JPWO2022189552A5 - - Google Patents

Info

Publication number

JPWO2022189552A5

JPWO2022189552A5 JP2023553726A JP2023553726A JPWO2022189552A5 JP WO2022189552 A5 JPWO2022189552 A5 JP WO2022189552A5 JP 2023553726 A JP2023553726 A JP 2023553726A JP 2023553726 A JP2023553726 A JP 2023553726A JP WO2022189552 A5 JPWO2022189552 A5 JP WO2022189552A5

Authority

JP

Japan

Prior art keywords

contact lens

preservative

free contact

treatment solution

lens treatment

Prior art date

2024-10-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000243 solution Substances 0.000 claims description 94
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 32
• 238000000034 method Methods 0.000 claims description 17
• 239000004386 Erythritol Substances 0.000 claims description 16
• UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 16
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 16
• UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 16
• 229940009714 erythritol Drugs 0.000 claims description 16
• 235000019414 erythritol Nutrition 0.000 claims description 16
• 239000001103 potassium chloride Substances 0.000 claims description 16
• 235000011164 potassium chloride Nutrition 0.000 claims description 16
• 239000006172 buffering agent Substances 0.000 claims description 13
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 12
• 229910021538 borax Inorganic materials 0.000 claims description 12
• 229920002674 hyaluronan Polymers 0.000 claims description 12
• 229960003160 hyaluronic acid Drugs 0.000 claims description 12
• 239000002736 nonionic surfactant Substances 0.000 claims description 12
• 229920001987 poloxamine Polymers 0.000 claims description 12
• 150000003839 salts Chemical class 0.000 claims description 12
• 235000010339 sodium tetraborate Nutrition 0.000 claims description 12
• BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 12
• KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 9
• 239000004327 boric acid Substances 0.000 claims description 9
• 229920002385 Sodium hyaluronate Polymers 0.000 claims description 8
• 239000011780 sodium chloride Substances 0.000 claims description 8
• 229940010747 sodium hyaluronate Drugs 0.000 claims description 8
• YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 8
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 4
• 235000010338 boric acid Nutrition 0.000 claims description 4
• 229920001983 poloxamer Polymers 0.000 claims description 4
• 229960000502 poloxamer Drugs 0.000 claims description 4
• WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical compound [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 claims description 4
• 239000000607 artificial tear Substances 0.000 claims description 2
• 230000001050 lubricating effect Effects 0.000 claims description 2
• 239000000314 lubricant Substances 0.000 description 12
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 9
• 239000004599 antimicrobial Substances 0.000 description 6
• XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 description 3
• 229940123208 Biguanide Drugs 0.000 description 3
• 239000002280 amphoteric surfactant Substances 0.000 description 3
• 239000003242 anti bacterial agent Substances 0.000 description 3
• 239000002738 chelating agent Substances 0.000 description 3
• 239000003795 chemical substances by application Substances 0.000 description 3
• 239000003974 emollient agent Substances 0.000 description 3
• 239000003889 eye drop Substances 0.000 description 3
• 229940012356 eye drops Drugs 0.000 description 3
• 239000003002 pH adjusting agent Substances 0.000 description 3
• 125000001453 quaternary ammonium group Chemical group 0.000 description 3
• 239000004034 viscosity adjusting agent Substances 0.000 description 3
• 238000012986 modification Methods 0.000 description 2
• 230000004048 modification Effects 0.000 description 2