KR100249068B1 - 아미디노 화합물 이의 제조방법 및 이를 포함하는 약제학적 조성물 - Google Patents

아미디노 화합물 이의 제조방법 및 이를 포함하는 약제학적 조성물 Download PDF

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Publication number
KR100249068B1
KR100249068B1 KR1019920009920A KR920009920A KR100249068B1 KR 100249068 B1 KR100249068 B1 KR 100249068B1 KR 1019920009920 A KR1019920009920 A KR 1019920009920A KR 920009920 A KR920009920 A KR 920009920A KR 100249068 B1 KR100249068 B1 KR 100249068B1
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KR
South Korea
Prior art keywords
phenyl
alkyl
pentoxy
phenoxy
compound
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Expired - Fee Related
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KR1019920009920A
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English (en)
Korean (ko)
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KR930000470A (ko
Inventor
마이클엠.모리씨
Original Assignee
더블류. 하링
노바티스 아게
지. 보이롤
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/10—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • C07C251/16—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/62—Compounds containing any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylcarbamates
    • C07C271/64—Y being a hydrogen or a carbon atom, e.g. benzoylcarbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/51—Y being a hydrogen or a carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Diaphragms For Electromechanical Transducers (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1019920009920A 1991-06-11 1992-06-09 아미디노 화합물 이의 제조방법 및 이를 포함하는 약제학적 조성물 Expired - Fee Related KR100249068B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71410891A 1991-06-11 1991-06-11
US7/714108 1991-06-11
US07/714108 1991-06-11

Publications (2)

Publication Number Publication Date
KR930000470A KR930000470A (ko) 1993-01-15
KR100249068B1 true KR100249068B1 (ko) 2000-03-15

Family

ID=24868773

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019920009920A Expired - Fee Related KR100249068B1 (ko) 1991-06-11 1992-06-09 아미디노 화합물 이의 제조방법 및 이를 포함하는 약제학적 조성물

Country Status (21)

Country Link
EP (1) EP0518819B1 (enExample)
JP (1) JP3370998B2 (enExample)
KR (1) KR100249068B1 (enExample)
AT (1) ATE125791T1 (enExample)
AU (1) AU653603B2 (enExample)
CA (1) CA2070795A1 (enExample)
CZ (1) CZ279630B6 (enExample)
DE (1) DE69203797T2 (enExample)
DK (1) DK0518819T3 (enExample)
ES (1) ES2075672T3 (enExample)
FI (1) FI922643A7 (enExample)
GR (1) GR3017028T3 (enExample)
HU (1) HU220226B (enExample)
IE (1) IE67513B1 (enExample)
IL (1) IL102105A (enExample)
MX (1) MX9202749A (enExample)
NO (1) NO178259C (enExample)
NZ (1) NZ243079A (enExample)
PH (1) PH30829A (enExample)
TW (1) TW201298B (enExample)
ZA (1) ZA924220B (enExample)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488160A (en) * 1991-06-11 1996-01-30 Ciba-Geigy Corporation Amidino compounds, their manufacture and method of treatment
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
JP3487851B2 (ja) * 1992-02-05 2004-01-19 ベーリンガー インゲルハイム コマンディトゲゼルシャフト 新規なアミジン誘導体、その製法、及びｌｔｂ４拮抗剤としての使用
DE4219158A1 (de) * 1992-06-11 1993-12-16 Thomae Gmbh Dr K Biphenylderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5432178A (en) * 1992-09-18 1995-07-11 Ono Pharmaceutical Co., Ltd. Amidinophenol derivatives
DE4234295A1 (de) * 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
DE4309285A1 (de) * 1993-03-23 1994-09-29 Boehringer Ingelheim Kg Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung
DE69431194T2 (de) * 1993-10-21 2002-12-12 G.D. Searle & Co., Chicago Amidino-derivate nützlich als no synthase-hemmer
CA2134192A1 (en) * 1993-11-12 1995-05-13 Michael L. Denney 5, 6-bicyclic glycoprotein iib/iiia antagonists
DE4424713A1 (de) * 1994-07-13 1996-01-18 Boehringer Ingelheim Kg Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe
DK0703216T3 (da) 1994-09-20 1999-10-18 Ono Pharmaceutical Co Amidinophenolderivater som proteaseinhibitorer
CA2265996A1 (en) 1996-09-26 1998-04-02 Roger Aki Fujimoto Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity
GB9928511D0 (en) * 1999-12-03 2000-02-02 Secr Defence Brit Orally administrable pharmaceutical product and method of fabrication therefor
US7507531B2 (en) 2002-10-17 2009-03-24 Decode Genetics Chf. Use of 5-lipoxygenase activating protein (FLAP) gene to assess susceptibility for myocardial infarction
US7851486B2 (en) 2002-10-17 2010-12-14 Decode Genetics Ehf. Susceptibility gene for myocardial infarction, stroke, and PAOD; methods of treatment
US20050272051A1 (en) * 2003-09-17 2005-12-08 Decode Genetics Ehf. Methods of preventing or treating recurrence of myocardial infarction
US8158362B2 (en) 2005-03-30 2012-04-17 Decode Genetics Ehf. Methods of diagnosing susceptibility to myocardial infarction and screening for an LTA4H haplotype
PT2332909E (pt) * 2005-04-13 2014-12-17 Astex Therapeutics Ltd Derivados de hidroxibenzamida e sua utilização como inibidores de hsp90
WO2017095722A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as blt1 antagonists
WO2017095724A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
WO2017095725A1 (en) 2015-11-30 2017-06-08 Merck Sharp & Dohme Corp. Aryl sulfonamides as blt1 antagonists
US10370368B2 (en) 2015-11-30 2019-08-06 Merck Sharp & Dohme Corp. Aryl acylsulfonamides as BLT1 antagonists

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1243322A (en) * 1984-01-23 1988-10-18 Joshua Rokach Antagonists of slow reacting substances of anaphylaxis
US4808604A (en) * 1985-10-03 1989-02-28 Ciba-Geigy Corporation N-(substituted phenyl) tetrazol-5-yl carboxamides and anti-allergic use thereof
AU626033B2 (en) * 1988-10-25 1992-07-23 Government Of The United States Of America, As Represented By The Secretary Of The Army, The Methods for the treatment and prophylaxis of pneumocystis carinii pneumonia and other diseases and compounds and formulations for use in said methods
EP0518818A3 (en) * 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament

Also Published As

Publication number Publication date
NO178259C (no) 1996-02-21
ZA924220B (en) 1993-02-24
HU220226B (hu) 2001-11-28
FI922643A0 (fi) 1992-06-08
NO178259B (no) 1995-11-13
CZ178092A3 (en) 1993-01-13
EP0518819B1 (en) 1995-08-02
ATE125791T1 (de) 1995-08-15
DE69203797T2 (de) 1996-02-08
MX9202749A (es) 1992-12-01
CA2070795A1 (en) 1992-12-12
KR930000470A (ko) 1993-01-15
IL102105A (en) 1996-10-31
IL102105A0 (en) 1993-01-14
GR3017028T3 (en) 1995-11-30
NZ243079A (en) 1994-11-25
ES2075672T3 (es) 1995-10-01
AU653603B2 (en) 1994-10-06
JPH05239009A (ja) 1993-09-17
NO922274D0 (no) 1992-06-10
AU1807392A (en) 1992-12-17
NO922274L (no) 1992-12-14
IE67513B1 (en) 1996-04-03
HUT62264A (en) 1993-04-28
EP0518819A2 (en) 1992-12-16
DK0518819T3 (da) 1995-09-25
FI922643A7 (fi) 1992-12-12
TW201298B (enExample) 1993-03-01
JP3370998B2 (ja) 2003-01-27
CZ279630B6 (cs) 1995-05-17
DE69203797D1 (de) 1995-09-07
PH30829A (en) 1997-10-17
IE921878A1 (en) 1992-12-16
EP0518819A3 (en) 1993-04-21
HU9201938D0 (en) 1992-08-28

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