JPWO2024228396A5 - - Google Patents
Info
- Publication number
- JPWO2024228396A5 JPWO2024228396A5 JP2025518161A JP2025518161A JPWO2024228396A5 JP WO2024228396 A5 JPWO2024228396 A5 JP WO2024228396A5 JP 2025518161 A JP2025518161 A JP 2025518161A JP 2025518161 A JP2025518161 A JP 2025518161A JP WO2024228396 A5 JPWO2024228396 A5 JP WO2024228396A5
- Authority
- JP
- Japan
- Prior art keywords
- oligonucleotide
- highly lipophilic
- protected
- building block
- protecting group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202363499274P | 2023-05-01 | 2023-05-01 | |
| PCT/JP2024/016835 WO2024228396A1 (ja) | 2023-05-01 | 2024-05-01 | オリゴヌクレオチド合成用の高脂溶性ヌクレオチドビルディングブロックおよびこれを用いたオリゴヌクレオチドの合成 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2024228396A1 JPWO2024228396A1 (https=) | 2024-11-07 |
| JPWO2024228396A5 true JPWO2024228396A5 (https=) | 2026-02-02 |
Family
ID=93332921
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025518161A Pending JPWO2024228396A1 (https=) | 2023-05-01 | 2024-05-01 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP4707286A1 (https=) |
| JP (1) | JPWO2024228396A1 (https=) |
| KR (1) | KR20260003278A (https=) |
| CN (1) | CN121464145A (https=) |
| WO (1) | WO2024228396A1 (https=) |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5891684A (en) * | 1992-10-15 | 1999-04-06 | Ribozyme Pharmaceuticals, Inc. | Base-modified enzymatic nucleic acid |
| ATE245161T1 (de) * | 1995-05-26 | 2003-08-15 | Genta Inc | Verfahren zur synthese von phosphororganischen verbindungen |
| US20040033973A1 (en) * | 2002-08-16 | 2004-02-19 | Muthiah Manoharan | Compounds and oligomeric compounds comprising novel nucleobases |
| WO2005070859A1 (ja) | 2004-01-27 | 2005-08-04 | Takeshi Wada | フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法 |
| JP5901610B2 (ja) * | 2010-04-12 | 2016-04-13 | ソマロジック・インコーポレーテッド | ５位修飾ピリミジンとその使用 |
| EP2816053B1 (en) * | 2012-02-17 | 2021-03-24 | Ajinomoto Co., Inc. | Base-protected oligonucleotide |
| TWI729028B (zh) | 2015-11-17 | 2021-06-01 | 日商日產化學工業股份有限公司 | 寡核苷酸的製造方法 |
| US12139507B2 (en) | 2018-05-02 | 2024-11-12 | Natias Inc. | Segment for use in synthesis of oligonucleotide, method for producing the same, and method for synthesizing oligonucleotide using the same |
| JP7393807B2 (ja) | 2019-05-21 | 2023-12-07 | 株式会社ナティアス | オリゴヌクレオチド合成に用いるマルチフルオラスブロックマーおよびこれを用いたオリゴヌクレオチド合成方法 |
-
2024
- 2024-05-01 WO PCT/JP2024/016835 patent/WO2024228396A1/ja not_active Ceased
- 2024-05-01 JP JP2025518161A patent/JPWO2024228396A1/ja active Pending
- 2024-05-01 CN CN202480045211.9A patent/CN121464145A/zh active Pending
- 2024-05-01 KR KR1020257040241A patent/KR20260003278A/ko active Pending
- 2024-05-01 EP EP24800127.3A patent/EP4707286A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2519406B2 (ja) | 保護剤を結合したオリゴヌクレオチド連鎖を含む新規化合物、及び該新規化合物の製造方法 | |
| US5198540A (en) | Process for the preparation of oligonucleotides in solution | |
| EP0208599B1 (fr) | Nouveaux supports, leur préparation et les intermédiaires obtenus, leur application à la synthèse d'oligonucléotides et les nouveaux nucléosides et oligonucléotides reliés aux supports ainsi obtenus | |
| DE69115702T2 (de) | Verbindungen und verfahren zur unterdrückung der genexpression | |
| US8304532B2 (en) | Method for preparing oligonucleotides | |
| JP7075680B2 (ja) | オリゴヌクレオチド合成用セグメントおよびその製造方法、ならびにそれを用いたオリゴヌクレオチドの合成方法 | |
| CA1265756A (fr) | Supports, la preparation de ces supports les intermediaires obtenus, leur application a la synthesed'oligonucleotides et les nucleosides et oligonucleotides relies aux supports ainsi obtenus | |
| EP0438203A2 (fr) | Dérivés de nucléosides et leur utilisation pour la synthèse d'oligonucléotides | |
| DE112004000265B4 (de) | Neuartige photolabile Schutzgruppen für verbesserte Verfahren zur Herstellung von Oligonukleotid-Arrays | |
| US5623068A (en) | Synthesis of DNA using substituted phenylacetyl-protected nucleotides | |
| AU716391B2 (en) | Solid phase synthesis of oligonucleotides | |
| JP7393807B2 (ja) | オリゴヌクレオチド合成に用いるマルチフルオラスブロックマーおよびこれを用いたオリゴヌクレオチド合成方法 | |
| DE69609511T2 (de) | Neue Synthons für die stereoselektive Oligonuklodsynthese | |
| CN1262557C (zh) | 制备硫代磷酸三酯的方法 | |
| DE69401136T2 (de) | Modifizierte Oligodeoxyribonukleotide, ihre Herstellung und ihre therapeutische Verwendung | |
| EP0816368B1 (en) | Chemical phoshorylation of oligonucleotides and reactants used therefor | |
| JPWO2024228396A5 (https=) | ||
| JP5253578B2 (ja) | オリゴヌクレオチドの合成方法 | |
| JPH0291088A (ja) | ホスファイトおよびヌクレオシド‐３’‐ホスファイト誘導体およびこれを用いるオリゴヌクレオチドの合成法 | |
| CA3066968C (en) | Improved process for preparing imetelstat | |
| US6107479A (en) | Process for the preparation of an oligomeric compound | |
| WO2020158687A1 (ja) | 光応答性ヌクレオチドアナログの製造方法 | |
| CN114315935B (zh) | 亚磷酰胺化的核苷衍生物及其合成方法、应用和试剂盒 | |
| WO2024228396A1 (ja) | オリゴヌクレオチド合成用の高脂溶性ヌクレオチドビルディングブロックおよびこれを用いたオリゴヌクレオチドの合成 | |
| KR20160145828A (ko) | 열 불안정성 모이어티를 포함하는 화합물 조성물 및 방법 |