatively nontoxic nature of the compounds, the ease of preparation and the fact that the compounds are well-tolerated. Gabapentin has few interactions with major classes of drugs since it is not metabolized in the liver, but rather excreted unchanged from the body. Further, the drugs are not metabolized in the body. The subjects treated with the method of the present invention are mammals, including humans.
S
Example 1 A 53-year-old man presented with a long history of back pain. His initial back injury resulted from a fall while installing a valve. Over the next few years he reinjured his back several times. The third injury caused significant disability and pain that did not respond to medications. As a result, surgery was performed four years ago and steel rods and hangers were inserted. Despite the surgery and subsequent rehabilitation, he had significant pain and disability. He could not stand straight and could not maintain any position (sitting, standing, or walking) for any length of time. He was maintained on an opiate pain relief regimen of transdermal Fentanyl patches and six Vicodin tablets per day but felt constant pain.
One year ago, his physician arranged for a trial of gabapentin. Starting with an initial dose of one 100 mg. Capsule three times a day, he began to experience pain relief within a few hours. He commented to his wife that for the first time in years he felt no pain. By the end of the second day, he felt well enough to go out socially. He went to a wedding where he felt good enough to dance for the first time in years. One year later, he is maintained on a regimen of gabapentin 300 mg. three times a day and the Fentanyl patch. Vicodin is available on an as needed basis, but he said he needs fewer tablets. Unlike before the gabapentin trial, he can stand straight and can walk again. The pain relief in his back condition has been sustained for over one year.
Example 2 This 50 year old Caucasian female patient was referred for diagnosis and management of her chief complaint of aching and fatigue and persistent muscle pain on a daily basis, with secondary or comorbid complaints of her legs jerking at night, as well as an intermittent band like pain around her head.
The history of the presenting illness, relative to the chief complaint, included the following symptom characteristics: Onset was gradual, beginning approximately 17 years ago, without any clear-cut relationship to trauma. The regional distribution of the current symptoms included pain that involves multiple areas and is generally bilateral and symmetric. This pain involved the trapezius muscles of the neck, anterior shoulders and scapulae, clavicles, lower costal margins, hips and buttocks, elbows, wrists and medial aspects of the knees.
Visual analysis of the Pain Drawing instrument completed by the patient revealed no clear-cut radicular or articular patterns. Pain occurred simultaneously in all areas, without clearly defined radiation or referred pain. The patient described the quality of the mufti-regional pain as aching, with independent burning pain in the feet and legs occurring only at night. As mentioned above, the headache was described as band-like. The timing was continuous, with frequent variations in severity. At the initial visit, the pain intensity of most areas was reported, using a standard Numeric Rating Scale (NRS-11, with zero being no pain and 10 representing the worst pain imaginable) as 4-6. The pain was made worse with exercise, during cold weather and generally increased at night. No specific agents or activities made the pain any better. Other symptoms included tingling of both feet.
Past medical history was positive for the usual childhood illnesses, but otherwise negative. Family history was positive for arthritis, heart disease and hypertension. Social history was negative for tobacco or alcohol. The allergy history was positive for codeine, meperidine (Demerol), carisoprodol (Soma) and penicillin.
Physical Examination The patient's weight was 150 pounds, height was 5'1". Vital signs at the initial visit were: Pulse-68 per minute, BP (Right arm sitting)-122/70, Respirations- 12 and p.o. Temperature- 97.2 F
General examination revealed that Head, eyes, ears, nose and throat were normal. Heart sounds were normal. Chest was clear. Abdomen revealed no acute abnormalities. Spinal examination revealed that active range of motion was reduced in the cervical spine. Paraspinal muscle spasm and tender points were noted at multiple sites during palpation. Straight leg raising produced pain at 70 degrees on the left, and at 80 degrees on the right.
Neurological examination revealed mental status changes (mild depression) which seemed to be appropriate for chronic pain. Speech was normal. Cranial nerves, including fundi, were normal. Upper extremity bulk, power, tone and range of motion were normal. Power was 4/5-5/5 in most muscle groups, but pain and soreness were noted by the patient. Reflexes were normal in both upper and lower extremities. Plantar reflexes were normal. Sensory examination was normal to cold, pin, and vibration. Stance and gait were within normal limits..
Impression / Differential Diagnosis Myofascial pain syndrome versus fibromyalgia syndrome, paraspinal muscle spasm, cervical radiculopathy, lumbar radiculopathy.
Diagnostic Test Results Needle EMGs of the upper extremities revealed moderate CS-6 root irritation on the right, but lower extremity EMGs were normal. Nerve Conduction Velocity studies of both upper and both lower extremities were fully normal. MRI
revealed degenerative changes at several levels in the cervical spine with some resulting foraminal narrowing on the right at CS-6, but no herniated intervertebral discs and no spinal stenosis. On the sagittal views there was straightening of the normal lordotic curve consistent with spasm.
SUBSTITUTE SHEET (RULE 26) General Classification of Pain Syndrome Primarily musculoskeletal pain (Myofascial pain syndrome vs.
fibromyalgia) with radiographic evidence for degenerative changes of the cervical spine, with secondary independent root irntation created by the associated neuroforaminal narrowing.
Treatment The patient had previously been unresponsive to OTC preparations such as acetaminophen and ibuprofen, and had been allergic to codeine, meperidine and carisoprodol. While diagnostic tests were being conducted she was provided a therapeutic trial of tizanidine hcl (Zanaflex) for her painful muscle spasms.
This was titrated upward over several days from 1 mg three times a day to 4 mg three 1 S times a day. At her follow-up appointment six weeks later she stated that she had noticed some improvement (up to 25% pain reduction)in her myofascial symptoms, but she could not tolerate the usual dose due to significant drowsiness.
She therefore had to reduce the tizanidine hcl to 1 mg at breakfast and lunch and 4 mg at bedtime, which reduced the effectiveness of the treatment.
Her various allergies to medication were discussed, as well as the benefit of avoidance of narcotic analgesics for chronic pain of this type. After an explanation of the adjuvant, (not indicated) use of antiepileptic drugs for some forms of neuropathic pain, and potential side effects, she was then offered a therapeutic trial of gabapentin (Neurontin). This was added on an ascending schedule, with increasing steps as follows: Day 1 and 2, 100 mg four times a day (with meals and at bedtime), Day 3 and 4, 200 mg four times a day, Day S and 6 300 mg four times a day, and thereafter 300 mg with each meal and 600 mg at bedtime. At her follow-up visit three weeks later she described her generalized aching and fatigue were slightly improved and she noted that she had a reduced number of what she described as "knotted up tender spots" in her back. However she had admitted that she had only taken one capsules of gabapentin at night, not two. She was instructed to increase her total daily dose by 25 % (300 mg) to a total daily dose of 1500 mg.
During that time she was seen for neurosurgical consultation regarding any possible corrective measures that might be directed toward the potential for neuroforaminal stenosis. He suggested cervical traction but she discontinued this after one or two sessions due to increased pain. At the time of his follow up visit, after the gabapentin 1500 mg/day had been added, the neurosurgeon's report indicated "she has improved significantly..her neck seems to have improved even more than the lower back..since she has improved to this degree she would like to maintain the current course of action".
She was reassessed in our clinic two weeks later and found to have a reduction of the total number of painful regions from 25 down to 6, and her general pain intensity had gone from 4-6, down to 1-2, with only an occasional site with pain of 4. She describes her general clinical response as "SO per cent improved" since her original visit. She was offered the option of increasing the gabapentin to 1800 mg/day by adding one 300 mg capsule at night. Thus far she has had no side effects from the addition or increasing scale of the gabapentin.
Example 3 This 67 year old Caucasian female patient was referred for diagnosis and management of her chief complaint of multiregional pain involving intrascapular, thoracic and lumbar areas, with secondary or comorbid complaints of generalized weakness, as well as right sided neck pain and upper extremity paresthesias.
The history of the presenting illness, relative to the chief complaint, included the following symptom characteristics: Onset was gradual, beginning approximately 10 years ago for the low back pain and 3-4 years ago for the other regional pain symptoms. There was no relationship to trauma. The regional distribution of the current symptoms included pain that involves multiple areas and was generally bilateral and symmetric except for the upper extremity pain that was greater on the right side. The pain involved the trapezius muscles of the neck, shoulders and scapulae, mid thoracic area, sacrum, knees and heels. Visual analysis of the Pain Drawing instrument completed by the patient revealed no clear-cut radicular or articular patterns. Pain occurred simultaneously in all areas, without clearly defined radiation or referred pain. The patient described the quality of the multiregional pain as aching, with only occasional shooting pain.
She also stated that many of the painful areas felt "swollen". At the initial visit, the pain intensity of most areas was reported, using a standard Numeric Rating Scale (NRS-11, with zero being no pain and 10 representing the worst pain imaginable) as 4-8 (average=6). The timing of the pain was continuous, with the intensity made worse with any kind of physical activity. No specific agents or reduction of activities made the pain any better. Other symptoms included unsteadiness while walking and a painful (antalgic) gait pattern.
Past medical history was positive for the usual childhood illnesses, headaches, hypertension and arthritis. Family history was positive for arthritis, heart disease and hypertension. Social history was negative for alcohol but the patient does smoke one ppd. The allergy history was positive for morphine, meperidine (Demerol), tetracycline and "all arthritis medications".
Physical Examination The patient's weight was 170 pounds, height was 5'S". Vital signs at the initial visit were: Pulse-64 per minute, BP (Right arm sitting)-148/88, Respirations- 16 and p.o. Temperature- 98.5 F
General examination revealed that Head, eyes, ears, nose and throat were normal. Heart sounds S1 and S2 were normal but there was a low-grade (III/VI) systolic murmur. Chest was clear. Abdomen revealed old hysterectomy scar.
Spinal examination revealed that active range of motion was only minimally reduced in the cervical spine. Paraspinal muscle spasm and tender points were noted at multiple sites during palpation. Straight leg raising was performed to 85 degrees bilaterally.

Neurological examination revealed mental status changes (mild depression) which seemed to be appropriate for chronic pain. Speech was normal.
Cranial nerves, including fundi, were normal. Upper extremity bulk, power, tone and range of motion were normal. Power was 4/5-5/5 in most muscle groups, but pain and soreness were noted by the patient. Reflexes were mildly reduced in both upper extremities, but patellars were reduced and achilles reflexes were absent bilaterally. Plantar reflexes were normal. Sensory examination revealed local hyperesthesia to touch and light palpation but was within normal limits to cold and pin. Vibration was mildly reduced bilaterally below the ankles.
Stance and gait were within normal limits.
Impression / Differential Diagnosis Myofascial pain syndrome versus fibromyalgia syndrome, paraspinal I 5 muscle spasm, cervical radiculopathy, lumbar radiculopathy.
Diagnostic Test Results Needle EMGs of the upper extremities revealed mild CS-6 root irritation on the left and mild C3-4 irritation on the right, but lower extremity EMGs were normal. Nerve Conduction Velocity studies of both upper and both lower extremities were fully normal. MRI revealed prominent bulging discs at CMS and CS-6, and moderately bulging discs at C3-4 and C6-7, but no disc herniation or spinal stenosis.
General Classification of Pain Syndrome Primarily musculoskeletal pain (Myofascial pain syndrome vs.
fibromyalgia) with radiographic evidence for changes of the cervical spine associated with bulging intervertebral discs.
Treatment WO 99/37296 PCT/US99/Ot290 The patient had previously been unresponsive to OTC preparations such as acetaminophen, and had not had any significant benefit from codeine containing compounds (Tylenol # 3, four times a day). She had been taking Robaxin 750 mg twice a day, which was tapered and discontinued due to its ineffectiveness. While diagnostic tests were being conducted she was provided a therapeutic trial of tizanidine Hcl (Zanaflex) for her aching and for painful muscle spasms. This was initiated at a low dose ( lmg three times a day) due to the patient's concerns about drowsiness. At her follow-up appointment six weeks later she stated that she had noticed some reduction in the number of painful areas and her pain intensity had decreased into the range of 2-5, with the average value of 3.5. She was instructed to titrate the tizanidine upward to 2 mg three times a day. Shortly thereafter she called to state that she "could not function" due to excessive sleepiness at 6 mg per day and she requested that this be reduced to mg a day (2 mg twice a day). She experienced sleepiness and dry mouth with 1 S even this low dose and decreased the tizanidine Hcl to 2mg once a day. She returned five weeks later stating that there was no change in her symptoms, specifically regarding the intrascapular pain, the intensity of which had increased from 2 to 5.
Her various allergies to medication were discussed, as well as the benefit of avoidance of narcotic analgesics for chronic pain of this type. After an explanation of the adjuvant, (not indicated) use of antiepileptic drugs for some forms of neuropathic pain, and potential side effects, she was then offered a therapeutic trial of gabapentin (Neurontin). This was added on an ascending schedule, with increasing steps as follows: Day 1 and 2, 100 mg four times a day (with meals and at bedtime), Day 3 and 4, 200 mg four times a day, Day 5 and 6 300 mg four times a day, and thereafter 300 mg with each meal and 600 mg at bedtime. At her follow-up visit five weeks later she stated that her intrascapular pain had been reduced in frequency and severity, and her pain had decreased to zero. Her pain drawing instrument was essentially blank, i.e. no shaded areas indicating any spontaneous pain. She did, however, have some residual trigger points and tender points, which were only symptomatic during direct palpation, and she chose to have these treated with trigger point injections during a WO 99/3729b PCT/US99/01290 previously scheduled visit to an anesthesiologist. She was seen again in our clinic two months later, still on gabapentin (Neurontin) and she continued to be pain free. She had not had any further trigger point injections, was only taking 2mg tizanidine hcl at bedtime for rest, and had reduced her gabapentin to 1200 mg per day from 1500 mg per day. She was taking no narcotic analgesics, but continued on her antihypertensive medication and her hormone supplement that she had been taking since the first visit.
During the subsequent three months the patient indicated that, since she had reduced her gabapentin from 1500 mg a day to 1200 mg a day that she noticed some slight and transient return of her symptoms. She requested that she be permitted to increase it back to 1500 mg a day. She has since remained essentially asymptomatic on the previous schedule. Her personal and pharmacy records indicate that she is not taking any narcotic analgesics.
Although the invention has been described with reference to specific preferred embodiments, those skilled in the art will recognize that variations and modifications may be made that are within the spirit of the invention and within the scope of the claims.

Claims (4)

What is claimed is:
1. A method for treating muscular and skeletal pain comprising administering a therapeutically effective amount of a compound of Formula I

wherein R1 is hydrogen or lower alkyl and n is an integer of from 4 to 6, and the pharmaceutically acceptable salts thereof.
2. The method according to claim 1 wherein the muscular and skeletal pain is lower back pain.
3. The method according to Claim 1 wherein the compound is gabapentin.
4. The method according to Claim 2 wherein the compound is gabapentin.
CA002309354A 1998-01-23 1999-01-22 Gabapentin and its derivatives for the treatment of muscular and skeletal pain Abandoned CA2309354A1 (en)

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