KR100537866B1 - Ｆｋｂｐ12에 대해 친화성 있는 화합물과 향신경성 인자를 함께 사용하여 신경 돌기의 성장을 자극하는 방법 및 조성물 - Google Patents

Ｆｋｂｐ12에 대해 친화성 있는 화합물과 향신경성 인자를 함께 사용하여 신경 돌기의 성장을 자극하는 방법 및 조성물 Download PDF

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Publication number
KR100537866B1
KR100537866B1 KR10-1999-7004194A KR19997004194A KR100537866B1 KR 100537866 B1 KR100537866 B1 KR 100537866B1 KR 19997004194 A KR19997004194 A KR 19997004194A KR 100537866 B1 KR100537866 B1 KR 100537866B1
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KR
South Korea
Prior art keywords
piperidine
pyridin
compound
formula
methyl
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR10-1999-7004194A
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English (en)
Korean (ko)
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KR20000068964A (ko
Inventor
젤리로버트이
수마이클
Original Assignee
버텍스 파마슈티칼스 인코포레이티드
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25012320&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR100537866(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 버텍스 파마슈티칼스 인코포레이티드 filed Critical 버텍스 파마슈티칼스 인코포레이티드
Publication of KR20000068964A publication Critical patent/KR20000068964A/ko
Application granted granted Critical
Publication of KR100537866B1 publication Critical patent/KR100537866B1/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR10-1999-7004194A 1996-11-13 1997-11-13 Ｆｋｂｐ12에 대해 친화성 있는 화합물과 향신경성 인자를 함께 사용하여 신경 돌기의 성장을 자극하는 방법 및 조성물 Expired - Fee Related KR100537866B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/749,114 US5780484A (en) 1996-11-13 1996-11-13 Methods for stimulating neurite growth with piperidine compounds
US8/749,114 1996-11-13
US08/749,114 1996-11-13
PCT/US1997/020868 WO1998020893A1 (en) 1996-11-13 1997-11-13 Methods and compositions for stimulating neurite growth using compounds with affinity for fkbp12 in combination with neurotrophic factors

Publications (2)

Publication Number Publication Date
KR20000068964A KR20000068964A (ko) 2000-11-25
KR100537866B1 true KR100537866B1 (ko) 2005-12-21

Family

ID=25012320

Family Applications (1)

Application Number Title Priority Date Filing Date
KR10-1999-7004194A Expired - Fee Related KR100537866B1 (ko) 1996-11-13 1997-11-13 Ｆｋｂｐ12에 대해 친화성 있는 화합물과 향신경성 인자를 함께 사용하여 신경 돌기의 성장을 자극하는 방법 및 조성물

Country Status (19)

Country Link
US (1) US5780484A (enExample)
EP (2) EP0941113A1 (enExample)
JP (1) JP2001503778A (enExample)
KR (1) KR100537866B1 (enExample)
CN (1) CN1168443C (enExample)
AR (1) AR015105A1 (enExample)
AU (1) AU741186B2 (enExample)
BR (1) BR9713037A (enExample)
CA (1) CA2270985A1 (enExample)
CO (1) CO5080733A1 (enExample)
EA (1) EA003530B1 (enExample)
IL (1) IL129557A0 (enExample)
IN (1) IN183409B (enExample)
NZ (1) NZ335396A (enExample)
PL (1) PL191249B1 (enExample)
TW (1) TW509572B (enExample)
UA (1) UA61090C2 (enExample)
WO (1) WO1998020893A1 (enExample)
ZA (1) ZA9710248B (enExample)

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US6150527A (en) * 1994-08-18 2000-11-21 Ariad Pharmaceuticals, Inc. Synthetic multimerizing agents
US5859031A (en) * 1995-06-07 1999-01-12 Gpi Nil Holdings, Inc. Small molecule inhibitors of rotamase enzyme activity
ZA98825B (en) * 1997-02-27 1998-10-19 Guilford Pharm Inc Method of using neurotrophic carbamates and ureas
US6242468B1 (en) * 1997-02-27 2001-06-05 Jia-He Li Carbamate and urea compositions and neurotrophic uses
US6514686B2 (en) 1997-04-28 2003-02-04 The University Of British Columbia Method and composition for modulating amyloidosis
US20010049381A1 (en) 1997-06-04 2001-12-06 Gpl Nil Holdings, Inc., Pyrrolidine derivative hair growth compositions and uses
US5945441A (en) 1997-06-04 1999-08-31 Gpi Nil Holdings, Inc. Pyrrolidine carboxylate hair revitalizing agents
US6852496B1 (en) * 1997-08-12 2005-02-08 Oregon Health And Science University Methods of screening for agents that promote nerve cell growth
US5968921A (en) 1997-10-24 1999-10-19 Orgegon Health Sciences University Compositions and methods for promoting nerve regeneration
HUP0102847A2 (hu) * 1998-06-03 2001-12-28 Amgen Inc. N-heterociklusos karbonsavak és izoszter karbonsavak karbamidjai és karbamátjai, előállításuk és alkalmazásuk, valamint e vegyületeket tartalmazó gyógyászati készítmények
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
HUP0102935A3 (en) 1998-06-03 2002-01-28 Gpi Nil Holdings Inc Wilmingto N-linked sulfonamides of n-heterocyclic carboxylic acids or carboxylic acid isosteres and pharmaceutical compositions containing them
PL345598A1 (en) 1998-07-17 2001-12-17 Agouron Pharma Compounds, compositions, and methods for stimulating neuronal growth and elongation
GB9815880D0 (en) 1998-07-21 1998-09-16 Pfizer Ltd Heterocycles
US6395758B1 (en) * 1998-08-14 2002-05-28 Gpi Nil Holdings, Inc. Small molecule carbamates or ureas for vision and memory disorders
US7338976B1 (en) * 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
US6376517B1 (en) * 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US6462072B1 (en) 1998-09-21 2002-10-08 Gpi Nil Holdings, Inc. Cyclic ester or amide derivatives
US6228872B1 (en) * 1998-11-12 2001-05-08 Bristol-Myers Squibb Company Neurotrophic diamide and carbamate agents
JP2003503480A (ja) * 1999-07-06 2003-01-28 バーテックス ファーマシューティカルズ インコーポレイテッド ニューロン活性を有するｎ−ヘテロ環誘導体
CN1382140A (zh) 1999-07-09 2002-11-27 奥索-麦克尼尔药品公司 具有神经营养活性的吡咯烷和哌啶、以及含有它们的相关组合物
US6734211B1 (en) 1999-07-09 2004-05-11 Oregon Health & Sciences University Compositions and methods for promoting nerve regeneration
WO2001017953A1 (en) * 1999-09-08 2001-03-15 Guilford Pharmaceuticals Inc. Non-peptidic cyclophilin binding compounds and their use
CA2386579A1 (en) * 1999-11-12 2001-05-25 Alcon, Inc. Neurophilin ligands for treating ocular conditions
US7253169B2 (en) 1999-11-12 2007-08-07 Gliamed, Inc. Aza compounds, pharmaceutical compositions and methods of use
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US6818643B1 (en) 1999-12-08 2004-11-16 Bristol-Myers Squibb Company Neurotrophic bicyclic diamides
WO2001046195A1 (en) 1999-12-21 2001-06-28 Gpi Nil Holdings, Inc. Hydantoin derivative compounds, pharmaceutical compositions, and methods of using same
MXPA03006666A (es) 2001-01-25 2004-05-31 Guilford Pharm Inc Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso.
WO2002096420A2 (en) * 2001-05-29 2002-12-05 Guilford Pharmaceuticals Inc. Method for treating nerve injury caused by surgery
US20040147433A1 (en) * 2001-06-14 2004-07-29 Marcus Keep Neuroimmunophilins for selective neuronal radioprotection
WO2003062773A1 (en) * 2002-01-24 2003-07-31 Pei Electronics, Inc. Compact integrated infrared scene projector
RU2005113247A (ru) * 2002-10-03 2006-01-20 Вертекс Фармасьютикалз Инкорпорейтед (Us) Производные пиперазина и пиперидина для лечения неврологических заболеваний
US20060189551A1 (en) * 2004-10-04 2006-08-24 Duke University Combination therapies for fungal pathogens
RU2394036C2 (ru) * 2004-12-20 2010-07-10 Вайет Аналоги рапамицина и их применение при лечении неврологических, пролиферативных и воспалительных заболеваний
EP1828203A2 (en) * 2004-12-20 2007-09-05 Wyeth Rapamycin derivatives and the uses thereof in the treatment of neurological disorders
MX2007010076A (es) 2005-02-17 2007-10-16 Astellas Pharma Inc Derivado de heterociclico-1-carboxilato que contiene nitrogeno no aromatico de piridilo.
AU2007210862A1 (en) * 2006-02-02 2007-08-09 Rinat Neuroscience Corp. Methods for treating unwanted weight loss or eating disorders by administering a trkB agonist
JP2009525319A (ja) * 2006-02-02 2009-07-09 ライナット ニューロサイエンス コーポレイション ｔｒｋＢアンタゴニストを投与することにより肥満を治療する方法
US11745029B2 (en) 2018-05-30 2023-09-05 Zap Surgical Systems, Inc. Radiosurgical neuromodulation close to critical structures
EP4284804A1 (en) 2021-01-26 2023-12-06 Schrödinger, Inc. Tricyclic compounds useful in the treatment of cancer, autoimmune and inflammatory disorders
CN116763768B (zh) * 2022-03-15 2026-03-20 润佳（苏州）医药科技有限公司 同位素富集的3-氨基-1-丙磺酸衍生物及其用途

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US9604852B2 (en) * 2012-09-28 2017-03-28 Dic Corporation α-alumina particles and method for manufacturing the same

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Also Published As

Publication number Publication date
PL333286A1 (en) 1999-11-22
EA003530B1 (ru) 2003-06-26
ZA9710248B (en) 1998-05-28
AU5439798A (en) 1998-06-03
IL129557A0 (en) 2000-02-29
KR20000068964A (ko) 2000-11-25
EP1666053A1 (en) 2006-06-07
UA61090C2 (uk) 2003-11-17
WO1998020893A1 (en) 1998-05-22
CA2270985A1 (en) 1998-05-22
NZ335396A (en) 2000-11-24
BR9713037A (pt) 2000-04-11
CN1168443C (zh) 2004-09-29
AR015105A1 (es) 2001-04-18
TW509572B (en) 2002-11-11
CO5080733A1 (es) 2001-09-25
CN1239434A (zh) 1999-12-22
AU741186B2 (en) 2001-11-22
US5780484A (en) 1998-07-14
IN183409B (enExample) 1999-12-25
EP0941113A1 (en) 1999-09-15
JP2001503778A (ja) 2001-03-21
EA199900463A1 (ru) 2000-02-28
PL191249B1 (pl) 2006-04-28

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