CA3207224A1 - Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes - Google Patents

Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes Download PDF

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Publication number
CA3207224A1
CA3207224A1 CA3207224A CA3207224A CA3207224A1 CA 3207224 A1 CA3207224 A1 CA 3207224A1 CA 3207224 A CA3207224 A CA 3207224A CA 3207224 A CA3207224 A CA 3207224A CA 3207224 A1 CA3207224 A1 CA 3207224A1
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ehgt
core
seq
expression construct
enhancer
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English (en)
French (fr)
Inventor
Bryan GORE
Edward Sebastian LEIN
Boaz P. LEVI
Deja MACHEN
Refugio MARTINEZ
John K. Mich
Jonathan Ting
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Allen Institute
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Allen Institute
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CA3207224A 2021-02-02 2022-02-02 Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes Pending CA3207224A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202163144743P 2021-02-02 2021-02-02
US63/144,743 2021-02-02
PCT/US2022/014956 WO2022169884A2 (en) 2021-02-02 2022-02-02 Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes

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CA3207224A1 true CA3207224A1 (en) 2022-08-11

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CA3207224A Pending CA3207224A1 (en) 2021-02-02 2022-02-02 Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes

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US (1) US20240117377A1 (https=)
EP (1) EP4288064A4 (https=)
JP (1) JP2024505027A (https=)
AU (1) AU2022217778A1 (https=)
CA (1) CA3207224A1 (https=)
WO (1) WO2022169884A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025019685A2 (en) * 2023-07-18 2025-01-23 Allen Institute Antisense oligonucleotides and artificial expression constructs for expressing rna in inhibitory neurons
AU2024346721A1 (en) * 2023-09-18 2026-04-09 Allen Institute Artificial expression constructs for modulating gene expression in neurons and astrocytes for the assessment and/or treatment of slc6a1-related disorders

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4955540B2 (ja) * 2004-06-04 2012-06-20 フラクスオーム サイエンセズ エイ／エス 多価不飽和脂肪酸生産のための代謝改変細胞
EP1859060A2 (en) * 2005-02-28 2007-11-28 Integragen Human autism susceptibility genes encoding a neurotransmitter transporter and uses thereof
EP3260540A1 (en) * 2010-11-12 2017-12-27 The General Hospital Corporation Polycomb-associated non-coding rnas
WO2013155222A2 (en) * 2012-04-10 2013-10-17 The Regents Of The University Of California Brain-specific enhancers for cell-based therapy
PE20170261A1 (es) * 2014-05-13 2017-04-12 Univ Pennsylvania Composiciones que comprenden virus adenoasociado (aav) que expresa constructos de anticuerpos duales y sus usos
CN110546257B (zh) * 2017-03-17 2024-03-01 阿德夫拉姆生物技术股份有限公司 用于增强基因表达的组合物和方法
AU2019253700B2 (en) * 2018-04-09 2025-08-14 Allen Institute Rescuing voltage-gated sodium channel function in inhibitory neurons
JP7695192B2 (ja) * 2018-10-08 2025-06-18 アレン インスティテュート 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物
CA3173609A1 (en) * 2020-03-27 2021-09-30 Allen Institute Artificial expression constructs for selectively modulating gene expression in non-neuronal brain cells

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Publication number Publication date
EP4288064A2 (en) 2023-12-13
WO2022169884A3 (en) 2022-09-15
JP2024505027A (ja) 2024-02-02
US20240117377A1 (en) 2024-04-11
EP4288064A4 (en) 2025-01-15
AU2022217778A1 (en) 2023-08-31
WO2022169884A2 (en) 2022-08-11
AU2022217778A9 (en) 2023-09-28

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