KR100194945B1 - 플루코나졸의 제조방법 - Google Patents

플루코나졸의 제조방법 Download PDF

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Publication number
KR100194945B1
KR100194945B1 KR1019970002700A KR19970002700A KR100194945B1 KR 100194945 B1 KR100194945 B1 KR 100194945B1 KR 1019970002700 A KR1019970002700 A KR 1019970002700A KR 19970002700 A KR19970002700 A KR 19970002700A KR 100194945 B1 KR100194945 B1 KR 100194945B1
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KR
South Korea
Prior art keywords
formula
reaction
compound represented
fluconazole
solvent
Prior art date
Application number
KR1019970002700A
Other languages
English (en)
Korean (ko)
Other versions
KR19980066917A (ko
Inventor
김용환
윤길중
박명환
Original Assignee
서치영
주식회사대웅제약
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 서치영, 주식회사대웅제약 filed Critical 서치영
Priority to KR1019970002700A priority Critical patent/KR100194945B1/ko
Priority to HU0000726A priority patent/HUP0000726A3/hu
Priority to SK1332-98A priority patent/SK133298A3/sk
Priority to CZ983083A priority patent/CZ308398A3/cs
Priority to AU58823/98A priority patent/AU5882398A/en
Priority to EP98902274A priority patent/EP1001947A1/en
Priority to PCT/KR1998/000018 priority patent/WO1998032744A1/en
Priority to PL98329117A priority patent/PL329117A1/xx
Publication of KR19980066917A publication Critical patent/KR19980066917A/ko
Application granted granted Critical
Publication of KR100194945B1 publication Critical patent/KR100194945B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1019970002700A 1997-01-29 1997-01-29 플루코나졸의 제조방법 KR100194945B1 (ko)

Priority Applications (8)

Application Number Priority Date Filing Date Title
KR1019970002700A KR100194945B1 (ko) 1997-01-29 1997-01-29 플루코나졸의 제조방법
HU0000726A HUP0000726A3 (en) 1997-01-29 1998-01-24 Process for manufacturing fluconazole
SK1332-98A SK133298A3 (en) 1997-01-29 1998-01-24 Process for manufacturing fluconazole
CZ983083A CZ308398A3 (cs) 1997-01-29 1998-01-24 Způsob přípravy flukonazolu
AU58823/98A AU5882398A (en) 1997-01-29 1998-01-24 Process for manufacturing fluconazole
EP98902274A EP1001947A1 (en) 1997-01-29 1998-01-24 Process for manufacturing fluconazole
PCT/KR1998/000018 WO1998032744A1 (en) 1997-01-29 1998-01-24 Process for manufacturing fluconazole
PL98329117A PL329117A1 (en) 1997-01-29 1998-01-24 Method of obtaining fluconazole

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019970002700A KR100194945B1 (ko) 1997-01-29 1997-01-29 플루코나졸의 제조방법

Publications (2)

Publication Number Publication Date
KR19980066917A KR19980066917A (ko) 1998-10-15
KR100194945B1 true KR100194945B1 (ko) 1999-06-15

Family

ID=19495904

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019970002700A KR100194945B1 (ko) 1997-01-29 1997-01-29 플루코나졸의 제조방법

Country Status (8)

Country Link
EP (1) EP1001947A1 (xx)
KR (1) KR100194945B1 (xx)
AU (1) AU5882398A (xx)
CZ (1) CZ308398A3 (xx)
HU (1) HUP0000726A3 (xx)
PL (1) PL329117A1 (xx)
SK (1) SK133298A3 (xx)
WO (1) WO1998032744A1 (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100341688B1 (ko) * 1999-04-16 2002-06-24 윤재승 플루코나졸의 제조방법
CZ304213B6 (cs) * 2001-03-23 2014-01-08 Richter Gedeon Vegyészeti Gyár Rt. Způsob přípravy monohydrátu a krystalických modifikací flukonazolu
BR102013027313B1 (pt) * 2013-10-23 2019-06-18 Iharabras S.A. Indústrias Químicas Processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso
KR20180101342A (ko) * 2015-11-17 2018-09-12 다우 아그로사이언시즈 엘엘씨 4-((6-(2-(2,4-디플루오로페닐)-1,1-디플루오로-2-히드록시-3-(1h-1,2,4-트리아졸-1-일)프로필)피리딘-3-일)옥시)벤조니트릴 및 제조방법
BR112018009915A2 (pt) * 2015-11-17 2018-11-13 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorfenil)-1,1-diflúor-2-hidróxi-3-(1h-1,2,4-triazol-1-il)propil)piridin-3-il)óxi)benzonitrila e processos de preparação
CN106749055A (zh) * 2016-12-19 2017-05-31 苏州天马精细化学品股份有限公司 一种氟康唑的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3262386D1 (en) * 1981-06-06 1985-03-28 Pfizer Ltd Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
CA2106032C (en) * 1993-09-13 1995-11-07 Gamini Weeratunga Methods for the manufacture of fluconazole and forms thereof, intermediates useful in the manufacture thereof, and combinations comprising fluconazole
CA2139079C (en) * 1994-12-23 1996-05-28 K.S. Keshava Murthy Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof

Also Published As

Publication number Publication date
HUP0000726A3 (en) 2002-02-28
PL329117A1 (en) 1999-03-15
KR19980066917A (ko) 1998-10-15
AU5882398A (en) 1998-08-18
WO1998032744A1 (en) 1998-07-30
CZ308398A3 (cs) 1999-03-17
SK133298A3 (en) 1999-04-13
EP1001947A1 (en) 2000-05-24
HUP0000726A2 (hu) 2000-11-28

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