JPWO2020076614A5 - - Google Patents
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- JPWO2020076614A5 JPWO2020076614A5 JP2021543981A JP2021543981A JPWO2020076614A5 JP WO2020076614 A5 JPWO2020076614 A5 JP WO2020076614A5 JP 2021543981 A JP2021543981 A JP 2021543981A JP 2021543981 A JP2021543981 A JP 2021543981A JP WO2020076614 A5 JPWO2020076614 A5 JP WO2020076614A5
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- JP
- Japan
- Prior art keywords
- expression construct
- composition
- artificial expression
- injection
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024187194A JP7829658B2 (ja) | 2018-10-08 | 2024-10-24 | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862742835P | 2018-10-08 | 2018-10-08 | |
| US62/742,835 | 2018-10-08 | ||
| US201862749012P | 2018-10-22 | 2018-10-22 | |
| US62/749,012 | 2018-10-22 | ||
| US201962810281P | 2019-02-25 | 2019-02-25 | |
| US62/810,281 | 2019-02-25 | ||
| PCT/US2019/054539 WO2020076614A1 (en) | 2018-10-08 | 2019-10-03 | Artificial expression constructs for selectively modulating gene expression in interneurons |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024187194A Division JP7829658B2 (ja) | 2018-10-08 | 2024-10-24 | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022513339A JP2022513339A (ja) | 2022-02-07 |
| JPWO2020076614A5 true JPWO2020076614A5 (https=) | 2022-10-11 |
| JP2022513339A5 JP2022513339A5 (https=) | 2022-10-11 |
| JP7695192B2 JP7695192B2 (ja) | 2025-06-18 |
Family
ID=70164665
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021543981A Active JP7695192B2 (ja) | 2018-10-08 | 2019-10-03 | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
| JP2024187194A Active JP7829658B2 (ja) | 2018-10-08 | 2024-10-24 | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024187194A Active JP7829658B2 (ja) | 2018-10-08 | 2024-10-24 | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12467064B2 (https=) |
| EP (1) | EP3864150A4 (https=) |
| JP (2) | JP7695192B2 (https=) |
| AU (2) | AU2019358806B2 (https=) |
| CA (1) | CA3115652A1 (https=) |
| WO (1) | WO2020076614A1 (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019253700B2 (en) | 2018-04-09 | 2025-08-14 | Allen Institute | Rescuing voltage-gated sodium channel function in inhibitory neurons |
| JP7695192B2 (ja) * | 2018-10-08 | 2025-06-18 | アレン インスティテュート | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
| US20230159952A1 (en) * | 2020-04-21 | 2023-05-25 | Allen Institute | Artificial expression constructs for selectively modulating gene expression in neocortical layer 5 glutamatergic neurons |
| EP4162041A4 (en) * | 2020-06-04 | 2024-10-16 | Allen Institute | ARTIFICIAL EXPRESSION CONSTRUCTS TO SELECTIVELY MODULATE GENE EXPRESSION IN INHIBITORY NEOCORTICAL NEURONS |
| WO2022036255A1 (en) * | 2020-08-14 | 2022-02-17 | Allen Institute | Artificial expression constructs for modulating gene expression in striatal neurons |
| GB202013940D0 (en) | 2020-09-04 | 2020-10-21 | Synpromics Ltd | Regulatory nucleic acid sequences |
| CA3207224A1 (en) * | 2021-02-02 | 2022-08-11 | Bryan GORE | Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes |
| CN116286917A (zh) * | 2021-12-14 | 2023-06-23 | 中国科学院深圳先进技术研究院 | 重组载体及其构建方法和应用 |
| JP2025520385A (ja) * | 2022-06-13 | 2025-07-03 | アレン インスティテュート | 中枢神経系の非神経細胞において遺伝子発現を調節するための人工発現コンストラクト |
| JP2025525378A (ja) * | 2022-06-21 | 2025-08-05 | リーゲル セラピューティクス，インコーポレイティッド | 遺伝子調節エレメント及びその使用 |
| CN119060958A (zh) * | 2023-12-15 | 2024-12-03 | 中国科学院深圳先进技术研究院 | 一种携带钙离子报告基因的神经元及其制备方法和应用 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2002A (en) | 1841-03-12 | Tor and planter for plowing | ||
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| US5252334A (en) | 1989-09-08 | 1993-10-12 | Cygnus Therapeutic Systems | Solid matrix system for transdermal drug delivery |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| US5851832A (en) | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
| US5766948A (en) | 1993-01-06 | 1998-06-16 | The Regents Of The University Of California | Method for production of neuroblasts |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US6001654A (en) | 1994-01-28 | 1999-12-14 | California Institute Of Technology | Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors |
| US5697899A (en) | 1995-02-07 | 1997-12-16 | Gensia | Feedback controlled drug delivery system |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US6048964A (en) | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
| US5656016A (en) | 1996-03-18 | 1997-08-12 | Abbott Laboratories | Sonophoretic drug delivery system |
| US5753506A (en) | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
| US5797898A (en) | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
| US5783208A (en) | 1996-07-19 | 1998-07-21 | Theratech, Inc. | Transdermal drug delivery matrix for coadministering estradiol and another steroid |
| US5779708A (en) | 1996-08-15 | 1998-07-14 | Cyberdent, Inc. | Intraosseous drug delivery device and method |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| WO2001036623A2 (en) * | 1999-11-05 | 2001-05-25 | Avigen, Inc. | Ecdysone-inducible adeno-associated virus expression vectors |
| US6395546B1 (en) | 2000-02-01 | 2002-05-28 | Neurogeneration, Inc. | Generation of dopaminergic neurons from human nervous system stem cells |
| WO2002064804A2 (en) | 2001-02-13 | 2002-08-22 | University Of Florida | A bi-directional dual promoter complex with enhanced promoter activity for transgene expression in eukaryotes |
| JP4906231B2 (ja) | 2001-09-14 | 2012-03-28 | ステム セル セラピューティクス インコーポレイテッド | プロラクチン誘導性の神経幹細胞数の増加ならびにその治療用途 |
| WO2003072751A2 (en) | 2002-02-25 | 2003-09-04 | Vanderbilt University | Expression system for human brain-specific voltage-gated sodium channel, type 1 |
| WO2009012176A2 (en) | 2007-07-14 | 2009-01-22 | The University Of Iowa Research Foundation | Methods and compositions for treating brain diseases |
| US20120308530A1 (en) | 2011-06-03 | 2012-12-06 | Beijing Allgens Medical Science & Technology Co., Ltd. | Materials Composition and Methods to Control Neural Progenitor and Stem Cell Attachment, Proliferation and Guide Cell Differentiation |
| WO2013142337A1 (en) | 2012-03-20 | 2013-09-26 | The Trustees Of The University Of Pennsylvania | Human papillomavirus 16 (hpv16) - related epilepsy |
| EP2888368A1 (en) | 2012-08-27 | 2015-07-01 | Friedrich Miescher Institute for Biomedical Research | Retinal off circuit-specific promoter |
| DE102014207498A1 (de) | 2014-04-17 | 2015-10-22 | Universitätsklinikum Hamburg-Eppendorf | Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark |
| WO2016161124A1 (en) * | 2015-03-31 | 2016-10-06 | New York University | Compositions and method for reducing seizures |
| DK3081263T3 (da) | 2015-04-17 | 2020-03-16 | P&X Medical Nv | Sammensætninger og redskaber til behandling af glaukom |
| WO2016186772A2 (en) | 2015-05-16 | 2016-11-24 | Genzyme Corporation | Gene editing of deep intronic mutations |
| KR102423442B1 (ko) | 2015-12-11 | 2022-07-20 | 캘리포니아 인스티튜트 오브 테크놀로지 | 아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드 |
| EA201992358A1 (ru) * | 2017-04-03 | 2020-03-24 | Инкоудид Терапьютикс, Инк. | Тканеселективная экспрессия трансгена |
| US11980671B2 (en) | 2017-07-26 | 2024-05-14 | Duke University | Use of bacterial voltage gated ion channels for human therapies |
| AU2019253700B2 (en) | 2018-04-09 | 2025-08-14 | Allen Institute | Rescuing voltage-gated sodium channel function in inhibitory neurons |
| JP7695192B2 (ja) | 2018-10-08 | 2025-06-18 | アレン インスティテュート | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
-
2019
- 2019-10-03 JP JP2021543981A patent/JP7695192B2/ja active Active
- 2019-10-03 EP EP19870829.9A patent/EP3864150A4/en active Pending
- 2019-10-03 AU AU2019358806A patent/AU2019358806B2/en active Active
- 2019-10-03 WO PCT/US2019/054539 patent/WO2020076614A1/en not_active Ceased
- 2019-10-03 US US17/283,232 patent/US12467064B2/en active Active
- 2019-10-03 CA CA3115652A patent/CA3115652A1/en active Pending
-
2024
- 2024-10-24 JP JP2024187194A patent/JP7829658B2/ja active Active
- 2024-12-31 US US19/007,152 patent/US20250223612A1/en active Pending
-
2025
- 2025-07-25 AU AU2025208516A patent/AU2025208516A1/en active Pending
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