JP2021525067A5 - - Google Patents

Info

Publication number
JP2021525067A5
JP2021525067A5 JP2020564146A JP2020564146A JP2021525067A5 JP 2021525067 A5 JP2021525067 A5 JP 2021525067A5 JP 2020564146 A JP2020564146 A JP 2020564146A JP 2020564146 A JP2020564146 A JP 2020564146A JP 2021525067 A5 JP2021525067 A5 JP 2021525067A5
Authority
JP
Japan
Prior art keywords
cell
manipulated
immune cells
seq
sequence
Prior art date
Application number
JP2020564146A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2019226946A5 (https=
JP2021525067A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2019/033837 external-priority patent/WO2019226946A1/en
Publication of JP2021525067A publication Critical patent/JP2021525067A/ja
Publication of JPWO2019226946A5 publication Critical patent/JPWO2019226946A5/ja
Publication of JP2021525067A5 publication Critical patent/JP2021525067A5/ja
Pending legal-status Critical Current

Links

JP2020564146A 2018-05-23 2019-05-23 T細胞悪性腫瘍の免疫療法のためのキメラ抗原受容体およびcd2の遺伝子編集 Pending JP2021525067A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862675525P 2018-05-23 2018-05-23
US62/675,525 2018-05-23
PCT/US2019/033837 WO2019226946A1 (en) 2018-05-23 2019-05-23 Chimeric antigen receptors and gene editing of cd2 for immunotherapy of t-cell malignancies

Publications (3)

Publication Number Publication Date
JP2021525067A JP2021525067A (ja) 2021-09-24
JPWO2019226946A5 JPWO2019226946A5 (https=) 2022-05-25
JP2021525067A5 true JP2021525067A5 (https=) 2022-05-25

Family

ID=68617214

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2020564146A Pending JP2021525067A (ja) 2018-05-23 2019-05-23 T細胞悪性腫瘍の免疫療法のためのキメラ抗原受容体およびcd2の遺伝子編集

Country Status (6)

Country Link
US (1) US20210214439A1 (https=)
EP (1) EP3784777A4 (https=)
JP (1) JP2021525067A (https=)
CN (1) CN112166186A (https=)
SG (1) SG11202101094TA (https=)
WO (1) WO2019226946A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20210008408A (ko) 2018-05-23 2021-01-21 싱가포르국립대학교 T-세포 악성 종양의 면역요법을 위한 cd2 표면 발현 및 키메라 항원 수용체의 발현에 대한 차단
KR20210091250A (ko) * 2018-11-14 2021-07-21 메디식스 테라퓨틱스 피티이 엘티디. Car-t 세포를 생성하기 위한 이중유전자 벡터 및 이의 용도
CN113667773A (zh) * 2021-08-19 2021-11-19 南昌艾迪康医学检验实验室有限公司 检测CarT细胞中是否存在RCL污染的引物、探针及试剂盒
EP4568685A2 (en) * 2022-08-11 2025-06-18 Medisix Therapeutics, Inc. Engineered immune cells expressing a car and a plurality of protein expression blockers and uses thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7237449B2 (ja) * 2015-02-27 2023-03-13 アイセル・ジーン・セラピューティクス・エルエルシー 血液系腫瘍を標的としたキメラ抗体受容体(CARs)の構成およびその使用方法
EP3294342A4 (en) * 2015-05-08 2018-11-07 President and Fellows of Harvard College Universal donor stem cells and related methods
NZ750256A (en) * 2016-08-03 2026-02-27 Dipersio John F Gene editing of car-t cells for the treatment of t cell malignancies with chimeric antigen receptors

Similar Documents

Publication Publication Date Title
CN110268049B (zh) 用于t细胞恶性肿瘤免疫疗法的cd7表达阻滞剂和嵌合抗原受体
Dai et al. Chimeric antigen receptors modified T-cells for cancer therapy
Dougan et al. Immune therapy for cancer
US20240197884A1 (en) Compositions and methods for targeted tumor immunotherapy
JP2022003043A (ja) 養子t細胞療法と腫瘍溶解性ウイルス補助療法とを組み合わせる方法
JP2019532953A (ja) 増強された有効性を有する免疫エフェクター細胞治療
CA3001859A1 (en) Compositions and methods for inhibition of lineage specific antigens
JP2021525067A5 (https=)
JP2021525068A5 (https=)
CN112867498A (zh) 使用嵌合抗原受体基因组编辑和转导t细胞以用于治疗t和b细胞恶性肿瘤的方法
JP7227630B2 (ja) Y182t突然変異を有するt細胞-抗原カプラおよびその方法ならびに使用
JP2021500878A (ja) 免疫療法のためのt細胞受容体
JP7812549B2 (ja) 人工免疫監視キメラ抗原受容体(ai-car)及びそれを発現する細胞
JP2020536531A (ja) 免疫療法としてのpd1特異的キメラ抗原受容体
Danhof et al. CARs and other T cell therapies for MM: the clinical experience
KR20240116708A (ko) 자연 살해 세포 및 이의 사용 방법
JP2021530971A (ja) 様々な構築物最適化を備えたt細胞抗原カプラ
JP2025525864A (ja) ナチュラルキラー細胞の機能を増強するための標的遺伝子の遺伝子編集
Savani et al. New targets for CAR T therapy in hematologic malignancies
JP2024519614A (ja) Prame特異的t細胞受容体とキメラ補助刺激受容体との組合せ
CN112585162B (zh) Ha-1特异性t细胞受体及其用途
EP4051317A1 (en) Sequential anti-cd19 therapy
CN109554349B (zh) Pd-1基因表达沉默的工程化免疫细胞
KR20200118010A (ko) 암의 만성 car 치료
JPWO2019226946A5 (https=)