JPWO2022189557A5 - - Google Patents

Info

Publication number

JPWO2022189557A5

JPWO2022189557A5 JP2023554392A JP2023554392A JPWO2022189557A5 JP WO2022189557 A5 JPWO2022189557 A5 JP WO2022189557A5 JP 2023554392 A JP2023554392 A JP 2023554392A JP 2023554392 A JP2023554392 A JP 2023554392A JP WO2022189557 A5 JPWO2022189557 A5 JP WO2022189557A5

Authority

JP

Japan

Prior art keywords

compatible solution

weight

total weight

ophthalmically compatible

ophthalmically

Prior art date

2025-01-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000243 solution Substances 0.000 claims description 137
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 58
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 40
• 238000000034 method Methods 0.000 claims description 33
• 150000003839 salts Chemical class 0.000 claims description 30
• 239000004386 Erythritol Substances 0.000 claims description 29
• UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 29
• UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 29
• 229940009714 erythritol Drugs 0.000 claims description 29
• 235000019414 erythritol Nutrition 0.000 claims description 29
• 239000001103 potassium chloride Substances 0.000 claims description 29
• 235000011164 potassium chloride Nutrition 0.000 claims description 29
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 25
• 229920002674 hyaluronan Polymers 0.000 claims description 25
• 229960003160 hyaluronic acid Drugs 0.000 claims description 25
• 239000011780 sodium chloride Substances 0.000 claims description 20
• 239000006172 buffering agent Substances 0.000 claims description 16
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
• KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 14
• 239000004327 boric acid Substances 0.000 claims description 14
• 229920002385 Sodium hyaluronate Polymers 0.000 claims description 9
• 229910021538 borax Inorganic materials 0.000 claims description 9
• 229940010747 sodium hyaluronate Drugs 0.000 claims description 9
• 235000010339 sodium tetraborate Nutrition 0.000 claims description 9
• YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims description 9
• BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 9
• 210000004087 cornea Anatomy 0.000 claims description 6
• 239000003889 eye drop Substances 0.000 claims description 5
• 229940012356 eye drops Drugs 0.000 claims description 5
• 208000003556 Dry Eye Syndromes Diseases 0.000 claims description 3
• 206010013774 Dry eye Diseases 0.000 claims description 3
• 230000002401 inhibitory effect Effects 0.000 claims description 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
• 239000000314 lubricant Substances 0.000 description 16
• 229960002645 boric acid Drugs 0.000 description 4
• 235000010338 boric acid Nutrition 0.000 description 4
• 239000002736 nonionic surfactant Substances 0.000 description 4
• 229960002816 potassium chloride Drugs 0.000 description 4
• 229960004599 sodium borate Drugs 0.000 description 4
• 239000004094 surface-active agent Substances 0.000 description 4
• 238000012986 modification Methods 0.000 description 2
• 230000004048 modification Effects 0.000 description 2
• 239000000607 artificial tear Substances 0.000 description 1
• 230000001050 lubricating effect Effects 0.000 description 1