JPWO2021231808A5 - - Google Patents
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- Publication number
- JPWO2021231808A5 JPWO2021231808A5 JP2022568815A JP2022568815A JPWO2021231808A5 JP WO2021231808 A5 JPWO2021231808 A5 JP WO2021231808A5 JP 2022568815 A JP2022568815 A JP 2022568815A JP 2022568815 A JP2022568815 A JP 2022568815A JP WO2021231808 A5 JPWO2021231808 A5 JP WO2021231808A5
- Authority
- JP
- Japan
- Prior art keywords
- construct
- cells
- seq
- acid sequence
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063024468P | 2020-05-13 | 2020-05-13 | |
| US63/024,468 | 2020-05-13 | ||
| US202163152835P | 2021-02-23 | 2021-02-23 | |
| US63/152,835 | 2021-02-23 | ||
| PCT/US2021/032354 WO2021231808A2 (en) | 2020-05-13 | 2021-05-13 | Compositions and methods for treating gjb2-associated hearing loss |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023526053A JP2023526053A (ja) | 2023-06-20 |
| JPWO2021231808A5 true JPWO2021231808A5 (https=) | 2024-05-23 |
| JP2023526053A5 JP2023526053A5 (https=) | 2024-05-23 |
Family
ID=78525016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022568815A Pending JP2023526053A (ja) | 2020-05-13 | 2021-05-13 | Ｇｊｂ２関連難聴を処置するための組成物および方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230183743A1 (https=) |
| EP (1) | EP4164695A4 (https=) |
| JP (1) | JP2023526053A (https=) |
| KR (1) | KR20230023641A (https=) |
| CN (1) | CN116096900A (https=) |
| AU (1) | AU2021270308A1 (https=) |
| CA (1) | CA3178197A1 (https=) |
| CL (1) | CL2022003147A1 (https=) |
| IL (1) | IL298091A (https=) |
| MX (1) | MX2022014085A (https=) |
| WO (1) | WO2021231808A2 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2020006435A (es) | 2017-12-19 | 2021-02-09 | Akouos Inc | Administracion de anticuerpos terapeuticos mediada por vector de virus adenoasociado (aav) en el oido interno. |
| US20230340038A1 (en) * | 2020-09-14 | 2023-10-26 | President And Fellows Of Harvard College | Recombinant adeno associated virus (raav) encoding gjb2 and uses thereof |
| JP2023541443A (ja) * | 2020-09-14 | 2023-10-02 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ＧＪＢ２をコードする組換えアデノ随伴ウイルス（ｒＡＡＶ）およびその使用。 |
| IL303317A (en) | 2020-12-01 | 2023-07-01 | Akouos Inc | ANTI-NATURAL ANTIBODY STRUCTURES AND RELATED METHODS FOR THE TREATMENT OF SYMPTOMS ASSOCIATED WITH VESTIBULAR SWANNOMA |
| US20250339560A1 (en) * | 2021-05-13 | 2025-11-06 | Akouos, Inc. | Gene therapy delivery compositions and methods for treating hearing loss |
| CN115651932A (zh) * | 2021-12-10 | 2023-01-31 | 浙江理工大学 | 一种靶向消化道肿瘤双靶向溶瘤腺病毒的构建方法及其应用 |
| CA3250345A1 (en) * | 2022-02-04 | 2023-08-10 | Decibel Therapeutics, Inc. | GJB2 REGULATORY ELEMENTS AND THEIR USES |
| CN116836975A (zh) * | 2022-03-25 | 2023-10-03 | 上海玮美基因科技有限责任公司 | 一种耳蜗和/或前庭细胞特异性启动子及其应用 |
| CN119061007A (zh) * | 2023-06-02 | 2024-12-03 | 苏州星奥拓维生物技术有限公司 | 耳蜗支持细胞基因治疗和再生的方法 |
| CN117924458A (zh) * | 2024-01-26 | 2024-04-26 | 嘉兴元圣生物科技有限公司 | 一种获取果蝠connexin30蛋白编码cDNA序列、氨基酸序列的方法及其序列的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0173552B1 (en) * | 1984-08-24 | 1991-10-09 | The Upjohn Company | Recombinant dna compounds and the expression of polypeptides such as tpa |
| US7387614B2 (en) * | 2003-08-26 | 2008-06-17 | University Of Maryland, Baltimore | Drug delivery to the inner ear and methods of using same |
| US20150050354A1 (en) * | 2012-04-02 | 2015-02-19 | Moderna Therapeutics, Inc. | Modified polynucleotides for the treatment of otic diseases and conditions |
| HUE037122T2 (hu) * | 2013-07-24 | 2018-08-28 | Commissariat Energie Atomique | Flekainid alkalmazása anti-konnexin szerként és eljárás pszichotróp farmakon hatásainak fokozására |
| SG11201804814YA (en) * | 2015-12-11 | 2018-07-30 | Massachusetts Eye & Ear Infirmary | Materials and methods for delivering nucleic acids to cochlear and vestibular cells |
| US12054724B2 (en) * | 2018-04-10 | 2024-08-06 | President And Fellows Of Harvard College | AAV vectors encoding clarin-1 or GJB2 and uses thereof |
| CA3115810A1 (en) * | 2018-10-11 | 2020-04-16 | Decibel Therapeutics, Inc. | Aav1 vectors and uses thereof for treatment of otic indications |
| CN118497276A (zh) * | 2018-11-07 | 2024-08-16 | 阿库斯股份有限公司 | 腺相关病毒载体用于在内耳中的毛细胞和支持细胞中校正基因缺陷/表达蛋白质的用途 |
| CA3153133A1 (en) * | 2019-09-30 | 2021-04-08 | Chris Bartolome | Adeno-associated virus (aav) systems for treatment of genetic hearing loss |
-
2021
- 2021-05-13 EP EP21803692.9A patent/EP4164695A4/en active Pending
- 2021-05-13 JP JP2022568815A patent/JP2023526053A/ja active Pending
- 2021-05-13 AU AU2021270308A patent/AU2021270308A1/en active Pending
- 2021-05-13 CA CA3178197A patent/CA3178197A1/en active Pending
- 2021-05-13 IL IL298091A patent/IL298091A/en unknown
- 2021-05-13 US US17/998,486 patent/US20230183743A1/en active Pending
- 2021-05-13 CN CN202180049197.6A patent/CN116096900A/zh active Pending
- 2021-05-13 MX MX2022014085A patent/MX2022014085A/es unknown
- 2021-05-13 WO PCT/US2021/032354 patent/WO2021231808A2/en not_active Ceased
- 2021-05-13 KR KR1020227043071A patent/KR20230023641A/ko active Pending
-
2022
- 2022-11-11 CL CL2022003147A patent/CL2022003147A1/es unknown
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