JPWO2022138736A5 - - Google Patents
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- Publication number
- JPWO2022138736A5 JPWO2022138736A5 JP2022571563A JP2022571563A JPWO2022138736A5 JP WO2022138736 A5 JPWO2022138736 A5 JP WO2022138736A5 JP 2022571563 A JP2022571563 A JP 2022571563A JP 2022571563 A JP2022571563 A JP 2022571563A JP WO2022138736 A5 JPWO2022138736 A5 JP WO2022138736A5
- Authority
- JP
- Japan
- Prior art keywords
- chromosome
- deletion
- detection method
- single cell
- pcr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000349 chromosome Anatomy 0.000 claims 26
- 210000004027 cell Anatomy 0.000 claims 22
- 108020004414 DNA Proteins 0.000 claims 18
- 238000001514 detection method Methods 0.000 claims 18
- 238000012217 deletion Methods 0.000 claims 15
- 230000037430 deletion Effects 0.000 claims 15
- 239000000523 sample Substances 0.000 claims 14
- 108091093088 Amplicon Proteins 0.000 claims 13
- 230000003321 amplification Effects 0.000 claims 10
- 238000003199 nucleic acid amplification method Methods 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 9
- 102000039446 nucleic acids Human genes 0.000 claims 9
- 150000007523 nucleic acids Chemical class 0.000 claims 9
- 208000036878 aneuploidy Diseases 0.000 claims 8
- 231100001075 aneuploidy Toxicity 0.000 claims 8
- 108020005196 Mitochondrial DNA Proteins 0.000 claims 7
- 230000004544 DNA amplification Effects 0.000 claims 4
- 239000000126 substance Substances 0.000 claims 4
- 210000003855 cell nucleus Anatomy 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 208000036282 monosomy chromosome 8 Diseases 0.000 claims 3
- 208000031261 Acute myeloid leukaemia Diseases 0.000 claims 2
- 208000033776 Myeloid Acute Leukemia Diseases 0.000 claims 2
- 230000002934 lysing effect Effects 0.000 claims 2
- 238000011002 quantification Methods 0.000 claims 2
- 208000026817 47,XYY syndrome Diseases 0.000 claims 1
- 101150106774 9 gene Proteins 0.000 claims 1
- 208000009575 Angelman syndrome Diseases 0.000 claims 1
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010005003 Bladder cancer Diseases 0.000 claims 1
- 208000003174 Brain Neoplasms Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 206010061765 Chromosomal mutation Diseases 0.000 claims 1
- 208000031639 Chromosome Deletion Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010011469 Crying Diseases 0.000 claims 1
- 208000000398 DiGeorge Syndrome Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 201000006360 Edwards syndrome Diseases 0.000 claims 1
- 206010014733 Endometrial cancer Diseases 0.000 claims 1
- 206010014759 Endometrial neoplasm Diseases 0.000 claims 1
- 206010014950 Eosinophilia Diseases 0.000 claims 1
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 1
- 241000282326 Felis catus Species 0.000 claims 1
- 101150054472 HER2 gene Proteins 0.000 claims 1
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 1
- 208000017924 Klinefelter Syndrome Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 101150105382 MET gene Proteins 0.000 claims 1
- 101150022024 MYCN gene Proteins 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 201000007224 Myeloproliferative neoplasm Diseases 0.000 claims 1
- 206010029260 Neuroblastoma Diseases 0.000 claims 1
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 201000009928 Patau syndrome Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 201000010769 Prader-Willi syndrome Diseases 0.000 claims 1
- 206010038389 Renal cancer Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 1
- 206010044686 Trisomy 13 Diseases 0.000 claims 1
- 208000006284 Trisomy 13 Syndrome Diseases 0.000 claims 1
- 208000007159 Trisomy 18 Syndrome Diseases 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 208000026928 Turner syndrome Diseases 0.000 claims 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 210000001766 X chromosome Anatomy 0.000 claims 1
- 206010056894 XYY syndrome Diseases 0.000 claims 1
- 210000002593 Y chromosome Anatomy 0.000 claims 1
- 210000004381 amniotic fluid Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 230000006037 cell lysis Effects 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 208000021668 chronic eosinophilic leukemia Diseases 0.000 claims 1
- 208000032852 chronic lymphocytic leukemia Diseases 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 108700020302 erbB-2 Genes Proteins 0.000 claims 1
- 201000004101 esophageal cancer Diseases 0.000 claims 1
- 230000001605 fetal effect Effects 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 238000012224 gene deletion Methods 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 201000010982 kidney cancer Diseases 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000008774 maternal effect Effects 0.000 claims 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 238000010839 reverse transcription Methods 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- 201000002510 thyroid cancer Diseases 0.000 claims 1
- 206010053884 trisomy 18 Diseases 0.000 claims 1
- 208000026485 trisomy X Diseases 0.000 claims 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1
- 201000005112 urinary bladder cancer Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020216149 | 2020-12-25 | ||
| JP2020216149 | 2020-12-25 | ||
| PCT/JP2021/047619 WO2022138736A1 (ja) | 2020-12-25 | 2021-12-22 | シングルセルごとの特定の核酸のコピー数の検出方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JPWO2022138736A1 JPWO2022138736A1 (https=) | 2022-06-30 |
| JPWO2022138736A5 true JPWO2022138736A5 (https=) | 2023-09-07 |
| JP7649442B2 JP7649442B2 (ja) | 2025-03-21 |
Family
ID=82157024
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022571563A Active JP7649442B2 (ja) | 2020-12-25 | 2021-12-22 | シングルセルごとの特定の核酸のコピー数の検出方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240043929A1 (https=) |
| EP (1) | EP4269614A4 (https=) |
| JP (1) | JP7649442B2 (https=) |
| KR (1) | KR20230107662A (https=) |
| CN (1) | CN116802314A (https=) |
| CA (1) | CA3206327A1 (https=) |
| TW (1) | TWI906439B (https=) |
| WO (1) | WO2022138736A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116356005B (zh) * | 2023-04-28 | 2023-09-26 | 宁波熙宁检测技术有限公司 | 一种检测car-t细胞拷贝数的组合物及其用途 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8574842B2 (en) * | 2009-12-22 | 2013-11-05 | The Board Of Trustees Of The Leland Stanford Junior University | Direct molecular diagnosis of fetal aneuploidy |
| US20130130930A1 (en) | 2011-11-17 | 2013-05-23 | Bhairavi Parikh | Methods and devices for obtaining and analyzing cells |
| SG11201404899VA (en) * | 2012-02-14 | 2014-10-30 | Univ Cornell | Method for relative quantification of nucleic acid sequence, expression, or copy changes, using combined nuclease, ligation, and polymerase reactions |
| AU2013302867A1 (en) * | 2012-08-13 | 2015-02-26 | The Regents Of The University Of California | Methods and systems for detecting biological components |
| JP7336091B2 (ja) * | 2016-08-02 | 2023-08-31 | 一般社団法人生命科学教育研究所 | 簡便な遺伝子検査法およびコピー数計測法ならびにその支援技術 |
| JP6234542B1 (ja) | 2016-12-27 | 2017-11-22 | 株式会社 TL Genomics | 胎児細胞由来染色体ｄｎａの取得方法 |
| KR20180102242A (ko) | 2017-03-06 | 2018-09-17 | 주식회사 우리은행 | 금융 자동화 기기의 비대면 채널 사용자 인증 방법 및 시스템 |
| US11254975B2 (en) * | 2018-05-24 | 2022-02-22 | National Center For Child Health And Development | Method of amplifying a polynucleotide of interest |
| JP2020000011A (ja) * | 2018-06-25 | 2020-01-09 | 株式会社理研ジェネシス | ゲノムｄｎａ中の標的領域のコピー数検出方法及び試薬キット |
| WO2021200749A1 (ja) * | 2020-04-01 | 2021-10-07 | 株式会社 ＴＬ Ｇｅｎｏｍｉｃｓ | 細胞の染色体又はその部分のコピー数を検出する方法 |
-
2021
- 2021-12-22 US US18/258,836 patent/US20240043929A1/en active Pending
- 2021-12-22 KR KR1020237020216A patent/KR20230107662A/ko active Pending
- 2021-12-22 WO PCT/JP2021/047619 patent/WO2022138736A1/ja not_active Ceased
- 2021-12-22 EP EP21910876.8A patent/EP4269614A4/en active Pending
- 2021-12-22 CN CN202180086085.8A patent/CN116802314A/zh active Pending
- 2021-12-22 JP JP2022571563A patent/JP7649442B2/ja active Active
- 2021-12-22 CA CA3206327A patent/CA3206327A1/en active Pending
- 2021-12-23 TW TW110148433A patent/TWI906439B/zh active
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