AU2002214029B2 - Cholesterol Lowering Benzo`b! Thiophenes and Benzo`d! Isothiazoles - Google Patents

Cholesterol Lowering Benzo`b! Thiophenes and Benzo`d! Isothiazoles Download PDF

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Publication number
AU2002214029B2
AU2002214029B2 AU2002214029A AU2002214029A AU2002214029B2 AU 2002214029 B2 AU2002214029 B2 AU 2002214029B2 AU 2002214029 A AU2002214029 A AU 2002214029A AU 2002214029 A AU2002214029 A AU 2002214029A AU 2002214029 B2 AU2002214029 B2 AU 2002214029B2
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AU
Australia
Prior art keywords
phenyl
benzo
bromo
methyl
ethyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2002214029A
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English (en)
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AU2002214029A1 (en
Inventor
Jean Ackermann
Johannes Aebi
Henrietta Dehmlow
Hans-Peter Maerki
Olivier Morand
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of AU2002214029A1 publication Critical patent/AU2002214029A1/en
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Publication of AU2002214029B2 publication Critical patent/AU2002214029B2/en
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/04—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D275/06—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings condensed with carbocyclic rings or ring systems with hetero atoms directly attached to the ring sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
AU2002214029A 2000-11-02 2001-10-26 Cholesterol Lowering Benzo`b! Thiophenes and Benzo`d! Isothiazoles Ceased AU2002214029B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP00123826.0 2000-11-02
EP00123826 2000-11-02
PCT/EP2001/012451 WO2002036584A1 (en) 2000-11-02 2001-10-26 Cholesterol lowering benzo`b! thiophenes and benzo`d! isothiazoles

Publications (2)

Publication Number Publication Date
AU2002214029A1 AU2002214029A1 (en) 2002-07-18
AU2002214029B2 true AU2002214029B2 (en) 2004-12-23

Family

ID=8170270

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2002214029A Ceased AU2002214029B2 (en) 2000-11-02 2001-10-26 Cholesterol Lowering Benzo`b! Thiophenes and Benzo`d! Isothiazoles
AU1402902A Pending AU1402902A (en) 2000-11-02 2001-10-26 Cholesterol lowering benzo`b] thiophenes and benzo`d] isothiazoles

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU1402902A Pending AU1402902A (en) 2000-11-02 2001-10-26 Cholesterol lowering benzo`b] thiophenes and benzo`d] isothiazoles

Country Status (21)

Country Link
US (3) US6951879B2 (https=)
EP (1) EP1334094B1 (https=)
JP (1) JP4012064B2 (https=)
KR (1) KR100545430B1 (https=)
CN (1) CN1261429C (https=)
AR (1) AR034271A1 (https=)
AT (1) ATE286042T1 (https=)
AU (2) AU2002214029B2 (https=)
BR (1) BR0115075A (https=)
CA (1) CA2426009C (https=)
DE (1) DE60108164T2 (https=)
DK (1) DK1334094T3 (https=)
ES (1) ES2233703T3 (https=)
GT (1) GT200100220A (https=)
MX (1) MXPA03003845A (https=)
PA (1) PA8531601A1 (https=)
PE (1) PE20020600A1 (https=)
PT (1) PT1334094E (https=)
UY (1) UY27009A1 (https=)
WO (1) WO2002036584A1 (https=)
ZA (1) ZA200302742B (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100566175B1 (ko) 2000-08-16 2006-03-29 에프. 호프만-라 로슈 아게 신규한 아미노사이클로헥산 유도체
US7012077B2 (en) * 2001-12-20 2006-03-14 Hoffmann-La Roche Inc. Substituted cyclohexane derivatives
EP1647549A1 (en) * 2004-10-14 2006-04-19 Laboratoire Theramex Indazoles, benzisoxazoles and benzisothiazoles as estrogenic agents
US7446210B2 (en) * 2004-10-26 2008-11-04 Janssen Pharmaceutica N.V. Factor Xa compounds
JP2008544987A (ja) * 2005-06-30 2008-12-11 バイエル・クロツプサイエンス・アクチエンゲゼルシヤフト 殺虫性の（二置換プロペニル）フェニルアルキル置換複素環式環を調製するための改善された方法
FR2913019A1 (fr) * 2007-02-23 2008-08-29 Cerep Sa Composes heterocycliques comme agents anti-neoplasiques ou inhibiteurs de proliferation cellulaire
CN101918416A (zh) * 2007-11-29 2010-12-15 兰贝克赛实验室有限公司 制备取代的1,3-氧硫杂环戊烷,尤其是拉米夫定的方法和中间体
WO2009069011A1 (en) * 2007-11-29 2009-06-04 Ranbaxy Laboratories Limited Process for the preparation of substituted 1,3-oxathiolanes
CN103596570B (zh) * 2010-12-27 2018-02-16 密苏里大学管委会 作为抗癌治疗的蛋白质靶的氧化鲨烯环化酶

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410539A (en) * 1980-10-23 1983-10-18 Pfizer Inc. Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them
EP0778271A2 (de) * 1995-12-08 1997-06-11 F. Hoffmann-La Roche Ag Aminoalkyl-substituierte benzo-heterocyclische Verbindungen
US5994371A (en) * 1993-03-19 1999-11-30 Eli Lilly And Company Carbamate derivatives of 3-aroylbenzo[b] thiophenes

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3598839A (en) * 1969-06-30 1971-08-10 Parke Davis & Co Phenylbenzothiophene compounds
GB8417559D0 (en) * 1984-07-10 1984-08-15 Pfizer Ltd Anti-diarrhoeal agents
DE3905364A1 (de) 1989-02-22 1990-08-23 Hoechst Ag Substituierte pyrimidin-derivate, verfahren zu ihrer herstellung und ihre verwendung als tool
EP0530149A1 (de) * 1991-08-30 1993-03-03 Ciba-Geigy Ag Schädlingsbekämpfungsmittel
CA2190699A1 (en) * 1995-12-08 1997-06-09 Johannes Aebi Tertiary amines
UA56197C2 (uk) 1996-11-08 2003-05-15 Зенека Лімітед Гетероциклічні похідні

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4410539A (en) * 1980-10-23 1983-10-18 Pfizer Inc. Heterocyclic thromboxane synthetase inhibitors and pharmaceutical compositions containing them
US5994371A (en) * 1993-03-19 1999-11-30 Eli Lilly And Company Carbamate derivatives of 3-aroylbenzo[b] thiophenes
EP0778271A2 (de) * 1995-12-08 1997-06-11 F. Hoffmann-La Roche Ag Aminoalkyl-substituierte benzo-heterocyclische Verbindungen

Also Published As

Publication number Publication date
CN1471522A (zh) 2004-01-28
EP1334094B1 (en) 2004-12-29
US7449483B2 (en) 2008-11-11
AU1402902A (en) 2002-05-15
CA2426009C (en) 2008-10-07
ATE286042T1 (de) 2005-01-15
CN1261429C (zh) 2006-06-28
EP1334094A1 (en) 2003-08-13
ZA200302742B (en) 2004-07-08
AR034271A1 (es) 2004-02-18
JP4012064B2 (ja) 2007-11-21
DE60108164D1 (de) 2005-02-03
US7173043B2 (en) 2007-02-06
KR100545430B1 (ko) 2006-01-24
US6951879B2 (en) 2005-10-04
US20020086891A1 (en) 2002-07-04
PA8531601A1 (es) 2003-02-14
CA2426009A1 (en) 2002-05-10
JP2004513124A (ja) 2004-04-30
US20070099985A1 (en) 2007-05-03
MXPA03003845A (es) 2003-07-28
US20050267200A1 (en) 2005-12-01
DK1334094T3 (da) 2005-05-02
BR0115075A (pt) 2003-07-29
KR20030045166A (ko) 2003-06-09
ES2233703T3 (es) 2005-06-16
DE60108164T2 (de) 2006-03-02
WO2002036584A1 (en) 2002-05-10
UY27009A1 (es) 2002-06-20
PE20020600A1 (es) 2002-07-08
GT200100220A (es) 2002-07-04
PT1334094E (pt) 2005-05-31

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MK14 Patent ceased section 143(a) (annual fees not paid) or expired