JPWO2024024551A5 - - Google Patents
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- Publication number
- JPWO2024024551A5 JPWO2024024551A5 JP2024537611A JP2024537611A JPWO2024024551A5 JP WO2024024551 A5 JPWO2024024551 A5 JP WO2024024551A5 JP 2024537611 A JP2024537611 A JP 2024537611A JP 2024537611 A JP2024537611 A JP 2024537611A JP WO2024024551 A5 JPWO2024024551 A5 JP WO2024024551A5
- Authority
- JP
- Japan
- Prior art keywords
- receptor
- cell
- artificial
- domain
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020003175 receptors Proteins 0.000 claims description 32
- 102000005962 receptors Human genes 0.000 claims description 32
- 108010031480 Artificial Receptors Proteins 0.000 claims description 26
- 210000002865 immune cell Anatomy 0.000 claims description 23
- 238000000034 method Methods 0.000 claims description 17
- 230000011664 signaling Effects 0.000 claims description 14
- 125000000539 amino acid group Chemical group 0.000 claims description 12
- 102000039446 nucleic acids Human genes 0.000 claims description 11
- 108020004707 nucleic acids Proteins 0.000 claims description 11
- 150000007523 nucleic acids Chemical class 0.000 claims description 11
- 239000003446 ligand Substances 0.000 claims description 9
- 230000019491 signal transduction Effects 0.000 claims description 8
- 210000001744 T-lymphocyte Anatomy 0.000 claims description 6
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims description 5
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims description 5
- 150000001413 amino acids Chemical class 0.000 claims description 5
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims description 4
- 108010087819 Fc receptors Proteins 0.000 claims description 4
- 102000009109 Fc receptors Human genes 0.000 claims description 4
- 102000004278 Receptor Protein-Tyrosine Kinases Human genes 0.000 claims description 4
- 108090000873 Receptor Protein-Tyrosine Kinases Proteins 0.000 claims description 4
- 108091008874 T cell receptors Proteins 0.000 claims description 4
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 claims description 4
- 210000002540 macrophage Anatomy 0.000 claims description 4
- 238000004519 manufacturing process Methods 0.000 claims description 4
- 210000000822 natural killer cell Anatomy 0.000 claims description 4
- 102000002659 Amyloid Precursor Protein Secretases Human genes 0.000 claims description 3
- 108010043324 Amyloid Precursor Protein Secretases Proteins 0.000 claims description 3
- 238000003776 cleavage reaction Methods 0.000 claims description 3
- 230000007017 scission Effects 0.000 claims description 3
- 101710137189 Amyloid-beta A4 protein Proteins 0.000 claims description 2
- 101710151993 Amyloid-beta precursor protein Proteins 0.000 claims description 2
- 102100022704 Amyloid-beta precursor protein Human genes 0.000 claims description 2
- 108010070047 Notch Receptors Proteins 0.000 claims description 2
- 102000005650 Notch Receptors Human genes 0.000 claims description 2
- DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 claims description 2
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 230000001105 regulatory effect Effects 0.000 claims description 2
- 230000005883 trogocytosis Effects 0.000 claims description 2
- 150000003668 tyrosines Chemical class 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 description 5
- 201000011510 cancer Diseases 0.000 description 5
- 239000008177 pharmaceutical agent Substances 0.000 description 3
- 241000124008 Mammalia Species 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022118674 | 2022-07-26 | ||
| PCT/JP2023/026123 WO2024024551A1 (ja) | 2022-07-26 | 2023-07-14 | シェディング構造を有する人工受容体 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2024024551A1 JPWO2024024551A1 (https=) | 2024-02-01 |
| JPWO2024024551A5 true JPWO2024024551A5 (https=) | 2025-04-16 |
Family
ID=89706357
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024537611A Pending JPWO2024024551A1 (https=) | 2022-07-26 | 2023-07-14 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20250361285A1 (https=) |
| EP (1) | EP4563703A4 (https=) |
| JP (1) | JPWO2024024551A1 (https=) |
| CN (1) | CN119744302A (https=) |
| WO (1) | WO2024024551A1 (https=) |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4937190A (en) | 1987-10-15 | 1990-06-26 | Wisconsin Alumni Research Foundation | Translation enhancer |
| US8278104B2 (en) | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US8048999B2 (en) | 2005-12-13 | 2011-11-01 | Kyoto University | Nuclear reprogramming factor |
| US7661738B2 (en) | 2006-11-28 | 2010-02-16 | Veritainer Corporation | Radiation detection unit for mounting a radiation sensor to a container crane |
| JP5813321B2 (ja) | 2007-03-23 | 2015-11-17 | ウィスコンシン アラムニ リサーチ ファンデーション | 体細胞の再プログラム化 |
| CN105861443A (zh) | 2007-04-07 | 2016-08-17 | 怀特黑德生物医学研究所 | 体细胞重编程 |
| EP2164951A2 (en) | 2007-05-30 | 2010-03-24 | The General Hospital Corporation | Methods of generating pluripotent cells from somatic cells |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| SG11201402502RA (en) | 2011-11-21 | 2015-01-29 | Sunnybrook Res Inst | Populations of hematopoietic progenitors and methods of enriching stem cells therefor |
| US10660915B2 (en) | 2014-11-13 | 2020-05-26 | Kyoto University | Method for induction of T cells from pluripotent stem cells |
| EP4289944A3 (en) * | 2015-10-08 | 2024-03-13 | National University Corporation Tokai National Higher Education and Research System | Method for preparing genetically-modified t cells which express chimeric antigen receptor |
| BR112019006006A2 (pt) * | 2016-09-28 | 2019-06-25 | Gavish-Galilee Bio Applications Ltd. | molécula de ácido nucleico, vetor, métodos para preparação de um receptor de antígeno quimérico inibidor, para preparar uma célula imune efetora segura, para selecionar um biomarcador personalizado e para tratar o câncer em um paciente com um tumor, célula imune efetora segura, e, combinação de duas ou mais moléculas de ácido nucleico. |
| US12454562B2 (en) * | 2018-12-06 | 2025-10-28 | The Board Of Trustees Of The Leland Stanford Junior University | Regulatable cell surface receptors and related compositions and methods |
| EP3966236A4 (en) * | 2019-05-07 | 2023-05-10 | The Board of Trustees of the Leland Stanford Junior University | Enhancement of polypeptides and chimeric antigen receptors via hinge domains |
| WO2021100585A1 (ja) * | 2019-11-20 | 2021-05-27 | 国立大学法人東海国立大学機構 | キメラ抗原受容体遺伝子改変リンパ球の調製方法 |
| US20230257705A1 (en) * | 2020-06-17 | 2023-08-17 | Kyoto University | Chimeric antigen receptor-expressing immunocompetent cells |
| JP2023535371A (ja) * | 2020-07-17 | 2023-08-17 | シミュレックス インコーポレイテッド | 免疫抑制シグナル伝達をリダイレクトするためのキメラＭｙＤ８８受容体ならびに関連する組成物および方法 |
| JP7096959B1 (ja) | 2021-02-02 | 2022-07-07 | 有限会社ル・グランクール | 自爪の発育促進方法 |
-
2023
- 2023-07-14 WO PCT/JP2023/026123 patent/WO2024024551A1/ja not_active Ceased
- 2023-07-14 US US18/998,362 patent/US20250361285A1/en active Pending
- 2023-07-14 JP JP2024537611A patent/JPWO2024024551A1/ja active Pending
- 2023-07-14 EP EP23846282.4A patent/EP4563703A4/en active Pending
- 2023-07-14 CN CN202380056553.6A patent/CN119744302A/zh active Pending
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