JP2023526057A - Ｃｒｉｓｐｒゲノム編集のための修飾されたガイドｒｎａ - Google Patents

Ｃｒｉｓｐｒゲノム編集のための修飾されたガイドｒｎａ Download PDF

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JP2023526057A
JP2023526057A JP2022568828A JP2022568828A JP2023526057A JP 2023526057 A JP2023526057 A JP 2023526057A JP 2022568828 A JP2022568828 A JP 2022568828A JP 2022568828 A JP2022568828 A JP 2022568828A JP 2023526057 A JP2023526057 A JP 2023526057A
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chemically modified
crrna
guide rna
tracrrna
rna
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JPWO2021231606A5 (https=
JP2023526057A5 (https=
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ジョセフ ソンタイマー，エリック
コボロバ，アナスタシア
ケネス ワッツ，ジョナサン
アムラニ，ナディア
チェン，ゾーシャン
ハスラー，マシュー
エチェベリア モレノ，ディマス
フランシス オルターマン，ジュリア
ウォルフ，スコット
建 山田
デビ，ギタリ
ジャン，ハン
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University of Massachusetts Amherst
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University of Massachusetts Amherst
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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JP2022568828A 2020-05-12 2021-05-12 Ｃｒｉｓｐｒゲノム編集のための修飾されたガイドｒｎａ Pending JP2023526057A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063023313P 2020-05-12 2020-05-12
US63/023,313 2020-05-12
PCT/US2021/032038 WO2021231606A2 (en) 2020-05-12 2021-05-12 Modified guide rnas for crispr genome editing

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JP2023526057A true JP2023526057A (ja) 2023-06-20
JPWO2021231606A5 JPWO2021231606A5 (https=) 2024-05-22
JP2023526057A5 JP2023526057A5 (https=) 2024-05-22

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JP2022568828A Pending JP2023526057A (ja) 2020-05-12 2021-05-12 Ｃｒｉｓｐｒゲノム編集のための修飾されたガイドｒｎａ

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US (1) US20210388348A1 (https=)
EP (1) EP4150091A4 (https=)
JP (1) JP2023526057A (https=)
CN (1) CN115956120A (https=)
AU (1) AU2021271004A1 (https=)
CA (1) CA3177463A1 (https=)
WO (1) WO2021231606A2 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024053964A1 (ko) * 2022-09-06 2024-03-14 주식회사 툴젠 캄필로박터 제주니 유래 cas9의 가이드 rna 구조변화를 통한 유전자교정 향상 시스템
IL324634A (en) 2023-05-15 2026-01-01 Nchroma Bio Inc Compositions and methods for epigenetic regulation of hbv gene expression

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150252358A1 (en) * 2014-03-10 2015-09-10 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
JP2017538427A (ja) * 2014-12-18 2017-12-28 インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド Ｃｒｉｓｐｒ系組成物及び使用方法
JP2018503386A (ja) * 2015-01-28 2018-02-08 パイオニア ハイ−ブレッド インターナショナル， インコーポレイテッド Ｃｒｉｓｐｒハイブリッドｄｎａ／ｒｎａポリヌクレオチドおよび使用方法
JP2018519811A (ja) * 2015-06-29 2018-07-26 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 修飾ｃｒｉｓｐｒ ｒｎａ及び修飾単一ｃｒｉｓｐｒ ｒｎａならびにその使用
WO2019011118A1 (zh) * 2017-07-14 2019-01-17 苏州克睿基因生物科技有限公司 一种基因编辑系统及基因编辑的方法
WO2019183000A1 (en) * 2018-03-19 2019-09-26 University Of Massachusetts Modified guide rnas for crispr genome editing
WO2019237069A1 (en) * 2018-06-08 2019-12-12 Intellia Therapeutics, Inc. Modified guide rnas for gene editing
JP2019536464A (ja) * 2016-12-08 2019-12-19 インテリア セラピューティクス，インコーポレイテッド 修飾されたガイドｒｎａ

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107709555A (zh) * 2015-05-15 2018-02-16 达尔马科恩有限公司 用于Cas9介导的基因编辑的合成的单向导RNA
WO2017058751A1 (en) * 2015-09-28 2017-04-06 North Carolina State University Methods and compositions for sequence specific antimicrobials
CA2947904A1 (en) * 2015-11-12 2017-05-12 Pfizer Inc. Tissue-specific genome engineering using crispr-cas9
CA3034931A1 (en) * 2016-09-23 2018-03-29 Board Of Trustees Of Southern Illinois University Tuning crispr/cas9 activity with chemically modified nucleotide substitutions
WO2018111946A1 (en) * 2016-12-12 2018-06-21 Integrated Dna Technologies, Inc. Genome editing detection
KR20210045360A (ko) * 2018-05-16 2021-04-26 신테고 코포레이션 가이드 rna 설계 및 사용을 위한 방법 및 시스템

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150252358A1 (en) * 2014-03-10 2015-09-10 Editas Medicine, Inc. Crispr/cas-related methods and compositions for treating leber's congenital amaurosis 10 (lca10)
JP2017538427A (ja) * 2014-12-18 2017-12-28 インテグレイテッド ディーエヌエイ テクノロジーズ インコーポレイテッド Ｃｒｉｓｐｒ系組成物及び使用方法
JP2018503386A (ja) * 2015-01-28 2018-02-08 パイオニア ハイ−ブレッド インターナショナル， インコーポレイテッド Ｃｒｉｓｐｒハイブリッドｄｎａ／ｒｎａポリヌクレオチドおよび使用方法
JP2018519811A (ja) * 2015-06-29 2018-07-26 アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． 修飾ｃｒｉｓｐｒ ｒｎａ及び修飾単一ｃｒｉｓｐｒ ｒｎａならびにその使用
JP2019536464A (ja) * 2016-12-08 2019-12-19 インテリア セラピューティクス，インコーポレイテッド 修飾されたガイドｒｎａ
WO2019011118A1 (zh) * 2017-07-14 2019-01-17 苏州克睿基因生物科技有限公司 一种基因编辑系统及基因编辑的方法
WO2019183000A1 (en) * 2018-03-19 2019-09-26 University Of Massachusetts Modified guide rnas for crispr genome editing
WO2019237069A1 (en) * 2018-06-08 2019-12-12 Intellia Therapeutics, Inc. Modified guide rnas for gene editing

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Publication number Publication date
WO2021231606A3 (en) 2021-12-16
EP4150091A4 (en) 2025-07-23
CA3177463A1 (en) 2021-11-18
WO2021231606A2 (en) 2021-11-18
AU2021271004A1 (en) 2023-01-19
CN115956120A (zh) 2023-04-11
US20210388348A1 (en) 2021-12-16
EP4150091A2 (en) 2023-03-22

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