JPWO2022040586A5 - - Google Patents
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- JPWO2022040586A5 JPWO2022040586A5 JP2023512389A JP2023512389A JPWO2022040586A5 JP WO2022040586 A5 JPWO2022040586 A5 JP WO2022040586A5 JP 2023512389 A JP2023512389 A JP 2023512389A JP 2023512389 A JP2023512389 A JP 2023512389A JP WO2022040586 A5 JPWO2022040586 A5 JP WO2022040586A5
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- 239000000203 mixture Substances 0.000 claims 54
- 230000027455 binding Effects 0.000 claims 39
- 108010073923 Vascular Endothelial Growth Factor C Proteins 0.000 claims 20
- 102000009520 Vascular Endothelial Growth Factor C Human genes 0.000 claims 17
- 239000013603 viral vector Substances 0.000 claims 15
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- 108020004707 nucleic acids Proteins 0.000 claims 14
- 102000039446 nucleic acids Human genes 0.000 claims 14
- 150000007523 nucleic acids Chemical class 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 13
- 108091007433 antigens Proteins 0.000 claims 13
- 102000036639 antigens Human genes 0.000 claims 13
- 230000000139 costimulatory effect Effects 0.000 claims 12
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 108700019146 Transgenes Proteins 0.000 claims 8
- 230000009149 molecular binding Effects 0.000 claims 8
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 claims 7
- 210000001744 T-lymphocyte Anatomy 0.000 claims 7
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- 229920001184 polypeptide Polymers 0.000 claims 7
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 102000004196 processed proteins & peptides Human genes 0.000 claims 7
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- BGFTWECWAICPDG-UHFFFAOYSA-N 2-[bis(4-chlorophenyl)methyl]-4-n-[3-[bis(4-chlorophenyl)methyl]-4-(dimethylamino)phenyl]-1-n,1-n-dimethylbenzene-1,4-diamine Chemical compound C1=C(C(C=2C=CC(Cl)=CC=2)C=2C=CC(Cl)=CC=2)C(N(C)C)=CC=C1NC(C=1)=CC=C(N(C)C)C=1C(C=1C=CC(Cl)=CC=1)C1=CC=C(Cl)C=C1 BGFTWECWAICPDG-UHFFFAOYSA-N 0.000 claims 2
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063068876P | 2020-08-21 | 2020-08-21 | |
| US63/068,876 | 2020-08-21 | ||
| US202163154609P | 2021-02-26 | 2021-02-26 | |
| US63/154,609 | 2021-02-26 | ||
| PCT/US2021/046994 WO2022040586A2 (en) | 2020-08-21 | 2021-08-20 | Compositions and methods for in vivo generation of car expressing cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023538118A JP2023538118A (ja) | 2023-09-06 |
| JPWO2022040586A5 true JPWO2022040586A5 (https=) | 2024-08-27 |
| JP2023538118A5 JP2023538118A5 (https=) | 2024-08-27 |
Family
ID=78000765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023512389A Pending JP2023538118A (ja) | 2020-08-21 | 2021-08-20 | Ｃａｒ発現細胞のインビボ生成のための組成物及び方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230302155A1 (https=) |
| EP (1) | EP4199960A2 (https=) |
| JP (1) | JP2023538118A (https=) |
| KR (1) | KR20230058427A (https=) |
| AU (1) | AU2021329404A1 (https=) |
| CA (1) | CA3188978A1 (https=) |
| CL (2) | CL2023000495A1 (https=) |
| IL (1) | IL300489A (https=) |
| MX (1) | MX2023002107A (https=) |
| TW (1) | TW202227124A (https=) |
| WO (1) | WO2022040586A2 (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2958943T3 (da) | 2013-02-20 | 2019-12-09 | Univ Pennsylvania | Behandling af cancer ved anvendelse af humaniseret anti-EGFRvIII kimær antigenreceptor |
| UY35468A (es) | 2013-03-16 | 2014-10-31 | Novartis Ag | Tratamiento de cáncer utilizando un receptor quimérico de antígeno anti-cd19 |
| US11028143B2 (en) | 2014-01-21 | 2021-06-08 | Novartis Ag | Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules |
| TWI750110B (zh) | 2014-07-21 | 2021-12-21 | 瑞士商諾華公司 | 使用人類化抗-ｂｃｍａ嵌合抗原受體治療癌症 |
| MX2017012939A (es) | 2015-04-08 | 2018-05-22 | Novartis Ag | Terapias cd20, terapias cd22 y terapias de combinacion con una celula que expresa un receptor quimerico de antigeno (car) de cd19. |
| AU2016297014B2 (en) | 2015-07-21 | 2021-06-17 | Novartis Ag | Methods for improving the efficacy and expansion of immune cells |
| EP3523331A1 (en) | 2016-10-07 | 2019-08-14 | Novartis AG | Chimeric antigen receptors for the treatment of cancer |
| JP7585034B2 (ja) | 2017-10-18 | 2024-11-18 | ノバルティス アーゲー | 選択的タンパク質分解のための組成物及び方法 |
| CA3100724A1 (en) | 2018-06-13 | 2019-12-19 | Novartis Ag | B-cell maturation antigen protein (bcma) chimeric antigen receptors and uses thereof |
| IL292924A (en) | 2019-11-26 | 2022-07-01 | Novartis Ag | Chimeric antigen receptors cd19 and cd22 and their uses |
| PH12022551291A1 (en) | 2019-11-26 | 2023-11-20 | Novartis Ag | Chimeric antigen receptors binding bcma and cd19 and uses thereof |
| JP2023547499A (ja) * | 2020-11-06 | 2023-11-10 | ノバルティス アーゲー | 抗体Ｆｃ変異体 |
| JP2024531364A (ja) * | 2021-08-20 | 2024-08-29 | ノバルティス アーゲー | キメラ抗原受容体発現細胞を作製する方法 |
| EP4587047A1 (en) | 2022-09-15 | 2025-07-23 | Novartis AG | Treatment of autoimmune disorders using chimeric antigen receptor therapy |
| CN120112650A (zh) | 2022-10-26 | 2025-06-06 | 诺华股份有限公司 | 慢病毒配制品 |
| KR20260021032A (ko) * | 2023-06-07 | 2026-02-12 | 신테카인, 인크. | 감소된 면역원성을 갖는 변형된 이뮤노글로불린 가변 중쇄 도메인 |
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2021
- 2021-08-20 US US18/022,058 patent/US20230302155A1/en active Pending
- 2021-08-20 TW TW110130966A patent/TW202227124A/zh unknown
- 2021-08-20 KR KR1020237009142A patent/KR20230058427A/ko active Pending
- 2021-08-20 WO PCT/US2021/046994 patent/WO2022040586A2/en not_active Ceased
- 2021-08-20 CA CA3188978A patent/CA3188978A1/en active Pending
- 2021-08-20 AU AU2021329404A patent/AU2021329404A1/en active Pending
- 2021-08-20 IL IL300489A patent/IL300489A/en unknown
- 2021-08-20 JP JP2023512389A patent/JP2023538118A/ja active Pending
- 2021-08-20 MX MX2023002107A patent/MX2023002107A/es unknown
- 2021-08-20 EP EP21783074.4A patent/EP4199960A2/en active Pending
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2023
- 2023-02-17 CL CL2023000495A patent/CL2023000495A1/es unknown
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2024
- 2024-03-12 CL CL2024000734A patent/CL2024000734A1/es unknown
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