ATE68698T1 - D-cycloserin und deren prodrugs zur verbesserung kognitiver faehigkeiten. - Google Patents
D-cycloserin und deren prodrugs zur verbesserung kognitiver faehigkeiten.Info
- Publication number
- ATE68698T1 ATE68698T1 AT88119863T AT88119863T ATE68698T1 AT E68698 T1 ATE68698 T1 AT E68698T1 AT 88119863 T AT88119863 T AT 88119863T AT 88119863 T AT88119863 T AT 88119863T AT E68698 T1 ATE68698 T1 AT E68698T1
- Authority
- AT
- Austria
- Prior art keywords
- cycloserin
- prodrugs
- improving cognitive
- cognitive skills
- skills
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Psychiatry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/127,121 US4904681A (en) | 1987-12-01 | 1987-12-01 | D-cycloserine and its prodrugs as cognitive enhancers |
EP88119863A EP0319824B1 (de) | 1987-12-01 | 1988-11-29 | D-Cycloserin und deren Prodrugs zur Verbesserung kognitiver Fähigkeiten |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE68698T1 true ATE68698T1 (de) | 1991-11-15 |
Family
ID=22428413
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT88119863T ATE68698T1 (de) | 1987-12-01 | 1988-11-29 | D-cycloserin und deren prodrugs zur verbesserung kognitiver faehigkeiten. |
Country Status (20)
Country | Link |
---|---|
US (1) | US4904681A (de) |
EP (2) | EP0319824B1 (de) |
JP (2) | JPH0621065B2 (de) |
KR (1) | KR0134198B1 (de) |
AT (1) | ATE68698T1 (de) |
AU (4) | AU622630B2 (de) |
CA (1) | CA1328617C (de) |
DE (1) | DE3865817D1 (de) |
DK (1) | DK173589B1 (de) |
ES (1) | ES2040314T3 (de) |
FI (1) | FI885559A0 (de) |
GR (1) | GR3003571T3 (de) |
IE (1) | IE61825B1 (de) |
IL (1) | IL88531A (de) |
NO (1) | NO885337D0 (de) |
NZ (1) | NZ227131A (de) |
PH (1) | PH26467A (de) |
PT (1) | PT89109B (de) |
WO (1) | WO1989005144A1 (de) |
ZA (1) | ZA888981B (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5187171A (en) * | 1989-01-09 | 1993-02-16 | G. D. Searle & Co. | Use of a glycine b partial agonist as an antipsychotic |
US5061721A (en) * | 1989-03-15 | 1991-10-29 | G. D. Searle & Co. | Composition containing d-cycloserine and d-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
US5260324A (en) * | 1990-02-06 | 1993-11-09 | G. D. Searle & Company | Composition containing D-cycloserine and D-alanine for memory and learning enhancement or treatment of a cognitive or psychotic disorder |
US5066665A (en) * | 1990-05-21 | 1991-11-19 | Warner-Lambert Co. | Substituted isoxazolidin-3-ones and derivatives thereof acting at muscarinic receptors |
JPH07505908A (ja) * | 1992-09-28 | 1995-06-29 | マックセチーニ、マリア ルイザ | Nmda受容体のアロステリックモジュレーター |
US5428069A (en) * | 1993-01-11 | 1995-06-27 | The United States Of America As Represented By The Department Of Health & Human Services | Treating cognition with, aminocyclopropanecarboxylic derivatives |
US5523323A (en) * | 1993-09-14 | 1996-06-04 | Maccecchini; Maria-Luisa | Use of partial agonists of the NMDA receptor to reduce opiate induced tolerance and dependence |
NZ260302A (en) * | 1994-04-13 | 1996-05-28 | New Zealand Meat Ind Res Inst | Treating bait aversion by including substances which disrupt the associative learning process into bait compositions |
AU4019395A (en) * | 1994-11-23 | 1996-06-17 | G.D. Searle & Co. | Use of amino-isoxazolidone compounds for improvement of implicit memory |
AU4128896A (en) * | 1994-11-23 | 1996-06-17 | G.D. Searle & Co. | Use of amino-isoxazolidone compounds for treatment of memory impairment following traumatic brain injury |
JPH11501619A (ja) * | 1995-02-15 | 1999-02-09 | ベアーズデン バイオ,インコーポレイテッド | アルキルカルボキシアミノ酸−カイネートレセプターのモジュレーター |
US6355681B2 (en) * | 1995-12-07 | 2002-03-12 | Glytech, Inc. | Glycine substitutes and precursors for treating a psychosis |
WO1997020553A1 (en) * | 1995-12-07 | 1997-06-12 | Javitt Daniel C | Treatment of negative and cognitive symptoms of schizophrenia with glycine uptake antagonists |
US6361957B1 (en) * | 1999-08-03 | 2002-03-26 | Glytech, Inc. | Assay for D-serine transport antagonist and use for treating psychosis |
FR2742748B1 (fr) * | 1995-12-21 | 1998-01-30 | Adir | Nouveau derive de 4-imidazolidinone, son procede de preparation et les compositions pharmaceutiques qui le contiennent |
KR100396114B1 (ko) * | 1996-10-31 | 2003-11-20 | 동아제약 주식회사 | D-시클로세린의 제조방법 |
PT1073432E (pt) | 1998-04-14 | 2007-10-22 | Gen Hospital Corp | Utilização da d-alanina ou da d-serina para o tratamento da esquizofrenia |
WO1999063989A1 (fr) | 1998-06-10 | 1999-12-16 | Meiji Seika Kaisha Ltd. | Traitements de l'ataxie spinocerebelleuse et compositions utiles pour traiter l'ataxie spinocerebelleuse |
US20040122090A1 (en) * | 2001-12-07 | 2004-06-24 | Lipton Stuart A. | Methods for treating neuropsychiatric disorders with nmda receptor antagonists |
US20060252761A1 (en) * | 2001-03-29 | 2006-11-09 | Michael Davis | Augmentation of extinction via administration of sub-antimicrobial doses of D-cycloserine |
US7750030B2 (en) * | 2001-03-29 | 2010-07-06 | Michael Davis | Acute pharmacologic augmentation of psychotherapy with enhancers of learning or conditioning |
CN1527813A (zh) * | 2001-04-02 | 2004-09-08 | О | 作为治疗剂的抗氧化剂硝基氧和亚硝氮碳基 |
US7160913B2 (en) * | 2002-09-13 | 2007-01-09 | Thomas Jefferson University | Methods and kit for treating Parkinson's disease |
RS20050851A (sr) | 2003-05-27 | 2008-04-04 | Forest Laboratories Inc., | Kombinacija antagonista nmda receptora i selektivnog inhibitora ponovnog preuzimanja serotonina za lečenje depresije i drugih poremećaja raspoloženja |
US7544478B2 (en) * | 2003-08-08 | 2009-06-09 | The Burnham Institute | Method for screening for compounds that modulate P16 mediated regulation of NMDA receptors |
US7619007B2 (en) | 2004-11-23 | 2009-11-17 | Adamas Pharmaceuticals, Inc. | Method and composition for administering an NMDA receptor antagonist to a subject |
WO2006121560A2 (en) | 2005-04-06 | 2006-11-16 | Adamas Pharmaceuticals, Inc. | Methods and compositions for treatment of cns disorders |
MX2011003015A (es) | 2008-09-18 | 2011-11-18 | Univ Northwestern | Moduladores del receptor de n-metil-d-aspartato, y usos de los mismos. |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
US8951968B2 (en) | 2009-10-05 | 2015-02-10 | Northwestern University | Methods of treating depression and other related diseases |
KR101692275B1 (ko) | 2010-02-11 | 2017-01-04 | 노오쓰웨스턴 유니버시티 | 2차 구조 안정화된 nmda 수용체 조절제 및 그의 용도 |
EP2542254B1 (de) | 2010-02-11 | 2018-09-26 | Northwestern University | Nmda-rezeptor-agonisten und ihre verwendungen |
MX2015009773A (es) | 2013-01-29 | 2016-08-05 | Aptinyx Inc | Moduladores de receptores nmda de espiro-lactama y sus usos. |
KR102410989B1 (ko) | 2013-01-29 | 2022-06-17 | 앱티닉스 인크. | 스피로-락탐 nmda 수용체 조절인자 및 그의 용도 |
ES2935352T3 (es) | 2013-01-29 | 2023-03-06 | Aptinyx Inc | Moduladores de receptores NMDA de espiro-lactama y sus usos |
WO2014120800A1 (en) | 2013-01-29 | 2014-08-07 | Naurex, Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
BR112015018095A2 (pt) | 2013-01-29 | 2017-07-18 | Naurex Inc | moduladores de receptor nmda de espiro-lactama e usos dos mesmos |
WO2017201285A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
WO2017201283A1 (en) | 2016-05-19 | 2017-11-23 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
CN109661398B (zh) | 2016-08-01 | 2022-07-05 | 阿普廷伊克斯股份有限公司 | 螺-内酰胺和二-螺-内酰胺nmda受体调节剂及其用途 |
CA3031534C (en) | 2016-08-01 | 2023-10-17 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
AU2017306164B2 (en) | 2016-08-01 | 2021-10-21 | Aptinyx Inc. | Spiro-lactam NMDA modulators and methods of using same |
ES2973283T3 (es) | 2016-08-01 | 2024-06-19 | Tenacia Biotechnology Hong Kong Co Ltd | Moduladores de receptores de NMDA espirolactámicos y usos de los mismos |
BR112019001768A2 (pt) | 2016-08-01 | 2019-06-11 | Aptinyx Inc | moduladores do receptor de spiro-lactamas nmda e usos dos mesmos |
EP3427729A1 (de) | 2017-07-13 | 2019-01-16 | Paris Sciences et Lettres - Quartier Latin | Probenecid zur behandlung von epileptischen erkrankungen, störungen oder zuständen |
WO2019152687A1 (en) | 2018-01-31 | 2019-08-08 | Aptinyx Inc. | Spiro-lactam nmda receptor modulators and uses thereof |
US12012413B2 (en) | 2019-11-11 | 2024-06-18 | Tenacia Biotechnology (Hong Kong) Co., Limited | Methods of treating painful diabetic peripheral neuropathy |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3010599A1 (de) * | 1979-03-22 | 1980-10-09 | Continental Pharma | Derivate von glycinamid, deren herstellung und verwendung |
-
1987
- 1987-12-01 US US07/127,121 patent/US4904681A/en not_active Expired - Lifetime
-
1988
- 1988-11-28 PH PH37866A patent/PH26467A/en unknown
- 1988-11-29 PT PT89109A patent/PT89109B/pt not_active IP Right Cessation
- 1988-11-29 AU AU26319/88A patent/AU622630B2/en not_active Ceased
- 1988-11-29 ES ES88119863T patent/ES2040314T3/es not_active Expired - Lifetime
- 1988-11-29 AT AT88119863T patent/ATE68698T1/de not_active IP Right Cessation
- 1988-11-29 EP EP88119863A patent/EP0319824B1/de not_active Expired - Lifetime
- 1988-11-29 IL IL88531A patent/IL88531A/xx not_active IP Right Cessation
- 1988-11-29 IE IE356788A patent/IE61825B1/en not_active IP Right Cessation
- 1988-11-29 NZ NZ227131A patent/NZ227131A/xx unknown
- 1988-11-29 DE DE88119863T patent/DE3865817D1/de not_active Expired - Fee Related
- 1988-11-30 FI FI885559A patent/FI885559A0/fi not_active Application Discontinuation
- 1988-11-30 NO NO885337A patent/NO885337D0/no unknown
- 1988-11-30 JP JP63303873A patent/JPH0621065B2/ja not_active Expired - Lifetime
- 1988-11-30 ZA ZA888981A patent/ZA888981B/xx unknown
- 1988-11-30 KR KR1019880015895A patent/KR0134198B1/ko not_active IP Right Cessation
- 1988-11-30 CA CA000584621A patent/CA1328617C/en not_active Expired - Fee Related
- 1988-11-30 DK DK198806690A patent/DK173589B1/da not_active IP Right Cessation
- 1988-12-01 AU AU28130/89A patent/AU2813089A/en not_active Abandoned
- 1988-12-01 EP EP89900543A patent/EP0421997A1/de not_active Withdrawn
- 1988-12-01 WO PCT/US1988/004244 patent/WO1989005144A1/en not_active Application Discontinuation
-
1992
- 1992-01-15 GR GR910401170T patent/GR3003571T3/el unknown
- 1992-02-10 AU AU10839/92A patent/AU1083992A/en not_active Abandoned
- 1992-07-03 JP JP4177094A patent/JPH05201859A/ja active Pending
-
1994
- 1994-10-26 AU AU77467/94A patent/AU7746794A/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2631988A (en) | 1989-06-01 |
AU7746794A (en) | 1995-01-05 |
CA1328617C (en) | 1994-04-19 |
ES2040314T3 (es) | 1995-04-01 |
IE883567L (en) | 1989-06-01 |
IE61825B1 (en) | 1994-11-30 |
EP0421997A1 (de) | 1991-04-17 |
AU1083992A (en) | 1992-05-07 |
FI885559A0 (fi) | 1988-11-30 |
PH26467A (en) | 1992-07-27 |
NO885337D0 (no) | 1988-11-30 |
JPH0621065B2 (ja) | 1994-03-23 |
AU2813089A (en) | 1989-07-05 |
PT89109A (pt) | 1989-12-29 |
EP0319824A1 (de) | 1989-06-14 |
DE3865817D1 (de) | 1991-11-28 |
NZ227131A (en) | 1991-09-25 |
WO1989005144A1 (en) | 1989-06-15 |
DK669088A (da) | 1989-06-02 |
AU622630B2 (en) | 1992-04-16 |
DK173589B1 (da) | 2001-04-02 |
JPH05201859A (ja) | 1993-08-10 |
ZA888981B (en) | 1990-01-31 |
DK669088D0 (da) | 1988-11-30 |
EP0319824B1 (de) | 1991-10-23 |
PT89109B (pt) | 1993-07-30 |
US4904681A (en) | 1990-02-27 |
IL88531A (en) | 1993-02-21 |
KR0134198B1 (ko) | 1998-04-21 |
GR3003571T3 (de) | 1993-03-16 |
KR890009392A (ko) | 1989-08-01 |
IL88531A0 (en) | 1989-06-30 |
JPH01193220A (ja) | 1989-08-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
REN | Ceased due to non-payment of the annual fee |