JPWO2023182274A5 - - Google Patents
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- Publication number
- JPWO2023182274A5 JPWO2023182274A5 JP2024510168A JP2024510168A JPWO2023182274A5 JP WO2023182274 A5 JPWO2023182274 A5 JP WO2023182274A5 JP 2024510168 A JP2024510168 A JP 2024510168A JP 2024510168 A JP2024510168 A JP 2024510168A JP WO2023182274 A5 JPWO2023182274 A5 JP WO2023182274A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- formula
- same
- nucleic acid
- hydrogen atom
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 238000000034 method Methods 0.000 claims 19
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 11
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 7
- 239000002773 nucleotide Substances 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 125000004432 carbon atom Chemical group C* 0.000 claims 6
- 238000007348 radical reaction Methods 0.000 claims 6
- 239000002683 reaction inhibitor Substances 0.000 claims 6
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 5
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 5
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 5
- 125000000548 ribosyl group Chemical group C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000004414 alkyl thio group Chemical group 0.000 claims 4
- 239000003963 antioxidant agent Substances 0.000 claims 4
- 230000003078 antioxidant effect Effects 0.000 claims 4
- 125000004452 carbocyclyl group Chemical group 0.000 claims 4
- 125000000623 heterocyclic group Chemical group 0.000 claims 4
- 125000003729 nucleotide group Chemical group 0.000 claims 4
- 125000006239 protecting group Chemical group 0.000 claims 4
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 230000000977 initiatory effect Effects 0.000 claims 3
- 150000002978 peroxides Chemical class 0.000 claims 3
- 239000002516 radical scavenger Substances 0.000 claims 3
- 150000003254 radicals Chemical group 0.000 claims 3
- 125000001424 substituent group Chemical group 0.000 claims 3
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 2
- -1 alkylammonium ion Chemical class 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 125000003368 amide group Chemical group 0.000 claims 2
- 150000001412 amines Chemical class 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 claims 2
- 125000000219 ethylidene group Chemical group [H]C(=[*])C([H])([H])[H] 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 239000004611 light stabiliser Substances 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 125000001981 tert-butyldimethylsilyl group Chemical group [H]C([H])([H])[Si]([H])(C([H])([H])[H])[*]C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical group [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 claims 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical group [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 1
- 229910001413 alkali metal ion Inorganic materials 0.000 claims 1
- GPRLSGONYQIRFK-UHFFFAOYSA-N hydron Chemical compound [H+] GPRLSGONYQIRFK-UHFFFAOYSA-N 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 239000006078 metal deactivator Substances 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 229910052698 phosphorus Inorganic materials 0.000 claims 1
- 239000011574 phosphorus Substances 0.000 claims 1
- 239000011593 sulfur Substances 0.000 claims 1
- 125000004434 sulfur atom Chemical group 0.000 claims 1
- 125000005207 tetraalkylammonium group Chemical group 0.000 claims 1
- 229940124543 ultraviolet light absorber Drugs 0.000 claims 1
- 239000006097 ultraviolet radiation absorber Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022047341 | 2022-03-23 | ||
| PCT/JP2023/010891 WO2023182274A1 (ja) | 2022-03-23 | 2023-03-20 | 核酸オリゴマーの製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2023182274A1 JPWO2023182274A1 (https=) | 2023-09-28 |
| JPWO2023182274A5 true JPWO2023182274A5 (https=) | 2024-12-03 |
Family
ID=88100953
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024510168A Pending JPWO2023182274A1 (https=) | 2022-03-23 | 2023-03-20 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US12509485B2 (https=) |
| EP (1) | EP4488282A4 (https=) |
| JP (1) | JPWO2023182274A1 (https=) |
| KR (1) | KR20240162536A (https=) |
| CN (1) | CN118891269A (https=) |
| WO (1) | WO2023182274A1 (https=) |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6077709A (en) | 1998-09-29 | 2000-06-20 | Isis Pharmaceuticals Inc. | Antisense modulation of Survivin expression |
| DK1149109T3 (da) | 1999-02-05 | 2010-01-11 | Ge Healthcare Bio Sciences | Fremgangsmåde til afbeskyttelse af oligonukleotider |
| US6261840B1 (en) | 2000-01-18 | 2001-07-17 | Isis Pharmaceuticals, Inc. | Antisense modulation of PTP1B expression |
| ES2386709T3 (es) | 2004-08-26 | 2012-08-27 | Nippon Shinyaku Co., Ltd. | Compuesto de fosforamidita y método para producir un oligo-ARN |
| US8158775B2 (en) * | 2006-02-27 | 2012-04-17 | Nippon Shinyaku Co., Ltd. | Method for detaching protecting group on nucleic acid |
| WO2008049085A1 (en) | 2006-10-18 | 2008-04-24 | Isis Pharmaceuticals, Inc. | Antisense compounds |
| HUE037500T2 (hu) | 2010-07-08 | 2018-08-28 | Bonac Corp | Egyszálú nukleinsav molekula a génexpresszió szabályozására |
| ES2527660T3 (es) | 2010-08-03 | 2015-01-28 | Bonac Corporation | Molécula de ARN monocatenario que tiene esqueleto alicíclico que contiene nitrógeno |
| WO2013027843A1 (ja) | 2011-08-25 | 2013-02-28 | 株式会社ボナック | 配糖体化合物、チオエーテルの製造方法、エーテル、エーテルの製造方法、配糖体化合物の製造方法、核酸の製造方法 |
| US9528111B2 (en) | 2012-01-07 | 2016-12-27 | Bonac Corporation | Single-stranded nucleic acid molecule having amino acid backbone |
| EP3241902B1 (en) | 2012-05-25 | 2018-02-28 | The Regents of The University of California | Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription |
| US10900034B2 (en) | 2014-12-03 | 2021-01-26 | Agilent Technologies, Inc. | Guide RNA with chemical modifications |
| JP6787398B2 (ja) | 2016-04-26 | 2020-11-18 | 住友化学株式会社 | 一本鎖核酸分子用モノマーの製造方法 |
| EP3604528A4 (en) | 2017-03-31 | 2021-01-13 | Bonac Corporation | CYCLIC NUCLEIC ACID MOLECULE WITH GENE EXPRESSION CONTROL FUNCTION |
| KR20250046363A (ko) | 2017-09-19 | 2025-04-02 | 알닐람 파마슈티칼스 인코포레이티드 | 트랜스타이레틴(ttr) 매개 아밀로이드증을 치료하기 위한 조성물 및 방법 |
| US20210188895A1 (en) | 2017-10-13 | 2021-06-24 | Bonac Corporation | Single-stranded nucleic acid molecule, and production method therefor |
| TWI830718B (zh) * | 2018-02-09 | 2024-02-01 | 日商住友化學股份有限公司 | 核酸分子之製造方法 |
| US20230192755A1 (en) * | 2020-04-14 | 2023-06-22 | Sumitomo Chemical Company, Limited | Composition containing nucleic acid oligomer |
| US20230242570A1 (en) * | 2020-07-09 | 2023-08-03 | Sumitomo Chemical Company, Limited | Method for producing nucleic acid oligomer |
| JP7570858B2 (ja) | 2020-09-11 | 2024-10-22 | 日鉄ステンレス株式会社 | マルテンサイト系ステンレス鋼板およびマルテンサイト系ステンレス鋼板の製造方法 |
| JP7719788B2 (ja) * | 2020-09-24 | 2025-08-06 | 住友化学株式会社 | 核酸オリゴマーの製造方法 |
-
2023
- 2023-03-20 KR KR1020247034021A patent/KR20240162536A/ko active Pending
- 2023-03-20 CN CN202380028404.9A patent/CN118891269A/zh active Pending
- 2023-03-20 EP EP23774869.4A patent/EP4488282A4/en active Pending
- 2023-03-20 WO PCT/JP2023/010891 patent/WO2023182274A1/ja not_active Ceased
- 2023-03-20 US US18/848,797 patent/US12509485B2/en active Active
- 2023-03-20 JP JP2024510168A patent/JPWO2023182274A1/ja active Pending
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