KR100292363B1 - 티아졸리딘디온유도체,그의제조방법및용도 - Google Patents

티아졸리딘디온유도체,그의제조방법및용도 Download PDF

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Publication number
KR100292363B1
KR100292363B1 KR1019930029987A KR930029987A KR100292363B1 KR 100292363 B1 KR100292363 B1 KR 100292363B1 KR 1019930029987 A KR1019930029987 A KR 1019930029987A KR 930029987 A KR930029987 A KR 930029987A KR 100292363 B1 KR100292363 B1 KR 100292363B1
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KR
South Korea
Prior art keywords
carbon atoms
cycloalkyl
group
oxazolyl
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1019930029987A
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English (en)
Korean (ko)
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KR940014392A (ko
Inventor
소다다까시
이께다히또시
이마이사치꼬
모모세유
Original Assignee
다케다 야쿠힌 고교 가부시키가이샤
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Publication of KR940014392A publication Critical patent/KR940014392A/ko
Application granted granted Critical
Publication of KR100292363B1 publication Critical patent/KR100292363B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
KR1019930029987A 1992-12-28 1993-12-27 티아졸리딘디온유도체,그의제조방법및용도 Expired - Fee Related KR100292363B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP34856892 1992-12-28
JP92-348568 1992-12-28
JP18099693 1993-07-22
JP93-180996 1993-07-23

Publications (2)

Publication Number Publication Date
KR940014392A KR940014392A (ko) 1994-07-18
KR100292363B1 true KR100292363B1 (ko) 2001-09-17

Family

ID=26500340

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019930029987A Expired - Fee Related KR100292363B1 (ko) 1992-12-28 1993-12-27 티아졸리딘디온유도체,그의제조방법및용도

Country Status (21)

Country Link
US (1) US5489602A (cg-RX-API-DMAC10.html)
EP (1) EP0605228B1 (cg-RX-API-DMAC10.html)
JP (1) JP3741452B2 (cg-RX-API-DMAC10.html)
KR (1) KR100292363B1 (cg-RX-API-DMAC10.html)
CN (1) CN1056372C (cg-RX-API-DMAC10.html)
AT (1) ATE190052T1 (cg-RX-API-DMAC10.html)
AU (1) AU666414B2 (cg-RX-API-DMAC10.html)
CA (1) CA2112283A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ288363B6 (cg-RX-API-DMAC10.html)
DE (1) DE69327944T2 (cg-RX-API-DMAC10.html)
DK (1) DK0605228T3 (cg-RX-API-DMAC10.html)
ES (1) ES2142852T3 (cg-RX-API-DMAC10.html)
FI (1) FI935887L (cg-RX-API-DMAC10.html)
GR (1) GR3033487T3 (cg-RX-API-DMAC10.html)
HU (1) HUT69383A (cg-RX-API-DMAC10.html)
MX (1) MX9400190A (cg-RX-API-DMAC10.html)
MY (1) MY110142A (cg-RX-API-DMAC10.html)
NO (1) NO300735B1 (cg-RX-API-DMAC10.html)
PT (1) PT605228E (cg-RX-API-DMAC10.html)
RU (1) RU2129553C1 (cg-RX-API-DMAC10.html)
TW (1) TW245716B (cg-RX-API-DMAC10.html)

Families Citing this family (27)

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IL113112A (en) * 1994-03-28 2000-06-01 Nissan Chemical Ind Ltd Pyridine substituted thiazolidinediones and pharmaceutical compositions comprising them
CA2195559A1 (en) * 1994-08-10 1996-02-22 Takashi Sohda Thiazolidinedione derivatives, their production and use
US5641796A (en) * 1994-11-01 1997-06-24 Eli Lilly And Company Oral hypoglycemic agents
US5925656A (en) * 1995-04-10 1999-07-20 Dr. Reddy's Research Foundation Compounds having antidiabetic, hypolipidemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5919782A (en) * 1996-05-06 1999-07-06 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
ZA973850B (en) * 1996-05-06 1997-12-02 Reddy Research Foundation Novel antidiabetic compounds having hypolipidaemic, anti-hypertensive properties, process for their preparation and pharmaceutical compositions containing them.
US5801173A (en) * 1996-05-06 1998-09-01 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US5889032A (en) * 1996-05-06 1999-03-30 Dr. Reddy's Research Foundation Heterocyclic compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
US6114526A (en) 1996-07-01 2000-09-05 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
AU744518B2 (en) 1996-07-01 2002-02-28 Dr. Reddy's Laboratories Limited Novel heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
US6372750B2 (en) 1996-07-01 2002-04-16 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compounds containing them and their use in the treatment of diabetes and related diseases
US5885997A (en) * 1996-07-01 1999-03-23 Dr. Reddy's Research Foundation Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
USRE39266E1 (en) 1996-07-01 2006-09-05 Dr. Reddy's Laboratories, Limited Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them and their use in the treatment of diabetes and related diseases
AU2995497A (en) * 1996-07-26 1997-11-19 Dr. Reddy's Research Foundation Thiazolidinedione compounds having antidiabetic, hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions thereof
RU2200161C2 (ru) * 1996-12-31 2003-03-10 Др. Редди'З Рисерч Фаундейшн Новые производные азолидиндиона, способ их получения (варианты), фармацевтические композиции на их основе, способ предупреждения или лечения, способ снижения глюкозы и промежуточное соединение
TW577875B (en) * 1997-01-31 2004-03-01 Shionogi & Co Pyrrolidine derivatives with inhibitory activity for phospholipase A2
WO1997041119A1 (en) * 1997-05-02 1997-11-06 Dr. Reddy's Research Foundation Novel antidiabetic compounds having hypolipidaemic, antihypertensive properties, process for their preparation and pharmaceutical compositions containing them
GB9726568D0 (en) * 1997-12-16 1998-02-11 Smithkline Beecham Plc Novel pharmaceutical
CN1158075C (zh) * 1998-12-01 2004-07-21 诺沃挪第克公司 新药物组合物及其制备方法
JP4316787B2 (ja) * 2000-01-11 2009-08-19 壽製薬株式会社 エーテル又はアミド誘導体、その製法並びにそれを含有する糖尿病治療剤、
US20030220374A1 (en) * 2002-01-14 2003-11-27 Pharmacia Corporation Compositions and methods of treatment involving peroxisome proliferator-activated receptor-gamma agonists and cyclooxygenase-2 selective inhibitors
US20030212138A1 (en) * 2002-01-14 2003-11-13 Pharmacia Corporation Combinations of peroxisome proliferator-activated receptor-alpha agonists and cyclooxygenase-2 selective inhibitors and therapeutic uses therefor
US20050107387A1 (en) * 2003-05-13 2005-05-19 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a peroxisome proliferator activated receptor agonist for the treatment of ischemic mediated central nervous system disorders
US7833513B2 (en) 2004-12-03 2010-11-16 Rhode Island Hospital Treatment of Alzheimer's Disease
JP5793505B2 (ja) * 2009-12-23 2015-10-14 ジャスコ ファーマシューティカルズ， エルエルシー アミノピリミジンキナーゼ阻害薬
CN101824032B (zh) * 2010-04-23 2015-09-09 浙江华海药业股份有限公司 一种制备盐酸吡格列酮的工艺改进方法
JP6215832B2 (ja) 2011-11-04 2017-10-18 ジャスコ ファーマスーティカルズ エルエルシーＪａｓｃｏ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， ＬＬＣ アミノピリミジンキナーゼ阻害剤

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5364586A (en) * 1976-11-19 1978-06-09 Takeda Chemical Industries Ltd Emission driving device for blood detector
JPS5522636A (en) * 1978-08-04 1980-02-18 Takeda Chem Ind Ltd Thiazoliding derivative
JPS5564586A (en) * 1978-11-09 1980-05-15 Takeda Chem Ind Ltd Thiazolidine derivative
US4296237A (en) * 1979-09-11 1981-10-20 Merck & Co., Inc. 4-(Pyridyl, piperazinyl and thiazolyl substituted thiazolyl)-3-hydroxy-3-pyrroline-2,5-diones
NZ202797A (en) * 1981-12-28 1985-08-30 Lilly Co Eli Pyrimidine derivatives and pharmaceutical compositions
WO1986006069A1 (fr) * 1985-04-09 1986-10-23 Takeda Chemical Industries, Ltd. Derives de thiazolidinedione, leur procede de preparation et composition medicinale les contenant
CN1003445B (zh) * 1984-10-03 1989-03-01 武田药品工业株式会社 噻唑烷二酮衍生物，其制备方法和用途
JPH06779B2 (ja) * 1985-06-10 1994-01-05 武田薬品工業株式会社 チアゾリジオン誘導体およびそれを含んでなる医薬組成物
US5130379A (en) * 1988-03-08 1992-07-14 Pfizer Inc. Hypoglycemic thiazolidinedione derivatives
MX15171A (es) * 1988-03-08 1993-05-01 Pfizer Derivados de tiazolidinodiona hipoglicemicos
US5143930A (en) * 1990-02-07 1992-09-01 Sankyo Company, Limited Thiazolidine derivatives with anti-diabetic activity, their preparation and their use
RU2066322C1 (ru) * 1991-06-28 1996-09-10 Киевский Государственный Университет Им.Т.Г.Шевченко 3-(4-метил-2-тиазолил)-6-пропил-7-(1-метил-1-этоксикарбонил)метоксихромон, обладающий гипогликемическим, гиполипидемическим действием и аналептическим действием

Also Published As

Publication number Publication date
PT605228E (pt) 2000-06-30
HU9303757D0 (en) 1994-04-28
HUT69383A (en) 1995-09-28
CA2112283A1 (en) 1994-06-29
JPH0782269A (ja) 1995-03-28
US5489602A (en) 1996-02-06
EP0605228B1 (en) 2000-03-01
DE69327944T2 (de) 2000-10-19
ES2142852T3 (es) 2000-05-01
FI935887A7 (fi) 1994-06-29
CN1094726A (zh) 1994-11-09
MX9400190A (es) 1994-07-29
CZ288363B6 (en) 2001-06-13
JP3741452B2 (ja) 2006-02-01
DK0605228T3 (da) 2000-06-05
NO300735B1 (no) 1997-07-14
NO934833L (no) 1994-06-29
MY110142A (en) 1998-02-28
RU2129553C1 (ru) 1999-04-27
CN1056372C (zh) 2000-09-13
AU666414B2 (en) 1996-02-08
TW245716B (cg-RX-API-DMAC10.html) 1995-04-21
ATE190052T1 (de) 2000-03-15
DE69327944D1 (de) 2000-04-06
CZ287693A3 (en) 1994-12-15
FI935887L (fi) 1994-06-29
NO934833D0 (no) 1993-12-27
GR3033487T3 (en) 2000-09-29
KR940014392A (ko) 1994-07-18
AU5261393A (en) 1994-07-07
EP0605228A1 (en) 1994-07-06
FI935887A0 (fi) 1993-12-27

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