JPWO2022183072A5 - - Google Patents
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- JPWO2022183072A5 JPWO2022183072A5 JP2023552220A JP2023552220A JPWO2022183072A5 JP WO2022183072 A5 JPWO2022183072 A5 JP WO2022183072A5 JP 2023552220 A JP2023552220 A JP 2023552220A JP 2023552220 A JP2023552220 A JP 2023552220A JP WO2022183072 A5 JPWO2022183072 A5 JP WO2022183072A5
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| EP4448550A2 (en) | 2021-12-15 | 2024-10-23 | Interius Biotherapeutics, Inc. | Pseudotyped viral particles, compositions comprising the same, and uses thereof |
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| WO2024059569A2 (en) * | 2022-09-12 | 2024-03-21 | The Board Of Trustees Of The Leland Stanford Junior University | Composition and method of universal pseudotyped retroviruses |
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| WO2024145599A1 (en) * | 2022-12-29 | 2024-07-04 | Kelonia Therapeutics, Inc. | Recombinant retrovirus, compositions, and methods of use |
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| WO2024207008A2 (en) * | 2023-03-30 | 2024-10-03 | Kelonia Therapeutics, Inc. | In vivo lentivirus animal models |
| WO2024213019A1 (zh) * | 2023-04-10 | 2024-10-17 | 深圳市济因生物科技有限公司 | 突变型vsvg及靶向载体 |
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| WO2024238153A1 (en) * | 2023-05-15 | 2024-11-21 | Umoja Biopharma, Inc. | Lentiviral delivery of anti-cd20 chimeric antigen receptors |
| EP4484563A1 (en) * | 2023-06-30 | 2025-01-01 | EsoBiotec | Viral vector and producer cell |
| WO2025011662A1 (zh) * | 2023-07-12 | 2025-01-16 | 深圳市济因生物科技有限公司 | 一种载体和体外转染非激活t细胞的方法 |
| WO2025021173A1 (zh) * | 2023-07-25 | 2025-01-30 | 深圳市济因生物科技有限公司 | 一种病毒载体及tcr亚基的应用 |
| WO2025036498A1 (zh) * | 2023-08-16 | 2025-02-20 | 深圳市济因生物科技有限公司 | 一种病毒载体及其在感染b细胞中的应用 |
| WO2025072257A1 (en) * | 2023-09-25 | 2025-04-03 | Kelonia Therapeutics, Inc. | Compositions for treating cancer |
| US12269882B1 (en) | 2023-09-25 | 2025-04-08 | Kelonia Therapeutics, Inc. | Antigen binding polypeptides |
| US12403194B2 (en) | 2023-09-25 | 2025-09-02 | Kelonia Therapeutics, Inc. | Compositions for treating cancer |
| CN116987157B (zh) * | 2023-09-27 | 2023-11-28 | 深圳华大生命科学研究院 | 一种弹状病毒包膜蛋白、含其的靶向慢病毒载体及其应用 |
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| CN119174831A (zh) * | 2024-11-26 | 2024-12-24 | 中国医学科学院医学实验动物研究所 | 基于冠状病毒Spike与hACE2互作介导的细胞特异性基因递送系统 |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283173A (en) | 1990-01-24 | 1994-02-01 | The Research Foundation Of State University Of New York | System to detect protein-protein interactions |
| NZ243082A (en) | 1991-06-28 | 1995-02-24 | Ici Plc | 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof |
| GB9300059D0 (en) | 1992-01-20 | 1993-03-03 | Zeneca Ltd | Quinazoline derivatives |
| TW225528B (enrdf_load_stackoverflow) | 1992-04-03 | 1994-06-21 | Ciba Geigy Ag | |
| GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
| US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
| ES2172670T3 (es) | 1995-07-06 | 2002-10-01 | Novartis Ag | Pirrolpirimidinas y procedimientos para su preparacion. |
| GB9518220D0 (en) | 1995-09-06 | 1995-11-08 | Medical Res Council | Checkpoint gene |
| US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
| GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
| HU228446B1 (en) | 1996-04-12 | 2013-03-28 | Warner Lambert Co | Kinazoline derivatives as irreversible inhibitors of protein-kinase, pharmaceutical compositions containing these compounds and use thereof |
| BR9709959A (pt) | 1996-06-24 | 2000-05-09 | Pfizer | Derivados tricìclicos de fenilamino substituìdo para o tratamento de doenças hiperproliferativas |
| CA2265630A1 (en) | 1996-09-13 | 1998-03-19 | Gerald Mcmahon | Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders |
| EP0837063A1 (en) | 1996-10-17 | 1998-04-22 | Pfizer Inc. | 4-Aminoquinazoline derivatives |
| CO4940418A1 (es) | 1997-07-18 | 2000-07-24 | Novartis Ag | Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso |
| DE60035676T2 (de) | 1999-04-29 | 2008-04-30 | Cell Genesys, Inc., South San Francisco | Verfahren und mittel für die herstellung von sicheren rekombinanten lentiviralen vektoren mit hohem titer |
| ATE319460T1 (de) | 1999-09-17 | 2006-03-15 | Wellstat Biologics Corp | Onkolytisches vesicular stomatitis virus |
| US6995162B2 (en) | 2001-01-12 | 2006-02-07 | Amgen Inc. | Substituted alkylamine derivatives and methods of use |
| CA2344208A1 (en) | 2001-04-30 | 2002-10-30 | Oxford Biomedica (Uk) Limited | Method |
| PT1478648E (pt) | 2002-02-01 | 2014-07-15 | Ariad Pharma Inc | Compostos contendo fósforo e suas utilizações |
| ES2348868T3 (es) | 2002-12-13 | 2010-12-16 | Genetix Pharmaceuticals Inc. | Vectores retrovirales terapeuticos para terapia genica. |
| US20080227736A1 (en) | 2004-06-03 | 2008-09-18 | Regents Of The University Of California, | Targeting Pseudotyped Retroviral Vectors |
| GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
| CA2611056C (en) | 2005-06-01 | 2016-06-28 | California Institute Of Technology | Method of targeted gene delivery using viral vectors |
| JO2660B1 (en) | 2006-01-20 | 2012-06-17 | نوفارتيس ايه جي | Pi-3 inhibitors and methods of use |
| US8008268B2 (en) | 2006-07-25 | 2011-08-30 | Merial Limited | Vaccines against vesicular stomatitis |
| EP1975239A1 (en) | 2006-09-27 | 2008-10-01 | Bundesrepublik Deutschland, letztvertreten durch den Präsidenten des Paul-Ehrlich-Instituts Prof. Dr. Johannes Löwer | Pseudotyping of retroviral vectors, methods for production and use thereof for targeted gene transfer and high-throughput screening |
| EP2019144A1 (en) | 2007-07-23 | 2009-01-28 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Vector particles for targeting CD34+ cells |
| CA2699202C (en) | 2007-09-12 | 2016-09-27 | F. Hoffmann-La Roche Ag | Combinations of phosphoinositide 3-kinase inhibitor compounds and chemotherapeutic agents, and methods of use |
| CA2701292C (en) | 2007-10-25 | 2015-03-24 | Genentech, Inc. | Process for making thienopyrimidine compounds |
| WO2010002993A1 (en) | 2008-07-01 | 2010-01-07 | Genocea Biosciences, Inc. | Antigen screening system |
| EP2655614B1 (en) | 2010-12-22 | 2017-03-15 | President and Fellows of Harvard College | Continuous directed evolution |
| WO2014016383A2 (en) | 2012-07-25 | 2014-01-30 | Theravectys | Glycoproteins for pseudotyping lentivectors |
| PT3824905T (pt) | 2012-08-20 | 2025-03-21 | Seattle Childrens Hospital Dba Seattle Childrens Res Inst | Método e composições para imunoterapêutica celular |
| EP3092306B1 (en) | 2014-01-10 | 2019-10-16 | Sirion Biotech GmbH | Pseudotyped lentiviral vectors |
| CA2936352A1 (en) | 2014-01-21 | 2015-07-30 | Albert Einstein College Of Medicine, Inc. | Cellular platform for rapid and comprehensive t-cell immunomonitoring |
| CN106456802B (zh) | 2014-01-30 | 2019-10-18 | 儿童医院医疗中心 | 一种改进的用于镰状细胞疾病基因校正的胎儿血红蛋白 |
| WO2015153969A1 (en) | 2014-04-04 | 2015-10-08 | The Board Of Trustees Of The Leland Stanford Junior University | Ligand discovery for t cell receptors |
| SG11201608744VA (en) | 2014-04-25 | 2016-11-29 | Bluebird Bio Inc | Improved methods for manufacturing adoptive cell therapies |
| US9759689B2 (en) | 2014-05-02 | 2017-09-12 | The Regents Of The University Of Michigan | Real-time detection and imaging of terahertz pulse radiation by using photoacoustic conversion |
| EP3031923A1 (en) | 2014-12-11 | 2016-06-15 | Institut Pasteur | Lentiviral vector-based japanese encephalitis immunogenic composition |
| US11111505B2 (en) | 2016-03-19 | 2021-09-07 | Exuma Biotech, Corp. | Methods and compositions for transducing lymphocytes and regulating the activity thereof |
| EP3235908A1 (en) | 2016-04-21 | 2017-10-25 | Ecole Normale Superieure De Lyon | Methods for selectively modulating the activity of distinct subtypes of cells |
| EP3684421A4 (en) | 2017-09-18 | 2021-08-04 | Children's Hospital Medical Center | STRONG INSULATOR AND ITS USES IN GENE ADMINISTRATION |
| GB201715052D0 (en) * | 2017-09-19 | 2017-11-01 | Oxford Genetics Ltd | Vectors |
| CA3076094A1 (en) | 2017-09-22 | 2019-03-28 | Centre National De La Recherche Scientifique (Cnrs) | Mutated glycoprotein of vesicular stomatitis virus |
| SG11202011837UA (en) * | 2018-06-01 | 2020-12-30 | Univ Southern California | Diverse antigen binding domains, novel platforms and other enhancements for cellular therapy |
| WO2020123936A1 (en) | 2018-12-14 | 2020-06-18 | Bluebird Bio, Inc. | Dimerizing agent regulated immunoreceptor complexes |
| CA3141018A1 (en) | 2019-05-20 | 2020-11-26 | Instituto De Biologia Experimental E Tecnologica (Ibet) | Modified envelope glycoproteins for retroviridae viral vector pseudotyping and process for obtaining it |
| CN114127305A (zh) | 2019-05-23 | 2022-03-01 | 麻省理工学院 | 经由逆转录病毒表面展示的配体发现和基因递送 |
| WO2022183072A1 (en) | 2021-02-26 | 2022-09-01 | Kelonia Therapeutics, Inc. | Lymphocyte targeted lentiviral vectors |
| MX2023012217A (es) | 2021-04-16 | 2024-03-05 | Massachusetts Inst Technology | Direccionamiento viral de celulas madre hematopoyeticas. |
| EP4448550A2 (en) | 2021-12-15 | 2024-10-23 | Interius Biotherapeutics, Inc. | Pseudotyped viral particles, compositions comprising the same, and uses thereof |
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