JPWO2023095896A5 - - Google Patents
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- Publication number
- JPWO2023095896A5 JPWO2023095896A5 JP2023562172A JP2023562172A JPWO2023095896A5 JP WO2023095896 A5 JPWO2023095896 A5 JP WO2023095896A5 JP 2023562172 A JP2023562172 A JP 2023562172A JP 2023562172 A JP2023562172 A JP 2023562172A JP WO2023095896 A5 JPWO2023095896 A5 JP WO2023095896A5
- Authority
- JP
- Japan
- Prior art keywords
- condition
- genetically modified
- microorganism
- aspartic acid
- activity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 244000005700 microbiome Species 0.000 claims 18
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 11
- 230000000694 effects Effects 0.000 claims 11
- 235000003704 aspartic acid Nutrition 0.000 claims 9
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 9
- 108091000041 Phosphoenolpyruvate Carboxylase Proteins 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 3
- 229940024606 amino acid Drugs 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 3
- 102000019259 Succinate Dehydrogenase Human genes 0.000 claims 2
- 108010012901 Succinate Dehydrogenase Proteins 0.000 claims 2
- 229940009098 aspartate Drugs 0.000 claims 2
- 239000006227 byproduct Substances 0.000 claims 2
- 230000005764 inhibitory process Effects 0.000 claims 2
- 150000007524 organic acids Chemical class 0.000 claims 2
- 239000000047 product Substances 0.000 claims 2
- 108010030844 2-methylcitrate synthase Proteins 0.000 claims 1
- 101710157142 2-methylene-furan-3-one reductase Proteins 0.000 claims 1
- 108010017192 4-hydroxy-4-methyl-2-oxoglutarate aldolase Proteins 0.000 claims 1
- 102100029589 Acylpyruvase FAHD1, mitochondrial Human genes 0.000 claims 1
- 108010071536 Citrate (Si)-synthase Proteins 0.000 claims 1
- 102000006732 Citrate synthase Human genes 0.000 claims 1
- 241000192125 Firmicutes Species 0.000 claims 1
- 102000003855 L-lactate dehydrogenase Human genes 0.000 claims 1
- 108700023483 L-lactate dehydrogenases Proteins 0.000 claims 1
- 108010069823 Oxaloacetate decarboxylase Proteins 0.000 claims 1
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 claims 1
- 101710189291 Quinone oxidoreductase Proteins 0.000 claims 1
- 102100034576 Quinone oxidoreductase Human genes 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 235000005985 organic acids Nutrition 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- DTBNBXWJWCWCIK-UHFFFAOYSA-N phosphoenolpyruvic acid Chemical class OC(=O)C(=C)OP(O)(O)=O DTBNBXWJWCWCIK-UHFFFAOYSA-N 0.000 claims 1
- 239000012429 reaction media Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021192344 | 2021-11-26 | ||
| PCT/JP2022/043626 WO2023095896A1 (ja) | 2021-11-26 | 2022-11-25 | 遺伝子組換え微生物、及びアスパラギン酸を生産する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPWO2023095896A1 JPWO2023095896A1 (https=) | 2023-06-01 |
| JPWO2023095896A5 true JPWO2023095896A5 (https=) | 2023-12-06 |
Family
ID=86539606
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023562172A Pending JPWO2023095896A1 (https=) | 2021-11-26 | 2022-11-25 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US20250197901A1 (https=) |
| JP (1) | JPWO2023095896A1 (https=) |
| WO (1) | WO2023095896A1 (https=) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58170488A (ja) * | 1982-03-31 | 1983-10-07 | Ajinomoto Co Inc | 発酵法によるｌ−アスパラギン酸の製造法 |
| EP1922405A4 (en) * | 2005-08-05 | 2009-04-01 | Univ Michigan State | GENE FROM ACTINOBACILLUS SUCCINOGENES 13OZ (ATCC 55618) FOR THE MANUFACTURE OF CHEMICALS FROM THE A. SUCCINOGENES C4 PATH |
| RU2010101135A (ru) * | 2010-01-15 | 2011-07-20 | Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" (ЗАО АГРИ) (RU) | Бактерия семейства enterobacteriaceae - продуцент l-аспартата или метаболитов, производных l-аспартата, и способ получения l-аспартата или метаболитов, производных l-аспартата |
| US12600991B2 (en) * | 2019-04-12 | 2026-04-14 | Green Earth Institute Co., Ltd. | Genetically modified microorganism for production of aspartic acid and downstream metabolites from aspartic acid as target substance, and method for producing target substance using same |
-
2022
- 2022-11-25 WO PCT/JP2022/043626 patent/WO2023095896A1/ja not_active Ceased
- 2022-11-25 US US18/712,730 patent/US20250197901A1/en active Pending
- 2022-11-25 JP JP2023562172A patent/JPWO2023095896A1/ja active Pending
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