ATE68698T1 - D-cycloserin und deren prodrugs zur verbesserung kognitiver faehigkeiten. - Google Patents

D-cycloserin und deren prodrugs zur verbesserung kognitiver faehigkeiten.

Info

Publication number
ATE68698T1
ATE68698T1 AT88119863T AT88119863T ATE68698T1 AT E68698 T1 ATE68698 T1 AT E68698T1 AT 88119863 T AT88119863 T AT 88119863T AT 88119863 T AT88119863 T AT 88119863T AT E68698 T1 ATE68698 T1 AT E68698T1
Authority
AT
Austria
Prior art keywords
cycloserin
prodrugs
improving cognitive
cognitive skills
skills
Prior art date
Application number
AT88119863T
Other languages
English (en)
Inventor
Alex A Cordi
Gail E Handelmann
Joseph B Monahan
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Application granted granted Critical
Publication of ATE68698T1 publication Critical patent/ATE68698T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Psychiatry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
AT88119863T 1987-12-01 1988-11-29 D-cycloserin und deren prodrugs zur verbesserung kognitiver faehigkeiten. ATE68698T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/127,121 US4904681A (en) 1987-12-01 1987-12-01 D-cycloserine and its prodrugs as cognitive enhancers
EP88119863A EP0319824B1 (de) 1987-12-01 1988-11-29 D-Cycloserin und deren Prodrugs zur Verbesserung kognitiver Fähigkeiten

Publications (1)

Publication Number Publication Date
ATE68698T1 true ATE68698T1 (de) 1991-11-15

Family

ID=22428413

Family Applications (1)

Application Number Title Priority Date Filing Date
AT88119863T ATE68698T1 (de) 1987-12-01 1988-11-29 D-cycloserin und deren prodrugs zur verbesserung kognitiver faehigkeiten.

Country Status (20)

Country Link
US (1) US4904681A (de)
EP (2) EP0319824B1 (de)
JP (2) JPH0621065B2 (de)
KR (1) KR0134198B1 (de)
AT (1) ATE68698T1 (de)
AU (4) AU622630B2 (de)
CA (1) CA1328617C (de)
DE (1) DE3865817D1 (de)
DK (1) DK173589B1 (de)
ES (1) ES2040314T3 (de)
FI (1) FI885559A0 (de)
GR (1) GR3003571T3 (de)
IE (1) IE61825B1 (de)
IL (1) IL88531A (de)
NO (1) NO885337D0 (de)
NZ (1) NZ227131A (de)
PH (1) PH26467A (de)
PT (1) PT89109B (de)
WO (1) WO1989005144A1 (de)
ZA (1) ZA888981B (de)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
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US5187171A (en) * 1989-01-09 1993-02-16 G. D. Searle & Co. Use of a glycine b partial agonist as an antipsychotic
US5061721A (en) * 1989-03-15 1991-10-29 G. D. Searle & Co. Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder
US5260324A (en) * 1990-02-06 1993-11-09 G. D. Searle & Company Composition containing D-cycloserine and D-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder
US5066665A (en) * 1990-05-21 1991-11-19 Warner-Lambert Co. Substituted isoxazolidin-3-ones and derivatives thereof acting at muscarinic receptors
JPH07505908A (ja) * 1992-09-28 1995-06-29 マックセチーニ、マリア　ルイザ Ｎｍｄａ受容体のアロステリックモジュレーター
US5428069A (en) * 1993-01-11 1995-06-27 The United States Of America As Represented By The Department Of Health & Human Services Treating cognition with, aminocyclopropanecarboxylic derivatives
US5523323A (en) * 1993-09-14 1996-06-04 Maccecchini; Maria-Luisa Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence
NZ260302A (en) * 1994-04-13 1996-05-28 New Zealand Meat Ind Res Inst Treating bait aversion by including substances which disrupt the associative learning process into bait compositions
AU4128896A (en) * 1994-11-23 1996-06-17 G.D. Searle & Co. Use of amino-isoxazolidone compounds for treatment of memory impairment following traumatic brain injury
WO1996015788A1 (en) * 1994-11-23 1996-05-30 G.D. Searle & Co. Use of amino-isoxazolidone compounds for improvement of implicit memory
EP0809624B1 (de) * 1995-02-15 2001-08-29 Bearsden Bio, Inc. Alkylcarboxy-aminosäure modulatoren für den kainat-rezeptor
ATE320804T1 (de) * 1995-12-07 2006-04-15 Daniel C Javitt Behandlung negativer und kognitiver symptome der schizophrenie mit antagonisten der glycinaufnahme
US6361957B1 (en) * 1999-08-03 2002-03-26 Glytech, Inc. Assay for D-serine transport antagonist and use for treating psychosis
US6355681B2 (en) * 1995-12-07 2002-03-12 Glytech, Inc. Glycine substitutes and precursors for treating a psychosis
FR2742748B1 (fr) * 1995-12-21 1998-01-30 Adir Nouveau derive de 4-imidazolidinone, son procede de preparation et les compositions pharmaceutiques qui le contiennent
KR100396114B1 (ko) * 1996-10-31 2003-11-20 동아제약 주식회사 D-시클로세린의 제조방법
EP2338482A3 (de) 1998-04-14 2011-12-21 The General Hospital Corporation Verfahren zur Behandlung neuropsychischer Erkrankungen
ES2262322T3 (es) * 1998-06-10 2006-11-16 Meiji Seika Kaisha, Ltd. Tratamiento de la degenaracion espinocereberal y comoposiciones utiles para el tratamiento de degeneracion espinocerebelar.
US20040122090A1 (en) * 2001-12-07 2004-06-24 Lipton Stuart A. Methods for treating neuropsychiatric disorders with nmda receptor antagonists
US20060252761A1 (en) * 2001-03-29 2006-11-09 Michael Davis Augmentation of extinction via administration of sub-antimicrobial doses of D-cycloserine
JP2004530666A (ja) * 2001-03-29 2004-10-07 エモリー　ユニバーシティ 学習または条件付けのエンハンサーを用いる精神療法の急性薬理学的増強
WO2002078615A2 (en) 2001-04-02 2002-10-10 Panorama Research, Inc. Antioxidant nitroxides and nitrones as therapeutic agents
US7160913B2 (en) * 2002-09-13 2007-01-09 Thomas Jefferson University Methods and kit for treating Parkinson's disease
UA80055C2 (en) * 2003-05-27 2007-08-10 Forest Laboratories Combination of nmda-receptor antagonist and selective inhibitor of serotonin reuptake for a depression and other pscihiatric disorders treatment
EP1660634A4 (de) * 2003-08-08 2009-02-18 Burnham Inst P16-vermittelte regulation von nmda-rezeptoren
US7619007B2 (en) 2004-11-23 2009-11-17 Adamas Pharmaceuticals, Inc. Method and composition for administering an NMDA receptor antagonist to a subject
WO2006121560A2 (en) 2005-04-06 2006-11-16 Adamas Pharmaceuticals, Inc. Methods and compositions for treatment of cns disorders
EP2331571B1 (de) 2008-09-18 2015-08-26 Northwestern University Nmda-rezeptormodulatoren und ihre verwendung
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
US8951968B2 (en) 2009-10-05 2015-02-10 Northwestern University Methods of treating depression and other related diseases
KR101692275B1 (ko) 2010-02-11 2017-01-04 노오쓰웨스턴 유니버시티 ２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도
SG183265A1 (en) 2010-02-11 2012-09-27 Univ Northwestern Secondary structure stabilized nmda receptor modulators and uses thereof
JP6531042B2 (ja) 2013-01-29 2019-06-12 アプティニックス インコーポレイテッド スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
EA201591405A1 (ru) 2013-01-29 2017-05-31 Аптиникс Инк. Спиролактамные модуляторы nmda-рецептора и их применение
KR20150110787A (ko) 2013-01-29 2015-10-02 노렉스, 인크. 스피로-락탐 nmda 수용체 조절인자 및 그의 용도
SI3514158T1 (sl) 2013-01-29 2023-03-31 Aptinyx Inc. Spirolaktamski modulatorji NMDA-receptorja in njihove uporabe
EA201591404A1 (ru) 2013-01-29 2016-01-29 Аптиникс Инк. Спиролактамные модуляторы рецептора nmda и их применение
PE20190174A1 (es) 2016-05-19 2019-02-01 Aptinyx Inc Moduladores del receptor espiro-lactama n-metil-d-aspartato y usos de los mismos
WO2017201285A1 (en) 2016-05-19 2017-11-23 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
IL264496B (en) 2016-08-01 2022-09-01 Aptinyx Inc Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
WO2018026798A1 (en) 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda modulators and methods of using same
BR112019001921A2 (pt) 2016-08-01 2019-05-14 Aptinyx Inc. moduladores do receptor nmda de espiro-lactama e seus usos
US10918637B2 (en) 2016-08-01 2021-02-16 Aptinyx Inc. Spiro-lactam NMDA receptor modulators and uses thereof
CA3031537A1 (en) 2016-08-01 2018-02-08 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
EP3427729A1 (de) 2017-07-13 2019-01-16 Paris Sciences et Lettres - Quartier Latin Probenecid zur behandlung von epileptischen erkrankungen, störungen oder zuständen
AU2019215058A1 (en) 2018-01-31 2020-09-17 Aptinyx Inc. Spiro-lactam nmda receptor modulators and uses thereof
US12012413B2 (en) 2019-11-11 2024-06-18 Tenacia Biotechnology (Hong Kong) Co., Limited Methods of treating painful diabetic peripheral neuropathy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3010599A1 (de) * 1979-03-22 1980-10-09 Continental Pharma Derivate von glycinamid, deren herstellung und verwendung

Also Published As

Publication number Publication date
JPH01193220A (ja) 1989-08-03
AU622630B2 (en) 1992-04-16
KR890009392A (ko) 1989-08-01
NZ227131A (en) 1991-09-25
DK669088D0 (da) 1988-11-30
IE61825B1 (en) 1994-11-30
EP0421997A1 (de) 1991-04-17
DK669088A (da) 1989-06-02
AU2813089A (en) 1989-07-05
EP0319824A1 (de) 1989-06-14
CA1328617C (en) 1994-04-19
US4904681A (en) 1990-02-27
JPH0621065B2 (ja) 1994-03-23
PT89109B (pt) 1993-07-30
AU2631988A (en) 1989-06-01
DE3865817D1 (de) 1991-11-28
ES2040314T3 (es) 1995-04-01
PT89109A (pt) 1989-12-29
AU1083992A (en) 1992-05-07
GR3003571T3 (de) 1993-03-16
KR0134198B1 (ko) 1998-04-21
DK173589B1 (da) 2001-04-02
ZA888981B (en) 1990-01-31
NO885337D0 (no) 1988-11-30
FI885559A0 (fi) 1988-11-30
IL88531A (en) 1993-02-21
AU7746794A (en) 1995-01-05
WO1989005144A1 (en) 1989-06-15
EP0319824B1 (de) 1991-10-23
JPH05201859A (ja) 1993-08-10
IE883567L (en) 1989-06-01
IL88531A0 (en) 1989-06-30
PH26467A (en) 1992-07-27

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Legal Events

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