|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4946778A
(en)
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5260203A
(en)
|
1986-09-02 |
1993-11-09 |
Enzon, Inc. |
Single polypeptide chain binding molecules
|
|
ATE87659T1
(de)
|
1986-09-02 |
1993-04-15 |
Enzon Lab Inc |
Bindungsmolekuele mit einzelpolypeptidkette.
|
|
CA2018248A1
(en)
|
1989-06-07 |
1990-12-07 |
Clyde W. Shearman |
Monoclonal antibodies against the human alpha/beta t-cell receptor, their production and use
|
|
DE3920358A1
(de)
|
1989-06-22 |
1991-01-17 |
Behringwerke Ag |
Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
|
|
EP1400536A1
(en)
|
1991-06-14 |
2004-03-24 |
Genentech Inc. |
Method for making humanized antibodies
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
DE69232137T2
(de)
|
1991-11-25 |
2002-05-29 |
Enzon Inc |
Multivalente antigen-bindende proteine
|
|
US5885573A
(en)
|
1993-06-01 |
1999-03-23 |
Arch Development Corporation |
Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
|
|
US6242568B1
(en)
|
1994-01-18 |
2001-06-05 |
The Scripps Research Institute |
Zinc finger protein derivatives and methods therefor
|
|
US6140466A
(en)
|
1994-01-18 |
2000-10-31 |
The Scripps Research Institute |
Zinc finger protein derivatives and methods therefor
|
|
ATE524545T1
(de)
|
1994-08-20 |
2011-09-15 |
Gendaq Ltd |
Verbesserungen bei oder im zusammenhang mit bindeproteinen zur erkennung von dna
|
|
GB9824544D0
(en)
|
1998-11-09 |
1999-01-06 |
Medical Res Council |
Screening system
|
|
US5789538A
(en)
|
1995-02-03 |
1998-08-04 |
Massachusetts Institute Of Technology |
Zinc finger proteins with high affinity new DNA binding specificities
|
|
US5925523A
(en)
|
1996-08-23 |
1999-07-20 |
President & Fellows Of Harvard College |
Intraction trap assay, reagents and uses thereof
|
|
GB2338237B
(en)
|
1997-02-18 |
2001-02-28 |
Actinova Ltd |
In vitro peptide or protein expression library
|
|
GB9703369D0
(en)
|
1997-02-18 |
1997-04-09 |
Lindqvist Bjorn H |
Process
|
|
GB9710809D0
(en)
|
1997-05-23 |
1997-07-23 |
Medical Res Council |
Nucleic acid binding proteins
|
|
CA2304208A1
(en)
|
1997-09-19 |
1999-03-25 |
Dana-Farber Cancer Institute, Inc. |
Intrabody-mediated control of immune reactions
|
|
US6410248B1
(en)
|
1998-01-30 |
2002-06-25 |
Massachusetts Institute Of Technology |
General strategy for selecting high-affinity zinc finger proteins for diverse DNA target sites
|
|
US6453242B1
(en)
|
1999-01-12 |
2002-09-17 |
Sangamo Biosciences, Inc. |
Selection of sites for targeting by zinc finger proteins and methods of designing zinc finger proteins to bind to preselected sites
|
|
US6534261B1
(en)
|
1999-01-12 |
2003-03-18 |
Sangamo Biosciences, Inc. |
Regulation of endogenous gene expression in cells using zinc finger proteins
|
|
US6794136B1
(en)
|
2000-11-20 |
2004-09-21 |
Sangamo Biosciences, Inc. |
Iterative optimization in the design of binding proteins
|
|
US20030044787A1
(en)
|
2000-05-16 |
2003-03-06 |
Joung J. Keith |
Methods and compositions for interaction trap assays
|
|
PT1377314E
(pt)
*
|
2001-01-26 |
2012-01-02 |
Inhibitex Inc |
Anticorpos monoclonais para a proteína clfa e método de utilização no tratamento ou prevenção de infecções
|
|
CA2461290C
(en)
|
2001-09-24 |
2014-11-25 |
Sangamo Biosciences, Inc. |
Modulation of stem cells using zinc finger proteins
|
|
AU2002361390A1
(en)
|
2001-12-14 |
2003-06-30 |
Friedrich-Alexander-Universitaet Erlangen-Nuernberg |
Anti-cd7 immunotoxin as fusion protein
|
|
BR0316101A
(pt)
*
|
2002-11-07 |
2005-09-27 |
Immunogen Inc |
Anticorpos anticd33 e processo para tratamento de leucemia melóide aguda usando os mesmos
|
|
US20090191213A9
(en)
|
2003-07-02 |
2009-07-30 |
Novo Nordisk A/S |
Compositions and methods for regulating NK cell activity
|
|
ES2393485T3
(es)
|
2003-07-02 |
2012-12-21 |
Innate Pharma |
Anticuerpos del receptor de NK pan-kir2dl y su uso en diagnóstico y terapia
|
|
US7888121B2
(en)
|
2003-08-08 |
2011-02-15 |
Sangamo Biosciences, Inc. |
Methods and compositions for targeted cleavage and recombination
|
|
US8409861B2
(en)
|
2003-08-08 |
2013-04-02 |
Sangamo Biosciences, Inc. |
Targeted deletion of cellular DNA sequences
|
|
WO2005017163A2
(en)
|
2003-08-15 |
2005-02-24 |
Imperial College Innovations Limited |
Phenotypic knockout of cell-surface proteins
|
|
US7435596B2
(en)
|
2004-11-04 |
2008-10-14 |
St. Jude Children's Research Hospital, Inc. |
Modified cell line and method for expansion of NK cell
|
|
US20130266551A1
(en)
|
2003-11-05 |
2013-10-10 |
St. Jude Children's Research Hospital, Inc. |
Chimeric receptors with 4-1bb stimulatory signaling domain
|
|
EP2287195B1
(en)
|
2004-07-01 |
2019-05-15 |
Novo Nordisk A/S |
Pan-kir2dl nk-receptor antibodies and their use in diagnostik and therapy
|
|
WO2006047637A1
(en)
|
2004-10-27 |
2006-05-04 |
Medimmune, Inc. |
Use of modulators of epha2 and ephrina1 for the treatment and prevention of infections
|
|
EP3072522B1
(en)
|
2005-01-06 |
2019-04-24 |
Novo Nordisk A/S |
Anti-kir combination treatments and methods
|
|
US20070036773A1
(en)
|
2005-08-09 |
2007-02-15 |
City Of Hope |
Generation and application of universal T cells for B-ALL
|
|
WO2007044616A2
(en)
|
2005-10-06 |
2007-04-19 |
Xencor, Inc. |
Optimized anti-cd30 antibodies
|
|
CN101675075B
(zh)
|
2007-03-01 |
2014-06-18 |
西福根有限公司 |
重组抗表皮生长因子受体抗体组合物
|
|
DK2185574T3
(da)
|
2007-09-07 |
2013-08-05 |
Agensys Inc |
Antistoffer og relaterede molekyler, der bindes til 24P4C12-proteiner
|
|
US8563314B2
(en)
|
2007-09-27 |
2013-10-22 |
Sangamo Biosciences, Inc. |
Methods and compositions for modulating PD1
|
|
EP2628753A1
(en)
|
2008-01-24 |
2013-08-21 |
Novo Nordisk A/S |
Humanized anti-human NKG2A monoclonal antibody
|
|
ES2826883T3
(es)
|
2009-10-14 |
2021-05-19 |
Janssen Biotech Inc |
Métodos de maduración por afinidad de anticuerpos
|
|
US9273283B2
(en)
|
2009-10-29 |
2016-03-01 |
The Trustees Of Dartmouth College |
Method of producing T cell receptor-deficient T cells expressing a chimeric receptor
|
|
PH12013501201A1
(en)
|
2010-12-09 |
2013-07-29 |
Univ Pennsylvania |
Use of chimeric antigen receptor-modified t cells to treat cancer
|
|
US8841418B2
(en)
*
|
2011-07-01 |
2014-09-23 |
Cellerant Therapeutics, Inc. |
Antibodies that specifically bind to TIM3
|
|
WO2013126712A1
(en)
|
2012-02-22 |
2013-08-29 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer
|
|
EP3241902B1
(en)
|
2012-05-25 |
2018-02-28 |
The Regents of The University of California |
Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
|
|
LT4461308T
(lt)
|
2012-07-13 |
2025-06-10 |
The Trustees Of The University Of Pennsylvania |
Car priešnavikinio aktyvumo toksiškumo valdymas
|
|
KR20150029714A
(ko)
|
2012-07-13 |
2015-03-18 |
더 트러스티스 오브 더 유니버시티 오브 펜실바니아 |
이중특이적 항체의 공-도입에 의한 car 세포의 활성 증강
|
|
EP2906684B8
(en)
|
2012-10-10 |
2020-09-02 |
Sangamo Therapeutics, Inc. |
T cell modifying compounds and uses thereof
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
KR101521224B1
(ko)
|
2012-12-20 |
2015-05-19 |
한양대학교 산학협력단 |
T 세포 특이적인 인간화 단일조각항체 전달체
|
|
WO2014106123A1
(en)
|
2012-12-27 |
2014-07-03 |
Aduro Biotech, Inc. |
Signal peptide fusion partners facilitating listerial expression of antigenic sequences and methods of preparation and use thereof
|
|
SG11201507026WA
(en)
|
2013-02-06 |
2015-10-29 |
Anthrogenesis Corp |
Modified t lymphocytes having improved specificity
|
|
US11311575B2
(en)
|
2013-05-13 |
2022-04-26 |
Cellectis |
Methods for engineering highly active T cell for immunotherapy
|
|
WO2014191128A1
(en)
|
2013-05-29 |
2014-12-04 |
Cellectis |
Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
|
|
US20160296562A1
(en)
|
2013-11-21 |
2016-10-13 |
Ucl Business Plc |
Cell
|
|
ES3063961T3
(en)
|
2014-02-14 |
2026-04-21 |
Cellectis |
Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
|
|
GB201405845D0
(en)
|
2014-04-01 |
2014-05-14 |
Ucl Business Plc |
Signalling system
|
|
RU2763795C2
(ru)
|
2014-04-23 |
2022-01-11 |
Джуно Терапьютикс, Инк. |
Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии
|
|
AU2015289644A1
(en)
|
2014-07-15 |
2017-02-02 |
Juno Therapeutics, Inc. |
Engineered cells for adoptive cell therapy
|
|
JP2017531430A
(ja)
|
2014-10-07 |
2017-10-26 |
セレクティスCellectis |
Carによって誘導される免疫細胞の活性を調節するための方法
|
|
KR102376244B1
(ko)
|
2014-12-24 |
2022-03-21 |
오토러스 리미티드 |
세포
|
|
CN113713091A
(zh)
|
2015-02-06 |
2021-11-30 |
新加坡国立大学 |
工程免疫细胞及其用途和生产方法
|
|
JP7237449B2
(ja)
|
2015-02-27 |
2023-03-13 |
アイセル・ジーン・セラピューティクス・エルエルシー |
血液系腫瘍を標的としたキメラ抗体受容体(CARs)の構成およびその使用方法
|
|
KR102133857B1
(ko)
|
2015-03-02 |
2020-07-20 |
이노베이티브 셀룰러 테라퓨틱스 코퍼레이션 리미티드 |
Pd-l1에 의해 유도된 면역관용의 감소
|
|
EP3294342A4
(en)
|
2015-05-08 |
2018-11-07 |
President and Fellows of Harvard College |
Universal donor stem cells and related methods
|
|
IL295224B2
(en)
|
2015-05-28 |
2025-07-01 |
Kite Pharma Inc |
Methods of conditioning patients for t cell therapy
|
|
US10751416B2
(en)
*
|
2015-07-13 |
2020-08-25 |
Centre Hospitalier Universitaire Vaudois (Chuv) |
IL-26 inhibitors
|
|
GB2592821B
(en)
|
2015-07-31 |
2022-01-12 |
Univ Minnesota |
Modified cells and methods of therapy
|
|
SG11201803330WA
(en)
|
2015-10-22 |
2018-05-30 |
Juno Therapeutics Gmbh |
Methods for culturing cells and kits and apparatus for same
|
|
CN108463547A
(zh)
|
2015-10-28 |
2018-08-28 |
生命技术股份公司 |
通过改变细胞表面信号和信号比选择性扩增不同的t细胞亚群
|
|
US11390658B2
(en)
|
2016-06-06 |
2022-07-19 |
St. Jude Children's Research Hospital |
Anti-CD7 chimeric antigen receptor and method of use thereof
|
|
CA2937157A1
(en)
|
2016-07-25 |
2018-01-25 |
Ucl Business Ltd |
Protein-based t-cell receptor knockdown
|
|
NZ750256A
(en)
|
2016-08-03 |
2026-02-27 |
Dipersio John F |
Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors
|
|
WO2018073393A2
(en)
|
2016-10-19 |
2018-04-26 |
Cellectis |
Tal-effector nuclease (talen) -modified allogenic cells suitable for therapy
|
|
SG11201903830TA
(en)
|
2016-11-22 |
2019-05-30 |
Nat Univ Singapore |
Blockade of cd7 expression and chimeric antigen receptors for immunotherapy of t-cell malignancies
|
|
US20190038733A1
(en)
|
2017-08-10 |
2019-02-07 |
National University Of Singapore |
T cell receptor-deficient chimeric antigen receptor t-cells and methods of use thereof
|
|
KR20210008408A
(ko)
|
2018-05-23 |
2021-01-21 |
싱가포르국립대학교 |
T-세포 악성 종양의 면역요법을 위한 cd2 표면 발현 및 키메라 항원 수용체의 발현에 대한 차단
|
|
WO2019226946A1
(en)
|
2018-05-23 |
2019-11-28 |
National University Of Singapore |
Chimeric antigen receptors and gene editing of cd2 for immunotherapy of t-cell malignancies
|