KR100545430B1 - 콜레스테롤 저하성 벤조[ｂ]티오펜 및 벤조[ｄ]이소티아졸 - Google Patents
콜레스테롤 저하성 벤조[ｂ]티오펜 및 벤조[ｄ]이소티아졸 Download PDFInfo
- Publication number
- KR100545430B1 KR100545430B1 KR1020037006161A KR20037006161A KR100545430B1 KR 100545430 B1 KR100545430 B1 KR 100545430B1 KR 1020037006161 A KR1020037006161 A KR 1020037006161A KR 20037006161 A KR20037006161 A KR 20037006161A KR 100545430 B1 KR100545430 B1 KR 100545430B1
- Authority
- KR
- South Korea
- Prior art keywords
- phenyl
- benzo
- bromo
- isothiazol
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC(*(C)(*)N)(N)[U] Chemical compound CC(*(C)(*)N)(N)[U] 0.000 description 9
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
- C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
- C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP00123826.0 | 2000-11-02 | ||
| EP00123826 | 2000-11-02 | ||
| PCT/EP2001/012451 WO2002036584A1 (en) | 2000-11-02 | 2001-10-26 | Cholesterol lowering benzo`b! thiophenes and benzo`d! isothiazoles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20030045166A KR20030045166A (ko) | 2003-06-09 |
| KR100545430B1 true KR100545430B1 (ko) | 2006-01-24 |
Family
ID=8170270
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020037006161A Expired - Fee Related KR100545430B1 (ko) | 2000-11-02 | 2001-10-26 | 콜레스테롤 저하성 벤조[ｂ]티오펜 및 벤조[ｄ]이소티아졸 |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US6951879B2 (https=) |
| EP (1) | EP1334094B1 (https=) |
| JP (1) | JP4012064B2 (https=) |
| KR (1) | KR100545430B1 (https=) |
| CN (1) | CN1261429C (https=) |
| AR (1) | AR034271A1 (https=) |
| AT (1) | ATE286042T1 (https=) |
| AU (2) | AU2002214029B2 (https=) |
| BR (1) | BR0115075A (https=) |
| CA (1) | CA2426009C (https=) |
| DE (1) | DE60108164T2 (https=) |
| DK (1) | DK1334094T3 (https=) |
| ES (1) | ES2233703T3 (https=) |
| GT (1) | GT200100220A (https=) |
| MX (1) | MXPA03003845A (https=) |
| PA (1) | PA8531601A1 (https=) |
| PE (1) | PE20020600A1 (https=) |
| PT (1) | PT1334094E (https=) |
| UY (1) | UY27009A1 (https=) |
| WO (1) | WO2002036584A1 (https=) |
| ZA (1) | ZA200302742B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100566175B1 (ko) | 2000-08-16 | 2006-03-29 | 에프. 호프만-라 로슈 아게 | 신규한 아미노사이클로헥산 유도체 |
| US7012077B2 (en) * | 2001-12-20 | 2006-03-14 | Hoffmann-La Roche Inc. | Substituted cyclohexane derivatives |
| EP1647549A1 (en) * | 2004-10-14 | 2006-04-19 | Laboratoire Theramex | Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents |
| US7446210B2 (en) * | 2004-10-26 | 2008-11-04 | Janssen Pharmaceutica N.V. | Factor Xa compounds |
| JP2008544987A (ja) * | 2005-06-30 | 2008-12-11 | バイエル・クロツプサイエンス・アクチエンゲゼルシヤフト | 殺虫性の（二置換プロペニル）フェニルアルキル置換複素環式環を調製するための改善された方法 |
| FR2913019A1 (fr) * | 2007-02-23 | 2008-08-29 | Cerep Sa | Composes heterocycliques comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire |
| CN101918416A (zh) * | 2007-11-29 | 2010-12-15 | 兰贝克赛实验室有限公司 | 制备取代的1,3-氧硫杂环戊烷,尤其是拉米夫定的方法和中间体 |
| WO2009069011A1 (en) * | 2007-11-29 | 2009-06-04 | Ranbaxy Laboratories Limited | Process for the preparation of substituted 1,3-oxathiolanes |
| CN103596570B (zh) * | 2010-12-27 | 2018-02-16 | 密苏里大学管委会 | 作为抗癌治疗的蛋白质靶的氧化鲨烯环化酶 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3598839A (en) * | 1969-06-30 | 1971-08-10 | Parke Davis & Co | Phenylbenzothiophene compounds |
| GR75101B (https=) * | 1980-10-23 | 1984-07-13 | Pfizer | |
| GB8417559D0 (en) * | 1984-07-10 | 1984-08-15 | Pfizer Ltd | Anti-diarrhoeal agents |
| DE3905364A1 (de) | 1989-02-22 | 1990-08-23 | Hoechst Ag | Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool |
| EP0530149A1 (de) * | 1991-08-30 | 1993-03-03 | Ciba-Geigy Ag | Schädlingsbekämpfungsmittel |
| US5482949A (en) * | 1993-03-19 | 1996-01-09 | Eli Lilly And Company | Sulfonate derivatives of 3-aroylbenzo[b]thiophenes |
| CA2190699A1 (en) * | 1995-12-08 | 1997-06-09 | Johannes Aebi | Tertiary amines |
| CA2190708A1 (en) * | 1995-12-08 | 1997-06-09 | Johannes Aebi | Aminoalkyl substituted benzo-heterocyclic compounds |
| UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
-
2001
- 2001-10-26 ES ES01982445T patent/ES2233703T3/es not_active Expired - Lifetime
- 2001-10-26 AU AU2002214029A patent/AU2002214029B2/en not_active Ceased
- 2001-10-26 CN CNB018182046A patent/CN1261429C/zh not_active Expired - Fee Related
- 2001-10-26 WO PCT/EP2001/012451 patent/WO2002036584A1/en not_active Ceased
- 2001-10-26 CA CA002426009A patent/CA2426009C/en not_active Expired - Fee Related
- 2001-10-26 AT AT01982445T patent/ATE286042T1/de active
- 2001-10-26 JP JP2002539343A patent/JP4012064B2/ja not_active Expired - Fee Related
- 2001-10-26 DK DK01982445T patent/DK1334094T3/da active
- 2001-10-26 MX MXPA03003845A patent/MXPA03003845A/es active IP Right Grant
- 2001-10-26 EP EP01982445A patent/EP1334094B1/en not_active Expired - Lifetime
- 2001-10-26 KR KR1020037006161A patent/KR100545430B1/ko not_active Expired - Fee Related
- 2001-10-26 AU AU1402902A patent/AU1402902A/xx active Pending
- 2001-10-26 DE DE60108164T patent/DE60108164T2/de not_active Expired - Lifetime
- 2001-10-26 PT PT01982445T patent/PT1334094E/pt unknown
- 2001-10-26 BR BR0115075-8A patent/BR0115075A/pt not_active Application Discontinuation
- 2001-10-30 PE PE2001001078A patent/PE20020600A1/es not_active Application Discontinuation
- 2001-10-31 GT GT200100220A patent/GT200100220A/es unknown
- 2001-10-31 US US09/999,424 patent/US6951879B2/en not_active Expired - Fee Related
- 2001-11-01 PA PA20018531601A patent/PA8531601A1/es unknown
- 2001-11-01 AR ARP010105115A patent/AR034271A1/es unknown
- 2001-11-01 UY UY27009A patent/UY27009A1/es not_active Application Discontinuation
-
2003
- 2003-04-08 ZA ZA200302742A patent/ZA200302742B/en unknown
-
2005
- 2005-07-08 US US11/178,164 patent/US7173043B2/en not_active Expired - Fee Related
-
2006
- 2006-12-06 US US11/634,573 patent/US7449483B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1471522A (zh) | 2004-01-28 |
| EP1334094B1 (en) | 2004-12-29 |
| US7449483B2 (en) | 2008-11-11 |
| AU1402902A (en) | 2002-05-15 |
| CA2426009C (en) | 2008-10-07 |
| ATE286042T1 (de) | 2005-01-15 |
| CN1261429C (zh) | 2006-06-28 |
| EP1334094A1 (en) | 2003-08-13 |
| ZA200302742B (en) | 2004-07-08 |
| AR034271A1 (es) | 2004-02-18 |
| JP4012064B2 (ja) | 2007-11-21 |
| AU2002214029B2 (en) | 2004-12-23 |
| DE60108164D1 (de) | 2005-02-03 |
| US7173043B2 (en) | 2007-02-06 |
| US6951879B2 (en) | 2005-10-04 |
| US20020086891A1 (en) | 2002-07-04 |
| PA8531601A1 (es) | 2003-02-14 |
| CA2426009A1 (en) | 2002-05-10 |
| JP2004513124A (ja) | 2004-04-30 |
| US20070099985A1 (en) | 2007-05-03 |
| MXPA03003845A (es) | 2003-07-28 |
| US20050267200A1 (en) | 2005-12-01 |
| DK1334094T3 (da) | 2005-05-02 |
| BR0115075A (pt) | 2003-07-29 |
| KR20030045166A (ko) | 2003-06-09 |
| ES2233703T3 (es) | 2005-06-16 |
| DE60108164T2 (de) | 2006-03-02 |
| WO2002036584A1 (en) | 2002-05-10 |
| UY27009A1 (es) | 2002-06-20 |
| PE20020600A1 (es) | 2002-07-08 |
| GT200100220A (es) | 2002-07-04 |
| PT1334094E (pt) | 2005-05-31 |
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