JPWO2021231606A5 - - Google Patents

Download PDF

Info

Publication number
JPWO2021231606A5
JPWO2021231606A5 JP2022568828A JP2022568828A JPWO2021231606A5 JP WO2021231606 A5 JPWO2021231606 A5 JP WO2021231606A5 JP 2022568828 A JP2022568828 A JP 2022568828A JP 2022568828 A JP2022568828 A JP 2022568828A JP WO2021231606 A5 JPWO2021231606 A5 JP WO2021231606A5
Authority
JP
Japan
Prior art keywords
crrna
rna
tracrrna
group
modification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022568828A
Other languages
English (en)
Japanese (ja)
Other versions
JP2023526057A (ja
JP2023526057A5 (https=
Publication date
Application filed filed Critical
Priority claimed from PCT/US2021/032038 external-priority patent/WO2021231606A2/en
Publication of JP2023526057A publication Critical patent/JP2023526057A/ja
Publication of JPWO2021231606A5 publication Critical patent/JPWO2021231606A5/ja
Publication of JP2023526057A5 publication Critical patent/JP2023526057A5/ja
Pending legal-status Critical Current

Links

JP2022568828A 2020-05-12 2021-05-12 Ｃｒｉｓｐｒゲノム編集のための修飾されたガイドｒｎａ Pending JP2023526057A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063023313P 2020-05-12 2020-05-12
US63/023,313 2020-05-12
PCT/US2021/032038 WO2021231606A2 (en) 2020-05-12 2021-05-12 Modified guide rnas for crispr genome editing

Publications (3)

Publication Number Publication Date
JP2023526057A JP2023526057A (ja) 2023-06-20
JPWO2021231606A5 true JPWO2021231606A5 (https=) 2024-05-22
JP2023526057A5 JP2023526057A5 (https=) 2024-05-22

Family

ID=78524997

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022568828A Pending JP2023526057A (ja) 2020-05-12 2021-05-12 Ｃｒｉｓｐｒゲノム編集のための修飾されたガイドｒｎａ

Country Status (7)

Country Link
US (1) US20210388348A1 (https=)
EP (1) EP4150091A4 (https=)
JP (1) JP2023526057A (https=)
CN (1) CN115956120A (https=)
AU (1) AU2021271004A1 (https=)
CA (1) CA3177463A1 (https=)
WO (1) WO2021231606A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024053964A1 (ko) * 2022-09-06 2024-03-14 주식회사 툴젠 캄필로박터 제주니 유래 cas9의 가이드 rna 구조변화를 통한 유전자교정 향상 시스템
IL324634A (en) 2023-05-15 2026-01-01 Nchroma Bio Inc Compositions and methods for epigenetic regulation of hbv gene expression

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015138510A1 (en) * 2014-03-10 2015-09-17 Editas Medicine., Inc. Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
CN112877327B (zh) * 2014-12-18 2024-11-22 综合基因技术公司 基于crispr的组合物和使用方法
EP3250691B9 (en) * 2015-01-28 2023-08-02 Caribou Biosciences, Inc. Crispr hybrid dna/rna polynucleotides and methods of use
CN107709555A (zh) * 2015-05-15 2018-02-16 达尔马科恩有限公司 用于Cas9介导的基因编辑的合成的单向导RNA
EP4545544A3 (en) * 2015-06-29 2025-10-08 Ionis Pharmaceuticals, Inc. Modified crispr rna and modified single crispr rna and uses thereof
WO2017058751A1 (en) * 2015-09-28 2017-04-06 North Carolina State University Methods and compositions for sequence specific antimicrobials
CA2947904A1 (en) * 2015-11-12 2017-05-12 Pfizer Inc. Tissue-specific genome engineering using crispr-cas9
CA3034931A1 (en) * 2016-09-23 2018-03-29 Board Of Trustees Of Southern Illinois University Tuning crispr/cas9 activity with chemically modified nucleotide substitutions
AU2017374044B2 (en) * 2016-12-08 2023-11-30 Intellia Therapeutics, Inc. Modified guide RNAs
WO2018111946A1 (en) * 2016-12-12 2018-06-21 Integrated Dna Technologies, Inc. Genome editing detection
WO2019011118A1 (zh) * 2017-07-14 2019-01-17 苏州克睿基因生物科技有限公司 一种基因编辑系统及基因编辑的方法
WO2019183000A1 (en) * 2018-03-19 2019-09-26 University Of Massachusetts Modified guide rnas for crispr genome editing
KR20210045360A (ko) * 2018-05-16 2021-04-26 신테고 코포레이션 가이드 rna 설계 및 사용을 위한 방법 및 시스템
WO2019237069A1 (en) * 2018-06-08 2019-12-12 Intellia Therapeutics, Inc. Modified guide rnas for gene editing

Similar Documents

Publication Publication Date Title
AU2005327517B2 (en) Oligonucleotides comprising a non-phosphate backbone linkage
EP1913011B1 (en) Oligonucleotides comprising a ligand tethered to a modified or non-natural nucleobase
JP2021040665A (ja) 多標的単一体コンジュゲート
EP3018208B1 (en) Improved nanoparticle type oligonucleotide structure having high efficiency and method for preparing same
EP4605531A1 (en) Heteroduplex rna editing oligonucleotide complexes
JP7690979B2 (ja) 一本鎖オリゴヌクレオチド
JP2009524419A (ja) Ｌｎａ修飾したホスホロチオール化オリゴヌクレオチド
TWI709406B (zh) 寡核酸組合物及其製備方法
CA3037042A1 (en) Modified oligonucleotides and methods of use
US20140350080A1 (en) Inhibition of viral gene expression
KR102401252B1 (ko) 다가 양이온 염 조성물을 사용한 폴리뉴클레오티드 제조의 방법
JP2020528910A (ja) オリゴヌクレオチド化合物の調製方法
CN118541482A (zh) 一种dsRNA、其制备方法及应用
Watts The medicinal chemistry of antisense oligonucleotides
US8247540B2 (en) Caged nucleotides and oligonucleotides and their application
JPWO2021231606A5 (https=)
WO2022219409A2 (en) Compositions containing nucleic acid nanoparticles and processes related to alteration of their physicochemical characteristics
AU2024353921A1 (en) Novel sirna constructs, therapeutics, and modifications
CN119144601A (zh) 抑制羧肽酶B2基因表达的siRNA、其缀合物和药物组合物及用途
JP2024535869A (ja) Ｗｆｄｃ２の発現を調節するアンチセンス化合物
WO1995031470A2 (en) Antisense inhibitors of gene expression
WO2024006672A2 (en) Modified guide rnas for crispr genome editing
EP4673453A1 (en) Double stranded oligonucleotide compositions for rna interference and methods relating thereto
Montulet Optimization of the Chemical Modification and Conjugation of Exon Skipping Antisense Oligonucleotides for the Gene Therapy of Duchenne Muscular Dystrophy
WO2025223315A1 (zh) 一种用于肝脏特异性递送的多靶标双链rna偶联物及药物组合物