JPWO2022189548A5 - - Google Patents

Info

Publication number

JPWO2022189548A5

JPWO2022189548A5 JP2023555213A JP2023555213A JPWO2022189548A5 JP WO2022189548 A5 JPWO2022189548 A5 JP WO2022189548A5 JP 2023555213 A JP2023555213 A JP 2023555213A JP 2023555213 A JP2023555213 A JP 2023555213A JP WO2022189548 A5 JPWO2022189548 A5 JP WO2022189548A5

Authority

JP

Japan

Prior art keywords

contact lens

treatment solution

lens treatment

total weight

solution

Prior art date

2025-01-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• 239000000243 solution Substances 0.000 claims description 111
• 238000000034 method Methods 0.000 claims description 36
• 239000004599 antimicrobial Substances 0.000 claims description 30
• XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims description 20
• 229940123208 Biguanide Drugs 0.000 claims description 20
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims description 20
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 20
• 150000003839 salts Chemical class 0.000 claims description 20
• 239000002736 nonionic surfactant Substances 0.000 claims description 15
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 14
• 229920002674 hyaluronan Polymers 0.000 claims description 14
• 229960003160 hyaluronic acid Drugs 0.000 claims description 14
• 239000006172 buffering agent Substances 0.000 claims description 12
• 239000004386 Erythritol Substances 0.000 claims description 11
• UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 11
• UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 11
• 229940009714 erythritol Drugs 0.000 claims description 11
• 235000019414 erythritol Nutrition 0.000 claims description 11
• 125000001453 quaternary ammonium group Chemical group 0.000 claims description 11
• 239000001103 potassium chloride Substances 0.000 claims description 10
• 235000011164 potassium chloride Nutrition 0.000 claims description 10
• 239000011780 sodium chloride Substances 0.000 claims description 10
• YMAWOPBAYDPSLA-UHFFFAOYSA-N glycylglycine Chemical compound [NH3+]CC(=O)NCC([O-])=O YMAWOPBAYDPSLA-UHFFFAOYSA-N 0.000 claims description 8
• 238000004140 cleaning Methods 0.000 claims description 7
• 230000000249 desinfective effect Effects 0.000 claims description 6
• 108010008488 Glycylglycine Proteins 0.000 claims description 4
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims description 4
• 229910021538 borax Inorganic materials 0.000 claims description 4
• KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 4
• 239000004327 boric acid Substances 0.000 claims description 4
• 239000000882 contact lens solution Substances 0.000 claims description 4
• 229940043257 glycylglycine Drugs 0.000 claims description 4
• 229920001983 poloxamer Polymers 0.000 claims description 4
• 229960000502 poloxamer Drugs 0.000 claims description 4
• 229920001987 poloxamine Polymers 0.000 claims description 4
• 235000010339 sodium tetraborate Nutrition 0.000 claims description 4
• WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical compound [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 claims description 4
• BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 4
• 150000003868 ammonium compounds Chemical group 0.000 claims description 2
• 238000002791 soaking Methods 0.000 claims 1
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 24
• 235000014113 dietary fatty acids Nutrition 0.000 description 6
• 239000000194 fatty acid Substances 0.000 description 6
• 229930195729 fatty acid Natural products 0.000 description 6
• 150000004665 fatty acids Chemical class 0.000 description 6
• 239000012458 free base Substances 0.000 description 6
• 150000003856 quaternary ammonium compounds Chemical class 0.000 description 5
• VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 3
• UCKMPCXJQFINFW-UHFFFAOYSA-N Sulphide Chemical compound [S-2] UCKMPCXJQFINFW-UHFFFAOYSA-N 0.000 description 3
• LFVVNPBBFUSSHL-UHFFFAOYSA-N alexidine Chemical compound CCCCC(CC)CNC(=N)NC(=N)NCCCCCCNC(=N)NC(=N)NCC(CC)CCCC LFVVNPBBFUSSHL-UHFFFAOYSA-N 0.000 description 3
• 229950010221 alexidine Drugs 0.000 description 3
• 150000001412 amines Chemical class 0.000 description 3
• 239000002280 amphoteric surfactant Substances 0.000 description 3
• 230000003115 biocidal effect Effects 0.000 description 3
• 125000004432 carbon atom Chemical group C* 0.000 description 3
• 239000002738 chelating agent Substances 0.000 description 3
• 239000003795 chemical substances by application Substances 0.000 description 3
• 150000001875 compounds Chemical class 0.000 description 3
• 239000003974 emollient agent Substances 0.000 description 3
• -1 glycerol monoalkyl ether Chemical class 0.000 description 3
• 239000003002 pH adjusting agent Substances 0.000 description 3
• 239000003755 preservative agent Substances 0.000 description 3
• 230000002335 preservative effect Effects 0.000 description 3
• 150000003505 terpenes Chemical class 0.000 description 3
• 235000007586 terpenes Nutrition 0.000 description 3
• 239000004034 viscosity adjusting agent Substances 0.000 description 3
• 238000012986 modification Methods 0.000 description 2
• 230000004048 modification Effects 0.000 description 2