KR100371062B1 - 안정성이향상된주사가능한택솔조성물및이를제형화하는방법 - Google Patents

안정성이향상된주사가능한택솔조성물및이를제형화하는방법 Download PDF

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Publication number
KR100371062B1
KR100371062B1 KR1019940702575A KR19940702575A KR100371062B1 KR 100371062 B1 KR100371062 B1 KR 100371062B1 KR 1019940702575 A KR1019940702575 A KR 1019940702575A KR 19940702575 A KR19940702575 A KR 19940702575A KR 100371062 B1 KR100371062 B1 KR 100371062B1
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KR
South Korea
Prior art keywords
solution
acid
taxol
injectable
ethanol
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KR1019940702575A
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English (en)
Korean (ko)
Inventor
로빈 루이스 엘리오트
그레고리 포울 핸드렉크
데이비드 카르베르
티모시 프로우트
헤르니타 에왈드
Original Assignee
에프.에이치.포울딩 앤드 컴퍼니 리미티드
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Publication of KR100371062B1 publication Critical patent/KR100371062B1/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1019940702575A 1992-11-27 1993-11-25 안정성이향상된주사가능한택솔조성물및이를제형화하는방법 KR100371062B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AUPL6074 1992-11-27
AUPL607492 1992-11-27

Publications (1)

Publication Number Publication Date
KR100371062B1 true KR100371062B1 (ko) 2003-04-21

Family

ID=3776561

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940702575A KR100371062B1 (ko) 1992-11-27 1993-11-25 안정성이향상된주사가능한택솔조성물및이를제형화하는방법

Country Status (8)

Country Link
KR (1) KR100371062B1 (fr)
CN (2) CN1096673A (fr)
AU (1) AU5553894A (fr)
IL (2) IL107776A0 (fr)
IN (1) IN176188B (fr)
NZ (1) NZ258044A (fr)
WO (1) WO1994012198A1 (fr)
ZA (1) ZA938844B (fr)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0674510T3 (da) * 1992-11-27 1999-05-10 Napro Biotherapeutics Inc Injicerbart præparat omfattende paclitaxel
TW406020B (en) * 1993-09-29 2000-09-21 Bristol Myers Squibb Co Stabilized pharmaceutical composition and its method for preparation and stabilizing solvent
FR2710534B1 (fr) * 1994-09-28 1996-07-05 Bristol Myers Squibb Co Solvant de stabilisation, composition pharmaceutique le contenant, et son procédé de préparation.
NL9500340A (nl) * 1995-02-22 1996-10-01 Yew Tree Pharmaceuticals B V Gestabiliseerde paclitaxel-oplossing en farmaceutisch preparaat dat deze oplossing bevat.
US5686488A (en) * 1995-08-25 1997-11-11 Alcon Laboratories, Inc. Polyethoxylated castor oil products as anti-inflammatory agents
DE19536165A1 (de) * 1995-09-28 1997-04-03 Basf Ag Verfahren zur Reinigung von alkoxylierten Fetten
CA2240595A1 (fr) * 1995-12-21 1997-07-03 Bijan Almassian Composition de taxane et procede s'y rapportant
KR100191446B1 (ko) * 1996-05-02 1999-06-15 송영욱 파클리탁셀 함유 전신성 홍반성 낭창치료제
KR100330373B1 (ko) * 1996-05-28 2002-11-07 주식회사한국신약 탁솔을 함유한 주사용 약제 조성물
KR100358934B1 (ko) * 1996-09-13 2003-01-29 주식회사한국신약 탁솔을함유한주사용약제조성물
US6045808A (en) * 1997-01-31 2000-04-04 Pharmacia & Upjohn Company Method for removing high boiling solvents from drug formulations by vacuum drying
ATE226070T1 (de) * 1997-05-30 2002-11-15 Man Woo Han Taxol enthaltende pharmazeutische injektionslösung
CN1101677C (zh) * 1997-05-30 2003-02-19 韩万愚 含有紫杉醇的药用注射溶液
BE1011216A3 (fr) * 1997-06-13 1999-06-01 Thissen En Abrege L T B Lab Forme pharmaceutique pour l'administration de paclitaxel, procede de preparation d'une composition de paclitaxel prete a l'emploi et utilisation de cette composition.
US6071952A (en) * 1998-12-02 2000-06-06 Mylan Pharmaceuticals, Inc. Stabilized injectable pharmaceutical compositions containing taxoid anti-neoplastic agents
US6919370B2 (en) 2000-11-28 2005-07-19 Transform Pharmaceuticals, Inc. Pharmaceutical formulations comprising paclitaxel, derivatives, and pharmaceutically acceptable salts thereof
DE10115740A1 (de) * 2001-03-26 2002-10-02 Ulrich Speck Zubereitung für die Restenoseprophylaxe
KR100774366B1 (ko) * 2001-09-10 2007-11-08 주식회사 중외제약 파클리탁셀 주사제 조성물
CZ294371B6 (cs) * 2002-06-10 2004-12-15 Pliva - Lachema, A. S. Stabilizovaná farmaceutická kompozice na bázi polyoxyethylovaného ricinového oleje a způsob její přípravy
PT2286795T (pt) * 2002-06-26 2017-01-27 Syncore Biotechnology Co Ltd Processo de produção de uma preparação lipossomal catiónica que compreende um composto lipófilo
JP2008543789A (ja) * 2005-06-17 2008-12-04 ホスピラ オーストラリア ピーティーワイ エルティーディー ドセタキセルの液体薬学的処方物
BRPI0615265A8 (pt) 2005-08-31 2018-03-06 Abraxis Bioscience Llc composições compreendendo agentes farmacêuticos pouco hidrossoluíveis e agentes antimicrobianos
CN101396354B (zh) * 2007-09-30 2010-12-01 江苏恒瑞医药股份有限公司 一种稳定的塔三烷类化合物液体组合物及其制备方法和其应用
CN101829051B (zh) * 2010-05-31 2012-09-12 南昌弘益科技有限公司 1’-乙酰氧基胡椒酚乙酸酯注射液
CN103432109B (zh) * 2013-09-01 2015-09-23 吴静 紫杉醇的药物组合物
US10561766B2 (en) 2015-09-15 2020-02-18 W. L. Gore & Associates, Inc. Drug composition and coating

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2601675B1 (fr) * 1986-07-17 1988-09-23 Rhone Poulenc Sante Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent
NZ224497A (en) * 1987-05-18 1990-04-26 Janssen Pharmaceutica Nv Pharmaceutical composition comprising flunarizine
US5157049A (en) * 1988-03-07 1992-10-20 The United States Of America As Represented By The Department Of Health & Human Services Method of treating cancers sensitive to treatment with water soluble derivatives of taxol
US4960790A (en) * 1989-03-09 1990-10-02 University Of Kansas Derivatives of taxol, pharmaceutical compositions thereof and methods for the preparation thereof
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
TW223634B (fr) * 1991-03-18 1994-05-11 Kingston David G I
ATE180477T1 (de) * 1991-04-19 1999-06-15 Univ Mississippi Verfahren und zubereitungen zur isolierung von taxanen

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Cancer Treat. Rep 71 (12) 1179-1184, 1987. *
J. Microencapsulation (1990), 7(2), 191-197 *

Also Published As

Publication number Publication date
CN1096673A (zh) 1994-12-28
IN176188B (fr) 1996-02-24
AU667142B2 (en) 1996-03-07
ZA938844B (en) 1994-08-02
AU5553894A (en) 1994-06-22
AU5196793A (en) 1994-06-09
WO1994012198A1 (fr) 1994-06-09
NZ258044A (en) 1995-12-21
CN1047305C (zh) 1999-12-15
IL107776A0 (en) 1994-02-27
IL126178A0 (en) 1999-05-09
CN1095266A (zh) 1994-11-23

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