KR100341994B1 - 가광견병비루스돌연변이체를포함하는아우제스키병및기타동물질병에대한백신 - Google Patents

가광견병비루스돌연변이체를포함하는아우제스키병및기타동물질병에대한백신 Download PDF

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KR100341994B1
KR100341994B1 KR1019950700064A KR19950700064A KR100341994B1 KR 100341994 B1 KR100341994 B1 KR 100341994B1 KR 1019950700064 A KR1019950700064 A KR 1019950700064A KR 19950700064 A KR19950700064 A KR 19950700064A KR 100341994 B1 KR100341994 B1 KR 100341994B1
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mutants
gene
mutant
virus
vaccine
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베르나르두스 페트루스 후베르투스 피터스
얀 마리아 안토니우수 폴
아르놀드 레오나르드 요셉 기엘켄스
로베르투스 야코부스 마리아 무르만
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악조 노벨 엔.브이.
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16722—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16734—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16711—Varicellovirus, e.g. human herpesvirus 3, Varicella Zoster, pseudorabies
    • C12N2710/16761—Methods of inactivation or attenuation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1019950700064A 1992-07-09 1993-07-08 가광견병비루스돌연변이체를포함하는아우제스키병및기타동물질병에대한백신 Expired - Fee Related KR100341994B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP92202096.1 1992-07-09
EP92202096 1992-07-09
PCT/NL1993/000146 WO1994001573A1 (en) 1992-07-09 1993-07-08 Vaccines against aujeszky's disease and other animal diseases containing pseudorabies virus mutants

Publications (1)

Publication Number Publication Date
KR100341994B1 true KR100341994B1 (ko) 2002-11-30

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KR1019950700064A Expired - Fee Related KR100341994B1 (ko) 1992-07-09 1993-07-08 가광견병비루스돌연변이체를포함하는아우제스키병및기타동물질병에대한백신

Country Status (18)

Country Link
US (1) US5674500A (enExample)
EP (1) EP0654086B1 (enExample)
JP (1) JPH07509127A (enExample)
KR (1) KR100341994B1 (enExample)
CN (1) CN1124159C (enExample)
AT (1) ATE189000T1 (enExample)
AU (1) AU684252B2 (enExample)
CA (1) CA2139507C (enExample)
DE (1) DE69327656T2 (enExample)
DK (1) DK0654086T3 (enExample)
ES (1) ES2143507T3 (enExample)
HU (1) HU220099B (enExample)
NZ (1) NZ254267A (enExample)
PL (1) PL174219B1 (enExample)
RU (1) RU2158308C2 (enExample)
TW (1) TW289731B (enExample)
WO (1) WO1994001573A1 (enExample)
ZA (1) ZA934882B (enExample)

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CA2103460C (en) * 1991-06-06 2000-09-26 Gert Wensvoort Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
US6007825A (en) * 1991-12-23 1999-12-28 American Cyanamid Company Serpulina hyodysenteriae vaccine comprising a tly gene mutant
US7223411B1 (en) 1992-07-31 2007-05-29 Dana-Farber Cancer Institute Herpesvirus replication defective mutants
US6380376B1 (en) * 1992-10-30 2002-04-30 Iowa State University Research Foundation Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US5695766A (en) * 1992-10-30 1997-12-09 Iowa State University Research Foundation Highly virulent porcine reproductive and respiratory syndrome viruses which produce lesions in pigs and vaccines that protect pigs against said syndrome
US6773908B1 (en) * 1992-10-30 2004-08-10 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids of porcine reproductive and respiratory syndrome virus (PRRSV)
US6592873B1 (en) * 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
WO1994021807A2 (en) * 1993-03-19 1994-09-29 Cantab Pharmaceuticals Research Limited Defective mutant non-retroviral virus (e.g. hsv) as vaccine
EP0659885A1 (en) * 1993-12-21 1995-06-28 Akzo Nobel N.V. Vaccine against viruses associated with antibody-dependent-enhancement of viral infectivity
EP0693551A1 (en) 1994-07-18 1996-01-24 Akzo Nobel N.V. gD-negative bovine herpesvirus mutant, capable of direct cell-to-cell transmission
WO2000053787A1 (en) * 1999-03-08 2000-09-14 Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. Prrsv vaccines
EP0839912A1 (en) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
US20040224327A1 (en) * 1996-10-30 2004-11-11 Meulenberg Johanna Jacoba Maria Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
US6399354B1 (en) 1998-07-31 2002-06-04 President And Fellows Of Harvard College Replication-competent virus expressing a detectable fusion protein
EP2251419B1 (en) * 1999-04-22 2012-05-30 United States Department of Agriculture Porcine reproductive and respiratory syndrome vaccine, based on isolate JA-142
US20050014264A1 (en) * 2002-12-11 2005-01-20 University Of Massachusetts Method of introducing siRNA into adipocytes
JP2008503727A (ja) * 2004-06-18 2008-02-07 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ ウイルス感染した生物およびワクチン接種した生物の同定
US7632636B2 (en) * 2004-09-21 2009-12-15 Boehringer Ingelheim Vetmedica, Inc. Porcine reproductive and respiratory syndrome isolates and methods of use
EP2369001B1 (en) 2005-06-24 2016-08-31 Regents of the University of Minnesota PRRS viruses, infectious clones, mutants thereof, and methods of use
CN101081298A (zh) * 2007-06-26 2007-12-05 陈少莺 一种猪伪狂犬病新型亚单位疫苗制备方法
WO2010025109A1 (en) * 2008-08-25 2010-03-04 Boehringer Ingelheim Vetmedia, Inc. Vaccine against highly pathogenic porcine reproductive and respiratory syndrome (hp prrs)
CN101457215B (zh) * 2008-12-01 2010-11-17 华中农业大学 重组猪伪狂犬病毒-猪繁殖与呼吸综合征病毒-猪圆环病毒基因工程毒株及应用
AR078253A1 (es) * 2009-09-02 2011-10-26 Boehringer Ingelheim Vetmed Metodos para reducir la actividad antivirica en composiciones pcv-2 y composiciones pcv-2 con mejor inmunogenicidad
RU2439150C1 (ru) * 2010-11-16 2012-01-10 Государственное научное учреждение Всероссийский научно-исследовательский институт ветеринарной вирусологии и микробиологии Штамм "ас-21/07" вируса ауески для изготовления вакцинных и диагностических препаратов
CN103370077B (zh) 2011-02-17 2016-10-26 贝林格尔.英格海姆维特梅迪卡有限公司 猪繁殖与呼吸综合征病毒的商业化规模生产方法
SG192820A1 (en) 2011-02-17 2013-09-30 Boehringer Ingelheim Vetmed Novel european prrsv strain
US9187731B2 (en) 2011-07-29 2015-11-17 Boehringer Ingelheim Vetmedica Gmbh PRRS virus inducing type I interferon in susceptible cells
EP2737058A1 (en) 2011-07-29 2014-06-04 Boehringer Ingelheim Vetmedica GmbH INFECTIOUS cDNA CLONE OF EUROPEAN PRRS VIRUS AND USES THEREOF
CN105073130A (zh) 2013-03-15 2015-11-18 勃林格殷格翰动物保健公司 猪生殖与呼吸综合征病毒、组合物、疫苗及使用方法
CN104250640A (zh) * 2014-08-22 2014-12-31 普莱柯生物工程股份有限公司 猪伪狂犬病病毒基因缺失株、疫苗组合物及其制备方法和应用
CN111560355A (zh) * 2015-03-20 2020-08-21 普莱柯生物工程股份有限公司 一种猪伪狂犬病病毒致弱方法、及其致弱的病毒株、疫苗组合物和应用

Family Cites Families (7)

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US4859587A (en) * 1984-06-04 1989-08-22 Institut Merieux Recombinant herpes simplex viruses, vaccines and methods
EP0231209B1 (en) * 1985-07-29 1991-02-06 The Upjohn Company Virus vaccine
US5352575A (en) * 1985-10-04 1994-10-04 The Upjohn Company Pseudorabies virus protein
US4999296A (en) * 1986-04-29 1991-03-12 Novagene, Inc. Thymidine kinase negative insertion mutants of pseudorabies virus and methods for the production of same
NL8902087A (nl) * 1989-08-17 1991-03-18 Stichting Tech Wetenschapp Niet-natuurlijk voorkomend pseudorabiesvirus en vaccins die dit bevatten.
ATE194657T1 (de) * 1990-09-25 2000-07-15 Cantab Pharma Res Bei einer transkomplementenden zellinie erzeugter defektiver virenimpfstoff
ATE288483T1 (de) * 1992-07-30 2005-02-15 Akzo Nobel Nv Nicht-verbreitendes lebendes herpesvirusvakzin

Also Published As

Publication number Publication date
ZA934882B (en) 1994-02-03
DE69327656D1 (de) 2000-02-24
HU9500039D0 (en) 1995-03-28
JPH07509127A (ja) 1995-10-12
CN1124159C (zh) 2003-10-15
WO1994001573A1 (en) 1994-01-20
TW289731B (enExample) 1996-11-01
EP0654086A1 (en) 1995-05-24
PL307049A1 (en) 1995-05-02
CA2139507C (en) 2005-04-19
PL174219B1 (pl) 1998-06-30
EP0654086B1 (en) 2000-01-19
DK0654086T3 (da) 2000-06-13
AU4589893A (en) 1994-01-31
AU684252B2 (en) 1997-12-11
CN1086143A (zh) 1994-05-04
RU95105518A (ru) 1997-03-27
ATE189000T1 (de) 2000-02-15
DE69327656T2 (de) 2000-08-03
CA2139507A1 (en) 1994-01-20
US5674500A (en) 1997-10-07
HUT70986A (en) 1995-11-28
RU2158308C2 (ru) 2000-10-27
ES2143507T3 (es) 2000-05-16
NZ254267A (en) 1996-08-27
HU220099B (hu) 2001-10-28

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