KR100406722B1 - 수분흡수능이 우수한 매트릭스형 경피투여제 - Google Patents
수분흡수능이 우수한 매트릭스형 경피투여제 Download PDFInfo
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- KR100406722B1 KR100406722B1 KR10-2001-0068525A KR20010068525A KR100406722B1 KR 100406722 B1 KR100406722 B1 KR 100406722B1 KR 20010068525 A KR20010068525 A KR 20010068525A KR 100406722 B1 KR100406722 B1 KR 100406722B1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
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- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
Claims (7)
- 약물보호층(Backing layer; 1), 유효약물함유 매트릭스층(2) 및 피부 부착전 제거되는 박리층(Release liner film; 3)이 적층된 매트릭스형 경피투여제에 있어서,상기 매트릭스(2)층 중에는 유효약물 1 ∼ 25 중량%, 아크릴계 점착제 40 ∼ 95 중량%, 분자량 100 ∼ 500만의 폴리비닐피롤리돈 1 ∼ 7 중량%, 분자량 2,000 ∼ 50,000의 폴리비닐피롤리돈 1 ∼ 13 중량%, 흡수촉진제로서 비이온성 계면활성제 0.1 ∼ 25 중량%, 테레펜계 부형제 0.1 ∼ 10 중량% 및 용해보조제용 용매 0.1 ∼ 10 중량%가 함유되어 있는 것임을 특징으로 하는 수분흡수능이 우수한 매트릭스형 경피투여제.
- 제 1 항에 있어서, 상기 매트릭스층(2)에는 추가로 콜로이달 실리카 0.5 ∼ 5 중량%가 함유되어 있는 것임을 특징으로 하는 수분흡수능이 우수한 매트릭스형 경피투여제.
- 제 1 항에 있어서, 상기 유효약물이 디클로페낙 디에틸암모늄인 것임을 특징으로 하는 수분흡수능이 우수한 매트릭스형 경피투여제.
- 제 1 항에서 있어서, 상기 아크릴계 점착제는 아크릴레이트 중합체 또는 아크릴레이트와 비닐 아세테이트의 공중합체인 것임을 특징으로 하는 수분흡수능이 우수한 매트릭스형 경피투여제.
- 제 1 항에 있어서, 상기 비이온성 계면활성제는 글리세롤 모노올리에이트, 글리세롤 모노라우레이트, 소비탄 모노올리에이트, 글리세롤 트리올리에이트 및 아이소프로필 미리스테이트 중에서 선택된 1종 이상인 것임을 특징으로 하는 수분흡수능이 우수한 매트릭스형 경피투여제.
- 제 1 항에 있어서, 상기 테레펜계 부형제는 멘톨, D-리모넨, 게라니올 및 네로리돌 중에서 선택된 1종 이상인 것임을 특징으로 하는 수분흡수능이 우수한 매트릭스형 경피투여제.
- 제 1 항에 있어서, 상기 용해보조제용 용매는 트리아세틴, 아이소프로필 알코올, 프로필렌 글라이콜, 다이메틸아세트아마이드, 프로필렌카보네이트, 다이에틸에탄올아민, 다이에틸아민, 트리에틸아민, N-메틸 모포린 및 벤즈암모늄 클로라이드 중에서 선택된 1종 이상의 것임을 특징으로 하는 수분흡수능이 우수한 매트릭스형 경피투여제.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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KR1020000065662 | 2000-11-06 | ||
KR20000065662 | 2000-11-06 |
Publications (2)
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KR20020035451A KR20020035451A (ko) | 2002-05-11 |
KR100406722B1 true KR100406722B1 (ko) | 2003-11-21 |
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KR10-2001-0068525A KR100406722B1 (ko) | 2000-11-06 | 2001-11-05 | 수분흡수능이 우수한 매트릭스형 경피투여제 |
Country Status (11)
Country | Link |
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US (1) | US7691404B2 (ko) |
EP (1) | EP1331929A1 (ko) |
JP (1) | JP3962684B2 (ko) |
KR (1) | KR100406722B1 (ko) |
CN (1) | CN100340237C (ko) |
AU (2) | AU2002214364B2 (ko) |
BR (1) | BRPI0116659B8 (ko) |
CA (1) | CA2427764C (ko) |
MX (1) | MXPA03003957A (ko) |
NZ (1) | NZ524940A (ko) |
WO (1) | WO2002036103A1 (ko) |
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- 2001-11-05 KR KR10-2001-0068525A patent/KR100406722B1/ko active IP Right Grant
- 2001-11-05 BR BRPI0116659A patent/BRPI0116659B8/pt not_active IP Right Cessation
- 2001-11-05 AU AU2002214364A patent/AU2002214364B2/en not_active Ceased
- 2001-11-05 AU AU1436402A patent/AU1436402A/xx active Pending
- 2001-11-05 WO PCT/KR2001/001869 patent/WO2002036103A1/en active IP Right Grant
- 2001-11-05 CA CA002427764A patent/CA2427764C/en not_active Expired - Lifetime
- 2001-11-05 MX MXPA03003957A patent/MXPA03003957A/es active IP Right Grant
- 2001-11-05 EP EP01982905A patent/EP1331929A1/en not_active Withdrawn
- 2001-11-05 CN CNB018182275A patent/CN100340237C/zh not_active Expired - Lifetime
- 2001-11-05 NZ NZ524940A patent/NZ524940A/en not_active IP Right Cessation
- 2001-11-05 US US10/415,628 patent/US7691404B2/en not_active Expired - Fee Related
- 2001-11-05 JP JP2002538915A patent/JP3962684B2/ja not_active Expired - Fee Related
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Also Published As
Publication number | Publication date |
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JP3962684B2 (ja) | 2007-08-22 |
CA2427764C (en) | 2007-05-08 |
KR20020035451A (ko) | 2002-05-11 |
CA2427764A1 (en) | 2002-05-10 |
CN100340237C (zh) | 2007-10-03 |
EP1331929A1 (en) | 2003-08-06 |
MXPA03003957A (es) | 2003-08-19 |
CN1705472A (zh) | 2005-12-07 |
AU2002214364B2 (en) | 2004-08-19 |
BR0116659B1 (pt) | 2013-12-24 |
US7691404B2 (en) | 2010-04-06 |
NZ524940A (en) | 2003-08-29 |
BRPI0116659B8 (pt) | 2021-05-25 |
WO2002036103A1 (en) | 2002-05-10 |
JP2004512356A (ja) | 2004-04-22 |
AU1436402A (en) | 2002-05-15 |
BR0116659A (pt) | 2003-10-07 |
US20040033254A1 (en) | 2004-02-19 |
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