CN116096900A - 用于治疗gjb2相关听力损失的组合物和方法 - Google Patents

用于治疗gjb2相关听力损失的组合物和方法 Download PDF

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CN116096900A
CN116096900A CN202180049197.6A CN202180049197A CN116096900A CN 116096900 A CN116096900 A CN 116096900A CN 202180049197 A CN202180049197 A CN 202180049197A CN 116096900 A CN116096900 A CN 116096900A
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cells
promoter
construct
seq
nucleic acid
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E.J.西蒙斯
R.恩格
D.R.伦兹
H.蒋
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Akus Co ltd
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Akus Co ltd
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
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    • A61M25/00—Catheters; Hollow probes
    • A61M25/0067—Catheters; Hollow probes characterised by the distal end, e.g. tips
    • A61M25/0082—Catheter tip comprising a tool
    • A61M25/0084—Catheter tip comprising a tool being one or more injection needles
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CN202180049197.6A 2020-05-13 2021-05-13 用于治疗gjb2相关听力损失的组合物和方法 Pending CN116096900A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063024468P 2020-05-13 2020-05-13
US63/024,468 2020-05-13
US202163152835P 2021-02-23 2021-02-23
US63/152,835 2021-02-23
PCT/US2021/032354 WO2021231808A2 (en) 2020-05-13 2021-05-13 Compositions and methods for treating gjb2-associated hearing loss

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CN116096900A true CN116096900A (zh) 2023-05-09

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US (1) US20230183743A1 (https=)
EP (1) EP4164695A4 (https=)
JP (1) JP2023526053A (https=)
KR (1) KR20230023641A (https=)
CN (1) CN116096900A (https=)
AU (1) AU2021270308A1 (https=)
CA (1) CA3178197A1 (https=)
CL (1) CL2022003147A1 (https=)
IL (1) IL298091A (https=)
MX (1) MX2022014085A (https=)
WO (1) WO2021231808A2 (https=)

Cited By (1)

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WO2024245357A1 (zh) * 2023-06-02 2024-12-05 苏州星奥拓维生物技术有限公司 耳蜗支持细胞基因治疗和再生的方法

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EP3727468A4 (en) 2017-12-19 2021-09-22 Akouos, Inc. AAV-MEDIATED THERAPEUTIC ANTIBODIES DELIVERY TO THE INTERNAL EAR
TW202227476A (zh) * 2020-09-14 2022-07-16 哈佛大學校長及研究員協會 編碼GJB2之重組腺相關病毒(rAAV)及其用途
US20230340038A1 (en) * 2020-09-14 2023-10-26 President And Fellows Of Harvard College Recombinant adeno associated virus (raav) encoding gjb2 and uses thereof
IL303317A (en) 2020-12-01 2023-07-01 Akouos Inc ANTI-NATURAL ANTIBODY STRUCTURES AND RELATED METHODS FOR THE TREATMENT OF SYMPTOMS ASSOCIATED WITH VESTIBULAR SWANNOMA
MX2023013394A (es) * 2021-05-13 2023-12-14 Akouos Inc Composiciones de suministro de terapia genica y metodos para tratar perdida auditiva.
CN115651932A (zh) * 2021-12-10 2023-01-31 浙江理工大学 一种靶向消化道肿瘤双靶向溶瘤腺病毒的构建方法及其应用
MX2024009520A (es) * 2022-02-04 2024-09-11 Decibel Therapeutics Inc Elementos reguladores de gjb2 y usos de los mismos.
CN116836975A (zh) * 2022-03-25 2023-10-03 上海玮美基因科技有限责任公司 一种耳蜗和/或前庭细胞特异性启动子及其应用
CN117924458A (zh) * 2024-01-26 2024-04-26 嘉兴元圣生物科技有限公司 一种获取果蝠connexin30蛋白编码cDNA序列、氨基酸序列的方法及其序列的应用

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CN109310745A (zh) * 2015-12-11 2019-02-05 马萨诸塞眼科耳科诊所 用于将核酸递送至耳蜗和前庭细胞的材料和方法
WO2020077295A1 (en) * 2018-10-11 2020-04-16 Decibel Therapeutics, Inc. Aav1 vectors and uses thereof for treatment of otic indications

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EP0173552B1 (en) * 1984-08-24 1991-10-09 The Upjohn Company Recombinant dna compounds and the expression of polypeptides such as tpa
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HRP20180487T1 (hr) * 2013-07-24 2018-05-04 Commissariat à l'énergie atomique et aux énergies alternatives Upotreba flekainida kao anti-koneksinskog sredstva i metoda za potenciranje učinaka psihotropnog lijeka
WO2019200016A1 (en) * 2018-04-10 2019-10-17 President And Fellows Of Harvard College Aav vectors encoding clarin-1 or gjb2 and uses thereof
EP4063510A1 (en) * 2018-11-07 2022-09-28 Akouos, Inc. Use of adeno-associated viral vectors to correct gene defects/ express proteins in hair cells and supporting cells in the inner ear
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WO2005009287A2 (en) * 2003-07-21 2005-02-03 University Of Maryland, Baltimore Drug delivery to the inner ear and methods of using same
CN109310745A (zh) * 2015-12-11 2019-02-05 马萨诸塞眼科耳科诊所 用于将核酸递送至耳蜗和前庭细胞的材料和方法
WO2020077295A1 (en) * 2018-10-11 2020-04-16 Decibel Therapeutics, Inc. Aav1 vectors and uses thereof for treatment of otic indications

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Publication number Priority date Publication date Assignee Title
WO2024245357A1 (zh) * 2023-06-02 2024-12-05 苏州星奥拓维生物技术有限公司 耳蜗支持细胞基因治疗和再生的方法

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WO2021231808A3 (en) 2021-12-23
EP4164695A4 (en) 2024-06-05
WO2021231808A2 (en) 2021-11-18
AU2021270308A1 (en) 2022-12-15
CL2022003147A1 (es) 2023-07-21
MX2022014085A (es) 2022-12-07
IL298091A (en) 2023-01-01
JP2023526053A (ja) 2023-06-20
CA3178197A1 (en) 2021-11-18
KR20230023641A (ko) 2023-02-17
EP4164695A2 (en) 2023-04-19

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