KR100255904B1 - 폴리락타이드 - Google Patents

폴리락타이드 Download PDF

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Publication number
KR100255904B1
KR100255904B1 KR1019910013171A KR910013171A KR100255904B1 KR 100255904 B1 KR100255904 B1 KR 100255904B1 KR 1019910013171 A KR1019910013171 A KR 1019910013171A KR 910013171 A KR910013171 A KR 910013171A KR 100255904 B1 KR100255904 B1 KR 100255904B1
Authority
KR
South Korea
Prior art keywords
polylactide
glycolide
solution
pharmaceutical composition
impure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019910013171A
Other languages
English (en)
Korean (ko)
Other versions
KR920003990A (ko
Inventor
프리코스 조비크 발터
Original Assignee
더블류. 하링
노바티스 아게
지. 보이롤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016882A external-priority patent/GB9016882D0/en
Priority claimed from GB909016840A external-priority patent/GB9016840D0/en
Application filed by 더블류. 하링, 노바티스 아게, 지. 보이롤 filed Critical 더블류. 하링
Publication of KR920003990A publication Critical patent/KR920003990A/ko
Application granted granted Critical
Publication of KR100255904B1 publication Critical patent/KR100255904B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019910013171A 1990-08-01 1991-07-31 폴리락타이드 Expired - Fee Related KR100255904B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB9016840 1990-08-01
GB909016882A GB9016882D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds
GB909016840A GB9016840D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds
GB9016882 1990-08-01
GB9016882.4 1990-08-01

Publications (2)

Publication Number Publication Date
KR920003990A KR920003990A (ko) 1992-03-27
KR100255904B1 true KR100255904B1 (ko) 2000-05-01

Family

ID=26297417

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019910013171A Expired - Fee Related KR100255904B1 (ko) 1990-08-01 1991-07-31 폴리락타이드

Country Status (27)

Country Link
EP (2) EP0816413B1 (enExample)
JP (1) JP3137368B2 (enExample)
KR (1) KR100255904B1 (enExample)
AT (1) AT402503B (enExample)
AU (1) AU650277B2 (enExample)
CA (1) CA2048200C (enExample)
CH (1) CH683772A5 (enExample)
CY (1) CY1986A (enExample)
DE (1) DE4124468B4 (enExample)
DK (2) DK0469520T3 (enExample)
ES (2) ES2243966T3 (enExample)
FI (2) FI108040B (enExample)
FR (1) FR2665453B1 (enExample)
GB (1) GB2246573B (enExample)
GR (1) GR3026322T3 (enExample)
HK (1) HK11797A (enExample)
HU (1) HUT59837A (enExample)
IE (1) IE66185B1 (enExample)
IL (1) IL99007A (enExample)
IT (1) IT1252944B (enExample)
LU (1) LU87985A1 (enExample)
MY (1) MY108621A (enExample)
NO (1) NO912960D0 (enExample)
NZ (1) NZ239184A (enExample)
PH (1) PH31047A (enExample)
PT (1) PT98491B (enExample)
TW (2) TW218025B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100880140B1 (ko) * 2001-07-10 2009-01-23 가부시끼가이샤 구레하 폴리히드록시카르복실산 및 이의 제조 방법
WO2011162534A3 (ko) * 2010-06-21 2012-05-03 주식회사 엘지화학 내열성이 우수한 폴리락타이드 수지 및 이의 제조방법

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US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
JPH06116381A (ja) * 1992-10-09 1994-04-26 Mitsui Toatsu Chem Inc ポリヒドロキシカルボン酸の精製方法
DE4412317A1 (de) * 1993-04-21 1994-10-27 Basf Ag Polylactid mit verbreiterter Molmassenverteilung
US5359026A (en) * 1993-07-30 1994-10-25 Cargill, Incorporated Poly(lactide) copolymer and process for manufacture thereof
US5496923A (en) * 1993-09-20 1996-03-05 Mitsui Toatsu Chemicals, Inc. Purification process of aliphatic polyester
CN1074923C (zh) * 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
IL128774A (en) * 1994-03-07 2001-05-20 Dow Chemical Co Composition comprising a dendritic poymer in complex with at least one unit of biological response modifier and a process for the preparation thereof
ES2187195T3 (es) 1998-09-11 2003-05-16 Gerhard Dr Schmidmaier Implantes biologicamente activos.
US6362308B1 (en) * 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
ES2541908T3 (es) * 2001-10-10 2015-07-28 Pierre Fabre Medicament Microesferas biodegradables de liberación prolongada y su procedimiento de preparación
FR2830448B1 (fr) * 2001-10-10 2004-03-19 Pf Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
AU2013204972B2 (en) * 2002-11-19 2016-04-21 Novartis Ag Pharmaceutical composition comprising octreotide microparticles
GB0226993D0 (en) * 2002-11-19 2002-12-24 Novartis Ag Organic compounds
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
ATE549011T1 (de) 2005-11-10 2012-03-15 Chemi Spa Formulierungen mit verzögerter freisetzung, die somatostatin-analoge wachstumshormoninhibitoren enthalten
CN101193531B (zh) 2006-11-29 2010-12-01 富准精密工业(深圳)有限公司 散热装置
KR101187487B1 (ko) * 2007-12-31 2012-10-02 주식회사 삼양바이오팜 고순도의 폴리 알파(α)-히드록시산의 소수성 고분자 블록을 포함하는 양친성 블록 공중합체 및 그의 제조방법
US20100256746A1 (en) * 2009-03-23 2010-10-07 Micell Technologies, Inc. Biodegradable polymers
JP5594996B2 (ja) 2009-09-14 2014-09-24 三菱重工業株式会社 航空機の操縦システム
EP2455414A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von hochmolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren hochmolekularen resorbierbaren Polyester und deren Verwendung
EP2455415A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von niedermolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren niedermolekularen resorbierbaren Polyester und deren Verwendung
CN105820332B (zh) * 2015-01-09 2018-06-29 北京化工大学 一种星形聚氨基酸和星形聚氨基酸载药纳米胶束及制备方法
WO2017132350A1 (en) 2016-01-29 2017-08-03 Tolmar Inc. Purification and decolorization of polymers
ES3052993T3 (en) * 2017-08-31 2026-01-16 Evonik Operations Gmbh Improved resorbable polymer purification process
GR1009392B (el) * 2017-09-19 2018-10-25 Φαρματεν Αβεε Φαρμακευτικο σκευασμα που περιλαμβανει ενα πεπτιδικο φαρμακο και μεθοδος για την παρασκευη αυτου
GB2568526A (en) * 2017-11-20 2019-05-22 Rebio Tech Oy Composition
CN112940234B (zh) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 一种高纯度聚乙丙交酯的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467970A (en) * 1975-05-02 1977-03-23 Ici Ltd Purification of polyethers
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production
US4677231A (en) * 1984-11-13 1987-06-30 Asahi Kasei Kogyo Kabushiki Kaisha Process for purification of polyether
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
JPH0610252B2 (ja) * 1985-08-21 1994-02-09 和光純薬工業株式会社 重合体の製造法
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
DE3708916A1 (de) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg Verfahren zur reinigung resorbierbarer polyester
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
CA2040141C (en) * 1990-04-13 2002-05-14 Minoru Yamada Biodegradable high-molecular polymers, production and use therof

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100880140B1 (ko) * 2001-07-10 2009-01-23 가부시끼가이샤 구레하 폴리히드록시카르복실산 및 이의 제조 방법
WO2011162534A3 (ko) * 2010-06-21 2012-05-03 주식회사 엘지화학 내열성이 우수한 폴리락타이드 수지 및 이의 제조방법
US8722845B2 (en) 2010-06-21 2014-05-13 Lg Chem, Ltd. Polylactide resin having excellent heat resistance and preparation method thereof
US9115248B2 (en) 2010-06-21 2015-08-25 Lg Chem, Ltd. Polylactide resin having excellent heat resistance and preparation method thereof

Also Published As

Publication number Publication date
IL99007A (en) 1994-12-29
PH31047A (en) 1998-02-03
EP0816413B1 (en) 2005-06-08
FI913641A0 (fi) 1991-07-30
MY108621A (en) 1996-10-31
IT1252944B (it) 1995-07-05
EP0469520A2 (en) 1992-02-05
HUT59837A (en) 1992-07-28
ITRM910553A1 (it) 1993-01-23
GB9116396D0 (en) 1991-09-11
TW282477B (enExample) 1996-08-01
FI111268B (fi) 2003-06-30
DK0816413T3 (da) 2005-08-29
PT98491B (pt) 1997-12-31
IE66185B1 (en) 1995-12-13
IL99007A0 (en) 1992-07-15
CA2048200A1 (en) 1992-02-02
ITRM910553A0 (it) 1991-07-23
CA2048200C (en) 1999-06-29
IE912697A1 (en) 1992-02-12
ES2112259T3 (es) 1998-04-01
EP0816413A2 (en) 1998-01-07
DK0469520T3 (da) 1998-09-23
FR2665453B1 (fr) 1995-01-27
CH683772A5 (de) 1994-05-13
PT98491A (pt) 1992-06-30
ATA151591A (de) 1996-10-15
EP0469520B1 (en) 1998-02-25
EP0469520A3 (en) 1992-10-07
NO912960D0 (no) 1991-07-30
DE4124468A1 (de) 1992-02-06
DE4124468B4 (de) 2010-10-28
FI108040B (fi) 2001-11-15
FI20011189L (fi) 2001-06-05
FR2665453A1 (fr) 1992-02-07
HK11797A (en) 1997-02-14
GB2246573A (en) 1992-02-05
AT402503B (de) 1997-06-25
NZ239184A (en) 1994-09-27
CY1986A (en) 1997-09-05
AU8143091A (en) 1992-02-27
JP3137368B2 (ja) 2001-02-19
LU87985A1 (fr) 1993-02-15
TW218025B (enExample) 1993-12-21
GB2246573B (en) 1994-05-11
JPH0641279A (ja) 1994-02-15
EP0816413A3 (en) 1998-11-11
ES2243966T3 (es) 2005-12-01
FI913641L (fi) 1992-02-02
AU650277B2 (en) 1994-06-16
GR3026322T3 (en) 1998-06-30
HU912452D0 (en) 1991-12-30
KR920003990A (ko) 1992-03-27

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