BR112021025740A2 - Recrutamento in situ, reprogramação e liberação de células car-t - Google Patents

Recrutamento in situ, reprogramação e liberação de células car-t

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Publication number
BR112021025740A2
BR112021025740A2 BR112021025740A BR112021025740A BR112021025740A2 BR 112021025740 A2 BR112021025740 A2 BR 112021025740A2 BR 112021025740 A BR112021025740 A BR 112021025740A BR 112021025740 A BR112021025740 A BR 112021025740A BR 112021025740 A2 BR112021025740 A2 BR 112021025740A2
Authority
BR
Brazil
Prior art keywords
cells
car
reprogramming
release
recruitment
Prior art date
Application number
BR112021025740A
Other languages
English (en)
Inventor
Gianpietro Dotti
Pritha Agarwalla
Yevgeny Brudno
Original Assignee
Univ North Carolina State
Univ North Carolina Chapel Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ North Carolina State, Univ North Carolina Chapel Hill filed Critical Univ North Carolina State
Publication of BR112021025740A2 publication Critical patent/BR112021025740A2/pt

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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

recrutamento in situ, reprogramação e liberação de células car-t. são divulgadas matrizes de hidrogel para uso no recrutamento e reprogramação de células car t, células car nk, células car nk t, macrófagos car, células nk infiltrantes de tumor, linfócitos infiltrantes de tumor e linfócitos infiltrantes de medula.
BR112021025740A 2019-06-21 2020-06-18 Recrutamento in situ, reprogramação e liberação de células car-t BR112021025740A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962864703P 2019-06-21 2019-06-21
PCT/US2020/038386 WO2020257423A1 (en) 2019-06-21 2020-06-18 In situ recruitment, reprogramming, and release of car-t cells

Publications (1)

Publication Number Publication Date
BR112021025740A2 true BR112021025740A2 (pt) 2022-02-22

Family

ID=74040894

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021025740A BR112021025740A2 (pt) 2019-06-21 2020-06-18 Recrutamento in situ, reprogramação e liberação de células car-t

Country Status (7)

Country Link
US (1) US20220354972A1 (pt)
EP (1) EP3986449A4 (pt)
JP (1) JP2022536983A (pt)
KR (1) KR20220035910A (pt)
CN (1) CN114025787A (pt)
BR (1) BR112021025740A2 (pt)
WO (1) WO2020257423A1 (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109536444B (zh) * 2018-12-11 2022-06-28 吉林省拓华生物科技有限公司 一种适用于恶性实体瘤肿瘤浸润t淋巴细胞的分离诱导方法
EP4199960A2 (en) * 2020-08-21 2023-06-28 Novartis AG Compositions and methods for in vivo generation of car expressing cells
CN116240173B (zh) * 2023-02-02 2024-09-27 西安电子科技大学 一种冷热肿瘤调控型car-单核/巨噬细胞及其制备方法和应用

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7855074B2 (en) * 2004-04-28 2010-12-21 Vaxdesign Corp. Artificial immune system: methods for making and use
WO2016098057A1 (en) * 2014-12-17 2016-06-23 Socovar, L.P. Chitosan-based hydrogel and applications thereof
JP7094533B2 (ja) * 2015-04-10 2022-07-04 プレジデント アンド フェローズ オブ ハーバード カレッジ 免疫細胞捕捉デバイスおよびその製造および使用方法
CN105132445B (zh) * 2015-10-23 2018-10-02 马健颖 一种特异识别肿瘤细胞的受体蛋白、t淋巴细胞及nk细胞
EP3439670A4 (en) * 2016-04-08 2019-11-27 The Regents of the University of California MODIFIED HYALURONIC ACID HYGELS AND PROTEINS FOR THE TEMPORARY RELEASE OF BIOLOGICAL ACTIVE SUBSTANCES
KR102497742B1 (ko) * 2016-08-30 2023-02-10 다나-파버 캔서 인스티튜트 인크. 약물 전달 조성물 및 그의 용도

Also Published As

Publication number Publication date
EP3986449A4 (en) 2023-08-02
CN114025787A (zh) 2022-02-08
US20220354972A1 (en) 2022-11-10
WO2020257423A1 (en) 2020-12-24
EP3986449A1 (en) 2022-04-27
JP2022536983A (ja) 2022-08-22
KR20220035910A (ko) 2022-03-22

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