GR3026322T3 - Process for the preparation of pure polylactide. - Google Patents

Process for the preparation of pure polylactide.

Info

Publication number
GR3026322T3
GR3026322T3 GR980400513T GR980400513T GR3026322T3 GR 3026322 T3 GR3026322 T3 GR 3026322T3 GR 980400513 T GR980400513 T GR 980400513T GR 980400513 T GR980400513 T GR 980400513T GR 3026322 T3 GR3026322 T3 GR 3026322T3
Authority
GR
Greece
Prior art keywords
preparation
pure polylactide
polylactide
pure
Prior art date
Application number
GR980400513T
Other languages
Greek (el)
English (en)
Inventor
Walter Prikoszovich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB909016882A external-priority patent/GB9016882D0/en
Priority claimed from GB909016840A external-priority patent/GB9016840D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of GR3026322T3 publication Critical patent/GR3026322T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/88—Post-polymerisation treatment
    • C08G63/90—Purification; Drying
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
    • C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
    • C08G63/08—Lactones or lactides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR980400513T 1990-08-01 1998-03-11 Process for the preparation of pure polylactide. GR3026322T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909016882A GB9016882D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds
GB909016840A GB9016840D0 (en) 1990-08-01 1990-08-01 Improvements in or relating to organic compounds

Publications (1)

Publication Number Publication Date
GR3026322T3 true GR3026322T3 (en) 1998-06-30

Family

ID=26297417

Family Applications (1)

Application Number Title Priority Date Filing Date
GR980400513T GR3026322T3 (en) 1990-08-01 1998-03-11 Process for the preparation of pure polylactide.

Country Status (27)

Country Link
EP (2) EP0816413B1 (enExample)
JP (1) JP3137368B2 (enExample)
KR (1) KR100255904B1 (enExample)
AT (1) AT402503B (enExample)
AU (1) AU650277B2 (enExample)
CA (1) CA2048200C (enExample)
CH (1) CH683772A5 (enExample)
CY (1) CY1986A (enExample)
DE (1) DE4124468B4 (enExample)
DK (2) DK0469520T3 (enExample)
ES (2) ES2243966T3 (enExample)
FI (2) FI108040B (enExample)
FR (1) FR2665453B1 (enExample)
GB (1) GB2246573B (enExample)
GR (1) GR3026322T3 (enExample)
HK (1) HK11797A (enExample)
HU (1) HUT59837A (enExample)
IE (1) IE66185B1 (enExample)
IL (1) IL99007A (enExample)
IT (1) IT1252944B (enExample)
LU (1) LU87985A1 (enExample)
MY (1) MY108621A (enExample)
NO (1) NO912960D0 (enExample)
NZ (1) NZ239184A (enExample)
PH (1) PH31047A (enExample)
PT (1) PT98491B (enExample)
TW (2) TW218025B (enExample)

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US5560929A (en) * 1986-08-18 1996-10-01 The Dow Chemical Company Structured copolymers and their use as absorbents, gels and carriers of metal ions
US5527524A (en) * 1986-08-18 1996-06-18 The Dow Chemical Company Dense star polymer conjugates
US5225521A (en) * 1991-12-31 1993-07-06 E. I. Du Pont De Nemours And Company Star-shaped hydroxyacid polymers
US6200558B1 (en) 1993-09-14 2001-03-13 The United States Of America As Represented By The Department Of Health And Human Services Biopolymer-bound nitric oxide-releasing compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5525357A (en) * 1992-08-24 1996-06-11 The United States Of America As Represented By The Department Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions incorporating same and methods of treating biological disorders using same
US5405919A (en) * 1992-08-24 1995-04-11 The United States Of America As Represented By The Secretary Of Health And Human Services Polymer-bound nitric oxide/nucleophile adduct compositions, pharmaceutical compositions and methods of treating biological disorders
JPH06116381A (ja) * 1992-10-09 1994-04-26 Mitsui Toatsu Chem Inc ポリヒドロキシカルボン酸の精製方法
DE4412317A1 (de) * 1993-04-21 1994-10-27 Basf Ag Polylactid mit verbreiterter Molmassenverteilung
US5359026A (en) * 1993-07-30 1994-10-25 Cargill, Incorporated Poly(lactide) copolymer and process for manufacture thereof
US5496923A (en) * 1993-09-20 1996-03-05 Mitsui Toatsu Chemicals, Inc. Purification process of aliphatic polyester
CN1074923C (zh) * 1993-11-19 2001-11-21 詹森药业有限公司 微囊密封的3-哌啶基取代的1,2-苯并异唑类和1,2-苯并异噻唑类
IL128774A (en) * 1994-03-07 2001-05-20 Dow Chemical Co Composition comprising a dendritic poymer in complex with at least one unit of biological response modifier and a process for the preparation thereof
ES2187195T3 (es) 1998-09-11 2003-05-16 Gerhard Dr Schmidmaier Implantes biologicamente activos.
US6362308B1 (en) * 2000-08-10 2002-03-26 Alkermes Controlled Therapeutics Inc. Ii Acid end group poly(d,l-lactide-co-glycolide) copolymers high glycolide content
ATE388182T1 (de) * 2001-07-10 2008-03-15 Kureha Corp Polyhydroxycarbonsäure und verfahren zu dessen herstellung
ES2541908T3 (es) * 2001-10-10 2015-07-28 Pierre Fabre Medicament Microesferas biodegradables de liberación prolongada y su procedimiento de preparación
FR2830448B1 (fr) * 2001-10-10 2004-03-19 Pf Medicament Microspheres biodegradables a liberation prolongee et leur procede de preparation
AU2013204972B2 (en) * 2002-11-19 2016-04-21 Novartis Ag Pharmaceutical composition comprising octreotide microparticles
GB0226993D0 (en) * 2002-11-19 2002-12-24 Novartis Ag Organic compounds
US20040097419A1 (en) * 2002-11-19 2004-05-20 Holger Petersen Organic compounds
ATE549011T1 (de) 2005-11-10 2012-03-15 Chemi Spa Formulierungen mit verzögerter freisetzung, die somatostatin-analoge wachstumshormoninhibitoren enthalten
CN101193531B (zh) 2006-11-29 2010-12-01 富准精密工业(深圳)有限公司 散热装置
KR101187487B1 (ko) * 2007-12-31 2012-10-02 주식회사 삼양바이오팜 고순도의 폴리 알파(α)-히드록시산의 소수성 고분자 블록을 포함하는 양친성 블록 공중합체 및 그의 제조방법
US20100256746A1 (en) * 2009-03-23 2010-10-07 Micell Technologies, Inc. Biodegradable polymers
JP5594996B2 (ja) 2009-09-14 2014-09-24 三菱重工業株式会社 航空機の操縦システム
DE202011110978U1 (de) * 2010-06-21 2017-11-27 Lg Chem, Ltd. Polylactidharz mit ausgezeichneter Wärmebeständigkeit
EP2455414A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von hochmolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren hochmolekularen resorbierbaren Polyester und deren Verwendung
EP2455415A1 (de) * 2010-11-17 2012-05-23 Evonik Röhm GmbH Verfahren zur Herstellung von niedermolekularen, resorbierbaren Polyestern, die mit dem Verfahren herstellbaren niedermolekularen resorbierbaren Polyester und deren Verwendung
CN105820332B (zh) * 2015-01-09 2018-06-29 北京化工大学 一种星形聚氨基酸和星形聚氨基酸载药纳米胶束及制备方法
WO2017132350A1 (en) 2016-01-29 2017-08-03 Tolmar Inc. Purification and decolorization of polymers
ES3052993T3 (en) * 2017-08-31 2026-01-16 Evonik Operations Gmbh Improved resorbable polymer purification process
GR1009392B (el) * 2017-09-19 2018-10-25 Φαρματεν Αβεε Φαρμακευτικο σκευασμα που περιλαμβανει ενα πεπτιδικο φαρμακο και μεθοδος για την παρασκευη αυτου
GB2568526A (en) * 2017-11-20 2019-05-22 Rebio Tech Oy Composition
CN112940234B (zh) * 2021-01-28 2022-05-03 广东粤港澳大湾区黄埔材料研究院 一种高纯度聚乙丙交酯的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467970A (en) * 1975-05-02 1977-03-23 Ici Ltd Purification of polyethers
US4273920A (en) * 1979-09-12 1981-06-16 Eli Lilly And Company Polymerization process and product
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production
US4677231A (en) * 1984-11-13 1987-06-30 Asahi Kasei Kogyo Kabushiki Kaisha Process for purification of polyether
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
JPH0610252B2 (ja) * 1985-08-21 1994-02-09 和光純薬工業株式会社 重合体の製造法
DE3641692A1 (de) * 1986-12-06 1988-06-09 Boehringer Ingelheim Kg Katalysatorfreie resorbierbare homopolymere und copolymere
DE3708916A1 (de) * 1987-03-19 1988-09-29 Boehringer Ingelheim Kg Verfahren zur reinigung resorbierbarer polyester
JP2714454B2 (ja) * 1988-11-07 1998-02-16 三井東圧化学株式会社 生体吸収性ポリエステルの製造方法
CA2040141C (en) * 1990-04-13 2002-05-14 Minoru Yamada Biodegradable high-molecular polymers, production and use therof

Also Published As

Publication number Publication date
IL99007A (en) 1994-12-29
PH31047A (en) 1998-02-03
EP0816413B1 (en) 2005-06-08
FI913641A0 (fi) 1991-07-30
MY108621A (en) 1996-10-31
IT1252944B (it) 1995-07-05
EP0469520A2 (en) 1992-02-05
HUT59837A (en) 1992-07-28
ITRM910553A1 (it) 1993-01-23
GB9116396D0 (en) 1991-09-11
TW282477B (enExample) 1996-08-01
FI111268B (fi) 2003-06-30
DK0816413T3 (da) 2005-08-29
PT98491B (pt) 1997-12-31
IE66185B1 (en) 1995-12-13
IL99007A0 (en) 1992-07-15
CA2048200A1 (en) 1992-02-02
ITRM910553A0 (it) 1991-07-23
CA2048200C (en) 1999-06-29
IE912697A1 (en) 1992-02-12
ES2112259T3 (es) 1998-04-01
EP0816413A2 (en) 1998-01-07
DK0469520T3 (da) 1998-09-23
FR2665453B1 (fr) 1995-01-27
CH683772A5 (de) 1994-05-13
PT98491A (pt) 1992-06-30
ATA151591A (de) 1996-10-15
EP0469520B1 (en) 1998-02-25
EP0469520A3 (en) 1992-10-07
NO912960D0 (no) 1991-07-30
DE4124468A1 (de) 1992-02-06
DE4124468B4 (de) 2010-10-28
FI108040B (fi) 2001-11-15
FI20011189L (fi) 2001-06-05
FR2665453A1 (fr) 1992-02-07
HK11797A (en) 1997-02-14
GB2246573A (en) 1992-02-05
AT402503B (de) 1997-06-25
KR100255904B1 (ko) 2000-05-01
NZ239184A (en) 1994-09-27
CY1986A (en) 1997-09-05
AU8143091A (en) 1992-02-27
JP3137368B2 (ja) 2001-02-19
LU87985A1 (fr) 1993-02-15
TW218025B (enExample) 1993-12-21
GB2246573B (en) 1994-05-11
JPH0641279A (ja) 1994-02-15
EP0816413A3 (en) 1998-11-11
ES2243966T3 (es) 2005-12-01
FI913641L (fi) 1992-02-02
AU650277B2 (en) 1994-06-16
HU912452D0 (en) 1991-12-30
KR920003990A (ko) 1992-03-27

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