KR0134198B1 - 인식력 향상제로서 d-시클로세린 및 그의 프로드럭 - Google Patents

인식력 향상제로서 d-시클로세린 및 그의 프로드럭

Info

Publication number
KR0134198B1
KR0134198B1 KR1019880015895A KR880015895A KR0134198B1 KR 0134198 B1 KR0134198 B1 KR 0134198B1 KR 1019880015895 A KR1019880015895 A KR 1019880015895A KR 880015895 A KR880015895 A KR 880015895A KR 0134198 B1 KR0134198 B1 KR 0134198B1
Authority
KR
South Korea
Prior art keywords
cycloserine
memory
compounds
glycine
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1019880015895A
Other languages
English (en)
Korean (ko)
Other versions
KR890009392A (ko
Inventor
에이. 코르디 알렉스
이. 한델만 게일
비. 모나한 조세프
Original Assignee
폴 디. 마튜카이티스
지.디.씰 앤드 컴파니
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 폴 디. 마튜카이티스, 지.디.씰 앤드 컴파니 filed Critical 폴 디. 마튜카이티스
Publication of KR890009392A publication Critical patent/KR890009392A/ko
Application granted granted Critical
Publication of KR0134198B1 publication Critical patent/KR0134198B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1019880015895A 1987-12-01 1988-11-30 인식력 향상제로서 d-시클로세린 및 그의 프로드럭 Expired - Fee Related KR0134198B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US127,121 1987-12-01
US07/127,121 US4904681A (en) 1987-12-01 1987-12-01 D-cycloserine and its prodrugs as cognitive enhancers
US127.121 1987-12-01

Publications (2)

Publication Number Publication Date
KR890009392A KR890009392A (ko) 1989-08-01
KR0134198B1 true KR0134198B1 (ko) 1998-04-21

Family

ID=22428413

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019880015895A Expired - Fee Related KR0134198B1 (ko) 1987-12-01 1988-11-30 인식력 향상제로서 d-시클로세린 및 그의 프로드럭

Country Status (20)

Country Link
US (1) US4904681A (enExample)
EP (2) EP0319824B1 (enExample)
JP (2) JPH0621065B2 (enExample)
KR (1) KR0134198B1 (enExample)
AT (1) ATE68698T1 (enExample)
AU (4) AU622630B2 (enExample)
CA (1) CA1328617C (enExample)
DE (1) DE3865817D1 (enExample)
DK (1) DK173589B1 (enExample)
ES (1) ES2040314T3 (enExample)
FI (1) FI885559A0 (enExample)
GR (1) GR3003571T3 (enExample)
IE (1) IE61825B1 (enExample)
IL (1) IL88531A (enExample)
NO (1) NO885337D0 (enExample)
NZ (1) NZ227131A (enExample)
PH (1) PH26467A (enExample)
PT (1) PT89109B (enExample)
WO (1) WO1989005144A1 (enExample)
ZA (1) ZA888981B (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187171A (en) * 1989-01-09 1993-02-16 G. D. Searle & Co. Use of a glycine b partial agonist as an antipsychotic
US5061721A (en) * 1989-03-15 1991-10-29 G. D. Searle & Co. Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder
US5260324A (en) * 1990-02-06 1993-11-09 G. D. Searle & Company Composition containing D-cycloserine and D-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder
US5066665A (en) * 1990-05-21 1991-11-19 Warner-Lambert Co. Substituted isoxazolidin-3-ones and derivatives thereof acting at muscarinic receptors
JPH07505908A (ja) * 1992-09-28 1995-06-29 マックセチーニ、マリア　ルイザ Ｎｍｄａ受容体のアロステリックモジュレーター
US5428069A (en) * 1993-01-11 1995-06-27 The United States Of America As Represented By The Department Of Health & Human Services Treating cognition with, aminocyclopropanecarboxylic derivatives
US5523323A (en) * 1993-09-14 1996-06-04 Maccecchini; Maria-Luisa Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence
NZ260302A (en) * 1994-04-13 1996-05-28 New Zealand Meat Ind Res Inst Treating bait aversion by including substances which disrupt the associative learning process into bait compositions
AU4019395A (en) * 1994-11-23 1996-06-17 G.D. Searle & Co. Use of amino-isoxazolidone compounds for improvement of implicit memory
WO1996015787A1 (en) * 1994-11-23 1996-05-30 G.D. Searle & Co. Use of amino-isoxazolidone compounds for treatment of memory impairment following traumatic brain injury
DE69614835T2 (de) * 1995-02-15 2002-04-25 Annovis, Inc. Alkylcarboxy-aminosäure modulatoren für den kainat-rezeptor
US6355681B2 (en) * 1995-12-07 2002-03-12 Glytech, Inc. Glycine substitutes and precursors for treating a psychosis
DK0871440T3 (da) * 1995-12-07 2006-07-10 Daniel C Javitt Behandling af negative og kognitive symptomer på skizofreni med glycinoptagelsesantagonister
US6361957B1 (en) 1999-08-03 2002-03-26 Glytech, Inc. Assay for D-serine transport antagonist and use for treating psychosis
FR2742748B1 (fr) * 1995-12-21 1998-01-30 Adir Nouveau derive de 4-imidazolidinone, son procede de preparation et les compositions pharmaceutiques qui le contiennent
KR100396114B1 (ko) * 1996-10-31 2003-11-20 동아제약 주식회사 D-시클로세린의 제조방법
DK1073432T3 (da) * 1998-04-14 2007-12-17 Gen Hospital Corp Anvendelse af D serin eller D alanin til behandling af skizofreni
DE69930624T2 (de) 1998-06-10 2006-09-14 Meiji Seika Kaisha Ltd. Arzneimittel für hinterstrangataxie und zusammensetzung zur behandlung von hinterstrangataxie
US20040122090A1 (en) * 2001-12-07 2004-06-24 Lipton Stuart A. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
US20060252761A1 (en) * 2001-03-29 2006-11-09 Michael Davis Augmentation of extinction via administration of sub-antimicrobial doses of D-cycloserine
US7750030B2 (en) * 2001-03-29 2010-07-06 Michael Davis Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning
EP1389181A4 (en) * 2001-04-02 2005-10-19 Panorama Res Inc ANTIOXIDANT NITROXIDES AND NITRONES AS THERAPEUTIC AGENTS
US7160913B2 (en) * 2002-09-13 2007-01-09 Thomas Jefferson University Methods and kit for treating Parkinson's disease
RS20050851A (sr) * 2003-05-27 2008-04-04 Forest Laboratories Inc., Kombinacija antagonista nmda receptora i selektivnog inhibitora ponovnog preuzimanja serotonina za lečenje depresije i drugih poremećaja raspoloženja
CA2534909A1 (en) * 2003-08-08 2005-02-17 The Burnham Institute P16 mediated regulation of nmda receptors
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
EP1874282B1 (en) * 2005-04-06 2010-09-15 Adamas Pharmaceuticals, Inc. Methods and compositions for treatment of cns disorders
BRPI0918868B8 (pt) 2008-09-18 2021-05-25 Naurex Inc compostos moduladores do receptor de nmda e composições compreendendo os mesmos
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8951968B2 (en) 2009-10-05 2015-02-10 Northwestern University Methods of treating depression and other related diseases
KR101692275B1 (ko) 2010-02-11 2017-01-04 노오쓰웨스턴 유니버시티 ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도
CN102933226A (zh) 2010-02-11 2013-02-13 西北大学 二级结构稳定化的nmda受体调节剂及其用途
TR201908596T4 (tr) 2013-01-29 2019-07-22 Aptinyx Inc Spiro-laktam NMDA reseptörü modülatörleri ve bunların kullanımları.
KR20150110586A (ko) 2013-01-29 2015-10-02 노렉스, 인크. 스피로-락탐 nmda 수용체 조절인자 및 그의 용도
SG11201505862TA (en) 2013-01-29 2015-08-28 Naurex Inc Spiro-lactam nmda receptor modulators and uses thereof
KR102410989B1 (ko) 2013-01-29 2022-06-17 앱티닉스 인크. 스피로-락탐 nmda 수용체 조절인자 및 그의 용도
KR20150110787A (ko) 2013-01-29 2015-10-02 노렉스, 인크. 스피로-락탐 nmda 수용체 조절인자 및 그의 용도
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
KR102128675B1 (ko) 2016-05-19 2020-06-30 앱티닉스 인크. 스피로-락탐 nmda 수용체 조정제 및 그의 용도
JP2019527235A (ja) 2016-08-01 2019-09-26 アプティニックス インコーポレイテッド スピロ−ラクタム及びビス−スピロ−ラクタムｎｍｄａ受容体修飾因子及びその使用
AU2017306136B2 (en) 2016-08-01 2021-10-21 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
PE20190504A1 (es) 2016-08-01 2019-04-10 Aptinyx Inc Moduladores del receptor nmda espiro-lactam y uso de los mismos
AU2017306152A1 (en) 2016-08-01 2019-01-31 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
PE20190501A1 (es) 2016-08-01 2019-04-10 Aptinyx Inc Moduladores nmda espiro-lactam y metodos de uso de los mismos
EP3427729A1 (en) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid for use in treating epileptic diseases, disorders or conditions
MX2020008107A (es) 2018-01-31 2020-09-25 Aptinyx Inc Moduladores del receptor nmda espiro-lactama y usos de los mismos.
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3010599A1 (de) * 1979-03-22 1980-10-09 Continental Pharma Derivate von glycinamid, deren herstellung und verwendung

Also Published As

Publication number Publication date
DE3865817D1 (enExample) 1991-11-28
KR890009392A (ko) 1989-08-01
WO1989005144A1 (en) 1989-06-15
CA1328617C (en) 1994-04-19
FI885559A0 (fi) 1988-11-30
IL88531A0 (en) 1989-06-30
AU1083992A (en) 1992-05-07
US4904681A (en) 1990-02-27
EP0319824A1 (en) 1989-06-14
DK173589B1 (da) 2001-04-02
EP0421997A1 (en) 1991-04-17
DK669088A (da) 1989-06-02
EP0319824B1 (en) 1991-10-23
AU2631988A (en) 1989-06-01
ZA888981B (en) 1990-01-31
IL88531A (en) 1993-02-21
GR3003571T3 (enExample) 1993-03-16
DK669088D0 (da) 1988-11-30
PT89109B (pt) 1993-07-30
NO885337D0 (no) 1988-11-30
ES2040314T3 (es) 1995-04-01
IE883567L (en) 1989-06-01
ATE68698T1 (de) 1991-11-15
AU2813089A (en) 1989-07-05
JPH0621065B2 (ja) 1994-03-23
NZ227131A (en) 1991-09-25
PH26467A (en) 1992-07-27
JPH05201859A (ja) 1993-08-10
AU622630B2 (en) 1992-04-16
AU7746794A (en) 1995-01-05
JPH01193220A (ja) 1989-08-03
IE61825B1 (en) 1994-11-30
PT89109A (pt) 1989-12-29

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