JP4817621B2 - コンタクトレンズケア方法及び組成物 - Google Patents
コンタクトレンズケア方法及び組成物 Download PDFInfo
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- JP4817621B2 JP4817621B2 JP2004201165A JP2004201165A JP4817621B2 JP 4817621 B2 JP4817621 B2 JP 4817621B2 JP 2004201165 A JP2004201165 A JP 2004201165A JP 2004201165 A JP2004201165 A JP 2004201165A JP 4817621 B2 JP4817621 B2 JP 4817621B2
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Description
即ち、本発明の要旨は、
〔1〕A)ポリオキシエチレンソルビタン脂肪酸エステル、およびB)緩衝剤を含有するコンタクトレンズケア用組成物中に、コンタクトレンズを1時間以上浸漬することを特徴とする、コンタクトレンズ又はコンタクトレンズケースへの微生物付着抑制方法、
〔2〕A)ポリオキシエチレンソルビタン脂肪酸エステル、B)緩衝剤、およびC)非イオン性界面活性剤を含有するコンタクトレンズケア用組成物中に、コンタクトレンズを1時間以上浸漬することを特徴とするコンタクトレンズ又はコンタクトレンズケースへの微生物付着抑制方法、
〔3〕〔1〕又は〔2〕に記載の方法に用いるコンタクトレンズケア用組成物に、さらにモノテルペンを含有するコンタクトレンズケア用組成物中に、コンタクトレンズを1時間以上浸漬することを特徴とするコンタクトレンズ又はコンタクトレンズケースへの微生物付着抑制方法、
〔4〕〔1〕乃至〔2〕のいずれかに記載の方法に用いるコンタクトレンズケア用組成物に、さらに抗菌剤を含有するコンタクトレンズケア用組成物中に、コンタクトレンズを1時間以上浸漬することを特徴とするコンタクトレンズ又はコンタクトレンズケースへの微生物付着抑制方法、
〔3〕〔1〕乃至〔4〕に記載の方法に用いるコンタクトレンズケア用組成物に関する。
本発明のコンタクトレンズケア方法によれば、コンタクトレンズ装用または保存中に微生物がコンタクトレンズ又はコンタクトレンズケースに付着又は侵入、増殖するのを抑制することができ、微生物付着に起因して生じる種々の問題を未然に防止することができる。
例えば、装用中のコンタクトレンズを清潔に保ち、異物感を抑えてレンズの曇りを軽減することができる。また、コンタクトレンズ素材の腐食・劣化を防止し、レンズ寿命を長くすることができる。さらに、コンタクトレンズ消毒又は洗浄用組成物中にコンタクトレンズを長時間浸漬しすぎて一旦減少した微生物が再び増殖してしまったり、微生物活動が活発な夏場や、洗面所やお風呂場等の水周りでの保管や取り扱いによってコンタクトレンズケースの内外が微生物汚染に曝される場合であっても、ケースに浸漬したコンタクトレンズを清潔に保つ効果がある。ひいては、コンタクトレンズに付着した微生物によって生じる危険性のある、ものもらい,結膜,角膜等の眼感染症,巨大乳頭結膜炎,角膜上皮障害等の合併症,視力低下などを予防できることが期待できる。
これらの非イオン性界面活性剤のなかでも、特に好ましくは、POE・POPブロックコポリマー、POE・POPブロックコポリマー置換エチレンジアミンである。POE・POPブロックコポリマーとしては、(登録商標)ポロクサマー((登録商標)Pluronic F127、P123、F98、F87、F85、F77、F83、P85、F88、F68、F38、L44)、(登録商標)ポロキサミン((登録商標)Tetronic 1508、1504、1307、1304、1107、1104、908、904、707、704、501、304等)などが挙げられ、市販のものを利用することができる。平均分子量として、2千〜2万が好ましく、5千〜1万5千がより好ましい。また、総分子中のエチレンオキシド含量が、40%以上であることが好ましく、70%以上がより好ましい。
試験菌は緑膿菌(Pseudomonas aerginosa ATCC9027)を用い、試験レンズは2ウィークアキュビュー(ジョンソン・アンド・ジョンソン株式会社製)を用いた。試験液は、表1に記載の処方に基づき、ポリソルベート80、Pluronic(登録商標)F127他を、それぞれ表に記載の濃度(w/v)%となるように調製した。
試験方法は以下の手順とした(n=5で試験実施)。
(1)レンズを12穴マルチプレートに入れた各試験液5mLに4時間浸漬した。
(2)滅菌したピンセットを使ってレンズを試験液から取り出し水滴を軽くふき取ってから、1×107CFU/mLに調整した試験菌液5mLに30分間浸漬した。
(3)浸漬後、レンズを試験菌液から取り出して水滴を軽くふき取ってから、スピッツ管に入れた5mLの市販のダルベッコリン酸食塩緩衝液(pH7.5、浸透圧300mOsm)に移し、手で穏やかに1分間浸とうした。
(4)レンズを(3)の緩衝液から取り出して軽く水滴をふき取ってから、新しいダルベッコリン酸食塩緩衝液にレンズを移し、超音波で3分間処理後、vortexで激しく1分攪拌した。
(5)上記(4)の緩衝液中の生菌数を、適宜希釈してメンブレンフィルター法で測定し、付着菌数とした。
一方、ポリオキシエチレンポリオキシプロピレンブロックコポリマーとリン酸水素ナトリウム、リン酸2水素ナトリウムを組み合わせた組成物中に4時間コンタクトレンズを浸漬しても、微生物付着抑制効果が十分得られなかった。
表2に記載の組成となるように調製した試験液(pH7.5)について試験例1と同様の方法で菌付着抑制効果を評価した結果を示す。付着抑制率(%)が、80%以上であるものを◎、60%以上80%未満であるものを○、60%未満であるものを×と評価した。
Claims (3)
- A)ポリソルベート80を0.002〜0.1重量%、B)ホウ酸緩衝剤又はリン酸緩衝剤から選ばれる緩衝剤を0.02〜2重量%、およびC)プルロニック(登録商標)F87およびプルロニック(登録商標)F127から選ばれる少なくとも1種の非イオン性界面活性剤を0.02〜0.5重量%含有するコンタクトレンズケア用組成物中に、コンタクトレンズを1時間以上浸漬することを特徴とする、コンタクトレンズ又はコンタクトレンズケースへの微生物付着抑制方法。
- 微生物が緑膿菌である、請求項1に記載の方法。
- 請求項1又は2に記載の方法に用いる、コンタクトレンズケア用組成物。
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