JP7695192B2 - 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 - Google Patents
介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 Download PDFInfo
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- JP7695192B2 JP7695192B2 JP2021543981A JP2021543981A JP7695192B2 JP 7695192 B2 JP7695192 B2 JP 7695192B2 JP 2021543981 A JP2021543981 A JP 2021543981A JP 2021543981 A JP2021543981 A JP 2021543981A JP 7695192 B2 JP7695192 B2 JP 7695192B2
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/65—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression using markers
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
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- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
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- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0619—Neurons
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A01K2217/052—Animals comprising random inserted nucleic acids (transgenic) inducing gain of function
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/106—Primate
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- C12N2510/00—Genetically modified cells
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14041—Use of virus, viral particle or viral elements as a vector
- C12N2750/14043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
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- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Chemical & Material Sciences (AREA)
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- Biotechnology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
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- Animal Behavior & Ethology (AREA)
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- Developmental Biology & Embryology (AREA)
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- Animal Husbandry (AREA)
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- Ophthalmology & Optometry (AREA)
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- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2024187194A JP7829658B2 (ja) | 2018-10-08 | 2024-10-24 | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862742835P | 2018-10-08 | 2018-10-08 | |
| US62/742,835 | 2018-10-08 | ||
| US201862749012P | 2018-10-22 | 2018-10-22 | |
| US62/749,012 | 2018-10-22 | ||
| US201962810281P | 2019-02-25 | 2019-02-25 | |
| US62/810,281 | 2019-02-25 | ||
| PCT/US2019/054539 WO2020076614A1 (en) | 2018-10-08 | 2019-10-03 | Artificial expression constructs for selectively modulating gene expression in interneurons |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024187194A Division JP7829658B2 (ja) | 2018-10-08 | 2024-10-24 | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2022513339A JP2022513339A (ja) | 2022-02-07 |
| JPWO2020076614A5 JPWO2020076614A5 (https=) | 2022-10-11 |
| JP2022513339A5 JP2022513339A5 (https=) | 2022-10-11 |
| JP7695192B2 true JP7695192B2 (ja) | 2025-06-18 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021543981A Active JP7695192B2 (ja) | 2018-10-08 | 2019-10-03 | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
| JP2024187194A Active JP7829658B2 (ja) | 2018-10-08 | 2024-10-24 | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2024187194A Active JP7829658B2 (ja) | 2018-10-08 | 2024-10-24 | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US12467064B2 (https=) |
| EP (1) | EP3864150A4 (https=) |
| JP (2) | JP7695192B2 (https=) |
| AU (2) | AU2019358806B2 (https=) |
| CA (1) | CA3115652A1 (https=) |
| WO (1) | WO2020076614A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025023947A (ja) * | 2018-10-08 | 2025-02-19 | アレン インスティテュート | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2019253700B2 (en) | 2018-04-09 | 2025-08-14 | Allen Institute | Rescuing voltage-gated sodium channel function in inhibitory neurons |
| US20230159952A1 (en) * | 2020-04-21 | 2023-05-25 | Allen Institute | Artificial expression constructs for selectively modulating gene expression in neocortical layer 5 glutamatergic neurons |
| EP4162041A4 (en) * | 2020-06-04 | 2024-10-16 | Allen Institute | ARTIFICIAL EXPRESSION CONSTRUCTS TO SELECTIVELY MODULATE GENE EXPRESSION IN INHIBITORY NEOCORTICAL NEURONS |
| WO2022036255A1 (en) * | 2020-08-14 | 2022-02-17 | Allen Institute | Artificial expression constructs for modulating gene expression in striatal neurons |
| GB202013940D0 (en) | 2020-09-04 | 2020-10-21 | Synpromics Ltd | Regulatory nucleic acid sequences |
| CA3207224A1 (en) * | 2021-02-02 | 2022-08-11 | Bryan GORE | Artificial expression constructs for modulating gene expression in gabaergic neurons and astrocytes |
| CN116286917A (zh) * | 2021-12-14 | 2023-06-23 | 中国科学院深圳先进技术研究院 | 重组载体及其构建方法和应用 |
| JP2025520385A (ja) * | 2022-06-13 | 2025-07-03 | アレン インスティテュート | 中枢神経系の非神経細胞において遺伝子発現を調節するための人工発現コンストラクト |
| JP2025525378A (ja) * | 2022-06-21 | 2025-08-05 | リーゲル セラピューティクス,インコーポレイティッド | 遺伝子調節エレメント及びその使用 |
| CN119060958A (zh) * | 2023-12-15 | 2024-12-03 | 中国科学院深圳先进技术研究院 | 一种携带钙离子报告基因的神经元及其制备方法和应用 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180078658A1 (en) | 2015-03-31 | 2018-03-22 | New York University | Compositions and method for reducing seizures |
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| US2002A (en) | 1841-03-12 | Tor and planter for plowing | ||
| US4736866B1 (en) | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
| US5252334A (en) | 1989-09-08 | 1993-10-12 | Cygnus Therapeutic Systems | Solid matrix system for transdermal drug delivery |
| US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
| US5851832A (en) | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
| US5766948A (en) | 1993-01-06 | 1998-06-16 | The Regents Of The University Of California | Method for production of neuroblasts |
| US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
| US6001654A (en) | 1994-01-28 | 1999-12-14 | California Institute Of Technology | Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors |
| US5697899A (en) | 1995-02-07 | 1997-12-16 | Gensia | Feedback controlled drug delivery system |
| IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
| US6048964A (en) | 1995-12-12 | 2000-04-11 | Stryker Corporation | Compositions and therapeutic methods using morphogenic proteins and stimulatory factors |
| US5656016A (en) | 1996-03-18 | 1997-08-12 | Abbott Laboratories | Sonophoretic drug delivery system |
| US5753506A (en) | 1996-05-23 | 1998-05-19 | Cns Stem Cell Technology, Inc. | Isolation propagation and directed differentiation of stem cells from embryonic and adult central nervous system of mammals |
| US5797898A (en) | 1996-07-02 | 1998-08-25 | Massachusetts Institute Of Technology | Microchip drug delivery devices |
| US5783208A (en) | 1996-07-19 | 1998-07-21 | Theratech, Inc. | Transdermal drug delivery matrix for coadministering estradiol and another steroid |
| US5779708A (en) | 1996-08-15 | 1998-07-14 | Cyberdent, Inc. | Intraosseous drug delivery device and method |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| WO2001036623A2 (en) * | 1999-11-05 | 2001-05-25 | Avigen, Inc. | Ecdysone-inducible adeno-associated virus expression vectors |
| US6395546B1 (en) | 2000-02-01 | 2002-05-28 | Neurogeneration, Inc. | Generation of dopaminergic neurons from human nervous system stem cells |
| WO2002064804A2 (en) | 2001-02-13 | 2002-08-22 | University Of Florida | A bi-directional dual promoter complex with enhanced promoter activity for transgene expression in eukaryotes |
| JP4906231B2 (ja) | 2001-09-14 | 2012-03-28 | ステム セル セラピューティクス インコーポレイテッド | プロラクチン誘導性の神経幹細胞数の増加ならびにその治療用途 |
| WO2003072751A2 (en) | 2002-02-25 | 2003-09-04 | Vanderbilt University | Expression system for human brain-specific voltage-gated sodium channel, type 1 |
| WO2009012176A2 (en) | 2007-07-14 | 2009-01-22 | The University Of Iowa Research Foundation | Methods and compositions for treating brain diseases |
| US20120308530A1 (en) | 2011-06-03 | 2012-12-06 | Beijing Allgens Medical Science & Technology Co., Ltd. | Materials Composition and Methods to Control Neural Progenitor and Stem Cell Attachment, Proliferation and Guide Cell Differentiation |
| WO2013142337A1 (en) | 2012-03-20 | 2013-09-26 | The Trustees Of The University Of Pennsylvania | Human papillomavirus 16 (hpv16) - related epilepsy |
| EP2888368A1 (en) | 2012-08-27 | 2015-07-01 | Friedrich Miescher Institute for Biomedical Research | Retinal off circuit-specific promoter |
| DE102014207498A1 (de) | 2014-04-17 | 2015-10-22 | Universitätsklinikum Hamburg-Eppendorf | Viraler Vektor für den zielgerichteten Gentransfer in Gehirn und Rückenmark |
| DK3081263T3 (da) | 2015-04-17 | 2020-03-16 | P&X Medical Nv | Sammensætninger og redskaber til behandling af glaukom |
| WO2016186772A2 (en) | 2015-05-16 | 2016-11-24 | Genzyme Corporation | Gene editing of deep intronic mutations |
| KR102423442B1 (ko) | 2015-12-11 | 2022-07-20 | 캘리포니아 인스티튜트 오브 테크놀로지 | 아데노-관련 바이러스를 지시하기 위한 타겟팅 펩타이드 |
| EA201992358A1 (ru) * | 2017-04-03 | 2020-03-24 | Инкоудид Терапьютикс, Инк. | Тканеселективная экспрессия трансгена |
| US11980671B2 (en) | 2017-07-26 | 2024-05-14 | Duke University | Use of bacterial voltage gated ion channels for human therapies |
| AU2019253700B2 (en) | 2018-04-09 | 2025-08-14 | Allen Institute | Rescuing voltage-gated sodium channel function in inhibitory neurons |
| JP7695192B2 (ja) | 2018-10-08 | 2025-06-18 | アレン インスティテュート | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
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2019
- 2019-10-03 JP JP2021543981A patent/JP7695192B2/ja active Active
- 2019-10-03 EP EP19870829.9A patent/EP3864150A4/en active Pending
- 2019-10-03 AU AU2019358806A patent/AU2019358806B2/en active Active
- 2019-10-03 WO PCT/US2019/054539 patent/WO2020076614A1/en not_active Ceased
- 2019-10-03 US US17/283,232 patent/US12467064B2/en active Active
- 2019-10-03 CA CA3115652A patent/CA3115652A1/en active Pending
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2024
- 2024-10-24 JP JP2024187194A patent/JP7829658B2/ja active Active
- 2024-12-31 US US19/007,152 patent/US20250223612A1/en active Pending
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2025
- 2025-07-25 AU AU2025208516A patent/AU2025208516A1/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20180078658A1 (en) | 2015-03-31 | 2018-03-22 | New York University | Compositions and method for reducing seizures |
Non-Patent Citations (2)
| Title |
|---|
| Nature Neuroscience,2016年,vol.19 no.12,pp.1743-1749 |
| The Journal of Neuroscience,2000年,vol.20 no.2,pp.709-721 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2025023947A (ja) * | 2018-10-08 | 2025-02-19 | アレン インスティテュート | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
| JP7829658B2 (ja) | 2018-10-08 | 2026-03-13 | アレン インスティテュート | 介在ニューロンにおける遺伝子発現を選択的に調節するための人工発現構築物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3864150A1 (en) | 2021-08-18 |
| JP2022513339A (ja) | 2022-02-07 |
| JP7829658B2 (ja) | 2026-03-13 |
| JP2025023947A (ja) | 2025-02-19 |
| AU2019358806A1 (en) | 2021-05-20 |
| AU2025208516A1 (en) | 2025-08-28 |
| WO2020076614A1 (en) | 2020-04-16 |
| AU2019358806B2 (en) | 2025-06-05 |
| EP3864150A4 (en) | 2022-08-24 |
| US20250223612A1 (en) | 2025-07-10 |
| US12467064B2 (en) | 2025-11-11 |
| CA3115652A1 (en) | 2020-04-16 |
| US20210348195A1 (en) | 2021-11-11 |
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