JPWO2021241446A1 - - Google Patents

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Publication number
JPWO2021241446A1
JPWO2021241446A1 JP2022526991A JP2022526991A JPWO2021241446A1 JP WO2021241446 A1 JPWO2021241446 A1 JP WO2021241446A1 JP 2022526991 A JP2022526991 A JP 2022526991A JP 2022526991 A JP2022526991 A JP 2022526991A JP WO2021241446 A1 JPWO2021241446 A1 JP WO2021241446A1
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Japan
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JP2022526991A
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JP7226651B2 (ja
JPWO2021241446A5 (https=
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/535—Production of labelled immunochemicals with enzyme label or co-enzymes, co-factors, enzyme inhibitors or enzyme substrates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/32—Nucleotides having a condensed ring system containing a six-membered ring having two N-atoms in the same ring, e.g. purine nucleotides, nicotineamide-adenine dinucleotide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/008—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions for determining co-enzymes or co-factors, e.g. NAD, ATP
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/66—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y113/00—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13)
    • C12Y113/12—Oxidoreductases acting on single donors with incorporation of molecular oxygen (oxygenases) (1.13) with incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)(1.13.12)
    • C12Y113/12007—Photinus-luciferin 4-monooxygenase (ATP-hydrolysing) (1.13.12.7), i.e. firefly-luciferase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/0104—Pyruvate kinase (2.7.1.40)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/02—Phosphotransferases with a carboxy group as acceptor (2.7.2)
    • C12Y207/02001—Acetate kinase (2.7.2.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C12Y207/04001—Polyphosphate kinase (2.7.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/04—Phosphotransferases with a phosphate group as acceptor (2.7.4)
    • C12Y207/04003—Adenylate kinase (2.7.4.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/07—Nucleotidyltransferases (2.7.7)
    • C12Y207/07004—Sulfate adenylyltransferase (2.7.7.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/09—Phosphotransferases with paired acceptors (2.7.9)
    • C12Y207/09001—Pyruvate, phosphate dikinase (2.7.9.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y602/00—Ligases forming carbon-sulfur bonds (6.2)
    • C12Y602/01—Acid-Thiol Ligases (6.2.1)
    • C12Y602/01001—Acetate-CoA ligase (6.2.1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/548—Carbohydrates, e.g. dextran
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/581—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with enzyme label (including co-enzymes, co-factors, enzyme inhibitors or substrates)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2304/00—Chemical means of detecting microorganisms
    • C12Q2304/60—Chemiluminescent detection using ATP-luciferin-luciferase system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2470/00—Immunochemical assays or immunoassays characterised by the reaction format or reaction type
    • G01N2470/04—Sandwich assay format

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
JP2022526991A 2020-05-25 2021-05-21 検体中の標的分子の検出方法、及び標的分子検出キット Active JP7226651B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020090398 2020-05-25
JP2020090398 2020-05-25
PCT/JP2021/019390 WO2021241446A1 (ja) 2020-05-25 2021-05-21 検体中の標的分子の検出方法、及び標的分子検出キット

Publications (3)

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JPWO2021241446A1 true JPWO2021241446A1 (https=) 2021-12-02
JPWO2021241446A5 JPWO2021241446A5 (https=) 2022-09-29
JP7226651B2 JP7226651B2 (ja) 2023-02-21

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JP2022526991A Active JP7226651B2 (ja) 2020-05-25 2021-05-21 検体中の標的分子の検出方法、及び標的分子検出キット

Country Status (6)

Country Link
US (1) US20230131011A1 (https=)
EP (1) EP4159755A4 (https=)
JP (1) JP7226651B2 (https=)
KR (1) KR102833537B1 (https=)
CN (1) CN115667929A (https=)
WO (1) WO2021241446A1 (https=)

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04265859A (ja) * 1991-02-21 1992-09-22 Kikkoman Corp 酵素免疫測定法
JPH0682447A (ja) * 1992-09-03 1994-03-22 Kikkoman Corp 酵素免疫測定法
JPH10502815A (ja) * 1994-07-13 1998-03-17 イギリス国 捕捉アッセイ
JP2001299390A (ja) * 2000-04-20 2001-10-30 Satake Corp Ａｔｐを連鎖的に増幅させる方法及び該方法を利用して極微量のａｔｐを検査する方法
JP2002535985A (ja) * 1999-02-05 2002-10-29 マイクロバイオロジカル リサーチ オーソリティ 低下させたバックグラウンドを用いるアッセイ
JP2006081506A (ja) * 2004-09-17 2006-03-30 Hiroshima Univ 微生物の高感度迅速検出方法
JP2009060809A (ja) * 2007-09-04 2009-03-26 Hiroshima Univ アデノシン三リン酸を増幅させるための反応器およびアデノシン三リン酸の増幅方法、並びにその利用
JP2013040800A (ja) * 2011-08-11 2013-02-28 Toyohashi Univ Of Technology 細胞放出物質検出装置、細胞放出物質検出方法および細胞放出物質検出用固定化酵素基板
JP2015042156A (ja) * 2013-08-26 2015-03-05 国立大学法人北海道大学 血液検体のａｔｐ測定方法及びキット

Family Cites Families (12)

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GB2055200B (en) * 1979-07-24 1984-05-02 Kolehmainen S Luminescent assays with enzymatic cycling enhancement of the sensitivity of bioluminescent and chemi
JPS59166099A (ja) 1983-03-11 1984-09-19 Toyo Jozo Co Ltd Ａｔｐまたはｎｍｎの高感度測定法
JPS6311848A (ja) 1986-07-02 1988-01-19 Oriental Yeast Co Ltd アデノシン３リン酸関連化合物の簡易測定法
JPS6423900A (en) 1987-07-16 1989-01-26 Sankyo Co Method for determining atp by method for enzymic amplification
JPH04360700A (ja) 1991-06-01 1992-12-14 Canon Inc Ａｔｐ測定用テスター
JP3409962B2 (ja) 1996-03-04 2003-05-26 キッコーマン株式会社 生物発光試薬及びその試薬を用いたアデノシンリン酸エステルの定量法並びにその試薬を用いたａｔｐ変換反応系に関与する物質の定量法
WO2001053513A1 (fr) * 2000-01-17 2001-07-26 Satake Corporation Systemes et procede de reaction de regeneration atp permettant d'examiner le nucleotide d'adenine, procede de detection d'arn et procede d'amplification d'atp
EP1415004A4 (en) 2001-07-03 2005-01-19 Univ Leland Stanford Junior BIOLUMINESCENCE REGENERATING CIRCULATION (BRC) FOR NUCLEIC ACID QUANTIFICATION
JP2003225098A (ja) 2002-02-04 2003-08-12 Unitika Ltd 土壌微生物数の測定方法およびその試薬
US20090162881A1 (en) * 2005-11-14 2009-06-25 Matsushita Electric Industrial Co., Ltd. Method of measuring adenine nucleotide
JP5245492B2 (ja) 2008-03-27 2013-07-24 ブラザー工業株式会社 インクジェット記録装置
WO2018147442A1 (ja) 2017-02-09 2018-08-16 キッコーマン株式会社 生体関連サンプル及び生体関連器具の清浄度測定キット及び方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04265859A (ja) * 1991-02-21 1992-09-22 Kikkoman Corp 酵素免疫測定法
JPH0682447A (ja) * 1992-09-03 1994-03-22 Kikkoman Corp 酵素免疫測定法
JPH10502815A (ja) * 1994-07-13 1998-03-17 イギリス国 捕捉アッセイ
JP2002535985A (ja) * 1999-02-05 2002-10-29 マイクロバイオロジカル リサーチ オーソリティ 低下させたバックグラウンドを用いるアッセイ
JP2001299390A (ja) * 2000-04-20 2001-10-30 Satake Corp Ａｔｐを連鎖的に増幅させる方法及び該方法を利用して極微量のａｔｐを検査する方法
JP2006081506A (ja) * 2004-09-17 2006-03-30 Hiroshima Univ 微生物の高感度迅速検出方法
JP2009060809A (ja) * 2007-09-04 2009-03-26 Hiroshima Univ アデノシン三リン酸を増幅させるための反応器およびアデノシン三リン酸の増幅方法、並びにその利用
JP2013040800A (ja) * 2011-08-11 2013-02-28 Toyohashi Univ Of Technology 細胞放出物質検出装置、細胞放出物質検出方法および細胞放出物質検出用固定化酵素基板
JP2015042156A (ja) * 2013-08-26 2015-03-05 国立大学法人北海道大学 血液検体のａｔｐ測定方法及びキット

Non-Patent Citations (3)

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Title
ITO, KATSUTOSHI ET AL.: "Highly Sensitive Simultaneous bioluminescent Measurement of Acetate Kinase and Pyruvate Phosphate Di", ANALYTICAL SCIENCES, vol. 19(1), JPN6021022719, 2003, pages 105 - 109, XP055880274, ISSN: 0004850090 *
SATOH TETSUYA ET AL.: "ATP Amplification for Ultrasensitive Bioluminescence Assay: Detection of a Single Bacterial Cell", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 68, no. 6, JPN6010029442, June 2004 (2004-06-01), pages 1216 - 1220, XP003000031, ISSN: 0004850091, DOI: 10.1271/bbb.68.1216 *
佐藤哲也ほか: "連鎖的ATP増幅反応を用いた超微量微生物の検出", 日本生物工学会大会講演要旨集, JPN6010029440, 25 August 2003 (2003-08-25), pages 54 - 2, ISSN: 0004850092 *

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Publication number Publication date
US20230131011A1 (en) 2023-04-27
JP7226651B2 (ja) 2023-02-21
EP4159755A1 (en) 2023-04-05
KR20220167333A (ko) 2022-12-20
EP4159755A4 (en) 2024-07-31
CN115667929A (zh) 2023-01-31
WO2021241446A1 (ja) 2021-12-02
KR102833537B1 (ko) 2025-07-11

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