JP2019533007A5 - - Google Patents
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- Publication number
- JP2019533007A5 JP2019533007A5 JP2019535971A JP2019535971A JP2019533007A5 JP 2019533007 A5 JP2019533007 A5 JP 2019533007A5 JP 2019535971 A JP2019535971 A JP 2019535971A JP 2019535971 A JP2019535971 A JP 2019535971A JP 2019533007 A5 JP2019533007 A5 JP 2019533007A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- membered
- optionally
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000001875 compounds Chemical class 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 9
- 125000001072 heteroaryl group Chemical group 0.000 claims 8
- 239000000825 pharmaceutical preparation Substances 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000005885 heterocycloalkylalkyl group Chemical group 0.000 claims 7
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 5
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 5
- 125000003710 aryl alkyl group Chemical group 0.000 claims 5
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 5
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 125000004446 heteroarylalkyl group Chemical group 0.000 claims 4
- -1 diastereomers Chemical class 0.000 claims 3
- 150000004677 hydrates Chemical class 0.000 claims 3
- 125000004043 oxo group Chemical group O=* 0.000 claims 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 2
- 239000013543 active substance Substances 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000005155 Picornaviridae Infections Diseases 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 230000000155 isotopic effect Effects 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022104373A JP2022137120A (ja) | 2016-09-13 | 2022-06-29 | 抗ウイルス化合物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16188559.5 | 2016-09-13 | ||
| EP16188559 | 2016-09-13 | ||
| PCT/EP2017/072880 WO2018050631A1 (en) | 2016-09-13 | 2017-09-12 | Antiviral compounds |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022104373A Division JP2022137120A (ja) | 2016-09-13 | 2022-06-29 | 抗ウイルス化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2019533007A JP2019533007A (ja) | 2019-11-14 |
| JP2019533007A5 true JP2019533007A5 (https=) | 2020-09-24 |
Family
ID=56926065
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019535971A Pending JP2019533007A (ja) | 2016-09-13 | 2017-09-12 | 抗ウイルス化合物 |
| JP2022104373A Pending JP2022137120A (ja) | 2016-09-13 | 2022-06-29 | 抗ウイルス化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022104373A Pending JP2022137120A (ja) | 2016-09-13 | 2022-06-29 | 抗ウイルス化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US11091428B2 (https=) |
| EP (1) | EP3512836A1 (https=) |
| JP (2) | JP2019533007A (https=) |
| CN (1) | CN110062753A (https=) |
| CA (1) | CA3036428A1 (https=) |
| WO (1) | WO2018050631A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018050631A1 (en) * | 2016-09-13 | 2018-03-22 | Haplogen Gmbh | Antiviral compounds |
| CN111303005B (zh) * | 2020-03-24 | 2023-09-08 | 乌海青石化学有限公司 | 含邻苯二甲酰亚胺结构的偶合组分及其制备方法和应用 |
| US20240199542A1 (en) * | 2021-03-22 | 2024-06-20 | Bayer Aktiengesellschaft | Substituted pyrrolidin-2-ones, salts thereof and their use as herbicidally active substances |
| EP4649086A1 (en) * | 2023-01-09 | 2025-11-19 | Merck Sharp & Dohme LLC | Protease inhibitors for treating or preventing coronavirus infection |
| WO2025171103A1 (en) * | 2024-02-08 | 2025-08-14 | Luxvitae Therapeutics Inc. | Amino acid derivatives and method of making the same |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5681543A (en) * | 1979-10-10 | 1981-07-03 | Ciba Geigy Ag | Manufacture of diether |
| JPH06273417A (ja) * | 1993-01-20 | 1994-09-30 | Ono Pharmaceut Co Ltd | メバロン酸に対する抗体、および該抗体を用いるメバロン酸の定量法 |
| RU2054415C1 (ru) * | 1994-03-02 | 1996-02-20 | Товарищество с ограниченной ответственностью "Пант" | Кетопантотенат кальция, обладающий ацетилирующей активностью d-пантотената кальция |
| RU2054000C1 (ru) * | 1994-03-02 | 1996-02-10 | Товарищество с ограниченной ответственностью "Пант" | Кетопантенол, обладающий ацетилирующей активностью d-пантотената кальция |
| EP0938477A4 (en) * | 1996-11-13 | 1999-12-29 | Cephalon Inc | BENZOTHIAZOLO AND RELATED HETEROCYCLIC GROUPS CONTAINING CYSTEIN AND SERINE PROTEASE INHIBITORS |
| CN1245486A (zh) * | 1996-12-11 | 2000-02-23 | Basf公司 | 用作钙蛋白酶抑制剂的酮苯甲酰胺 |
| JP3892187B2 (ja) * | 1998-11-12 | 2007-03-14 | 生化学工業株式会社 | 環状アミド誘導体 |
| AU779321B2 (en) | 1999-08-04 | 2005-01-20 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis |
| US20030045710A1 (en) * | 2000-04-06 | 2003-03-06 | Bruice Thomas C. | Methods for identifying, obtaining and using new polyketide compounds |
| AU3659102A (en) * | 2000-12-12 | 2002-06-24 | Schering Corp | Diaryl peptides as ns3-serine protease inhibitors of hepatits c virus |
| US20020177594A1 (en) * | 2001-03-14 | 2002-11-28 | Curtin Michael L. | Inhibitors of histone deacetylase |
| US20100330063A1 (en) * | 2007-12-17 | 2010-12-30 | Gliamed, Inc. | Stem-like cells, method for de-differentiating mammalian somatic cells into stem-like cells, and method for differentiating stem-like cells |
| US8236798B2 (en) * | 2009-05-07 | 2012-08-07 | Abbott Gmbh & Co. Kg | Carboxamide compounds and their use as calpain inhibitors |
| KR101781789B1 (ko) | 2010-01-27 | 2017-09-26 | 에이비 파르마 리미티드. | C형 간염 바이러스 억제제로 사용되는 다환 헤테로사이클릭 화합물 |
| US20130211209A1 (en) | 2010-06-18 | 2013-08-15 | Majid Sarrafzadeh | Energy aware sensor management for wearable medical systems optimization |
| TWI642684B (zh) * | 2011-05-27 | 2018-12-01 | Ｒｑｘ製藥股份有限公司 | 廣效性抗生素 |
| CA2850003C (en) * | 2011-09-27 | 2020-01-07 | Kansas State University Research Foundation | Broad-spectrum antivirals against 3c or 3c-like proteases of picornavirus-like supercluster: picornaviruses, caliciviruses and coronaviruses |
| US20140256698A1 (en) | 2013-03-11 | 2014-09-11 | Virobay, Inc. | Cathepsin inhibitors |
| GB201305750D0 (en) | 2013-03-28 | 2013-05-15 | Syngenta Ltd | Herbicidal Compounds |
| CN106458990B (zh) | 2014-04-04 | 2019-06-07 | 希洛斯医药品股份有限公司 | 细胞周期蛋白依赖性激酶7(cdk7)的抑制剂 |
| WO2018050631A1 (en) * | 2016-09-13 | 2018-03-22 | Haplogen Gmbh | Antiviral compounds |
-
2017
- 2017-09-12 WO PCT/EP2017/072880 patent/WO2018050631A1/en not_active Ceased
- 2017-09-12 US US16/333,159 patent/US11091428B2/en active Active
- 2017-09-12 CN CN201780069960.5A patent/CN110062753A/zh active Pending
- 2017-09-12 EP EP17771706.3A patent/EP3512836A1/en not_active Withdrawn
- 2017-09-12 JP JP2019535971A patent/JP2019533007A/ja active Pending
- 2017-09-12 CA CA3036428A patent/CA3036428A1/en active Pending
-
2021
- 2021-06-28 US US17/361,246 patent/US20220356148A1/en not_active Abandoned
-
2022
- 2022-06-29 JP JP2022104373A patent/JP2022137120A/ja active Pending
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