KR20260003278A - 올리고뉴클레오타이드 합성용 고지용성 뉴클레오타이드 빌딩 블록 및 이를 이용한 올리고뉴클레오타이드의 합성 - Google Patents

올리고뉴클레오타이드 합성용 고지용성 뉴클레오타이드 빌딩 블록 및 이를 이용한 올리고뉴클레오타이드의 합성

Info

Publication number
KR20260003278A
KR20260003278A KR1020257040241A KR20257040241A KR20260003278A KR 20260003278 A KR20260003278 A KR 20260003278A KR 1020257040241 A KR1020257040241 A KR 1020257040241A KR 20257040241 A KR20257040241 A KR 20257040241A KR 20260003278 A KR20260003278 A KR 20260003278A
Authority
KR
South Korea
Prior art keywords
oligonucleotide
tbdps
dmtr
mmtr
tmtr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
KR1020257040241A
Other languages
English (en)
Korean (ko)
Inventor
마사노리 카타오카
요헤이 츠지
치하루 후쿠이
리오 야마시타
케이이치 마츠모토
미즈키 와타리
유토 아카이
히데히코 코다마
Original Assignee
나티아스 인크.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 나티아스 인크. filed Critical 나티아스 인크.
Publication of KR20260003278A publication Critical patent/KR20260003278A/ko
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Saccharide Compounds (AREA)
KR1020257040241A 2023-05-01 2024-05-01 올리고뉴클레오타이드 합성용 고지용성 뉴클레오타이드 빌딩 블록 및 이를 이용한 올리고뉴클레오타이드의 합성 Pending KR20260003278A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202363499274P 2023-05-01 2023-05-01
US63/499,274 2023-05-01
PCT/JP2024/016835 WO2024228396A1 (ja) 2023-05-01 2024-05-01 オリゴヌクレオチド合成用の高脂溶性ヌクレオチドビルディングブロックおよびこれを用いたオリゴヌクレオチドの合成

Publications (1)

Publication Number Publication Date
KR20260003278A true KR20260003278A (ko) 2026-01-06

Family

ID=93332921

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020257040241A Pending KR20260003278A (ko) 2023-05-01 2024-05-01 올리고뉴클레오타이드 합성용 고지용성 뉴클레오타이드 빌딩 블록 및 이를 이용한 올리고뉴클레오타이드의 합성

Country Status (5)

Country Link
EP (1) EP4707286A1 (https=)
JP (1) JPWO2024228396A1 (https=)
KR (1) KR20260003278A (https=)
CN (1) CN121464145A (https=)
WO (1) WO2024228396A1 (https=)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005070859A1 (ja) 2004-01-27 2005-08-04 Takeshi Wada フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
WO2017086397A1 (ja) 2015-11-17 2017-05-26 日産化学工業株式会社 オリゴヌクレオチドの製造方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5891684A (en) * 1992-10-15 1999-04-06 Ribozyme Pharmaceuticals, Inc. Base-modified enzymatic nucleic acid
ATE245161T1 (de) * 1995-05-26 2003-08-15 Genta Inc Verfahren zur synthese von phosphororganischen verbindungen
US20040033973A1 (en) * 2002-08-16 2004-02-19 Muthiah Manoharan Compounds and oligomeric compounds comprising novel nucleobases
JP5901610B2 (ja) * 2010-04-12 2016-04-13 ソマロジック・インコーポレーテッド ５位修飾ピリミジンとその使用
EP2816053B1 (en) * 2012-02-17 2021-03-24 Ajinomoto Co., Inc. Base-protected oligonucleotide
US12139507B2 (en) 2018-05-02 2024-11-12 Natias Inc. Segment for use in synthesis of oligonucleotide, method for producing the same, and method for synthesizing oligonucleotide using the same
JP7393807B2 (ja) 2019-05-21 2023-12-07 株式会社ナティアス オリゴヌクレオチド合成に用いるマルチフルオラスブロックマーおよびこれを用いたオリゴヌクレオチド合成方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005070859A1 (ja) 2004-01-27 2005-08-04 Takeshi Wada フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
WO2017086397A1 (ja) 2015-11-17 2017-05-26 日産化学工業株式会社 オリゴヌクレオチドの製造方法

Also Published As

Publication number Publication date
WO2024228396A1 (ja) 2024-11-07
EP4707286A1 (en) 2026-03-11
JPWO2024228396A1 (https=) 2024-11-07
CN121464145A (zh) 2026-02-03

Similar Documents

Publication Publication Date Title
JP7803520B2 (ja) オリゴヌクレオチド合成用セグメントおよびその製造方法、ならびにそれを用いたオリゴヌクレオチドの合成方法
EP2609107B1 (en) Block synthesis of oligoribonucleotides
AU2998800A (en) N-acylphosphoramidites and their use in oligonucleotide synthesis
IE74706B1 (en) A method of linking nucleosides with a siloxane bridge
EP3398955A1 (en) Oligonucleotide production method, and nucleoside, nucleotide, or oligonucleotide
Gimenez Molina et al. Assembly of short oligoribonucleotides from commercially available building blocks on a tetrapodal soluble support
US12264174B2 (en) Process for preparing imetelstat
CN100484949C (zh) 用于rna寡核苷酸合成中的核苷亚磷酰胺及其合成方法
KR20260003278A (ko) 올리고뉴클레오타이드 합성용 고지용성 뉴클레오타이드 빌딩 블록 및 이를 이용한 올리고뉴클레오타이드의 합성
EP3925964A1 (en) Production method for oligonucleotides
JPH06135988A (ja) ヌクレオシド誘導体
CN117980285A (zh) 纯化二氯乙酸的制造方法
JP7818760B2 (ja) ヌクレオシド誘導体の製造方法
JPH11503425A (ja) 共有結合的に架橋されたオリゴヌクレオチド、その製造法、およびその製造法に用いられるシントン
WO2021080021A1 (ja) オリゴヌクレオチドを製造する方法
WO2021243443A1 (en) Method for the preparation of oligonucleotides
Nawrot et al. Bis (hydroxymethyl) phosphinic acid analogues of acyclic nucleosides; synthesis and incorporation into short DNA oligomers
JP2003002895A (ja) 核酸の合成法
Yagodkin et al. Universal linker phosphoramidite
US5726301A (en) CAC H-phosphonate and its use in the synthesis of oligonucleotides
Münch et al. The (2-Cyano-1-phenyl) ethoxycarbonyl (CPEOC) Group-A New Protecting Group for Oligoribonucleotide Synthesis
HK40031465A (en) Improved process for preparing imetelstat
HK40031465B (en) Improved process for preparing imetelstat
CN118852303A (zh) 胞苷乙烯基磷酸酯化合物的制备方法及其应用
WO2014022839A1 (en) Exocylic nitrogen atom protected nucloside and method for producing and using the same

Legal Events

Date Code Title Description
D11 Substantive examination requested

Free format text: ST27 STATUS EVENT CODE: A-1-2-D10-D11-EXM-PA0201 (AS PROVIDED BY THE NATIONAL OFFICE)

P11 Amendment of application requested

Free format text: ST27 STATUS EVENT CODE: A-2-2-P10-P11-NAP-X000 (AS PROVIDED BY THE NATIONAL OFFICE)

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

Q12 Application published

Free format text: ST27 STATUS EVENT CODE: A-1-1-Q10-Q12-NAP-PG1501 (AS PROVIDED BY THE NATIONAL OFFICE)