SK133298A3 - Process for manufacturing fluconazole - Google Patents

Process for manufacturing fluconazole Download PDF

Info

Publication number
SK133298A3
SK133298A3 SK1332-98A SK133298A SK133298A3 SK 133298 A3 SK133298 A3 SK 133298A3 SK 133298 A SK133298 A SK 133298A SK 133298 A3 SK133298 A3 SK 133298A3
Authority
SK
Slovakia
Prior art keywords
formula
fluconazole
reaction
compound
monohydrate
Prior art date
Application number
SK1332-98A
Other languages
English (en)
Slovak (sk)
Inventor
Yong Fan Kim
Geal Jung Yoon
Myung Hwan Park
Original Assignee
Dae Woong Pharma
Dae Woong Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dae Woong Pharma, Dae Woong Chemical Co Ltd filed Critical Dae Woong Pharma
Publication of SK133298A3 publication Critical patent/SK133298A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK1332-98A 1997-01-29 1998-01-24 Process for manufacturing fluconazole SK133298A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1019970002700A KR100194945B1 (ko) 1997-01-29 1997-01-29 플루코나졸의 제조방법
PCT/KR1998/000018 WO1998032744A1 (en) 1997-01-29 1998-01-24 Process for manufacturing fluconazole

Publications (1)

Publication Number Publication Date
SK133298A3 true SK133298A3 (en) 1999-04-13

Family

ID=19495904

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1332-98A SK133298A3 (en) 1997-01-29 1998-01-24 Process for manufacturing fluconazole

Country Status (8)

Country Link
EP (1) EP1001947A1 (xx)
KR (1) KR100194945B1 (xx)
AU (1) AU5882398A (xx)
CZ (1) CZ308398A3 (xx)
HU (1) HUP0000726A3 (xx)
PL (1) PL329117A1 (xx)
SK (1) SK133298A3 (xx)
WO (1) WO1998032744A1 (xx)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100341688B1 (ko) * 1999-04-16 2002-06-24 윤재승 플루코나졸의 제조방법
EP1373227B1 (en) * 2001-03-23 2005-11-09 Richter Gedeon Vegyeszeti Gyar R.T. Process for preparing fluconazole and its crystal modifications
BR102013027313B1 (pt) * 2013-10-23 2019-06-18 Iharabras S.A. Indústrias Químicas Processo para a preparação seletiva de (1h-1,2,4-triazol-1-il) alcanóis, composto hidrazinil alcanol obtido por tal processo e seu uso
TWI636049B (zh) * 2015-11-17 2018-09-21 美商維愛美製藥公司 製備４－（（６－（２－（２，４－二氟苯基）－１，１－二氟－２－羥基－３－（１ｈ－１，２，４－三唑－１－基）丙基）吡啶－３－基）氧基）苄腈之方法
CA3005743A1 (en) * 2015-11-17 2017-05-26 Dow Agrosciences Llc 4-((6-(2-(2,4-difluorophenyl)-1,1-difluoro-2-hydroxy-3-(1h-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile and processes of preparation
CN106749055A (zh) * 2016-12-19 2017-05-31 苏州天马精细化学品股份有限公司 一种氟康唑的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3262386D1 (en) * 1981-06-06 1985-03-28 Pfizer Ltd Antifungal agents, processes for their preparation, and pharmaceutical compositions containing them
CA2106032C (en) * 1993-09-13 1995-11-07 Gamini Weeratunga Methods for the manufacture of fluconazole and forms thereof, intermediates useful in the manufacture thereof, and combinations comprising fluconazole
CA2139079C (en) * 1994-12-23 1996-05-28 K.S. Keshava Murthy Commercial process for the manufacture of fluconazole and intermediates useful in the manufacture thereof

Also Published As

Publication number Publication date
HUP0000726A3 (en) 2002-02-28
EP1001947A1 (en) 2000-05-24
HUP0000726A2 (hu) 2000-11-28
KR100194945B1 (ko) 1999-06-15
AU5882398A (en) 1998-08-18
PL329117A1 (en) 1999-03-15
KR19980066917A (ko) 1998-10-15
WO1998032744A1 (en) 1998-07-30
CZ308398A3 (cs) 1999-03-17

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