JPWO2021231726A5 - - Google Patents
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- Publication number
- JPWO2021231726A5 JPWO2021231726A5 JP2022568810A JP2022568810A JPWO2021231726A5 JP WO2021231726 A5 JPWO2021231726 A5 JP WO2021231726A5 JP 2022568810 A JP2022568810 A JP 2022568810A JP 2022568810 A JP2022568810 A JP 2022568810A JP WO2021231726 A5 JPWO2021231726 A5 JP WO2021231726A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- alkyl
- halogen
- compound
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 150000001875 compounds Chemical class 0.000 claims description 98
- 125000000217 alkyl group Chemical group 0.000 claims description 87
- 150000003839 salts Chemical class 0.000 claims description 85
- 229910052736 halogen Inorganic materials 0.000 claims description 72
- 150000002367 halogens Chemical group 0.000 claims description 72
- 125000001424 substituent group Chemical group 0.000 claims description 65
- 125000000623 heterocyclic group Chemical group 0.000 claims description 62
- 229910052739 hydrogen Inorganic materials 0.000 claims description 53
- 239000001257 hydrogen Substances 0.000 claims description 53
- 229910052799 carbon Inorganic materials 0.000 claims description 32
- 150000002431 hydrogen Chemical group 0.000 claims description 31
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 21
- 125000000304 alkynyl group Chemical group 0.000 claims description 14
- 125000003342 alkenyl group Chemical group 0.000 claims description 13
- 125000001188 haloalkyl group Chemical group 0.000 claims description 11
- 229910052757 nitrogen Inorganic materials 0.000 claims description 8
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 7
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 6
- 125000001072 heteroaryl group Chemical group 0.000 claims description 6
- 239000008194 pharmaceutical composition Substances 0.000 claims description 6
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 claims description 4
- 229910052760 oxygen Inorganic materials 0.000 claims description 4
- 229910052717 sulfur Inorganic materials 0.000 claims description 4
- 101000812677 Homo sapiens Nucleotide pyrophosphatase Proteins 0.000 claims description 3
- 102100039306 Nucleotide pyrophosphatase Human genes 0.000 claims description 3
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 125000003107 substituted aryl group Chemical group 0.000 claims description 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
- 125000002837 carbocyclic group Chemical group 0.000 description 8
- 125000003118 aryl group Chemical group 0.000 description 6
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 description 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 description 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 description 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 2
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
- 101710196623 Stimulator of interferon genes protein Proteins 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 125000004076 pyridyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063024937P | 2020-05-14 | 2020-05-14 | |
| US63/024,937 | 2020-05-14 | ||
| PCT/US2021/032249 WO2021231726A1 (en) | 2020-05-14 | 2021-05-13 | Enpp1 modulators and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023526050A JP2023526050A (ja) | 2023-06-20 |
| JP2023526050A5 JP2023526050A5 (https=) | 2024-05-20 |
| JPWO2021231726A5 true JPWO2021231726A5 (https=) | 2024-05-20 |
Family
ID=76250495
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022568810A Pending JP2023526050A (ja) | 2020-05-14 | 2021-05-13 | Ｅｎｐｐ１モジュレーターおよびその使用 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20230183188A1 (https=) |
| EP (1) | EP4149927A1 (https=) |
| JP (1) | JP2023526050A (https=) |
| KR (1) | KR20230012535A (https=) |
| CN (1) | CN116348451A (https=) |
| AR (1) | AR122090A1 (https=) |
| AU (1) | AU2021273001A1 (https=) |
| BR (1) | BR112022023112A2 (https=) |
| CA (1) | CA3178372A1 (https=) |
| IL (1) | IL298169A (https=) |
| MX (1) | MX2022014126A (https=) |
| TW (1) | TW202208336A (https=) |
| WO (1) | WO2021231726A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3182410A1 (en) * | 2020-05-04 | 2021-11-11 | Volastra Therapeutics, Inc. | Imino sulfanone inhibitors of enpp1 |
| EP4236928A4 (en) | 2020-10-30 | 2024-08-28 | 1Cbio, Inc. | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP1) INHIBITORS AND THEIR USES |
| WO2023086638A1 (en) * | 2021-11-15 | 2023-05-19 | Vir Biotechnology, Inc. | Enpp1 modulators and uses thereof |
| WO2023220402A1 (en) * | 2022-05-13 | 2023-11-16 | Gossamer Bio Services, Inc. | Enpp1 modulators and products and uses thereof |
| US12397517B2 (en) | 2023-10-23 | 2025-08-26 | Unik World Industrial Co., Ltd. | Vehicle-mounted air compressor |
| US20250320204A1 (en) * | 2023-11-29 | 2025-10-16 | Riboscience Llc | 7-aza bicyclic heteroaryl derivatives as ectonucleotide pyrophosphatase phosphodiesterase 1 inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| US6334997B1 (en) | 1994-03-25 | 2002-01-01 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| WO2017066964A1 (en) * | 2015-10-22 | 2017-04-27 | Merck Sharp & Dohme Corp. | Oxazolidinone compounds and methods of use thereof as antibacterial agents |
| CN110446503A (zh) * | 2016-12-22 | 2019-11-12 | 马福制药公司 | 磷酸二酯酶抑制剂及微生物治疗方法 |
| MX2020002183A (es) * | 2017-08-31 | 2020-10-05 | Abbvie Inc | Inhibidores de la ectonucleótido pirofosfatasa-fosfodiesterasa 1 (enpp-1) y usos de los mismos. |
| WO2019177971A1 (en) * | 2018-03-12 | 2019-09-19 | Mavupharma, Inc. | Ectonucleotide pyrophosphatase-phosphodiesterase 1 (enpp-1) inhibitors and uses thereof |
| CN115151253B (zh) * | 2019-09-23 | 2025-04-15 | 南京征祥医药有限公司 | 磷酸二酯酶抑制剂及用途 |
| CA3182410A1 (en) * | 2020-05-04 | 2021-11-11 | Volastra Therapeutics, Inc. | Imino sulfanone inhibitors of enpp1 |
-
2021
- 2021-05-13 BR BR112022023112A patent/BR112022023112A2/pt not_active Application Discontinuation
- 2021-05-13 TW TW110117372A patent/TW202208336A/zh unknown
- 2021-05-13 JP JP2022568810A patent/JP2023526050A/ja active Pending
- 2021-05-13 AU AU2021273001A patent/AU2021273001A1/en not_active Abandoned
- 2021-05-13 CA CA3178372A patent/CA3178372A1/en active Pending
- 2021-05-13 EP EP21729757.1A patent/EP4149927A1/en not_active Withdrawn
- 2021-05-13 CN CN202180060383.XA patent/CN116348451A/zh active Pending
- 2021-05-13 AR ARP210101325A patent/AR122090A1/es not_active Application Discontinuation
- 2021-05-13 KR KR1020227043581A patent/KR20230012535A/ko not_active Withdrawn
- 2021-05-13 MX MX2022014126A patent/MX2022014126A/es unknown
- 2021-05-13 IL IL298169A patent/IL298169A/en unknown
- 2021-05-13 WO PCT/US2021/032249 patent/WO2021231726A1/en not_active Ceased
-
2022
- 2022-11-16 US US17/988,575 patent/US20230183188A1/en not_active Abandoned