JPWO2022169884A5 - - Google Patents

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Publication number
JPWO2022169884A5
JPWO2022169884A5 JP2023545204A JP2023545204A JPWO2022169884A5 JP WO2022169884 A5 JPWO2022169884 A5 JP WO2022169884A5 JP 2023545204 A JP2023545204 A JP 2023545204A JP 2023545204 A JP2023545204 A JP 2023545204A JP WO2022169884 A5 JPWO2022169884 A5 JP WO2022169884A5
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JP
Japan
Prior art keywords
seq
sequence
set forth
expression construct
enhancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023545204A
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English (en)
Japanese (ja)
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JP2024505027A (ja
JP2024505027A5 (https=
Publication date
Application filed filed Critical
Priority claimed from PCT/US2022/014956 external-priority patent/WO2022169884A2/en
Publication of JP2024505027A publication Critical patent/JP2024505027A/ja
Publication of JPWO2022169884A5 publication Critical patent/JPWO2022169884A5/ja
Publication of JP2024505027A5 publication Critical patent/JP2024505027A5/ja
Pending legal-status Critical Current

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JP2023545204A 2021-02-02 2022-02-02 Gaba作動性ニューロン及び星状膠細胞における遺伝子発現の調節のための人工発現構築物 Pending JP2024505027A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163144743P 2021-02-02 2021-02-02
US63/144,743 2021-02-02
PCT/US2022/014956 WO2022169884A2 (en) 2021-02-02 2022-02-02 Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes

Publications (3)

Publication Number Publication Date
JP2024505027A JP2024505027A (ja) 2024-02-02
JPWO2022169884A5 true JPWO2022169884A5 (https=) 2025-02-10
JP2024505027A5 JP2024505027A5 (https=) 2025-02-10

Family

ID=82742483

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023545204A Pending JP2024505027A (ja) 2021-02-02 2022-02-02 Gaba作動性ニューロン及び星状膠細胞における遺伝子発現の調節のための人工発現構築物

Country Status (6)

Country Link
US (1) US20240117377A1 (https=)
EP (1) EP4288064A4 (https=)
JP (1) JP2024505027A (https=)
AU (1) AU2022217778A1 (https=)
CA (1) CA3207224A1 (https=)
WO (1) WO2022169884A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025019685A2 (en) * 2023-07-18 2025-01-23 Allen Institute Antisense oligonucleotides and artificial expression constructs for expressing rna in inhibitory neurons
AU2024346721A1 (en) * 2023-09-18 2026-04-09 Allen Institute Artificial expression constructs for modulating gene expression in neurons and astrocytes for the assessment and/or treatment of slc6a1-related disorders

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4955540B2 (ja) * 2004-06-04 2012-06-20 フラクスオーム サイエンセズ エイ/エス 多価不飽和脂肪酸生産のための代謝改変細胞
EP1859060A2 (en) * 2005-02-28 2007-11-28 Integragen Human autism susceptibility genes encoding a neurotransmitter transporter and uses thereof
EP3260540A1 (en) * 2010-11-12 2017-12-27 The General Hospital Corporation Polycomb-associated non-coding rnas
WO2013155222A2 (en) * 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
PE20170261A1 (es) * 2014-05-13 2017-04-12 Univ Pennsylvania Composiciones que comprenden virus adenoasociado (aav) que expresa constructos de anticuerpos duales y sus usos
CN110546257B (zh) * 2017-03-17 2024-03-01 阿德夫拉姆生物技术股份有限公司 用于增强基因表达的组合物和方法
AU2019253700B2 (en) * 2018-04-09 2025-08-14 Allen Institute Rescuing voltage-gated sodium channel function in inhibitory neurons
JP7695192B2 (ja) * 2018-10-08 2025-06-18 アレン インスティテュート 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物
CA3173609A1 (en) * 2020-03-27 2021-09-30 Allen Institute Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells

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