KR100271461B1 - 비타민 d 아미드 유도체 - Google Patents

비타민 d 아미드 유도체 Download PDF

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Publication number
KR100271461B1
KR100271461B1 KR1019940701503A KR19940701503A KR100271461B1 KR 100271461 B1 KR100271461 B1 KR 100271461B1 KR 1019940701503 A KR1019940701503 A KR 1019940701503A KR 19940701503 A KR19940701503 A KR 19940701503A KR 100271461 B1 KR100271461 B1 KR 100271461B1
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KR
South Korea
Prior art keywords
group
compound
dihydroxy
isomer
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019940701503A
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English (en)
Korean (ko)
Inventor
로버트 헨리 헤스
가담 수바 레디
순다라 카투감 스리니바사세티 세티
Original Assignee
마우리스 엠.페체트
리서치 인스티튜트 포 메디신 앤드 케미스트리 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB919123712A external-priority patent/GB9123712D0/en
Priority claimed from GB929209658A external-priority patent/GB9209658D0/en
Application filed by 마우리스 엠.페체트, 리서치 인스티튜트 포 메디신 앤드 케미스트리 인코포레이티드 filed Critical 마우리스 엠.페체트
Application granted granted Critical
Publication of KR100271461B1 publication Critical patent/KR100271461B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
KR1019940701503A 1991-11-07 1992-11-06 비타민 d 아미드 유도체 Expired - Fee Related KR100271461B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB919123712A GB9123712D0 (en) 1991-11-07 1991-11-07 Chemical compounds
GB9123712.3 1991-11-07
GB9209658.5 1992-05-05
GB929209658A GB9209658D0 (en) 1992-05-05 1992-05-05 Chemical compounds
PCT/EP1992/002577 WO1993009093A1 (en) 1991-11-07 1992-11-06 Vitamin d amide derivatives

Publications (1)

Publication Number Publication Date
KR100271461B1 true KR100271461B1 (ko) 2000-11-15

Family

ID=26299825

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019940701503A Expired - Fee Related KR100271461B1 (ko) 1991-11-07 1992-11-06 비타민 d 아미드 유도체

Country Status (20)

Country Link
US (2) US5494905A (cg-RX-API-DMAC7.html)
EP (1) EP0614455B1 (cg-RX-API-DMAC7.html)
JP (1) JP3282811B2 (cg-RX-API-DMAC7.html)
KR (1) KR100271461B1 (cg-RX-API-DMAC7.html)
AT (1) ATE134366T1 (cg-RX-API-DMAC7.html)
AU (1) AU664213B2 (cg-RX-API-DMAC7.html)
CA (1) CA2121678C (cg-RX-API-DMAC7.html)
CZ (1) CZ288031B6 (cg-RX-API-DMAC7.html)
DE (1) DE69208478T2 (cg-RX-API-DMAC7.html)
DK (1) DK0614455T3 (cg-RX-API-DMAC7.html)
ES (1) ES2083771T3 (cg-RX-API-DMAC7.html)
FI (1) FI106119B (cg-RX-API-DMAC7.html)
GR (1) GR3019601T3 (cg-RX-API-DMAC7.html)
HU (1) HU221008B1 (cg-RX-API-DMAC7.html)
NO (1) NO305315B1 (cg-RX-API-DMAC7.html)
NZ (1) NZ245041A (cg-RX-API-DMAC7.html)
PL (1) PL171580B1 (cg-RX-API-DMAC7.html)
RU (1) RU2139276C1 (cg-RX-API-DMAC7.html)
SK (1) SK281302B6 (cg-RX-API-DMAC7.html)
WO (1) WO1993009093A1 (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL171580B1 (pl) * 1991-11-07 1997-05-30 Res Inst Medicine Chem Sposób wytwarzania nowych analogów witaminy D3 PL PL PL
IL107185A (en) * 1992-10-06 1998-02-22 Schering Ag Vitamin d, 25-carboxylic acid derivatives and pharmaceutical compositions containing the same
US5662604A (en) * 1993-02-12 1997-09-02 Asahi Kasei Kogyo Kabushiki Kaisha Monitoring method of renal lesions without clinical signs
GB9309422D0 (en) * 1993-05-07 1993-06-23 Res Inst Medicine Chem Chemical compounds
GB9325415D0 (en) * 1993-12-13 1994-02-16 Res Inst Medicine Chem Chemical compounds
GB9405715D0 (en) * 1994-03-23 1994-05-11 Res Inst Medicine Chem Chemical compounds
US5661141A (en) * 1995-03-27 1997-08-26 Petrow; Vladimir 19-oxygenated steroids as therapeutic agents
US5678570A (en) * 1995-04-14 1997-10-21 The University Of North Carolina At Chapel Hill Method of treating cardiac arrest
US5696103A (en) * 1995-11-17 1997-12-09 Syntex (U.S.A.) Inc. Method for treating osteoporosis
DE19619036A1 (de) * 1996-04-30 1997-11-13 Schering Ag Neue Vitamin D-Derivate mit carbo- oder heterocyclischen Substituenten an C-25, Verfahren zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6043385A (en) * 1997-12-16 2000-03-28 Hoffman-La Roche Inc. Vitamin D derivatives
GB9804861D0 (en) 1998-03-06 1998-04-29 Res Inst Medicine Chem Chemical compounds
EP1123921A4 (en) * 1998-10-23 2003-08-20 Teijin Ltd VITAMIN D 3 DERIVATIVES? AND MEDICINES FOR INFLAMMATORY RESPIRATORY DISEASES CONTAINING THEM
DE19935771A1 (de) * 1999-07-23 2001-02-01 Schering Ag Neue Vitamin D-Derivate mit cyclischen Substrukturen in den Seitenketten, Verfahren und Zwischenprodukte zu ihrer Herstellung und die Verwendung zur Herstellung von Arzneimitteln
US6703380B2 (en) 1999-09-29 2004-03-09 Colotech A/S Prevention of cancer
DK1220676T3 (da) 1999-09-29 2005-09-05 Colotech As Forebyggelse af colorektal cancer
WO2001030751A2 (en) * 1999-10-25 2001-05-03 Strakan Limited USES OF 1,25-DIHYDROXY-5,6-trans VITAMIN D COMPOUNDS AND DERIVATIVES THEREOF
CN100469764C (zh) * 2000-06-15 2009-03-18 中外制药株式会社 维生素d衍生物
CA2586679A1 (en) 2004-11-12 2006-05-18 Bioxell Spa Combined use of vitamin d derivatives and anti-proliferative agents for treating bladder cancer
EP2018366A4 (en) * 2006-05-16 2010-08-04 Univ Mcgill HYBRID MOLECULES WITH MIXED VITAMIN D RECEPTOR AGONISM AND HISTONDEACETYLASE RESISTANT PROPERTIES
WO2009117831A1 (en) * 2008-03-27 2009-10-01 The Royal Institution For The Advancement Of Learning/Mcgill University Hybrid molecules having mixed vitamin d receptor agonism and histone deacetylase inhibitory properties
US8987235B2 (en) 2011-05-17 2015-03-24 Wisconsin Alumni Research Foundation N-cyclopropyl-(20R)-2-methylene-19,26,27-trinor-25-aza-vitamin D analogs and their uses
IL300818A (en) * 2020-09-15 2023-04-01 Teijin Pharma Ltd A vitamin D derivative with a cyclic amine in the side chain

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217288A (en) * 1977-03-24 1980-08-12 Wisconsin Alumni Research Foundation Anti-vitamin D compounds
FR2426044A2 (fr) * 1978-05-19 1979-12-14 Wisconsin Research Foundation Derives de la vitamine d3 ayant une activite anti-vitamine d
CA1317962C (en) * 1987-07-29 1993-05-18 Naoto Hashimoto Cell proliferation inhibitors
US5206230A (en) * 1991-06-05 1993-04-27 Daikin Industries, Ltd. Fluorine-containing vitamin D3 analogues and pharmaceutical composition containing the same
PL171580B1 (pl) * 1991-11-07 1997-05-30 Res Inst Medicine Chem Sposób wytwarzania nowych analogów witaminy D3 PL PL PL

Also Published As

Publication number Publication date
HUT67140A (en) 1995-02-28
PL171580B1 (pl) 1997-05-30
EP0614455B1 (en) 1996-02-21
CZ288031B6 (cs) 2001-04-11
FI942114L (fi) 1994-05-06
HU9401372D0 (en) 1994-08-29
CZ111294A3 (en) 1995-03-15
NZ245041A (en) 1995-03-28
US5494905A (en) 1996-02-27
NO941683D0 (no) 1994-05-06
WO1993009093A1 (en) 1993-05-13
RU2139276C1 (ru) 1999-10-10
US5686435A (en) 1997-11-11
DE69208478D1 (de) 1996-03-28
HU221008B1 (hu) 2002-07-29
DK0614455T3 (da) 1996-03-18
CA2121678A1 (en) 1993-05-13
ES2083771T3 (es) 1996-04-16
AU664213B2 (en) 1995-11-09
SK281302B6 (sk) 2001-02-12
AU2901492A (en) 1993-06-07
FI106119B (fi) 2000-11-30
JPH07502499A (ja) 1995-03-16
JP3282811B2 (ja) 2002-05-20
NO305315B1 (no) 1999-05-10
EP0614455A1 (en) 1994-09-14
GR3019601T3 (en) 1996-07-31
DE69208478T2 (de) 1996-09-05
ATE134366T1 (de) 1996-03-15
CA2121678C (en) 2005-03-15
SK52294A3 (en) 1994-11-09
NO941683L (cg-RX-API-DMAC7.html) 1994-06-27
FI942114A0 (fi) 1994-05-06

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