KR100190777B1 - 리포코르틴을 에스케리키아 콜라이내에서 제조하기 위한 최적의 발효방법 - Google Patents

리포코르틴을 에스케리키아 콜라이내에서 제조하기 위한 최적의 발효방법 Download PDF

Info

Publication number
KR100190777B1
KR100190777B1 KR1019900011693A KR900011693A KR100190777B1 KR 100190777 B1 KR100190777 B1 KR 100190777B1 KR 1019900011693 A KR1019900011693 A KR 1019900011693A KR 900011693 A KR900011693 A KR 900011693A KR 100190777 B1 KR100190777 B1 KR 100190777B1
Authority
KR
South Korea
Prior art keywords
lactose
glucose
iptg
product
coli
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1019900011693A
Other languages
English (en)
Korean (ko)
Other versions
KR910004811A (ko
Inventor
마티아스그로테
Original Assignee
필립 슈타인, 헤리베르트 부그
베링베르케 악티엔 게젤샤프트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 필립 슈타인, 헤리베르트 부그, 베링베르케 악티엔 게젤샤프트 filed Critical 필립 슈타인, 헤리베르트 부그
Publication of KR910004811A publication Critical patent/KR910004811A/ko
Application granted granted Critical
Publication of KR100190777B1 publication Critical patent/KR100190777B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/72—Expression systems using regulatory sequences derived from the lac-operon
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
KR1019900011693A 1989-08-02 1990-07-31 리포코르틴을 에스케리키아 콜라이내에서 제조하기 위한 최적의 발효방법 Expired - Lifetime KR100190777B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DEP3925550.6 1989-08-02
DE39255506 1989-08-02
DE3925550A DE3925550A1 (de) 1989-08-02 1989-08-02 Optimierte fermentationsverfahren zur herstellung von fremdproteinen in e.coli

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1019980038815A Division KR100190779B1 (ko) 1989-08-02 1998-09-19 리포코르틴을 에스케리키아 콜라이내에서 제조하기 위한최적의 발효방법

Publications (2)

Publication Number Publication Date
KR910004811A KR910004811A (ko) 1991-03-29
KR100190777B1 true KR100190777B1 (ko) 1999-06-01

Family

ID=6386347

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1019900011693A Expired - Lifetime KR100190777B1 (ko) 1989-08-02 1990-07-31 리포코르틴을 에스케리키아 콜라이내에서 제조하기 위한 최적의 발효방법
KR1019980038815A Expired - Lifetime KR100190779B1 (ko) 1989-08-02 1998-09-19 리포코르틴을 에스케리키아 콜라이내에서 제조하기 위한최적의 발효방법
KR1019980038814A Expired - Lifetime KR100190778B1 (en) 1989-08-02 1998-09-19 Optimized fermentation processes for the preparation of lipocortins in e-coli

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1019980038815A Expired - Lifetime KR100190779B1 (ko) 1989-08-02 1998-09-19 리포코르틴을 에스케리키아 콜라이내에서 제조하기 위한최적의 발효방법
KR1019980038814A Expired - Lifetime KR100190778B1 (en) 1989-08-02 1998-09-19 Optimized fermentation processes for the preparation of lipocortins in e-coli

Country Status (11)

Country Link
EP (1) EP0411501B1 (enrdf_load_stackoverflow)
JP (1) JP2977241B2 (enrdf_load_stackoverflow)
KR (3) KR100190777B1 (enrdf_load_stackoverflow)
AT (1) ATE111528T1 (enrdf_load_stackoverflow)
AU (1) AU624982B2 (enrdf_load_stackoverflow)
CA (1) CA2022487C (enrdf_load_stackoverflow)
DE (2) DE3925550A1 (enrdf_load_stackoverflow)
DK (1) DK0411501T3 (enrdf_load_stackoverflow)
ES (1) ES2060876T3 (enrdf_load_stackoverflow)
IE (1) IE65040B1 (enrdf_load_stackoverflow)
PT (1) PT94876B (enrdf_load_stackoverflow)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9215550D0 (en) * 1992-07-22 1992-09-02 Celltech Ltd Protein expression system
AT397812B (de) * 1992-12-18 1994-07-25 Polymun Scient Gmbh Verfahren zur expression von genen unter kontrolle des lac-operators
KR0151534B1 (ko) * 1995-10-30 1998-08-17 이종호 유기산 생성이 억제된 대장균 변이주
CN101365785A (zh) * 2002-07-01 2009-02-11 阿基昂生命科学公司,以生物技术资源部的名义经营 用于生产葡糖胺和n-乙酰氨基葡糖的方法和物质
CN102471787B (zh) * 2009-07-28 2016-01-20 三井化学株式会社 乳酸制造方法
JPWO2015178466A1 (ja) * 2014-05-21 2017-04-20 味の素株式会社 フィブロイン様タンパク質の製造法
CN111850072B (zh) * 2019-04-29 2022-08-16 暨南大学 Peptibody多表位疫苗发酵生产工艺与应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4746608A (en) * 1983-08-22 1988-05-24 Kyowa Hakko Kogyo Co., Ltd. Process for producing peptides
CA1319630C (en) * 1987-02-19 1993-06-29 Satori Sone Method of regulating expression of a foreign gene by controlling the sugar concentration in a medium and a process of producing a foreign gene product thereby

Also Published As

Publication number Publication date
EP0411501A1 (de) 1991-02-06
KR100190779B1 (ko) 1999-06-01
DE59007117D1 (de) 1994-10-20
PT94876B (pt) 1997-04-30
KR910004811A (ko) 1991-03-29
DK0411501T3 (da) 1995-01-16
CA2022487A1 (en) 1991-02-03
DE3925550C2 (enrdf_load_stackoverflow) 1991-08-08
DE3925550A1 (de) 1991-02-07
IE902785A1 (en) 1991-02-27
IE65040B1 (en) 1995-10-04
KR100190778B1 (en) 1999-06-01
ATE111528T1 (de) 1994-09-15
JPH0376595A (ja) 1991-04-02
ES2060876T3 (es) 1994-12-01
CA2022487C (en) 2001-12-11
JP2977241B2 (ja) 1999-11-15
AU6000590A (en) 1991-02-07
EP0411501B1 (de) 1994-09-14
AU624982B2 (en) 1992-06-25
PT94876A (pt) 1991-04-18

Similar Documents

Publication Publication Date Title
JP2662390B2 (ja) インシユリン類似体
US4831120A (en) Method for recovering a purified animal growth hormone or polypeptide analog thereof from a bacterial cell
US4693973A (en) DNA sequences, recombinant DNA molecules and processes for producing bovine growth hormone-like polypeptides in high yield
JP2766999B2 (ja) プロペプチド
US6773899B2 (en) Phage-dependent superproduction of biologically active protein and peptides
KR100190777B1 (ko) 리포코르틴을 에스케리키아 콜라이내에서 제조하기 위한 최적의 발효방법
JPH01501840A (ja) 繊維芽細胞成長因子の産生
US6033875A (en) Method of improved production of insulin-like growth factor
EP1556498A1 (en) Method for producing recombinant human interferon alpha 2b polypeptide in pichia pastoris
RU2575598C9 (ru) Способ получения белка альфа5-интерферона
DE3783305T2 (de) Expressionsvektor fuer menschlichen insulinaehnlichen wachstumsfaktor-i.
US6054291A (en) Expression vectors for enhanced production of polypeptides, plasmids containing the vectors, hosts containing the plasmids, products manufactured thereby and related methods
US5126252A (en) Expressions vectors containing Lambda PL promoter and T1 T2 RNA termination sequence, plasmids containing the vectors, hosts containing the plasmids and relatedmethods
US5198361A (en) Plasmids for production of met-asp-gln bovine growth hormone, hosts containing the plasmids, products manufactured thereby and related methods
US5147789A (en) Stabilized expression vectors containing lambda pl promoter and the gene for the CI434 repressor, plasmids containing the vectors, hosts containing the plasmids and related methods
US5151364A (en) Expression vectors containing lambdapl promoter, T1 T2 RRNA termination sequence, and origin of replication derived from a constitutive high copy number plasmid, and hosts containing the plasmids
JP7565087B2 (ja) 組換えタンパク質の製造方法
US5081020A (en) Expression vectors containing λPL promoter, T1 T2 rRNA termination sequence and origin of replication derived from a constitutive high copy number plasmid hosts and related methods
WO2024173571A1 (en) Interleukin formulations for in vivo use
WO2024173576A1 (en) Interleukin formulations for ex vivo use
SU1752313A1 (ru) Способ получени кислотного гидролизата белоксодержащего материала
Nham et al. Overexpression and purification of full-length acidic fibroblast growth factor in E. coli
KR20040026508A (ko) 박테리아에서의 외래단백질의 생산성을 증가시키는 방법
JPH03259092A (ja) 蛋白質の製造法
JPH0482900A (ja) 新規ｍ―ｃｓｆ及びその製造方法

Legal Events

Date Code Title Description
PA0109 Patent application

Patent event code: PA01091R01D

Comment text: Patent Application

Patent event date: 19900731

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 19950729

Comment text: Request for Examination of Application

Patent event code: PA02011R01I

Patent event date: 19900731

Comment text: Patent Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 19980420

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 19981029

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 19990121

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 19990122

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20011229

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20030107

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20040112

Start annual number: 6

End annual number: 6

PR1001 Payment of annual fee

Payment date: 20041220

Start annual number: 7

End annual number: 7

PR1001 Payment of annual fee

Payment date: 20051221

Start annual number: 8

End annual number: 8

PR1001 Payment of annual fee

Payment date: 20070110

Start annual number: 9

End annual number: 9

PR1001 Payment of annual fee

Payment date: 20080107

Start annual number: 10

End annual number: 10

PR1001 Payment of annual fee

Payment date: 20090109

Start annual number: 11

End annual number: 11

PR1001 Payment of annual fee

Payment date: 20100111

Start annual number: 12

End annual number: 12

PR1001 Payment of annual fee

Payment date: 20101222

Start annual number: 13

End annual number: 13

FPAY Annual fee payment

Payment date: 20120109

Year of fee payment: 14

PR1001 Payment of annual fee

Payment date: 20120109

Start annual number: 14

End annual number: 14

FPAY Annual fee payment

Payment date: 20130107

Year of fee payment: 15

PR1001 Payment of annual fee

Payment date: 20130107

Start annual number: 15

End annual number: 15

EXPY Expiration of term
PC1801 Expiration of term

Termination date: 20140721

Termination category: Expiration of duration