JPWO2022015656A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2022015656A5
JPWO2022015656A5 JP2023501559A JP2023501559A JPWO2022015656A5 JP WO2022015656 A5 JPWO2022015656 A5 JP WO2022015656A5 JP 2023501559 A JP2023501559 A JP 2023501559A JP 2023501559 A JP2023501559 A JP 2023501559A JP WO2022015656 A5 JPWO2022015656 A5 JP WO2022015656A5
Authority
JP
Japan
Prior art keywords
group
compound
glycine
antibody
absent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2023501559A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023534437A (ja
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/041304 external-priority patent/WO2022015656A1/en
Publication of JP2023534437A publication Critical patent/JP2023534437A/ja
Priority to JP2023214174A priority Critical patent/JP7776485B2/ja
Publication of JPWO2022015656A5 publication Critical patent/JPWO2022015656A5/ja
Pending legal-status Critical Current

Links

JP2023501559A 2020-07-13 2021-07-12 タンパク質中のグルタミン残基にコンジュゲートされたカンプトテシンアナログおよびその使用 Pending JP2023534437A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023214174A JP7776485B2 (ja) 2020-07-13 2023-12-19 タンパク質中のグルタミン残基にコンジュゲートされたカンプトテシンアナログおよびその使用

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063051172P 2020-07-13 2020-07-13
US63/051,172 2020-07-13
US202163154531P 2021-02-26 2021-02-26
US63/154,531 2021-02-26
PCT/US2021/041304 WO2022015656A1 (en) 2020-07-13 2021-07-12 Camptothecin analogs conjugated to a glutamine residue in a protein, and their use

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023214174A Division JP7776485B2 (ja) 2020-07-13 2023-12-19 タンパク質中のグルタミン残基にコンジュゲートされたカンプトテシンアナログおよびその使用

Publications (2)

Publication Number Publication Date
JP2023534437A JP2023534437A (ja) 2023-08-09
JPWO2022015656A5 true JPWO2022015656A5 (enExample) 2024-07-19

Family

ID=77168491

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2023501559A Pending JP2023534437A (ja) 2020-07-13 2021-07-12 タンパク質中のグルタミン残基にコンジュゲートされたカンプトテシンアナログおよびその使用
JP2023214174A Active JP7776485B2 (ja) 2020-07-13 2023-12-19 タンパク質中のグルタミン残基にコンジュゲートされたカンプトテシンアナログおよびその使用

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023214174A Active JP7776485B2 (ja) 2020-07-13 2023-12-19 タンパク質中のグルタミン残基にコンジュゲートされたカンプトテシンアナログおよびその使用

Country Status (14)

Country Link
US (2) US20220072141A1 (enExample)
EP (2) EP4406608A3 (enExample)
JP (2) JP2023534437A (enExample)
KR (2) KR20240038138A (enExample)
CN (2) CN118085100A (enExample)
AU (2) AU2021308190A1 (enExample)
BR (1) BR112023000489A2 (enExample)
CA (1) CA3183184A1 (enExample)
CL (1) CL2023000098A1 (enExample)
CO (1) CO2023001402A2 (enExample)
IL (2) IL299153A (enExample)
MA (1) MA71650A (enExample)
MX (2) MX2023000544A (enExample)
WO (1) WO2022015656A1 (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3166732A1 (en) * 2020-01-22 2021-07-29 Medimmune Limited Compounds and conjugates thereof
EP4223318A4 (en) * 2020-09-30 2024-12-18 Duality Biologics (Suzhou) Co., Ltd. Antitumor compound, and preparation method therefor and use thereof
CN118829449A (zh) * 2022-01-12 2024-10-22 瑞泽恩制药公司 与蛋白中的谷氨酰胺残基缀合的喜树碱类似物及其用途
US20250114472A1 (en) * 2022-01-24 2025-04-10 Beijing Chempion Biotechnology Co., Ltd. Conjugate and use thereof
EP4489791A1 (en) * 2022-03-09 2025-01-15 Merck Patent GmbH Anti-gd2 antibodies, immunoconjugates and therapeutic uses thereof
WO2023217064A1 (zh) * 2022-05-09 2023-11-16 同宜医药(苏州)有限公司 一种喜树碱衍生物,基于其的抗体-药物偶联物和药物组合物,及其应用
WO2024026474A1 (en) 2022-07-29 2024-02-01 Regeneron Pharmaceuticals, Inc. Compositions and methods for transferrin receptor (tfr)-mediated delivery to the brain and muscle
IL319866A (en) * 2022-09-30 2025-05-01 Beigene Switzerland Gmbh Ligand-drug conjugates of exatacan analogs and their medical use
AU2023379457A1 (en) 2022-11-14 2025-05-15 Regeneron Pharmaceuticals, Inc. Compositions and methods for fibroblast growth factor receptor 3-mediated delivery to astrocytes
KR20250133813A (ko) 2022-12-21 2025-09-08 리제너론 파마슈티칼스 인코포레이티드 Adc 접합을 위한 토포이소머라아제 i 억제제의 전구약물 및 이의 사용 방법
EP4661914A1 (en) 2023-02-09 2025-12-17 Regeneron Pharmaceuticals, Inc. Antibody-drug conjugates via inverse electron demand diels-alder reactions
WO2025014533A1 (en) 2023-07-10 2025-01-16 Regeneron Pharmaceuticals, Inc. Anti-human cacng1 antibody-drug conjugates and uses thereof
WO2025038752A1 (en) * 2023-08-14 2025-02-20 Cancer Targeted Technology Llc Psma binding ligand-linker conjugates and methods for use thereof
EP4537854A1 (en) * 2023-10-04 2025-04-16 Formosa Laboratories, Inc. Compound for conjugation, conjugate and pharmaceutical composition comprising the same
WO2025078841A2 (en) 2023-10-11 2025-04-17 Antikor Biopharma Limited Antibodies, conjugates, and uses thereof
WO2025103474A1 (zh) * 2023-11-17 2025-05-22 成都康弘生物科技有限公司 双毒素抗体药物偶联物及其用途
WO2025199666A1 (en) * 2024-03-25 2025-10-02 Canwell Biotech Limited Multivalent linkers for high loading antibody-drug conjugates, and compositions and methods thereof

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
CA2008368C (en) 1989-01-24 2003-04-08 Jeffrey Greve Soluble molecule related to but distinct from icam-1
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
DE122004000008I1 (de) 1991-06-14 2005-06-09 Genentech Inc Humanisierter Heregulin Antikörper.
US5714586A (en) 1995-06-07 1998-02-03 American Cyanamid Company Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates
US7087411B2 (en) 1999-06-08 2006-08-08 Regeneron Pharmaceuticals, Inc. Fusion protein capable of binding VEGF
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US20070258987A1 (en) 2000-11-28 2007-11-08 Seattle Genetics, Inc. Recombinant Anti-Cd30 Antibodies and Uses Thereof
CA2481503A1 (en) 2002-04-05 2003-10-23 Agensys, Inc. Nucleic acid and corresponding protein entitled 98p4b6 useful in treatment and detection of cancer
US20050276812A1 (en) 2004-06-01 2005-12-15 Genentech, Inc. Antibody-drug conjugates and methods
WO2005079490A2 (en) 2004-02-13 2005-09-01 Nuvelo, Inc. Methods of therapy and diagnosis using targeting of cells that express steap2 polypeptides
TW200539855A (en) 2004-03-15 2005-12-16 Wyeth Corp Calicheamicin conjugates
JP2008521828A (ja) 2004-11-29 2008-06-26 シアトル ジェネティックス, インコーポレイテッド 操作された抗体およびイムノコンジュゲート
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
NO347649B1 (no) 2006-12-14 2024-02-12 Regeneron Pharma Humant antistoff eller antistoff fragment som spesifikt binder human deltaliknende ligand 4 (hDII4), nukleinsyremolekyl som koder for slike og vektor og vert-vektorsystemer, samt fremgangsmåte for fremstilling, sammensetning og anvendelse.
WO2008122039A2 (en) 2007-04-02 2008-10-09 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Selenocysteine mediated hybrid antibody molecules
DK2167963T3 (da) 2007-05-23 2019-06-24 Ventana Med Syst Inc Polymerbærere til immunhistokemi og in situ-hybridisering
BRPI0911442A2 (pt) 2008-04-30 2019-03-12 Immunogen, Inc. conjugados potentes e ligantes hidrofílicos
EP2326349B1 (en) 2008-07-21 2015-02-25 Polytherics Limited Novel reagents and method for conjugating biological molecules
JO3182B1 (ar) 2009-07-29 2018-03-08 Regeneron Pharma مضادات حيوية بشرية عالية الالفة مع تولد الاوعية البشرية - 2
AU2010283632B2 (en) 2009-08-10 2016-08-25 Ucl Business Plc Reversible covalent linkage of functional molecules
TWI540136B (zh) 2010-04-15 2016-07-01 梅迪繆思有限公司 吡咯并苯并二氮呯及其共軛物
US20130244905A1 (en) 2010-07-06 2013-09-19 Ed Grabczyk Reporter for RNA Polymerase II Termination
CA3250882A1 (en) 2010-08-02 2025-11-29 Regeneron Pharamaceuticals, Inc. Mice that Make Binding Proteins Comprising VL Domains
MX345538B (es) 2011-05-27 2017-02-03 Ambrx Inc Composiciones que contienen, metodos que incluyen, y usos de derivados de dolastatina enlazados a aminoacidos no naturales.
US8815226B2 (en) 2011-06-10 2014-08-26 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
CA2850096C (en) 2011-10-14 2018-07-03 Spirogen Sarl Synthesis method and intermediates useful in the preparation of pyrrolobenzodiazepines
WO2013055990A1 (en) 2011-10-14 2013-04-18 Seattle Genetics, Inc. Pyrrolobenzodiazepines and targeted conjugates
US9399073B2 (en) 2011-10-14 2016-07-26 Seattle Genetics, Inc. Pyrrolobenzodiazepines
WO2013068874A1 (en) 2011-11-11 2013-05-16 Pfizer Inc. Antibody-drug conjugates
CA2857398A1 (en) 2011-12-05 2013-06-13 Igenica Biotherapeutics, Inc. Antibody-drug conjugates and related compounds, compositions, and methods
EP2818480B1 (en) * 2012-02-24 2020-08-26 Alteogen Inc. Modified antibody in which motif comprising cysteine residue is bound, modified antibody-drug conjugate comprising the modified antibody, and production method for same
IL302494B2 (en) 2012-10-11 2024-11-01 Daiichi Sankyo Co Ltd Antibody-drug conjugates and methods for their preparation
CN105142672B (zh) 2012-10-23 2019-04-05 西纳福克斯股份有限公司 经修饰的抗体、抗体-缀合物及其制备方法
AU2014283185B2 (en) * 2013-06-21 2019-05-02 Araris Biotech Ltd. Enzymatic conjugation of polypeptides
JP6608823B2 (ja) 2013-08-26 2019-11-20 レゲネロン ファーマシューティカルス,インコーポレーテッド マクロライドジアステレオマーを含む医薬組成物、その合成方法、及び治療上の使用
SMT202500030T1 (it) * 2014-01-31 2025-03-12 Daiichi Sankyo Co Ltd Coniugato anticorpo anti-her2-farmaco
JP2017114763A (ja) * 2014-03-26 2017-06-29 第一三共株式会社 抗cd98抗体−薬物コンジュゲート
PT3789042T (pt) * 2014-04-10 2025-01-14 Daiichi Sankyo Europe Gmbh Método para produzir conjugado anticorpo-fármaco anti-her3
US9951141B2 (en) 2014-06-02 2018-04-24 Regeneron Pharmaceuticals, Inc. Antibody-drug conjugates, their preparation and their therapeutic use
TWI710573B (zh) * 2015-01-26 2020-11-21 美商再生元醫藥公司 抗伊波拉病毒醣蛋白之人類抗體
CA2978942A1 (en) * 2015-03-13 2016-09-22 Cytomx Therapeutics, Inc. Anti-pdl1 antibodies, activatable anti-pdl1 antibodies, and methods of use thereof
KR101757977B1 (ko) 2015-06-26 2017-07-13 아주대학교산학협력단 바이오 잉크의 제조방법 및 3d 프린터 적용
AU2017211120C1 (en) 2016-01-25 2021-10-07 Regeneron Pharmaceuticals, Inc. Maytansinoid derivatives, conjugates thereof, and methods of use
WO2017147542A2 (en) 2016-02-26 2017-08-31 Regeneron Pharmaceuticals, Inc. Optimized transglutaminase site-specific antibody conjugation
MY199468A (en) * 2016-09-23 2023-10-31 Regeneron Pharma Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof
KR20250114431A (ko) * 2016-11-08 2025-07-29 리제너론 파마슈티칼스 인코포레이티드 스테로이드 및 이의 단백질-접합체
TWI782930B (zh) 2016-11-16 2022-11-11 美商再生元醫藥公司 抗met抗體,結合met之雙特異性抗原結合分子及其使用方法
WO2018182341A1 (ko) 2017-03-29 2018-10-04 주식회사 레고켐 바이오사이언스 피롤로벤조디아제핀 이량체 전구체 및 이의 리간드-링커 접합체 화합물
CA3063872A1 (en) * 2017-05-18 2018-11-22 Regeneron Pharmaceuticals, Inc. Bis-octahydrophenanthrene carboxamides and protein conjugates thereof
US11629122B2 (en) 2017-05-24 2023-04-18 The Board Of Regents Of The University Of Texas System Linkers for antibody drug conjugates
CA3067829A1 (en) * 2017-06-23 2018-12-27 VelosBio Inc. Ror1 antibody immunoconjugates
KR102871690B1 (ko) 2018-04-30 2025-10-16 리제너론 파마슈티칼스 인코포레이티드 Her2 및/또는 aplp2에 결합하는 항체 및 이중특이적 항원-결합 분자 및 접합체 그리고 이들의 용도
KR20210008008A (ko) * 2018-05-09 2021-01-20 리제너론 파마슈티칼스 인코포레이티드 항-msr1 항체 및 이의 사용 방법
SG11202010496WA (en) * 2018-05-18 2020-12-30 Daiichi Sankyo Co Ltd Anti-muc1 antibody-drug conjugate
US12209180B2 (en) * 2018-11-20 2025-01-28 Regeneron Pharmaceuticals, Inc. Bis-octahydrophenanthrene carboxamide derivatives and protein conjugates thereof for use as LXR agonists
WO2020245229A1 (en) * 2019-06-03 2020-12-10 Synaffix B.V. Acetal-based cleavable linkers
CN110974975B (zh) * 2019-12-12 2023-10-20 成都百利多特生物药业有限责任公司 一种快速释放的抗体药物偶联物
AU2021228225A1 (en) * 2020-02-28 2022-09-01 Regeneron Pharmaceuticals, Inc. Bispecific antigen binding molecules that bind HER2, and methods of use thereof

Similar Documents

Publication Publication Date Title
JPWO2022015656A5 (enExample)
CN112261954B (zh) 具有针对抗体的亲和性物质和生物正交性官能团的化合物或其盐
JP7431261B2 (ja) 自己安定化リンカー結合体
TWI811726B (zh) 改良配體-藥物結合物之藥物動力學之聚乙二醇化藥物連接子
TWI680765B (zh) 自行穩定之接合劑共軛物
KR20210053871A (ko) 캄프토테신 접합체
AU2015210578B2 (en) Ligand-cytotoxic drug conjugate, preparation method therefor, and uses thereof
CN108779127A (zh) 美登素类化合物衍生物、其偶联物和使用方法
BR112020020466A2 (pt) Conjugados de peptídeo de camptotecina
JP2017514905A5 (enExample)
EP4406606A2 (de) Binder-wirkstoff-konjugate (adcs) und binder-prodrug-konjugate (apdcs) mit enzymatisch spaltbaren g
JP2018502844A (ja) Ksp阻害剤の脱グリコシル化抗tweakr抗体との抗体薬物複合体(adc類)
CN106255513A (zh) 用于药物偶联物的含磺酰胺连接系统
KR20180030993A (ko) 항체-약물 접합체 중의 공유결합 링커 및 이의 제조방법 및 사용방법
PL172837B1 (pl) Preparat farmaceutyczny zawierajacy koniugaty tioeterowe PL PL PL PL PL
JP2018520130A (ja) キネシンスピンドルタンパク質(ksp)阻害剤の抗cd123抗体との抗体薬物複合体
CN113456829A (zh) 新型亲水连接体和其在配体-药物共轭偶联物上的应用
JP2018525334A (ja) キネシンスピンドルタンパク質(ksp)阻害剤の抗tweakr抗体との抗体薬物複合体
JP7397058B2 (ja) 細胞障害性薬物の複合体及び前記複合体のプロドラッグの形態
JPWO2019232449A5 (enExample)
JP2024178320A (ja) チオール多重リンカーを有するadc
CN119095625A (zh) 抗体-药物偶联物
CN119156232A (zh) 抗体-药物偶联物前体及其合成中间体
WO2022154127A1 (ja) 化合物またはその塩、およびそれらにより得られる抗体
JPWO2020089687A5 (enExample)